Non-structural maintenance of chromosomes element 4

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICN7_LEIIN

TriTrypDb:

LINF_360015500

Length:

228

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 35, 42

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	yes	yes: 12

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.350
CLV_NRD_NRD_1	125	127	PF00675	0.335
CLV_PCSK_SKI1_1	107	111	PF00082	0.426
CLV_PCSK_SKI1_1	126	130	PF00082	0.455
CLV_PCSK_SKI1_1	193	197	PF00082	0.337
CLV_PCSK_SKI1_1	47	51	PF00082	0.384
CLV_PCSK_SKI1_1	92	96	PF00082	0.362
DEG_APCC_DBOX_1	64	72	PF00400	0.496
DEG_APCC_DBOX_1	91	99	PF00400	0.365
DEG_Nend_UBRbox_4	1	3	PF02207	0.517
DEG_SPOP_SBC_1	3	7	PF00917	0.464
DOC_CYCLIN_RxL_1	88	99	PF00134	0.369
DOC_MAPK_gen_1	101	112	PF00069	0.346
DOC_MAPK_MEF2A_6	105	114	PF00069	0.341
DOC_MAPK_NFAT4_5	107	115	PF00069	0.341
DOC_PP1_RVXF_1	109	115	PF00149	0.323
DOC_PP4_FxxP_1	23	26	PF00568	0.560
DOC_SPAK_OSR1_1	174	178	PF12202	0.335
DOC_USP7_MATH_1	29	33	PF00917	0.472
DOC_USP7_UBL2_3	219	223	PF12436	0.401
DOC_USP7_UBL2_3	30	34	PF12436	0.479
LIG_14-3-3_CanoR_1	47	52	PF00244	0.631
LIG_Actin_WH2_2	115	132	PF00022	0.430
LIG_Actin_WH2_2	34	49	PF00022	0.505
LIG_BRCT_BRCA1_1	19	23	PF00533	0.551
LIG_eIF4E_1	17	23	PF01652	0.476
LIG_FHA_1	135	141	PF00498	0.400
LIG_FHA_1	144	150	PF00498	0.424
LIG_FHA_1	152	158	PF00498	0.340
LIG_FHA_1	16	22	PF00498	0.410
LIG_FHA_1	3	9	PF00498	0.511
LIG_FHA_2	48	54	PF00498	0.382
LIG_FHA_2	84	90	PF00498	0.362
LIG_Integrin_isoDGR_2	124	126	PF01839	0.364
LIG_LIR_Apic_2	20	26	PF02991	0.518
LIG_LIR_Nem_3	166	172	PF02991	0.310
LIG_NRBOX	93	99	PF00104	0.392
LIG_Pex14_2	114	118	PF04695	0.308
LIG_Pex14_2	212	216	PF04695	0.340
LIG_PTB_Apo_2	210	217	PF02174	0.344
LIG_SH2_STAT5	17	20	PF00017	0.477
LIG_SUMO_SIM_par_1	152	161	PF11976	0.472
LIG_SUMO_SIM_par_1	93	99	PF11976	0.475
LIG_TRAF2_1	158	161	PF00917	0.346
LIG_UBA3_1	211	219	PF00899	0.381
LIG_UBA3_1	94	102	PF00899	0.361
LIG_WRC_WIRS_1	115	120	PF05994	0.295
MOD_CK1_1	135	141	PF00069	0.421
MOD_CK1_1	15	21	PF00069	0.510
MOD_CK1_1	32	38	PF00069	0.451
MOD_CK1_1	6	12	PF00069	0.682
MOD_CK2_1	130	136	PF00069	0.543
MOD_CK2_1	155	161	PF00069	0.460
MOD_CK2_1	83	89	PF00069	0.371
MOD_Cter_Amidation	124	127	PF01082	0.350
MOD_GlcNHglycan	13	17	PF01048	0.438
MOD_GlcNHglycan	132	135	PF01048	0.496
MOD_GlcNHglycan	178	181	PF01048	0.437
MOD_GSK3_1	130	137	PF00069	0.491
MOD_GSK3_1	151	158	PF00069	0.370
MOD_GSK3_1	2	9	PF00069	0.511
MOD_N-GLC_1	39	44	PF02516	0.492
MOD_NEK2_1	129	134	PF00069	0.387
MOD_NEK2_1	218	223	PF00069	0.378
MOD_NEK2_1	39	44	PF00069	0.503
MOD_PIKK_1	39	45	PF00454	0.497
MOD_PIKK_1	6	12	PF00454	0.505
MOD_PK_1	145	151	PF00069	0.416
MOD_PKB_1	45	53	PF00069	0.471
MOD_Plk_1	12	18	PF00069	0.438
MOD_Plk_1	135	141	PF00069	0.332
MOD_Plk_1	151	157	PF00069	0.349
MOD_Plk_2-3	83	89	PF00069	0.414
MOD_Plk_4	17	23	PF00069	0.429
MOD_SUMO_for_1	84	87	PF00179	0.389
MOD_SUMO_rev_2	81	86	PF00179	0.405
TRG_DiLeu_BaEn_2	170	176	PF01217	0.306
TRG_DiLeu_BaEn_2	182	188	PF01217	0.332
TRG_DiLeu_BaEn_4	160	166	PF01217	0.321
TRG_NES_CRM1_1	167	178	PF08389	0.318
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX7	Leptomonas seymouri	86%	100%
A0A0S4JAX8	Bodo saltans	26%	100%
A0A1X0P947	Trypanosomatidae	67%	100%
A0A3S5H817	Leishmania donovani	100%	100%
A0A422NTY7	Trypanosoma rangeli	68%	100%
A4HNV6	Leishmania braziliensis	90%	100%
E9ASL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q1X9	Leishmania major	96%	100%
V5B9W8	Trypanosoma cruzi	63%	100%