Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICM5_LEIIN

TriTrypDb:

LINF_360016700

Length:

153

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 2
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.627
CLV_PCSK_KEX2_1	143	145	PF00082	0.562
CLV_PCSK_SKI1_1	135	139	PF00082	0.390
CLV_PCSK_SKI1_1	46	50	PF00082	0.403
DOC_PP2B_LxvP_1	139	142	PF13499	0.438
DOC_USP7_MATH_1	126	130	PF00917	0.336
DOC_USP7_UBL2_3	99	103	PF12436	0.466
DOC_WW_Pin1_4	128	133	PF00397	0.369
LIG_14-3-3_CanoR_1	117	125	PF00244	0.465
LIG_BIR_II_1	1	5	PF00653	0.376
LIG_EH1_1	7	15	PF00400	0.483
LIG_eIF4E_1	89	95	PF01652	0.371
LIG_FHA_1	106	112	PF00498	0.473
LIG_FHA_1	136	142	PF00498	0.396
LIG_FHA_1	5	11	PF00498	0.439
LIG_FHA_1	59	65	PF00498	0.336
LIG_FHA_1	89	95	PF00498	0.359
LIG_LIR_Apic_2	91	96	PF02991	0.418
LIG_LIR_Gen_1	35	44	PF02991	0.396
LIG_LIR_Gen_1	7	15	PF02991	0.432
LIG_LIR_Nem_3	131	137	PF02991	0.421
LIG_LIR_Nem_3	35	41	PF02991	0.420
LIG_LIR_Nem_3	7	11	PF02991	0.465
LIG_Pex14_2	34	38	PF04695	0.422
LIG_Pex14_2	4	8	PF04695	0.448
LIG_SH2_CRK	134	138	PF00017	0.331
LIG_SH2_CRK	89	93	PF00017	0.405
LIG_SH2_NCK_1	89	93	PF00017	0.335
LIG_SH2_SRC	93	96	PF00017	0.285
LIG_SH2_STAP1	89	93	PF00017	0.335
LIG_SH2_STAT5	93	96	PF00017	0.331
LIG_WRC_WIRS_1	1	6	PF05994	0.462
LIG_WW_3	26	30	PF00397	0.493
MOD_CDK_SPxxK_3	128	135	PF00069	0.376
MOD_CMANNOS	79	82	PF00535	0.353
MOD_GlcNHglycan	128	131	PF01048	0.367
MOD_GSK3_1	33	40	PF00069	0.379
MOD_GSK3_1	48	55	PF00069	0.359
MOD_NEK2_1	19	24	PF00069	0.367
MOD_NEK2_1	4	9	PF00069	0.444
MOD_NEK2_1	78	83	PF00069	0.479
MOD_NEK2_2	88	93	PF00069	0.344
MOD_PIKK_1	106	112	PF00454	0.345
MOD_PIKK_1	39	45	PF00454	0.315
MOD_PK_1	37	43	PF00069	0.362
MOD_PKA_2	116	122	PF00069	0.467
MOD_Plk_4	88	94	PF00069	0.331
MOD_ProDKin_1	128	134	PF00069	0.369
MOD_SUMO_rev_2	70	78	PF00179	0.382
TRG_ENDOCYTIC_2	134	137	PF00928	0.314
TRG_ENDOCYTIC_2	89	92	PF00928	0.397
TRG_ER_diArg_1	142	144	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R1	Leptomonas seymouri	47%	100%
A0A1X0P821	Trypanosomatidae	33%	100%
A0A3Q8IJY0	Leishmania donovani	100%	100%
A4HNW9	Leishmania braziliensis	67%	100%
E9ASM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1W7	Leishmania major	94%	100%