RNA editing complex protein MP61

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP61

Species:

Leishmania infantum

UniProt:

A4ICM9_LEIIN

TriTrypDb:

LINF_360016300

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0004521	RNA endonuclease activity	5	11
GO:0004525	ribonuclease III activity	6	11
GO:0004540	RNA nuclease activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.413
CLV_MEL_PAP_1	561	567	PF00089	0.559
CLV_NRD_NRD_1	119	121	PF00675	0.474
CLV_NRD_NRD_1	144	146	PF00675	0.570
CLV_NRD_NRD_1	225	227	PF00675	0.390
CLV_NRD_NRD_1	228	230	PF00675	0.397
CLV_NRD_NRD_1	24	26	PF00675	0.761
CLV_NRD_NRD_1	432	434	PF00675	0.762
CLV_NRD_NRD_1	518	520	PF00675	0.671
CLV_NRD_NRD_1	528	530	PF00675	0.646
CLV_NRD_NRD_1	57	59	PF00675	0.671
CLV_NRD_NRD_1	8	10	PF00675	0.658
CLV_NRD_NRD_1	85	87	PF00675	0.674
CLV_NRD_NRD_1	88	90	PF00675	0.695
CLV_PCSK_FUR_1	226	230	PF00082	0.412
CLV_PCSK_FUR_1	526	530	PF00082	0.564
CLV_PCSK_FUR_1	86	90	PF00082	0.764
CLV_PCSK_KEX2_1	119	121	PF00082	0.568
CLV_PCSK_KEX2_1	144	146	PF00082	0.479
CLV_PCSK_KEX2_1	156	158	PF00082	0.320
CLV_PCSK_KEX2_1	227	229	PF00082	0.409
CLV_PCSK_KEX2_1	24	26	PF00082	0.757
CLV_PCSK_KEX2_1	432	434	PF00082	0.762
CLV_PCSK_KEX2_1	518	520	PF00082	0.663
CLV_PCSK_KEX2_1	528	530	PF00082	0.627
CLV_PCSK_KEX2_1	7	9	PF00082	0.631
CLV_PCSK_KEX2_1	85	87	PF00082	0.674
CLV_PCSK_KEX2_1	88	90	PF00082	0.695
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.397
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.427
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.722
CLV_PCSK_PC7_1	3	9	PF00082	0.651
CLV_PCSK_SKI1_1	144	148	PF00082	0.530
CLV_PCSK_SKI1_1	228	232	PF00082	0.463
CLV_PCSK_SKI1_1	235	239	PF00082	0.411
CLV_PCSK_SKI1_1	240	244	PF00082	0.416
CLV_PCSK_SKI1_1	275	279	PF00082	0.381
CLV_PCSK_SKI1_1	97	101	PF00082	0.741
CLV_Separin_Metazoa	186	190	PF03568	0.392
CLV_Separin_Metazoa	568	572	PF03568	0.710
DEG_APCC_DBOX_1	227	235	PF00400	0.507
DEG_APCC_DBOX_1	503	511	PF00400	0.678
DEG_Nend_UBRbox_3	1	3	PF02207	0.713
DEG_SPOP_SBC_1	139	143	PF00917	0.526
DOC_CDC14_PxL_1	212	220	PF14671	0.418
DOC_CKS1_1	103	108	PF01111	0.739
DOC_CKS1_1	66	71	PF01111	0.739
DOC_CYCLIN_yClb1_LxF_4	404	410	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.564
DOC_MAPK_gen_1	226	236	PF00069	0.389
DOC_MAPK_gen_1	400	409	PF00069	0.453
DOC_MAPK_gen_1	518	525	PF00069	0.470
DOC_MAPK_gen_1	7	16	PF00069	0.715
DOC_MAPK_MEF2A_6	130	139	PF00069	0.547
DOC_MAPK_MEF2A_6	180	187	PF00069	0.381
DOC_MAPK_MEF2A_6	518	527	PF00069	0.610
DOC_MAPK_MEF2A_6	7	16	PF00069	0.629
DOC_MAPK_NFAT4_5	180	188	PF00069	0.380
DOC_MAPK_NFAT4_5	7	15	PF00069	0.628
DOC_PP1_RVXF_1	263	269	PF00149	0.406
DOC_PP2B_LxvP_1	100	103	PF13499	0.777
DOC_PP2B_LxvP_1	12	15	PF13499	0.663
DOC_PP2B_LxvP_1	572	575	PF13499	0.611
DOC_PP4_FxxP_1	66	69	PF00568	0.743
DOC_USP7_MATH_1	45	49	PF00917	0.664
DOC_WW_Pin1_4	102	107	PF00397	0.721
DOC_WW_Pin1_4	191	196	PF00397	0.427
DOC_WW_Pin1_4	322	327	PF00397	0.471
DOC_WW_Pin1_4	559	564	PF00397	0.595
DOC_WW_Pin1_4	65	70	PF00397	0.647
LIG_14-3-3_CanoR_1	205	212	PF00244	0.405
LIG_14-3-3_CanoR_1	3	7	PF00244	0.713
LIG_14-3-3_CanoR_1	571	575	PF00244	0.719
LIG_14-3-3_CanoR_1	8	13	PF00244	0.711
LIG_Actin_WH2_2	457	474	PF00022	0.545
LIG_APCC_ABBA_1	147	152	PF00400	0.376
LIG_BIR_III_4	75	79	PF00653	0.650
LIG_BRCT_BRCA1_1	259	263	PF00533	0.423
LIG_BRCT_BRCA1_1	282	286	PF00533	0.546
LIG_DLG_GKlike_1	423	431	PF00625	0.685
LIG_eIF4E_1	369	375	PF01652	0.531
LIG_FHA_1	17	23	PF00498	0.606
LIG_FHA_1	244	250	PF00498	0.447
LIG_FHA_1	355	361	PF00498	0.591
LIG_FHA_1	363	369	PF00498	0.536
LIG_FHA_1	456	462	PF00498	0.677
LIG_FHA_1	48	54	PF00498	0.571
LIG_FHA_1	560	566	PF00498	0.658
LIG_FHA_2	192	198	PF00498	0.408
LIG_FHA_2	349	355	PF00498	0.529
LIG_FHA_2	481	487	PF00498	0.724
LIG_FXI_DFP_1	150	154	PF00024	0.404
LIG_GBD_Chelix_1	336	344	PF00786	0.351
LIG_Integrin_RGD_1	433	435	PF01839	0.683
LIG_Integrin_RGDW_4	433	436	PF00362	0.684
LIG_LIR_Apic_2	440	446	PF02991	0.684
LIG_LIR_Apic_2	448	452	PF02991	0.581
LIG_LIR_Gen_1	121	129	PF02991	0.609
LIG_LIR_Gen_1	143	153	PF02991	0.405
LIG_LIR_Gen_1	200	211	PF02991	0.465
LIG_LIR_Gen_1	260	269	PF02991	0.417
LIG_LIR_Gen_1	298	304	PF02991	0.549
LIG_LIR_Gen_1	338	348	PF02991	0.504
LIG_LIR_Gen_1	482	493	PF02991	0.673
LIG_LIR_Nem_3	121	125	PF02991	0.674
LIG_LIR_Nem_3	148	153	PF02991	0.380
LIG_LIR_Nem_3	200	206	PF02991	0.431
LIG_LIR_Nem_3	260	266	PF02991	0.426
LIG_LIR_Nem_3	298	303	PF02991	0.557
LIG_LIR_Nem_3	338	344	PF02991	0.350
LIG_LIR_Nem_3	482	488	PF02991	0.579
LIG_NRBOX	229	235	PF00104	0.385
LIG_PCNA_yPIPBox_3	392	402	PF02747	0.517
LIG_PDZ_Class_3	582	587	PF00595	0.556
LIG_Pex14_2	118	122	PF04695	0.633
LIG_Pex14_2	146	150	PF04695	0.384
LIG_PTB_Apo_2	159	166	PF02174	0.399
LIG_SH2_CRK	443	447	PF00017	0.741
LIG_SH2_CRK	449	453	PF00017	0.712
LIG_SH2_GRB2like	63	66	PF00017	0.720
LIG_SH2_NCK_1	443	447	PF00017	0.646
LIG_SH2_STAP1	369	373	PF00017	0.511
LIG_SH2_STAP1	380	384	PF00017	0.457
LIG_SH2_STAT5	191	194	PF00017	0.441
LIG_SH2_STAT5	232	235	PF00017	0.395
LIG_SH2_STAT5	276	279	PF00017	0.375
LIG_SH2_STAT5	347	350	PF00017	0.472
LIG_SH2_STAT5	369	372	PF00017	0.496
LIG_SH3_1	449	455	PF00018	0.657
LIG_SH3_3	100	106	PF00018	0.682
LIG_SH3_3	12	18	PF00018	0.564
LIG_SH3_3	449	455	PF00018	0.719
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.680
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.664
LIG_SUMO_SIM_par_1	135	143	PF11976	0.585
LIG_UBA3_1	230	238	PF00899	0.394
LIG_WRC_WIRS_1	244	249	PF05994	0.535
LIG_WRC_WIRS_1	485	490	PF05994	0.494
MOD_CDK_SPK_2	322	327	PF00069	0.471
MOD_CDK_SPK_2	559	564	PF00069	0.666
MOD_CK1_1	123	129	PF00069	0.684
MOD_CK1_1	138	144	PF00069	0.558
MOD_CK1_1	254	260	PF00069	0.655
MOD_CK1_1	280	286	PF00069	0.528
MOD_CK1_1	48	54	PF00069	0.658
MOD_CK2_1	191	197	PF00069	0.469
MOD_Cter_Amidation	56	59	PF01082	0.753
MOD_GlcNHglycan	126	129	PF01048	0.698
MOD_GlcNHglycan	256	259	PF01048	0.558
MOD_GlcNHglycan	33	36	PF01048	0.636
MOD_GlcNHglycan	55	58	PF01048	0.617
MOD_GlcNHglycan	557	560	PF01048	0.729
MOD_GSK3_1	120	127	PF00069	0.672
MOD_GSK3_1	135	142	PF00069	0.572
MOD_GSK3_1	243	250	PF00069	0.584
MOD_GSK3_1	29	36	PF00069	0.722
MOD_GSK3_1	327	334	PF00069	0.427
MOD_GSK3_1	423	430	PF00069	0.717
MOD_GSK3_1	47	54	PF00069	0.645
MOD_GSK3_1	480	487	PF00069	0.500
MOD_GSK3_1	534	541	PF00069	0.641
MOD_GSK3_1	555	562	PF00069	0.669
MOD_N-GLC_1	161	166	PF02516	0.411
MOD_N-GLC_1	247	252	PF02516	0.600
MOD_N-GLC_2	2	4	PF02516	0.633
MOD_N-GLC_2	207	209	PF02516	0.554
MOD_NEK2_1	243	248	PF00069	0.573
MOD_NEK2_1	348	353	PF00069	0.535
MOD_NEK2_1	427	432	PF00069	0.624
MOD_NEK2_1	471	476	PF00069	0.697
MOD_NEK2_1	479	484	PF00069	0.676
MOD_NEK2_1	52	57	PF00069	0.711
MOD_NEK2_1	538	543	PF00069	0.693
MOD_NEK2_1	555	560	PF00069	0.619
MOD_NEK2_2	295	300	PF00069	0.574
MOD_NEK2_2	412	417	PF00069	0.461
MOD_NEK2_2	521	526	PF00069	0.614
MOD_NEK2_2	534	539	PF00069	0.536
MOD_PIKK_1	348	354	PF00454	0.535
MOD_PKA_1	8	14	PF00069	0.695
MOD_PKA_2	2	8	PF00069	0.707
MOD_PKA_2	570	576	PF00069	0.713
MOD_Plk_1	161	167	PF00069	0.414
MOD_Plk_1	412	418	PF00069	0.580
MOD_Plk_1	466	472	PF00069	0.538
MOD_Plk_1	505	511	PF00069	0.683
MOD_Plk_4	161	167	PF00069	0.391
MOD_Plk_4	277	283	PF00069	0.423
MOD_Plk_4	336	342	PF00069	0.349
MOD_Plk_4	48	54	PF00069	0.645
MOD_Plk_4	505	511	PF00069	0.607
MOD_Plk_4	68	74	PF00069	0.662
MOD_ProDKin_1	102	108	PF00069	0.717
MOD_ProDKin_1	191	197	PF00069	0.429
MOD_ProDKin_1	322	328	PF00069	0.478
MOD_ProDKin_1	559	565	PF00069	0.593
MOD_ProDKin_1	65	71	PF00069	0.644
MOD_SUMO_for_1	577	580	PF00179	0.673
TRG_AP2beta_CARGO_1	148	157	PF09066	0.405
TRG_DiLeu_BaEn_1	95	100	PF01217	0.710
TRG_DiLeu_BaEn_2	263	269	PF01217	0.517
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.534
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.573
TRG_ENDOCYTIC_2	314	317	PF00928	0.481
TRG_ENDOCYTIC_2	485	488	PF00928	0.559
TRG_ENDOCYTIC_2	63	66	PF00928	0.720
TRG_ER_diArg_1	118	120	PF00400	0.568
TRG_ER_diArg_1	144	146	PF00400	0.567
TRG_ER_diArg_1	226	229	PF00400	0.402
TRG_ER_diArg_1	23	25	PF00400	0.754
TRG_ER_diArg_1	517	519	PF00400	0.670
TRG_ER_diArg_1	525	528	PF00400	0.622
TRG_ER_diArg_1	8	10	PF00400	0.663
TRG_ER_diArg_1	85	88	PF00400	0.685
TRG_NLS_Bipartite_1	144	160	PF00514	0.399
TRG_NLS_MonoExtN_4	226	231	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V7	Leptomonas seymouri	47%	99%
A0A1X0P9H0	Trypanosomatidae	47%	100%
A0A3R7KSN8	Trypanosoma rangeli	46%	100%
A0A3S7XAI5	Leishmania donovani	100%	100%
A4HNW5	Leishmania braziliensis	77%	100%
D0A2T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q6T449	Leishmania major	92%	100%
V5BZU7	Trypanosoma cruzi	46%	100%