RNA editing complex protein MP67

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP67

Species:

Leishmania infantum

UniProt:

A4ICP2_LEIIN

TriTrypDb:

LINF_360014900

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	9
GO:0004525	ribonuclease III activity	6	9
GO:0004540	RNA nuclease activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	9
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	9
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:0004129	cytochrome-c oxidase activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0009055	electron transfer activity	3	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016491	oxidoreductase activity	2	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.435
CLV_NRD_NRD_1	171	173	PF00675	0.367
CLV_NRD_NRD_1	183	185	PF00675	0.691
CLV_NRD_NRD_1	203	205	PF00675	0.310
CLV_NRD_NRD_1	404	406	PF00675	0.578
CLV_NRD_NRD_1	434	436	PF00675	0.620
CLV_NRD_NRD_1	441	443	PF00675	0.605
CLV_NRD_NRD_1	465	467	PF00675	0.715
CLV_NRD_NRD_1	485	487	PF00675	0.409
CLV_NRD_NRD_1	578	580	PF00675	0.705
CLV_PCSK_KEX2_1	111	113	PF00082	0.708
CLV_PCSK_KEX2_1	171	173	PF00082	0.338
CLV_PCSK_KEX2_1	183	185	PF00082	0.454
CLV_PCSK_KEX2_1	203	205	PF00082	0.230
CLV_PCSK_KEX2_1	37	39	PF00082	0.432
CLV_PCSK_KEX2_1	404	406	PF00082	0.552
CLV_PCSK_KEX2_1	433	435	PF00082	0.616
CLV_PCSK_KEX2_1	441	443	PF00082	0.598
CLV_PCSK_KEX2_1	450	452	PF00082	0.513
CLV_PCSK_KEX2_1	465	467	PF00082	0.709
CLV_PCSK_KEX2_1	578	580	PF00082	0.705
CLV_PCSK_KEX2_1	76	78	PF00082	0.468
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.576
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.495
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.526
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.468
CLV_PCSK_SKI1_1	150	154	PF00082	0.521
CLV_PCSK_SKI1_1	156	160	PF00082	0.460
CLV_PCSK_SKI1_1	208	212	PF00082	0.325
CLV_PCSK_SKI1_1	217	221	PF00082	0.318
CLV_PCSK_SKI1_1	25	29	PF00082	0.583
CLV_PCSK_SKI1_1	259	263	PF00082	0.462
CLV_PCSK_SKI1_1	329	333	PF00082	0.397
CLV_PCSK_SKI1_1	550	554	PF00082	0.514
CLV_PCSK_SKI1_1	71	75	PF00082	0.449
DEG_APCC_DBOX_1	207	215	PF00400	0.418
DEG_APCC_DBOX_1	549	557	PF00400	0.505
DOC_CDC14_PxL_1	422	430	PF14671	0.559
DOC_CYCLIN_RxL_1	150	164	PF00134	0.365
DOC_MAPK_gen_1	183	189	PF00069	0.659
DOC_MAPK_gen_1	203	213	PF00069	0.261
DOC_MAPK_gen_1	433	440	PF00069	0.641
DOC_MAPK_gen_1	441	447	PF00069	0.542
DOC_MAPK_gen_1	76	83	PF00069	0.453
DOC_MAPK_HePTP_8	158	170	PF00069	0.273
DOC_MAPK_MEF2A_6	161	170	PF00069	0.411
DOC_MAPK_MEF2A_6	433	440	PF00069	0.631
DOC_MAPK_MEF2A_6	76	85	PF00069	0.456
DOC_PP1_RVXF_1	327	334	PF00149	0.396
DOC_PP2B_LxvP_1	95	98	PF13499	0.541
DOC_USP7_MATH_1	127	131	PF00917	0.564
DOC_USP7_MATH_1	287	291	PF00917	0.303
DOC_USP7_MATH_1	436	440	PF00917	0.622
DOC_USP7_MATH_1	446	450	PF00917	0.669
DOC_USP7_MATH_1	469	473	PF00917	0.566
DOC_USP7_MATH_1	520	524	PF00917	0.745
DOC_USP7_MATH_1	98	102	PF00917	0.553
DOC_USP7_MATH_2	98	104	PF00917	0.504
DOC_WW_Pin1_4	120	125	PF00397	0.516
DOC_WW_Pin1_4	136	141	PF00397	0.386
DOC_WW_Pin1_4	233	238	PF00397	0.448
DOC_WW_Pin1_4	259	264	PF00397	0.374
DOC_WW_Pin1_4	456	461	PF00397	0.614
DOC_WW_Pin1_4	530	535	PF00397	0.611
DOC_WW_Pin1_4	536	541	PF00397	0.584
DOC_WW_Pin1_4	89	94	PF00397	0.525
LIG_14-3-3_CanoR_1	112	118	PF00244	0.652
LIG_14-3-3_CanoR_1	156	161	PF00244	0.553
LIG_14-3-3_CanoR_1	172	178	PF00244	0.302
LIG_14-3-3_CanoR_1	184	190	PF00244	0.471
LIG_14-3-3_CanoR_1	191	196	PF00244	0.315
LIG_14-3-3_CanoR_1	221	227	PF00244	0.529
LIG_14-3-3_CanoR_1	25	33	PF00244	0.394
LIG_14-3-3_CanoR_1	265	270	PF00244	0.338
LIG_14-3-3_CanoR_1	350	356	PF00244	0.483
LIG_14-3-3_CanoR_1	435	441	PF00244	0.557
LIG_14-3-3_CanoR_1	451	460	PF00244	0.486
LIG_14-3-3_CanoR_1	554	564	PF00244	0.492
LIG_14-3-3_CanoR_1	565	569	PF00244	0.430
LIG_14-3-3_CanoR_1	573	577	PF00244	0.638
LIG_Actin_WH2_2	373	391	PF00022	0.439
LIG_BRCT_BRCA1_1	109	113	PF00533	0.543
LIG_BRCT_BRCA1_1	138	142	PF00533	0.511
LIG_BRCT_BRCA1_1	185	189	PF00533	0.492
LIG_eIF4E_1	136	142	PF01652	0.513
LIG_FHA_1	276	282	PF00498	0.374
LIG_FHA_1	333	339	PF00498	0.596
LIG_FHA_1	575	581	PF00498	0.760
LIG_FHA_2	157	163	PF00498	0.481
LIG_FHA_2	26	32	PF00498	0.466
LIG_FHA_2	361	367	PF00498	0.344
LIG_FHA_2	389	395	PF00498	0.433
LIG_FHA_2	82	88	PF00498	0.432
LIG_HP1_1	70	74	PF01393	0.356
LIG_LIR_Apic_2	342	347	PF02991	0.539
LIG_LIR_Gen_1	130	140	PF02991	0.502
LIG_LIR_Gen_1	162	170	PF02991	0.354
LIG_LIR_Gen_1	186	195	PF02991	0.504
LIG_LIR_Gen_1	245	253	PF02991	0.425
LIG_LIR_Nem_3	130	135	PF02991	0.569
LIG_LIR_Nem_3	162	166	PF02991	0.406
LIG_LIR_Nem_3	186	192	PF02991	0.478
LIG_LIR_Nem_3	245	250	PF02991	0.432
LIG_LIR_Nem_3	255	261	PF02991	0.427
LIG_LIR_Nem_3	299	303	PF02991	0.331
LIG_LIR_Nem_3	342	346	PF02991	0.479
LIG_MAD2	25	33	PF02301	0.417
LIG_MYND_1	93	97	PF01753	0.513
LIG_NRBOX	327	333	PF00104	0.391
LIG_Pex14_1	205	209	PF04695	0.353
LIG_Pex14_1	339	343	PF04695	0.502
LIG_PTAP_UEV_1	539	544	PF05743	0.527
LIG_REV1ctd_RIR_1	254	262	PF16727	0.357
LIG_RPA_C_Fungi	199	211	PF08784	0.371
LIG_SH2_CRK	154	158	PF00017	0.422
LIG_SH2_CRK	298	302	PF00017	0.338
LIG_SH2_CRK	344	348	PF00017	0.482
LIG_SH2_CRK	422	426	PF00017	0.551
LIG_SH2_NCK_1	105	109	PF00017	0.770
LIG_SH2_NCK_1	344	348	PF00017	0.482
LIG_SH2_SRC	136	139	PF00017	0.484
LIG_SH2_STAP1	41	45	PF00017	0.372
LIG_SH2_STAT5	209	212	PF00017	0.403
LIG_SH2_STAT5	283	286	PF00017	0.342
LIG_SH2_STAT5	300	303	PF00017	0.284
LIG_SH2_STAT5	355	358	PF00017	0.358
LIG_SH2_STAT5	395	398	PF00017	0.513
LIG_SH3_1	421	427	PF00018	0.544
LIG_SH3_2	460	465	PF14604	0.583
LIG_SH3_3	121	127	PF00018	0.543
LIG_SH3_3	421	427	PF00018	0.544
LIG_SH3_3	454	460	PF00018	0.633
LIG_SH3_3	528	534	PF00018	0.612
LIG_SH3_3	537	543	PF00018	0.543
LIG_SH3_3	90	96	PF00018	0.585
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.392
LIG_SUMO_SIM_par_1	156	162	PF11976	0.307
LIG_SUMO_SIM_par_1	190	199	PF11976	0.472
LIG_SUMO_SIM_par_1	293	299	PF11976	0.390
LIG_TRAF2_1	391	394	PF00917	0.340
LIG_TRAF2_1	9	12	PF00917	0.513
LIG_TRAF2_1	97	100	PF00917	0.510
LIG_TRAF2_2	97	102	PF00917	0.509
LIG_UBA3_1	210	215	PF00899	0.343
LIG_WRC_WIRS_1	82	87	PF05994	0.412
LIG_WW_3	180	184	PF00397	0.455
MOD_CDK_SPxK_1	259	265	PF00069	0.369
MOD_CDK_SPxxK_3	233	240	PF00069	0.442
MOD_CK1_1	101	107	PF00069	0.534
MOD_CK1_1	116	122	PF00069	0.645
MOD_CK1_1	194	200	PF00069	0.376
MOD_CK1_1	222	228	PF00069	0.443
MOD_CK1_1	449	455	PF00069	0.707
MOD_CK1_1	522	528	PF00069	0.678
MOD_CK1_1	58	64	PF00069	0.554
MOD_CK1_1	91	97	PF00069	0.567
MOD_CK2_1	156	162	PF00069	0.490
MOD_CK2_1	18	24	PF00069	0.396
MOD_CK2_1	193	199	PF00069	0.416
MOD_CK2_1	233	239	PF00069	0.535
MOD_CK2_1	360	366	PF00069	0.345
MOD_CK2_1	388	394	PF00069	0.379
MOD_CK2_1	81	87	PF00069	0.423
MOD_Cter_Amidation	35	38	PF01082	0.390
MOD_Cter_Amidation	484	487	PF01082	0.499
MOD_GlcNHglycan	34	37	PF01048	0.512
MOD_GlcNHglycan	406	409	PF01048	0.537
MOD_GlcNHglycan	526	529	PF01048	0.588
MOD_GlcNHglycan	544	547	PF01048	0.483
MOD_GlcNHglycan	566	569	PF01048	0.584
MOD_GSK3_1	103	110	PF00069	0.572
MOD_GSK3_1	111	118	PF00069	0.643
MOD_GSK3_1	191	198	PF00069	0.492
MOD_GSK3_1	452	459	PF00069	0.802
MOD_GSK3_1	501	508	PF00069	0.545
MOD_GSK3_1	519	526	PF00069	0.668
MOD_GSK3_1	538	545	PF00069	0.561
MOD_GSK3_1	548	555	PF00069	0.489
MOD_GSK3_1	58	65	PF00069	0.472
MOD_N-GLC_1	523	528	PF02516	0.550
MOD_NEK2_1	107	112	PF00069	0.659
MOD_NEK2_1	113	118	PF00069	0.666
MOD_NEK2_1	193	198	PF00069	0.528
MOD_NEK2_1	213	218	PF00069	0.374
MOD_NEK2_1	257	262	PF00069	0.481
MOD_NEK2_1	367	372	PF00069	0.331
MOD_NEK2_1	376	381	PF00069	0.277
MOD_NEK2_1	501	506	PF00069	0.555
MOD_NEK2_1	55	60	PF00069	0.457
MOD_NEK2_1	75	80	PF00069	0.468
MOD_NEK2_1	81	86	PF00069	0.414
MOD_NEK2_2	173	178	PF00069	0.420
MOD_NEK2_2	436	441	PF00069	0.508
MOD_PIKK_1	503	509	PF00454	0.507
MOD_PKA_1	111	117	PF00069	0.494
MOD_PKA_1	183	189	PF00069	0.498
MOD_PKA_1	404	410	PF00069	0.530
MOD_PKA_1	487	493	PF00069	0.469
MOD_PKA_2	111	117	PF00069	0.605
MOD_PKA_2	183	189	PF00069	0.498
MOD_PKA_2	349	355	PF00069	0.489
MOD_PKA_2	404	410	PF00069	0.530
MOD_PKA_2	452	458	PF00069	0.578
MOD_PKA_2	564	570	PF00069	0.663
MOD_PKA_2	572	578	PF00069	0.592
MOD_Plk_1	101	107	PF00069	0.703
MOD_Plk_1	376	382	PF00069	0.377
MOD_Plk_4	265	271	PF00069	0.355
MOD_Plk_4	367	373	PF00069	0.495
MOD_Plk_4	81	87	PF00069	0.358
MOD_ProDKin_1	120	126	PF00069	0.513
MOD_ProDKin_1	136	142	PF00069	0.377
MOD_ProDKin_1	233	239	PF00069	0.447
MOD_ProDKin_1	259	265	PF00069	0.369
MOD_ProDKin_1	456	462	PF00069	0.612
MOD_ProDKin_1	530	536	PF00069	0.612
MOD_ProDKin_1	89	95	PF00069	0.542
MOD_SUMO_rev_2	322	331	PF00179	0.328
MOD_SUMO_rev_2	63	70	PF00179	0.355
TRG_DiLeu_BaEn_1	327	332	PF01217	0.387
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.439
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.534
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.469
TRG_ENDOCYTIC_2	298	301	PF00928	0.299
TRG_ENDOCYTIC_2	343	346	PF00928	0.468
TRG_ENDOCYTIC_2	422	425	PF00928	0.552
TRG_ER_diArg_1	170	172	PF00400	0.361
TRG_ER_diArg_1	182	184	PF00400	0.693
TRG_ER_diArg_1	202	204	PF00400	0.288
TRG_ER_diArg_1	205	208	PF00400	0.342
TRG_ER_diArg_1	433	435	PF00400	0.671
TRG_ER_diArg_1	440	442	PF00400	0.657
TRG_ER_diArg_1	464	466	PF00400	0.658
TRG_ER_diArg_1	578	580	PF00400	0.694
TRG_NLS_Bipartite_1	433	454	PF00514	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V7	Leptomonas seymouri	39%	93%
A0A1X0P8F1	Trypanosomatidae	34%	90%
A0A3S7XAF0	Leishmania donovani	100%	100%
A0A422MWV0	Trypanosoma rangeli	35%	98%
E9AIX5	Leishmania braziliensis	77%	100%
E9ASL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1Y4	Leishmania major	93%	100%