Flagellar C1a complex subunit C1a-32

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar C1a complex subunit C1a-32 - putative

Species:

Leishmania infantum

UniProt:

A4ICN0_LEIIN

TriTrypDb:

LINF_360016200

Length:

286

Annotations

Annotations by Jardim et al.

Flagella, Flagellar C1a complex subunit C1a-32

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

A4ICN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.524
CLV_NRD_NRD_1	284	286	PF00675	0.580
CLV_PCSK_KEX2_1	284	286	PF00082	0.580
CLV_PCSK_KEX2_1	32	34	PF00082	0.446
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.599
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.446
CLV_PCSK_PC7_1	28	34	PF00082	0.437
CLV_PCSK_PC7_1	280	286	PF00082	0.570
CLV_PCSK_SKI1_1	48	52	PF00082	0.363
DEG_APCC_DBOX_1	232	240	PF00400	0.367
DOC_MAPK_MEF2A_6	48	57	PF00069	0.438
DOC_USP7_MATH_1	268	272	PF00917	0.557
DOC_USP7_MATH_1	67	71	PF00917	0.308
DOC_USP7_MATH_2	153	159	PF00917	0.400
DOC_USP7_UBL2_3	190	194	PF12436	0.410
DOC_WW_Pin1_4	70	75	PF00397	0.331
LIG_14-3-3_CanoR_1	111	115	PF00244	0.224
LIG_14-3-3_CanoR_1	116	126	PF00244	0.165
LIG_14-3-3_CanoR_1	218	224	PF00244	0.422
LIG_14-3-3_CanoR_1	48	57	PF00244	0.339
LIG_14-3-3_CanoR_1	98	103	PF00244	0.279
LIG_Actin_WH2_2	145	162	PF00022	0.392
LIG_Actin_WH2_2	15	30	PF00022	0.414
LIG_BIR_II_1	1	5	PF00653	0.382
LIG_BRCT_BRCA1_1	77	81	PF00533	0.375
LIG_DLG_GKlike_1	98	105	PF00625	0.343
LIG_eIF4E_1	60	66	PF01652	0.392
LIG_FHA_1	159	165	PF00498	0.565
LIG_FHA_1	4	10	PF00498	0.361
LIG_FHA_1	75	81	PF00498	0.392
LIG_FHA_2	195	201	PF00498	0.483
LIG_FHA_2	257	263	PF00498	0.511
LIG_LIR_Gen_1	101	110	PF02991	0.293
LIG_LIR_Gen_1	6	11	PF02991	0.487
LIG_LIR_LC3C_4	107	110	PF02991	0.325
LIG_LIR_Nem_3	138	144	PF02991	0.256
LIG_LIR_Nem_3	58	63	PF02991	0.371
LIG_LIR_Nem_3	6	10	PF02991	0.361
LIG_LIR_Nem_3	70	75	PF02991	0.343
LIG_LIR_Nem_3	78	84	PF02991	0.150
LIG_LIR_Nem_3	97	102	PF02991	0.372
LIG_PTB_Apo_2	222	229	PF02174	0.494
LIG_RPA_C_Fungi	222	234	PF08784	0.409
LIG_SH2_CRK	102	106	PF00017	0.343
LIG_SH2_CRK	149	153	PF00017	0.284
LIG_SH2_STAP1	119	123	PF00017	0.412
LIG_SH2_STAT5	147	150	PF00017	0.287
LIG_SH3_3	111	117	PF00018	0.249
LIG_SH3_3	170	176	PF00018	0.462
LIG_SUMO_SIM_anti_2	247	256	PF11976	0.503
LIG_SUMO_SIM_par_1	160	167	PF11976	0.483
LIG_TRAF2_1	197	200	PF00917	0.467
MOD_CDC14_SPxK_1	73	76	PF00782	0.298
MOD_CDK_SPxK_1	70	76	PF00069	0.298
MOD_CK1_1	158	164	PF00069	0.422
MOD_CK1_1	244	250	PF00069	0.491
MOD_CK1_1	270	276	PF00069	0.608
MOD_CK1_1	279	285	PF00069	0.677
MOD_CK1_1	46	52	PF00069	0.474
MOD_CK1_1	70	76	PF00069	0.392
MOD_CK2_1	194	200	PF00069	0.442
MOD_CK2_1	256	262	PF00069	0.537
MOD_GlcNHglycan	178	181	PF01048	0.555
MOD_GlcNHglycan	270	273	PF01048	0.581
MOD_GSK3_1	131	138	PF00069	0.357
MOD_GSK3_1	207	214	PF00069	0.550
MOD_GSK3_1	219	226	PF00069	0.666
MOD_GSK3_1	241	248	PF00069	0.551
MOD_GSK3_1	268	275	PF00069	0.550
MOD_GSK3_1	276	283	PF00069	0.625
MOD_GSK3_1	42	49	PF00069	0.495
MOD_GSK3_1	70	77	PF00069	0.315
MOD_GSK3_1	94	101	PF00069	0.281
MOD_N-GLC_1	164	169	PF02516	0.504
MOD_NEK2_1	136	141	PF00069	0.219
MOD_NEK2_1	223	228	PF00069	0.555
MOD_NEK2_1	75	80	PF00069	0.309
MOD_PIKK_1	48	54	PF00454	0.355
MOD_PIKK_1	67	73	PF00454	0.349
MOD_PKA_2	110	116	PF00069	0.343
MOD_PKA_2	12	18	PF00069	0.513
MOD_PKA_2	279	285	PF00069	0.765
MOD_PKA_2	94	100	PF00069	0.298
MOD_PKB_1	274	282	PF00069	0.632
MOD_Plk_1	223	229	PF00069	0.493
MOD_Plk_1	88	94	PF00069	0.343
MOD_Plk_4	118	124	PF00069	0.408
MOD_Plk_4	131	137	PF00069	0.202
MOD_Plk_4	76	82	PF00069	0.276
MOD_ProDKin_1	70	76	PF00069	0.331
MOD_SUMO_rev_2	249	259	PF00179	0.430
TRG_DiLeu_BaEn_1	249	254	PF01217	0.394
TRG_ENDOCYTIC_2	102	105	PF00928	0.249
TRG_ENDOCYTIC_2	119	122	PF00928	0.249
TRG_ENDOCYTIC_2	149	152	PF00928	0.300
TRG_ENDOCYTIC_2	60	63	PF00928	0.401
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE82	Leptomonas seymouri	70%	100%
A0A0S4JAR9	Bodo saltans	33%	95%
A0A1X0P8D5	Trypanosomatidae	43%	100%
A0A3Q8IVT9	Leishmania donovani	100%	100%
A0A3R7MW02	Trypanosoma rangeli	42%	100%
A1A4V9	Homo sapiens	25%	86%
A4HNW4	Leishmania braziliensis	84%	100%
D0A2T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1X2	Leishmania major	97%	100%
V5BQE4	Trypanosoma cruzi	45%	100%