LeishMANIAdb
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RNA editing complex protein MP67

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA editing complex protein MP67
Gene product:
RNA editing complex protein MP67
Species:
Leishmania infantum
UniProt:
A4ICP2_LEIIN
TriTrypDb:
LINF_360014900
Length:
582

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4ICP2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP2

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006396 RNA processing 6 9
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016070 RNA metabolic process 5 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0043170 macromolecule metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 9
GO:0004129 cytochrome-c oxidase activity 4 1
GO:0004518 nuclease activity 4 9
GO:0004519 endonuclease activity 5 9
GO:0004521 RNA endonuclease activity 5 9
GO:0004525 ribonuclease III activity 6 9
GO:0004540 RNA nuclease activity 4 9
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0009055 electron transfer activity 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 16 18 PF00675 0.435
CLV_NRD_NRD_1 171 173 PF00675 0.367
CLV_NRD_NRD_1 183 185 PF00675 0.691
CLV_NRD_NRD_1 203 205 PF00675 0.310
CLV_NRD_NRD_1 404 406 PF00675 0.578
CLV_NRD_NRD_1 434 436 PF00675 0.620
CLV_NRD_NRD_1 441 443 PF00675 0.605
CLV_NRD_NRD_1 465 467 PF00675 0.715
CLV_NRD_NRD_1 485 487 PF00675 0.409
CLV_NRD_NRD_1 578 580 PF00675 0.705
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7V7 Leptomonas seymouri 39% 93%
A0A1X0P8F1 Trypanosomatidae 34% 90%
A0A3S7XAF0 Leishmania donovani 100% 100%
A0A422MWV0 Trypanosoma rangeli 35% 98%
E9AIX5 Leishmania braziliensis 77% 100%
E9ASL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q1Y4 Leishmania major 93% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS