Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICM6_LEIIN

TriTrypDb:

LINF_360016600

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4ICM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.439
CLV_NRD_NRD_1	14	16	PF00675	0.546
CLV_NRD_NRD_1	167	169	PF00675	0.663
CLV_NRD_NRD_1	307	309	PF00675	0.703
CLV_NRD_NRD_1	317	319	PF00675	0.594
CLV_NRD_NRD_1	53	55	PF00675	0.679
CLV_NRD_NRD_1	573	575	PF00675	0.502
CLV_PCSK_KEX2_1	14	16	PF00082	0.546
CLV_PCSK_KEX2_1	167	169	PF00082	0.666
CLV_PCSK_KEX2_1	309	311	PF00082	0.713
CLV_PCSK_KEX2_1	317	319	PF00082	0.608
CLV_PCSK_KEX2_1	52	54	PF00082	0.696
CLV_PCSK_KEX2_1	572	574	PF00082	0.499
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.713
CLV_PCSK_PC7_1	568	574	PF00082	0.471
CLV_PCSK_SKI1_1	241	245	PF00082	0.654
CLV_PCSK_SKI1_1	309	313	PF00082	0.717
CLV_PCSK_SKI1_1	387	391	PF00082	0.629
CLV_PCSK_SKI1_1	429	433	PF00082	0.684
CLV_PCSK_SKI1_1	448	452	PF00082	0.642
DEG_APCC_DBOX_1	386	394	PF00400	0.436
DEG_APCC_DBOX_1	435	443	PF00400	0.440
DEG_MDM2_SWIB_1	394	402	PF02201	0.443
DEG_SCF_FBW7_2	520	526	PF00400	0.499
DEG_SPOP_SBC_1	2	6	PF00917	0.822
DOC_CKS1_1	520	525	PF01111	0.493
DOC_CKS1_1	537	542	PF01111	0.355
DOC_CYCLIN_RxL_1	384	392	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.484
DOC_MAPK_gen_1	167	174	PF00069	0.398
DOC_MAPK_gen_1	385	393	PF00069	0.378
DOC_MAPK_gen_1	462	470	PF00069	0.456
DOC_MAPK_gen_1	52	60	PF00069	0.536
DOC_MAPK_JIP1_4	168	174	PF00069	0.360
DOC_MAPK_JIP1_4	385	391	PF00069	0.378
DOC_MAPK_MEF2A_6	385	393	PF00069	0.378
DOC_MAPK_MEF2A_6	52	60	PF00069	0.477
DOC_MAPK_RevD_3	38	53	PF00069	0.588
DOC_PP2B_LxvP_1	82	85	PF13499	0.468
DOC_PP4_FxxP_1	534	537	PF00568	0.447
DOC_PP4_FxxP_1	556	559	PF00568	0.376
DOC_USP7_MATH_1	163	167	PF00917	0.530
DOC_USP7_MATH_1	209	213	PF00917	0.485
DOC_USP7_MATH_1	227	231	PF00917	0.393
DOC_USP7_MATH_1	272	276	PF00917	0.449
DOC_USP7_MATH_1	304	308	PF00917	0.414
DOC_USP7_MATH_1	373	377	PF00917	0.419
DOC_USP7_MATH_1	492	496	PF00917	0.425
DOC_USP7_MATH_1	535	539	PF00917	0.565
DOC_USP7_UBL2_3	309	313	PF12436	0.429
DOC_WW_Pin1_4	179	184	PF00397	0.378
DOC_WW_Pin1_4	281	286	PF00397	0.375
DOC_WW_Pin1_4	429	434	PF00397	0.486
DOC_WW_Pin1_4	454	459	PF00397	0.454
DOC_WW_Pin1_4	498	503	PF00397	0.385
DOC_WW_Pin1_4	511	516	PF00397	0.366
DOC_WW_Pin1_4	519	524	PF00397	0.488
DOC_WW_Pin1_4	52	57	PF00397	0.489
DOC_WW_Pin1_4	536	541	PF00397	0.431
DOC_WW_Pin1_4	67	72	PF00397	0.472
LIG_14-3-3_CanoR_1	124	132	PF00244	0.523
LIG_14-3-3_CanoR_1	241	249	PF00244	0.478
LIG_14-3-3_CanoR_1	414	420	PF00244	0.354
LIG_14-3-3_CanoR_1	434	440	PF00244	0.443
LIG_14-3-3_CanoR_1	477	483	PF00244	0.399
LIG_APCC_ABBAyCdc20_2	308	314	PF00400	0.463
LIG_Clathr_ClatBox_1	354	358	PF01394	0.435
LIG_Clathr_ClatBox_1	406	410	PF01394	0.381
LIG_CtBP_PxDLS_1	351	355	PF00389	0.389
LIG_EVH1_2	56	60	PF00568	0.528
LIG_FHA_1	159	165	PF00498	0.496
LIG_FHA_1	180	186	PF00498	0.408
LIG_FHA_1	242	248	PF00498	0.461
LIG_FHA_1	30	36	PF00498	0.429
LIG_FHA_1	379	385	PF00498	0.488
LIG_FHA_1	403	409	PF00498	0.393
LIG_FHA_1	470	476	PF00498	0.401
LIG_FHA_1	53	59	PF00498	0.470
LIG_FHA_1	537	543	PF00498	0.498
LIG_FHA_1	565	571	PF00498	0.618
LIG_FHA_1	68	74	PF00498	0.475
LIG_FHA_1	78	84	PF00498	0.446
LIG_FHA_1	90	96	PF00498	0.425
LIG_FHA_2	129	135	PF00498	0.389
LIG_FHA_2	399	405	PF00498	0.336
LIG_FHA_2	479	485	PF00498	0.398
LIG_GBD_Chelix_1	27	35	PF00786	0.480
LIG_LIR_Apic_2	281	285	PF02991	0.360
LIG_LIR_Apic_2	452	458	PF02991	0.473
LIG_LIR_Gen_1	133	141	PF02991	0.444
LIG_LIR_LC3C_4	80	84	PF02991	0.456
LIG_LIR_Nem_3	100	105	PF02991	0.421
LIG_LIR_Nem_3	133	139	PF02991	0.438
LIG_LIR_Nem_3	337	341	PF02991	0.407
LIG_LIR_Nem_3	504	509	PF02991	0.439
LIG_NRBOX	290	296	PF00104	0.443
LIG_NRBOX	481	487	PF00104	0.414
LIG_PCNA_yPIPBox_3	14	28	PF02747	0.459
LIG_PCNA_yPIPBox_3	400	414	PF02747	0.392
LIG_PCNA_yPIPBox_3	462	474	PF02747	0.484
LIG_Pex14_2	220	224	PF04695	0.392
LIG_Pex14_2	394	398	PF04695	0.444
LIG_SH2_CRK	136	140	PF00017	0.443
LIG_SH2_CRK	282	286	PF00017	0.420
LIG_SH2_CRK	415	419	PF00017	0.344
LIG_SH2_NCK_1	415	419	PF00017	0.368
LIG_SH2_SRC	370	373	PF00017	0.379
LIG_SH2_STAP1	136	140	PF00017	0.443
LIG_SH2_STAT3	184	187	PF00017	0.394
LIG_SH2_STAT5	184	187	PF00017	0.394
LIG_SH2_STAT5	370	373	PF00017	0.438
LIG_SH2_STAT5	455	458	PF00017	0.456
LIG_SH2_STAT5	553	556	PF00017	0.378
LIG_SH2_STAT5	94	97	PF00017	0.546
LIG_SH3_3	534	540	PF00018	0.435
LIG_SH3_3	82	88	PF00018	0.398
LIG_SUMO_SIM_anti_2	228	236	PF11976	0.414
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.384
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.462
LIG_SUMO_SIM_par_1	31	36	PF11976	0.387
LIG_SUMO_SIM_par_1	404	410	PF11976	0.340
LIG_SUMO_SIM_par_1	471	476	PF11976	0.381
LIG_SUMO_SIM_par_1	70	75	PF11976	0.374
LIG_TRFH_1	555	559	PF08558	0.429
LIG_UBA3_1	442	448	PF00899	0.412
LIG_UBA3_1	485	491	PF00899	0.439
LIG_WRC_WIRS_1	338	343	PF05994	0.385
LIG_WRC_WIRS_1	99	104	PF05994	0.421
MOD_CDC14_SPxK_1	284	287	PF00782	0.348
MOD_CDK_SPK_2	429	434	PF00069	0.427
MOD_CDK_SPK_2	511	516	PF00069	0.385
MOD_CDK_SPxK_1	281	287	PF00069	0.347
MOD_CDK_SPxxK_3	429	436	PF00069	0.480
MOD_CDK_SPxxK_3	498	505	PF00069	0.379
MOD_CK1_1	176	182	PF00069	0.354
MOD_CK1_1	273	279	PF00069	0.461
MOD_CK1_1	281	287	PF00069	0.414
MOD_CK1_1	361	367	PF00069	0.396
MOD_CK1_1	98	104	PF00069	0.446
MOD_CK2_1	398	404	PF00069	0.338
MOD_CK2_1	478	484	PF00069	0.401
MOD_CK2_1	498	504	PF00069	0.422
MOD_Cter_Amidation	12	15	PF01082	0.610
MOD_GlcNHglycan	108	111	PF01048	0.754
MOD_GlcNHglycan	114	117	PF01048	0.806
MOD_GlcNHglycan	136	139	PF01048	0.601
MOD_GlcNHglycan	175	178	PF01048	0.609
MOD_GlcNHglycan	24	27	PF01048	0.351
MOD_GlcNHglycan	256	259	PF01048	0.634
MOD_GlcNHglycan	322	325	PF01048	0.701
MOD_GlcNHglycan	360	363	PF01048	0.599
MOD_GlcNHglycan	415	418	PF01048	0.619
MOD_GlcNHglycan	49	52	PF01048	0.737
MOD_GlcNHglycan	528	531	PF01048	0.788
MOD_GSK3_1	106	113	PF00069	0.534
MOD_GSK3_1	130	137	PF00069	0.405
MOD_GSK3_1	158	165	PF00069	0.551
MOD_GSK3_1	2	9	PF00069	0.815
MOD_GSK3_1	205	212	PF00069	0.555
MOD_GSK3_1	29	36	PF00069	0.376
MOD_GSK3_1	337	344	PF00069	0.395
MOD_GSK3_1	389	396	PF00069	0.366
MOD_GSK3_1	398	405	PF00069	0.390
MOD_GSK3_1	43	50	PF00069	0.475
MOD_GSK3_1	437	444	PF00069	0.430
MOD_GSK3_1	456	463	PF00069	0.459
MOD_GSK3_1	469	476	PF00069	0.317
MOD_GSK3_1	507	514	PF00069	0.405
MOD_GSK3_1	89	96	PF00069	0.518
MOD_N-GLC_1	110	115	PF02516	0.638
MOD_N-GLC_1	200	205	PF02516	0.659
MOD_N-GLC_1	318	323	PF02516	0.675
MOD_N-GLC_2	569	571	PF02516	0.518
MOD_NEK2_1	270	275	PF00069	0.429
MOD_NEK2_1	29	34	PF00069	0.429
MOD_NEK2_1	341	346	PF00069	0.491
MOD_NEK2_1	389	394	PF00069	0.419
MOD_NEK2_1	420	425	PF00069	0.483
MOD_NEK2_1	451	456	PF00069	0.469
MOD_NEK2_1	460	465	PF00069	0.482
MOD_NEK2_1	507	512	PF00069	0.403
MOD_NEK2_1	564	569	PF00069	0.536
MOD_NEK2_1	60	65	PF00069	0.459
MOD_OFUCOSY	175	180	PF10250	0.570
MOD_PIKK_1	123	129	PF00454	0.472
MOD_PIKK_1	146	152	PF00454	0.606
MOD_PK_1	167	173	PF00069	0.459
MOD_PKA_1	167	173	PF00069	0.430
MOD_PKA_2	123	129	PF00069	0.482
MOD_PKA_2	167	173	PF00069	0.430
MOD_PKA_2	413	419	PF00069	0.352
MOD_PKA_2	43	49	PF00069	0.536
MOD_PKA_2	435	441	PF00069	0.511
MOD_PKA_2	6	12	PF00069	0.756
MOD_Plk_4	167	173	PF00069	0.400
MOD_Plk_4	290	296	PF00069	0.512
MOD_Plk_4	33	39	PF00069	0.359
MOD_Plk_4	389	395	PF00069	0.384
MOD_Plk_4	398	404	PF00069	0.393
MOD_Plk_4	441	447	PF00069	0.428
MOD_Plk_4	451	457	PF00069	0.454
MOD_Plk_4	469	475	PF00069	0.348
MOD_Plk_4	60	66	PF00069	0.549
MOD_Plk_4	77	83	PF00069	0.389
MOD_Plk_4	98	104	PF00069	0.453
MOD_ProDKin_1	179	185	PF00069	0.376
MOD_ProDKin_1	281	287	PF00069	0.374
MOD_ProDKin_1	429	435	PF00069	0.483
MOD_ProDKin_1	454	460	PF00069	0.449
MOD_ProDKin_1	498	504	PF00069	0.384
MOD_ProDKin_1	511	517	PF00069	0.367
MOD_ProDKin_1	519	525	PF00069	0.494
MOD_ProDKin_1	52	58	PF00069	0.486
MOD_ProDKin_1	536	542	PF00069	0.429
MOD_ProDKin_1	67	73	PF00069	0.466
MOD_SUMO_for_1	515	518	PF00179	0.399
TRG_DiLeu_BaEn_1	404	409	PF01217	0.386
TRG_DiLeu_BaEn_2	544	550	PF01217	0.318
TRG_ENDOCYTIC_2	136	139	PF00928	0.442
TRG_ENDOCYTIC_2	415	418	PF00928	0.342
TRG_ENDOCYTIC_2	508	511	PF00928	0.394
TRG_ENDOCYTIC_2	553	556	PF00928	0.374
TRG_ER_diArg_1	14	16	PF00400	0.746
TRG_ER_diArg_1	167	169	PF00400	0.466
TRG_ER_diArg_1	213	216	PF00400	0.464
TRG_ER_diArg_1	308	311	PF00400	0.510
TRG_ER_diArg_1	316	318	PF00400	0.507
TRG_ER_diArg_1	433	436	PF00400	0.459
TRG_ER_diArg_1	52	54	PF00400	0.474
TRG_ER_diArg_1	572	574	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I575	Leptomonas seymouri	37%	99%
A0A1X0P896	Trypanosomatidae	25%	100%
A0A3Q8IKB7	Leishmania donovani	100%	100%
A4HNW8	Leishmania braziliensis	66%	100%
E9ASM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1W8	Leishmania major	91%	100%