LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICN8_LEIIN
TriTrypDb:
LINF_360015400
Length:
916

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4ICN8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICN8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 239 243 PF00656 0.724
CLV_C14_Caspase3-7 323 327 PF00656 0.454
CLV_C14_Caspase3-7 643 647 PF00656 0.700
CLV_C14_Caspase3-7 747 751 PF00656 0.815
CLV_NRD_NRD_1 163 165 PF00675 0.681
CLV_NRD_NRD_1 30 32 PF00675 0.552
CLV_NRD_NRD_1 387 389 PF00675 0.544
CLV_NRD_NRD_1 407 409 PF00675 0.635
CLV_NRD_NRD_1 446 448 PF00675 0.638
CLV_NRD_NRD_1 458 460 PF00675 0.492
CLV_NRD_NRD_1 589 591 PF00675 0.484
CLV_NRD_NRD_1 617 619 PF00675 0.608
CLV_NRD_NRD_1 665 667 PF00675 0.604
CLV_NRD_NRD_1 906 908 PF00675 0.529
CLV_NRD_NRD_1 909 911 PF00675 0.497
CLV_PCSK_FUR_1 587 591 PF00082 0.483
CLV_PCSK_FUR_1 614 618 PF00082 0.568
CLV_PCSK_FUR_1 907 911 PF00082 0.519
CLV_PCSK_KEX2_1 163 165 PF00082 0.709
CLV_PCSK_KEX2_1 387 389 PF00082 0.544
CLV_PCSK_KEX2_1 407 409 PF00082 0.635
CLV_PCSK_KEX2_1 445 447 PF00082 0.636
CLV_PCSK_KEX2_1 458 460 PF00082 0.485
CLV_PCSK_KEX2_1 589 591 PF00082 0.484
CLV_PCSK_KEX2_1 616 618 PF00082 0.642
CLV_PCSK_KEX2_1 665 667 PF00082 0.604
CLV_PCSK_KEX2_1 869 871 PF00082 0.491
CLV_PCSK_KEX2_1 908 910 PF00082 0.520
CLV_PCSK_PC1ET2_1 869 871 PF00082 0.491
CLV_PCSK_PC1ET2_1 908 910 PF00082 0.520
CLV_PCSK_PC7_1 383 389 PF00082 0.528
CLV_PCSK_PC7_1 403 409 PF00082 0.553
CLV_PCSK_SKI1_1 387 391 PF00082 0.505
CLV_PCSK_SKI1_1 41 45 PF00082 0.516
CLV_PCSK_SKI1_1 471 475 PF00082 0.484
CLV_PCSK_SKI1_1 652 656 PF00082 0.638
DEG_APCC_DBOX_1 142 150 PF00400 0.492
DEG_APCC_DBOX_1 382 390 PF00400 0.722
DEG_APCC_KENBOX_2 767 771 PF00400 0.700
DEG_SCF_FBW7_1 15 22 PF00400 0.788
DEG_SPOP_SBC_1 413 417 PF00917 0.681
DEG_SPOP_SBC_1 673 677 PF00917 0.829
DEG_SPOP_SBC_1 794 798 PF00917 0.868
DEG_SPOP_SBC_1 810 814 PF00917 0.678
DOC_CKS1_1 16 21 PF01111 0.787
DOC_CKS1_1 270 275 PF01111 0.670
DOC_CYCLIN_yCln2_LP_2 253 259 PF00134 0.767
DOC_MAPK_gen_1 266 276 PF00069 0.670
DOC_MAPK_gen_1 510 519 PF00069 0.574
DOC_MAPK_gen_1 684 691 PF00069 0.783
DOC_MAPK_gen_1 766 775 PF00069 0.703
DOC_PP2B_LxvP_1 14 17 PF13499 0.764
DOC_PP2B_LxvP_1 253 256 PF13499 0.691
DOC_PP4_FxxP_1 449 452 PF00568 0.749
DOC_PP4_FxxP_1 522 525 PF00568 0.678
DOC_PP4_FxxP_1 679 682 PF00568 0.807
DOC_USP7_MATH_1 102 106 PF00917 0.601
DOC_USP7_MATH_1 342 346 PF00917 0.443
DOC_USP7_MATH_1 413 417 PF00917 0.771
DOC_USP7_MATH_1 43 47 PF00917 0.748
DOC_USP7_MATH_1 489 493 PF00917 0.610
DOC_USP7_MATH_1 596 600 PF00917 0.729
DOC_USP7_MATH_1 622 626 PF00917 0.737
DOC_USP7_MATH_1 673 677 PF00917 0.885
DOC_USP7_MATH_1 682 686 PF00917 0.770
DOC_USP7_MATH_1 702 706 PF00917 0.614
DOC_USP7_MATH_1 714 718 PF00917 0.669
DOC_USP7_MATH_1 743 747 PF00917 0.756
DOC_USP7_MATH_1 801 805 PF00917 0.820
DOC_USP7_MATH_1 809 813 PF00917 0.758
DOC_USP7_UBL2_3 762 766 PF12436 0.799
DOC_USP7_UBL2_3 858 862 PF12436 0.708
DOC_WW_Pin1_4 114 119 PF00397 0.522
DOC_WW_Pin1_4 15 20 PF00397 0.789
DOC_WW_Pin1_4 189 194 PF00397 0.524
DOC_WW_Pin1_4 269 274 PF00397 0.682
DOC_WW_Pin1_4 421 426 PF00397 0.693
DOC_WW_Pin1_4 448 453 PF00397 0.733
DOC_WW_Pin1_4 618 623 PF00397 0.787
DOC_WW_Pin1_4 678 683 PF00397 0.794
DOC_WW_Pin1_4 892 897 PF00397 0.738
LIG_14-3-3_CanoR_1 126 130 PF00244 0.413
LIG_14-3-3_CanoR_1 387 395 PF00244 0.718
LIG_14-3-3_CanoR_1 458 464 PF00244 0.784
LIG_14-3-3_CanoR_1 626 635 PF00244 0.744
LIG_14-3-3_CanoR_1 778 785 PF00244 0.749
LIG_14-3-3_CanoR_1 788 794 PF00244 0.773
LIG_14-3-3_CanoR_1 870 875 PF00244 0.726
LIG_BIR_II_1 1 5 PF00653 0.686
LIG_BIR_III_4 106 110 PF00653 0.501
LIG_BRCT_BRCA1_1 363 367 PF00533 0.422
LIG_BRCT_BRCA1_1 434 438 PF00533 0.669
LIG_BRCT_BRCA1_1 491 495 PF00533 0.710
LIG_BRCT_BRCA1_1 598 602 PF00533 0.685
LIG_BRCT_BRCA1_1 675 679 PF00533 0.827
LIG_deltaCOP1_diTrp_1 847 852 PF00928 0.692
LIG_EVH1_1 16 20 PF00568 0.787
LIG_FHA_1 126 132 PF00498 0.418
LIG_FHA_1 195 201 PF00498 0.447
LIG_FHA_1 20 26 PF00498 0.744
LIG_FHA_1 207 213 PF00498 0.333
LIG_FHA_1 230 236 PF00498 0.665
LIG_FHA_1 270 276 PF00498 0.588
LIG_FHA_1 290 296 PF00498 0.311
LIG_FHA_1 413 419 PF00498 0.710
LIG_FHA_1 488 494 PF00498 0.664
LIG_FHA_1 50 56 PF00498 0.661
LIG_FHA_1 502 508 PF00498 0.615
LIG_FHA_1 547 553 PF00498 0.765
LIG_FHA_1 707 713 PF00498 0.722
LIG_FHA_1 782 788 PF00498 0.781
LIG_FHA_2 237 243 PF00498 0.713
LIG_FHA_2 646 652 PF00498 0.715
LIG_FHA_2 862 868 PF00498 0.708
LIG_LIR_Apic_2 676 682 PF02991 0.818
LIG_LIR_Apic_2 719 724 PF02991 0.772
LIG_LIR_Apic_2 873 877 PF02991 0.723
LIG_LIR_Gen_1 175 186 PF02991 0.468
LIG_LIR_Gen_1 282 290 PF02991 0.328
LIG_LIR_Gen_1 344 353 PF02991 0.444
LIG_LIR_Gen_1 426 437 PF02991 0.749
LIG_LIR_Gen_1 492 501 PF02991 0.670
LIG_LIR_Gen_1 769 776 PF02991 0.764
LIG_LIR_Gen_1 847 855 PF02991 0.792
LIG_LIR_Nem_3 119 125 PF02991 0.519
LIG_LIR_Nem_3 175 181 PF02991 0.460
LIG_LIR_Nem_3 282 287 PF02991 0.426
LIG_LIR_Nem_3 319 324 PF02991 0.430
LIG_LIR_Nem_3 344 349 PF02991 0.444
LIG_LIR_Nem_3 364 370 PF02991 0.208
LIG_LIR_Nem_3 468 473 PF02991 0.746
LIG_LIR_Nem_3 492 498 PF02991 0.678
LIG_LIR_Nem_3 769 775 PF02991 0.764
LIG_LIR_Nem_3 847 851 PF02991 0.788
LIG_MLH1_MIPbox_1 434 438 PF16413 0.707
LIG_OCRL_FandH_1 367 379 PF00620 0.564
LIG_PCNA_PIPBox_1 261 270 PF02747 0.665
LIG_Pex14_1 40 44 PF04695 0.757
LIG_Pex14_1 848 852 PF04695 0.721
LIG_REV1ctd_RIR_1 365 375 PF16727 0.543
LIG_SH2_CRK 178 182 PF00017 0.438
LIG_SH2_CRK 470 474 PF00017 0.686
LIG_SH2_CRK 721 725 PF00017 0.714
LIG_SH2_GRB2like 96 99 PF00017 0.523
LIG_SH2_NCK_1 173 177 PF00017 0.511
LIG_SH2_NCK_1 322 326 PF00017 0.498
LIG_SH2_NCK_1 721 725 PF00017 0.714
LIG_SH2_PTP2 346 349 PF00017 0.461
LIG_SH2_PTP2 76 79 PF00017 0.499
LIG_SH2_SRC 173 176 PF00017 0.513
LIG_SH2_SRC 178 181 PF00017 0.461
LIG_SH2_SRC 721 724 PF00017 0.741
LIG_SH2_STAT3 725 728 PF00017 0.787
LIG_SH2_STAT3 86 89 PF00017 0.410
LIG_SH2_STAT5 180 183 PF00017 0.518
LIG_SH2_STAT5 346 349 PF00017 0.538
LIG_SH2_STAT5 57 60 PF00017 0.591
LIG_SH2_STAT5 76 79 PF00017 0.298
LIG_SH2_STAT5 772 775 PF00017 0.707
LIG_SH3_1 616 622 PF00018 0.755
LIG_SH3_3 14 20 PF00018 0.786
LIG_SH3_3 252 258 PF00018 0.675
LIG_SH3_3 329 335 PF00018 0.456
LIG_SH3_3 419 425 PF00018 0.679
LIG_SH3_3 560 566 PF00018 0.741
LIG_SH3_3 616 622 PF00018 0.755
LIG_SH3_3 788 794 PF00018 0.718
LIG_SUMO_SIM_anti_2 209 215 PF11976 0.527
LIG_SUMO_SIM_par_1 272 277 PF11976 0.588
LIG_SUMO_SIM_par_1 415 424 PF11976 0.777
LIG_TRAF2_1 172 175 PF00917 0.517
LIG_TRAF2_1 478 481 PF00917 0.753
LIG_WRC_WIRS_1 200 205 PF05994 0.472
LIG_WRC_WIRS_1 350 355 PF05994 0.461
LIG_WW_3 662 666 PF00397 0.756
MOD_CDC14_SPxK_1 681 684 PF00782 0.748
MOD_CDK_SPxK_1 678 684 PF00069 0.750
MOD_CDK_SPxxK_3 189 196 PF00069 0.594
MOD_CK1_1 144 150 PF00069 0.656
MOD_CK1_1 199 205 PF00069 0.564
MOD_CK1_1 237 243 PF00069 0.673
MOD_CK1_1 289 295 PF00069 0.482
MOD_CK1_1 421 427 PF00069 0.654
MOD_CK1_1 678 684 PF00069 0.812
MOD_CK1_1 69 75 PF00069 0.538
MOD_CK1_1 780 786 PF00069 0.658
MOD_CK1_1 836 842 PF00069 0.707
MOD_CK1_1 880 886 PF00069 0.670
MOD_CK1_1 892 898 PF00069 0.576
MOD_CK1_1 97 103 PF00069 0.713
MOD_CK2_1 448 454 PF00069 0.615
MOD_CK2_1 551 557 PF00069 0.615
MOD_CK2_1 655 661 PF00069 0.694
MOD_CK2_1 853 859 PF00069 0.744
MOD_Cter_Amidation 161 164 PF01082 0.530
MOD_DYRK1A_RPxSP_1 618 622 PF00069 0.692
MOD_GlcNHglycan 149 152 PF01048 0.710
MOD_GlcNHglycan 154 157 PF01048 0.628
MOD_GlcNHglycan 27 30 PF01048 0.634
MOD_GlcNHglycan 276 279 PF01048 0.497
MOD_GlcNHglycan 355 358 PF01048 0.538
MOD_GlcNHglycan 363 366 PF01048 0.406
MOD_GlcNHglycan 691 694 PF01048 0.757
MOD_GlcNHglycan 71 74 PF01048 0.538
MOD_GlcNHglycan 712 715 PF01048 0.812
MOD_GlcNHglycan 716 719 PF01048 0.789
MOD_GlcNHglycan 754 758 PF01048 0.802
MOD_GlcNHglycan 779 782 PF01048 0.760
MOD_GlcNHglycan 842 845 PF01048 0.651
MOD_GlcNHglycan 880 883 PF01048 0.665
MOD_GSK3_1 15 22 PF00069 0.730
MOD_GSK3_1 192 199 PF00069 0.636
MOD_GSK3_1 208 215 PF00069 0.258
MOD_GSK3_1 285 292 PF00069 0.480
MOD_GSK3_1 330 337 PF00069 0.601
MOD_GSK3_1 349 356 PF00069 0.314
MOD_GSK3_1 403 410 PF00069 0.734
MOD_GSK3_1 414 421 PF00069 0.669
MOD_GSK3_1 423 430 PF00069 0.512
MOD_GSK3_1 49 56 PF00069 0.608
MOD_GSK3_1 598 605 PF00069 0.728
MOD_GSK3_1 618 625 PF00069 0.678
MOD_GSK3_1 673 680 PF00069 0.808
MOD_GSK3_1 689 696 PF00069 0.714
MOD_GSK3_1 702 709 PF00069 0.611
MOD_GSK3_1 710 717 PF00069 0.732
MOD_GSK3_1 776 783 PF00069 0.724
MOD_GSK3_1 789 796 PF00069 0.610
MOD_GSK3_1 799 806 PF00069 0.720
MOD_GSK3_1 809 816 PF00069 0.585
MOD_GSK3_1 836 843 PF00069 0.724
MOD_GSK3_1 84 91 PF00069 0.604
MOD_GSK3_1 877 884 PF00069 0.668
MOD_LATS_1 624 630 PF00433 0.727
MOD_N-GLC_1 237 242 PF02516 0.533
MOD_N-GLC_1 299 304 PF02516 0.606
MOD_N-GLC_1 330 335 PF02516 0.652
MOD_N-GLC_1 413 418 PF02516 0.631
MOD_N-GLC_1 840 845 PF02516 0.714
MOD_N-GLC_1 97 102 PF02516 0.737
MOD_N-GLC_2 706 708 PF02516 0.751
MOD_NEK2_1 108 113 PF00069 0.782
MOD_NEK2_1 125 130 PF00069 0.424
MOD_NEK2_1 141 146 PF00069 0.558
MOD_NEK2_1 152 157 PF00069 0.589
MOD_NEK2_1 208 213 PF00069 0.463
MOD_NEK2_1 219 224 PF00069 0.419
MOD_NEK2_1 234 239 PF00069 0.598
MOD_NEK2_1 245 250 PF00069 0.572
MOD_NEK2_1 274 279 PF00069 0.433
MOD_NEK2_1 286 291 PF00069 0.427
MOD_NEK2_1 299 304 PF00069 0.538
MOD_NEK2_1 324 329 PF00069 0.581
MOD_NEK2_1 353 358 PF00069 0.532
MOD_NEK2_1 412 417 PF00069 0.740
MOD_NEK2_1 418 423 PF00069 0.774
MOD_NEK2_1 501 506 PF00069 0.556
MOD_NEK2_1 598 603 PF00069 0.627
MOD_NEK2_1 645 650 PF00069 0.613
MOD_NEK2_1 655 660 PF00069 0.702
MOD_NEK2_1 753 758 PF00069 0.758
MOD_NEK2_1 776 781 PF00069 0.696
MOD_NEK2_1 787 792 PF00069 0.697
MOD_NEK2_2 279 284 PF00069 0.383
MOD_NEK2_2 489 494 PF00069 0.494
MOD_PIKK_1 194 200 PF00454 0.487
MOD_PIKK_1 423 429 PF00454 0.723
MOD_PIKK_1 531 537 PF00454 0.613
MOD_PIKK_1 561 567 PF00454 0.734
MOD_PIKK_1 801 807 PF00454 0.789
MOD_PIKK_1 815 821 PF00454 0.616
MOD_PIKK_1 88 94 PF00454 0.584
MOD_PK_1 459 465 PF00069 0.696
MOD_PKA_1 387 393 PF00069 0.633
MOD_PKA_1 407 413 PF00069 0.799
MOD_PKA_1 617 623 PF00069 0.729
MOD_PKA_2 125 131 PF00069 0.497
MOD_PKA_2 144 150 PF00069 0.375
MOD_PKA_2 36 42 PF00069 0.696
MOD_PKA_2 370 376 PF00069 0.559
MOD_PKA_2 387 393 PF00069 0.451
MOD_PKA_2 407 413 PF00069 0.799
MOD_PKA_2 617 623 PF00069 0.716
MOD_PKA_2 777 783 PF00069 0.680
MOD_PKA_2 787 793 PF00069 0.722
MOD_PKB_1 870 878 PF00069 0.651
MOD_Plk_1 174 180 PF00069 0.566
MOD_Plk_1 330 336 PF00069 0.590
MOD_Plk_1 413 419 PF00069 0.592
MOD_Plk_1 645 651 PF00069 0.665
MOD_Plk_1 887 893 PF00069 0.673
MOD_Plk_1 97 103 PF00069 0.741
MOD_Plk_2-3 646 652 PF00069 0.640
MOD_Plk_2-3 861 867 PF00069 0.629
MOD_Plk_4 10 16 PF00069 0.744
MOD_Plk_4 116 122 PF00069 0.673
MOD_Plk_4 208 214 PF00069 0.436
MOD_Plk_4 279 285 PF00069 0.426
MOD_Plk_4 342 348 PF00069 0.514
MOD_Plk_4 414 420 PF00069 0.693
MOD_Plk_4 501 507 PF00069 0.583
MOD_Plk_4 53 59 PF00069 0.564
MOD_Plk_4 861 867 PF00069 0.640
MOD_ProDKin_1 114 120 PF00069 0.640
MOD_ProDKin_1 15 21 PF00069 0.741
MOD_ProDKin_1 189 195 PF00069 0.654
MOD_ProDKin_1 269 275 PF00069 0.584
MOD_ProDKin_1 421 427 PF00069 0.610
MOD_ProDKin_1 448 454 PF00069 0.665
MOD_ProDKin_1 618 624 PF00069 0.737
MOD_ProDKin_1 678 684 PF00069 0.750
MOD_ProDKin_1 892 898 PF00069 0.670
MOD_SUMO_rev_2 861 871 PF00179 0.588
TRG_DiLeu_BaEn_1 116 121 PF01217 0.645
TRG_DiLeu_BaEn_1 468 473 PF01217 0.632
TRG_DiLeu_BaLyEn_6 270 275 PF01217 0.555
TRG_DiLeu_LyEn_5 468 473 PF01217 0.632
TRG_ENDOCYTIC_2 178 181 PF00928 0.567
TRG_ENDOCYTIC_2 346 349 PF00928 0.538
TRG_ENDOCYTIC_2 429 432 PF00928 0.735
TRG_ENDOCYTIC_2 470 473 PF00928 0.680
TRG_ENDOCYTIC_2 76 79 PF00928 0.427
TRG_ENDOCYTIC_2 772 775 PF00928 0.626
TRG_ER_diArg_1 142 145 PF00400 0.588
TRG_ER_diArg_1 163 165 PF00400 0.585
TRG_ER_diArg_1 386 388 PF00400 0.680
TRG_ER_diArg_1 445 447 PF00400 0.696
TRG_ER_diArg_1 458 461 PF00400 0.773
TRG_ER_diArg_1 587 590 PF00400 0.593
TRG_ER_diArg_1 614 617 PF00400 0.788
TRG_ER_diArg_1 664 666 PF00400 0.759
TRG_ER_diArg_1 906 909 PF00400 0.654
TRG_Pf-PMV_PEXEL_1 163 168 PF00026 0.588
TRG_Pf-PMV_PEXEL_1 387 391 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 471 475 PF00026 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1X5 Leptomonas seymouri 32% 100%
A0A3S7XAF2 Leishmania donovani 99% 100%
A4HNV5 Leishmania braziliensis 50% 100%
E9ASL6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q1Y0 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS