Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICN2_LEIIN

TriTrypDb:

LINF_360016000

Length:

548

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4ICN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.741
CLV_NRD_NRD_1	141	143	PF00675	0.614
CLV_NRD_NRD_1	255	257	PF00675	0.662
CLV_NRD_NRD_1	340	342	PF00675	0.598
CLV_NRD_NRD_1	350	352	PF00675	0.608
CLV_NRD_NRD_1	445	447	PF00675	0.464
CLV_NRD_NRD_1	529	531	PF00675	0.407
CLV_NRD_NRD_1	542	544	PF00675	0.399
CLV_PCSK_FUR_1	443	447	PF00082	0.491
CLV_PCSK_KEX2_1	122	124	PF00082	0.782
CLV_PCSK_KEX2_1	141	143	PF00082	0.595
CLV_PCSK_KEX2_1	255	257	PF00082	0.662
CLV_PCSK_KEX2_1	326	328	PF00082	0.624
CLV_PCSK_KEX2_1	445	447	PF00082	0.440
CLV_PCSK_KEX2_1	529	531	PF00082	0.408
CLV_PCSK_KEX2_1	541	543	PF00082	0.405
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.631
CLV_PCSK_PC7_1	137	143	PF00082	0.673
CLV_PCSK_PC7_1	441	447	PF00082	0.498
CLV_PCSK_SKI1_1	331	335	PF00082	0.609
CLV_PCSK_SKI1_1	344	348	PF00082	0.479
CLV_PCSK_SKI1_1	437	441	PF00082	0.395
CLV_PCSK_SKI1_1	462	466	PF00082	0.406
CLV_PCSK_SKI1_1	529	533	PF00082	0.361
CLV_PCSK_SKI1_1	543	547	PF00082	0.429
DEG_APCC_DBOX_1	326	334	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.601
DOC_ANK_TNKS_1	164	171	PF00023	0.336
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	447	453	PF00134	0.677
DOC_MAPK_gen_1	122	130	PF00069	0.522
DOC_MAPK_gen_1	443	451	PF00069	0.697
DOC_MAPK_MEF2A_6	445	453	PF00069	0.711
DOC_MAPK_MEF2A_6	462	470	PF00069	0.510
DOC_MAPK_NFAT4_5	446	454	PF00069	0.675
DOC_MAPK_RevD_3	532	548	PF00069	0.692
DOC_PP2B_LxvP_1	227	230	PF13499	0.445
DOC_PP2B_LxvP_1	447	450	PF13499	0.671
DOC_PP2B_LxvP_1	451	454	PF13499	0.574
DOC_PP2B_LxvP_1	473	476	PF13499	0.369
DOC_PP4_FxxP_1	71	74	PF00568	0.441
DOC_USP7_MATH_1	182	186	PF00917	0.440
DOC_USP7_MATH_1	206	210	PF00917	0.495
DOC_USP7_MATH_1	262	266	PF00917	0.483
DOC_USP7_MATH_1	28	32	PF00917	0.538
DOC_USP7_MATH_1	325	329	PF00917	0.454
DOC_USP7_MATH_1	455	459	PF00917	0.686
DOC_USP7_UBL2_3	331	335	PF12436	0.396
DOC_WW_Pin1_4	110	115	PF00397	0.548
DOC_WW_Pin1_4	16	21	PF00397	0.650
DOC_WW_Pin1_4	215	220	PF00397	0.483
DOC_WW_Pin1_4	258	263	PF00397	0.503
LIG_14-3-3_CanoR_1	32	37	PF00244	0.565
LIG_Actin_WH2_2	326	343	PF00022	0.410
LIG_APCC_ABBA_1	237	242	PF00400	0.441
LIG_BIR_III_4	157	161	PF00653	0.440
LIG_BRCT_BRCA1_1	220	224	PF00533	0.468
LIG_deltaCOP1_diTrp_1	58	63	PF00928	0.488
LIG_EH1_1	416	424	PF00400	0.363
LIG_EH1_1	521	529	PF00400	0.363
LIG_eIF4E_1	417	423	PF01652	0.363
LIG_FHA_1	33	39	PF00498	0.515
LIG_FHA_1	396	402	PF00498	0.408
LIG_FHA_2	309	315	PF00498	0.432
LIG_FHA_2	40	46	PF00498	0.543
LIG_LIR_Apic_2	68	74	PF02991	0.442
LIG_LIR_Gen_1	149	158	PF02991	0.407
LIG_LIR_Gen_1	221	232	PF02991	0.454
LIG_LIR_Gen_1	424	434	PF02991	0.358
LIG_LIR_Gen_1	469	478	PF02991	0.429
LIG_LIR_LC3C_4	472	475	PF02991	0.480
LIG_LIR_Nem_3	149	155	PF02991	0.413
LIG_LIR_Nem_3	190	196	PF02991	0.361
LIG_LIR_Nem_3	221	227	PF02991	0.445
LIG_LIR_Nem_3	424	430	PF02991	0.371
LIG_LIR_Nem_3	469	473	PF02991	0.383
LIG_MYND_1	476	480	PF01753	0.378
LIG_NRBOX	329	335	PF00104	0.472
LIG_PAM2_1	362	374	PF00658	0.409
LIG_PCNA_PIPBox_1	464	473	PF02747	0.433
LIG_Pex14_1	59	63	PF04695	0.482
LIG_SH2_CRK	354	358	PF00017	0.430
LIG_SH2_STAP1	143	147	PF00017	0.419
LIG_SH2_STAT5	133	136	PF00017	0.439
LIG_SH2_STAT5	522	525	PF00017	0.383
LIG_SH3_3	111	117	PF00018	0.581
LIG_SH3_3	410	416	PF00018	0.362
LIG_SH3_3	471	477	PF00018	0.449
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.480
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.407
LIG_SUMO_SIM_par_1	229	234	PF11976	0.387
LIG_SUMO_SIM_par_1	33	40	PF11976	0.496
LIG_SUMO_SIM_par_1	515	520	PF11976	0.295
LIG_TRAF2_1	65	68	PF00917	0.472
LIG_TRAF2_1	94	97	PF00917	0.479
LIG_UBA3_1	370	378	PF00899	0.362
LIG_WRC_WIRS_1	467	472	PF05994	0.266
MOD_CDK_SPxK_1	110	116	PF00069	0.578
MOD_CK1_1	181	187	PF00069	0.437
MOD_CK1_1	19	25	PF00069	0.673
MOD_CK1_1	307	313	PF00069	0.360
MOD_CK1_1	458	464	PF00069	0.642
MOD_CK2_1	103	109	PF00069	0.521
MOD_CK2_1	262	268	PF00069	0.468
MOD_CK2_1	275	281	PF00069	0.445
MOD_CK2_1	308	314	PF00069	0.438
MOD_CK2_1	39	45	PF00069	0.502
MOD_CK2_1	466	472	PF00069	0.480
MOD_CMANNOS	82	85	PF00535	0.665
MOD_GlcNHglycan	105	108	PF01048	0.684
MOD_GlcNHglycan	180	183	PF01048	0.557
MOD_GlcNHglycan	208	211	PF01048	0.731
MOD_GlcNHglycan	21	24	PF01048	0.700
MOD_GlcNHglycan	277	280	PF01048	0.602
MOD_GlcNHglycan	383	388	PF01048	0.660
MOD_GlcNHglycan	39	42	PF01048	0.674
MOD_GlcNHglycan	455	458	PF01048	0.454
MOD_GlcNHglycan	519	522	PF01048	0.455
MOD_GSK3_1	178	185	PF00069	0.379
MOD_GSK3_1	201	208	PF00069	0.459
MOD_GSK3_1	214	221	PF00069	0.493
MOD_GSK3_1	258	265	PF00069	0.500
MOD_GSK3_1	28	35	PF00069	0.542
MOD_GSK3_1	304	311	PF00069	0.405
MOD_GSK3_1	395	402	PF00069	0.392
MOD_GSK3_1	99	106	PF00069	0.509
MOD_LATS_1	30	36	PF00433	0.501
MOD_N-GLC_1	153	158	PF02516	0.633
MOD_N-GLC_1	206	211	PF02516	0.628
MOD_NEK2_1	178	183	PF00069	0.432
MOD_NEK2_1	201	206	PF00069	0.387
MOD_NEK2_1	251	256	PF00069	0.416
MOD_NEK2_1	394	399	PF00069	0.410
MOD_NEK2_1	466	471	PF00069	0.449
MOD_NEK2_1	517	522	PF00069	0.332
MOD_NEK2_1	523	528	PF00069	0.312
MOD_NEK2_2	366	371	PF00069	0.427
MOD_PIKK_1	268	274	PF00454	0.401
MOD_PIKK_1	502	508	PF00454	0.370
MOD_PKA_2	274	280	PF00069	0.362
MOD_PKA_2	502	508	PF00069	0.402
MOD_PKA_2	99	105	PF00069	0.464
MOD_Plk_1	148	154	PF00069	0.416
MOD_Plk_2-3	39	45	PF00069	0.520
MOD_Plk_4	353	359	PF00069	0.356
MOD_Plk_4	366	372	PF00069	0.293
MOD_Plk_4	466	472	PF00069	0.451
MOD_Plk_4	512	518	PF00069	0.351
MOD_Plk_4	523	529	PF00069	0.320
MOD_Plk_4	535	541	PF00069	0.650
MOD_ProDKin_1	110	116	PF00069	0.548
MOD_ProDKin_1	16	22	PF00069	0.656
MOD_ProDKin_1	215	221	PF00069	0.481
MOD_ProDKin_1	258	264	PF00069	0.506
MOD_SUMO_rev_2	320	328	PF00179	0.460
MOD_SUMO_rev_2	39	49	PF00179	0.490
TRG_DiLeu_BaEn_1	289	294	PF01217	0.316
TRG_DiLeu_BaEn_1	329	334	PF01217	0.471
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.413
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.450
TRG_DiLeu_LyEn_5	390	395	PF01217	0.405
TRG_ENDOCYTIC_2	354	357	PF00928	0.413
TRG_ER_diArg_1	141	143	PF00400	0.407
TRG_ER_diArg_1	442	445	PF00400	0.657
TRG_ER_diArg_1	52	55	PF00400	0.456
TRG_ER_diArg_1	528	530	PF00400	0.495
TRG_ER_diArg_1	540	543	PF00400	0.636
TRG_NLS_Bipartite_1	326	345	PF00514	0.410
TRG_NLS_MonoExtC_3	340	345	PF00514	0.400
TRG_NLS_MonoExtN_4	339	345	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R2	Leptomonas seymouri	43%	99%
A0A1X0P8Z7	Trypanosomatidae	22%	97%
A0A3Q8INF1	Leishmania donovani	100%	100%
A0A3R7NN64	Trypanosoma rangeli	25%	97%
A4HNW2	Leishmania braziliensis	67%	99%
D0A2T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
E9ASM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1X4	Leishmania major	90%	100%
V5BV13	Trypanosoma cruzi	25%	85%