Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HORMA domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICM3_LEIIN

TriTrypDb:

LINF_360016900

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.436
CLV_NRD_NRD_1	144	146	PF00675	0.424
CLV_NRD_NRD_1	147	149	PF00675	0.398
CLV_NRD_NRD_1	385	387	PF00675	0.598
CLV_NRD_NRD_1	524	526	PF00675	0.686
CLV_NRD_NRD_1	534	536	PF00675	0.642
CLV_PCSK_FUR_1	145	149	PF00082	0.411
CLV_PCSK_KEX2_1	146	148	PF00082	0.416
CLV_PCSK_KEX2_1	385	387	PF00082	0.598
CLV_PCSK_KEX2_1	524	526	PF00082	0.686
CLV_PCSK_KEX2_1	533	535	PF00082	0.656
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.513
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.591
CLV_PCSK_PC7_1	520	526	PF00082	0.660
CLV_PCSK_SKI1_1	179	183	PF00082	0.411
CLV_PCSK_SKI1_1	246	250	PF00082	0.582
CLV_PCSK_SKI1_1	385	389	PF00082	0.544
CLV_PCSK_SKI1_1	43	47	PF00082	0.411
CLV_PCSK_SKI1_1	528	532	PF00082	0.690
CLV_PCSK_SKI1_1	69	73	PF00082	0.375
CLV_PCSK_SKI1_1	93	97	PF00082	0.363
DEG_APCC_DBOX_1	76	84	PF00400	0.411
DOC_CYCLIN_RxL_1	90	98	PF00134	0.338
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.510
DOC_MAPK_MEF2A_6	43	50	PF00069	0.411
DOC_PP2B_LxvP_1	46	49	PF13499	0.407
DOC_PP4_FxxP_1	450	453	PF00568	0.480
DOC_USP7_MATH_1	23	27	PF00917	0.332
DOC_USP7_MATH_1	271	275	PF00917	0.775
DOC_USP7_MATH_1	279	283	PF00917	0.688
DOC_USP7_MATH_1	292	296	PF00917	0.774
DOC_USP7_MATH_1	339	343	PF00917	0.721
DOC_WW_Pin1_4	189	194	PF00397	0.411
DOC_WW_Pin1_4	458	463	PF00397	0.628
DOC_WW_Pin1_4	469	474	PF00397	0.807
LIG_14-3-3_CanoR_1	111	117	PF00244	0.411
LIG_14-3-3_CanoR_1	179	184	PF00244	0.411
LIG_14-3-3_CanoR_1	22	30	PF00244	0.347
LIG_14-3-3_CanoR_1	32	40	PF00244	0.353
LIG_14-3-3_CanoR_1	528	536	PF00244	0.751
LIG_BRCT_BRCA1_1	97	101	PF00533	0.396
LIG_Clathr_ClatBox_1	493	497	PF01394	0.534
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.411
LIG_FHA_1	126	132	PF00498	0.513
LIG_FHA_1	157	163	PF00498	0.411
LIG_FHA_1	180	186	PF00498	0.411
LIG_FHA_1	251	257	PF00498	0.645
LIG_FHA_1	258	264	PF00498	0.767
LIG_FHA_1	304	310	PF00498	0.714
LIG_FHA_1	392	398	PF00498	0.540
LIG_FHA_1	472	478	PF00498	0.646
LIG_FHA_1	498	504	PF00498	0.504
LIG_FHA_1	56	62	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.498
LIG_FHA_2	119	125	PF00498	0.436
LIG_FHA_2	184	190	PF00498	0.411
LIG_FHA_2	517	523	PF00498	0.448
LIG_FHA_2	60	66	PF00498	0.357
LIG_LIR_Apic_2	195	199	PF02991	0.513
LIG_LIR_Apic_2	448	453	PF02991	0.423
LIG_LIR_Apic_2	479	483	PF02991	0.411
LIG_LIR_Gen_1	186	196	PF02991	0.411
LIG_LIR_Gen_1	392	403	PF02991	0.437
LIG_LIR_Nem_3	186	191	PF02991	0.411
LIG_LIR_Nem_3	392	398	PF02991	0.396
LIG_LIR_Nem_3	422	427	PF02991	0.529
LIG_NRBOX	392	398	PF00104	0.438
LIG_NRBOX	498	504	PF00104	0.523
LIG_Pex14_1	284	288	PF04695	0.717
LIG_SH2_CRK	188	192	PF00017	0.397
LIG_SH2_CRK	424	428	PF00017	0.529
LIG_SH2_NCK_1	188	192	PF00017	0.411
LIG_SH2_SRC	196	199	PF00017	0.438
LIG_SH2_STAT5	105	108	PF00017	0.411
LIG_SH2_STAT5	395	398	PF00017	0.454
LIG_SH2_STAT5	517	520	PF00017	0.511
LIG_SH2_STAT5	79	82	PF00017	0.411
LIG_SH2_STAT5	99	102	PF00017	0.183
LIG_SH3_2	276	281	PF14604	0.795
LIG_SH3_3	136	142	PF00018	0.474
LIG_SH3_3	270	276	PF00018	0.705
LIG_SH3_3	459	465	PF00018	0.717
LIG_SH3_3	479	485	PF00018	0.453
LIG_SH3_4	464	471	PF00018	0.674
LIG_SUMO_SIM_anti_2	436	442	PF11976	0.489
LIG_SUMO_SIM_par_1	263	270	PF11976	0.587
LIG_TRAF2_1	150	153	PF00917	0.411
LIG_TRAF2_1	334	337	PF00917	0.794
LIG_TRAF2_1	519	522	PF00917	0.626
LIG_TYR_ITSM	184	191	PF00017	0.411
MOD_CDK_SPK_2	458	463	PF00069	0.628
MOD_CDK_SPxK_1	458	464	PF00069	0.570
MOD_CDK_SPxxK_3	471	478	PF00069	0.733
MOD_CK1_1	132	138	PF00069	0.473
MOD_CK1_1	224	230	PF00069	0.411
MOD_CK1_1	26	32	PF00069	0.360
MOD_CK1_1	274	280	PF00069	0.696
MOD_CK1_1	286	292	PF00069	0.639
MOD_CK1_1	3	9	PF00069	0.677
MOD_CK1_1	348	354	PF00069	0.586
MOD_CK1_1	471	477	PF00069	0.743
MOD_CK2_1	147	153	PF00069	0.411
MOD_CK2_1	157	163	PF00069	0.411
MOD_CK2_1	279	285	PF00069	0.696
MOD_CK2_1	330	336	PF00069	0.696
MOD_CK2_1	340	346	PF00069	0.688
MOD_CK2_1	378	384	PF00069	0.726
MOD_CK2_1	516	522	PF00069	0.571
MOD_CK2_1	53	59	PF00069	0.362
MOD_GlcNHglycan	134	137	PF01048	0.513
MOD_GlcNHglycan	253	256	PF01048	0.643
MOD_GlcNHglycan	268	272	PF01048	0.746
MOD_GlcNHglycan	281	284	PF01048	0.717
MOD_GlcNHglycan	295	298	PF01048	0.608
MOD_GlcNHglycan	332	335	PF01048	0.793
MOD_GlcNHglycan	350	353	PF01048	0.527
MOD_GlcNHglycan	380	383	PF01048	0.670
MOD_GlcNHglycan	407	410	PF01048	0.615
MOD_GlcNHglycan	432	436	PF01048	0.594
MOD_GSK3_1	125	132	PF00069	0.462
MOD_GSK3_1	179	186	PF00069	0.411
MOD_GSK3_1	221	228	PF00069	0.391
MOD_GSK3_1	246	253	PF00069	0.608
MOD_GSK3_1	267	274	PF00069	0.780
MOD_GSK3_1	279	286	PF00069	0.687
MOD_GSK3_1	401	408	PF00069	0.566
MOD_GSK3_1	464	471	PF00069	0.596
MOD_GSK3_1	497	504	PF00069	0.508
MOD_GSK3_1	512	519	PF00069	0.455
MOD_GSK3_1	53	60	PF00069	0.349
MOD_N-GLC_1	103	108	PF02516	0.411
MOD_N-GLC_1	126	131	PF02516	0.466
MOD_N-GLC_1	8	13	PF02516	0.485
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	157	162	PF00069	0.509
MOD_NEK2_1	183	188	PF00069	0.411
MOD_NEK2_1	376	381	PF00069	0.593
MOD_NEK2_1	401	406	PF00069	0.466
MOD_NEK2_1	95	100	PF00069	0.396
MOD_PIKK_1	129	135	PF00454	0.462
MOD_PIKK_1	464	470	PF00454	0.650
MOD_PIKK_1	8	14	PF00454	0.495
MOD_PKA_1	147	153	PF00069	0.411
MOD_PKA_2	147	153	PF00069	0.411
MOD_PKA_2	183	189	PF00069	0.411
MOD_PKA_2	21	27	PF00069	0.407
MOD_PKA_2	250	256	PF00069	0.677
MOD_PKA_2	348	354	PF00069	0.629
MOD_PKA_2	443	449	PF00069	0.595
MOD_PKB_1	145	153	PF00069	0.411
MOD_Plk_1	126	132	PF00069	0.377
MOD_Plk_1	284	290	PF00069	0.693
MOD_Plk_1	391	397	PF00069	0.546
MOD_Plk_1	512	518	PF00069	0.521
MOD_Plk_1	81	87	PF00069	0.411
MOD_Plk_2-3	59	65	PF00069	0.411
MOD_Plk_4	157	163	PF00069	0.513
MOD_Plk_4	183	189	PF00069	0.411
MOD_Plk_4	391	397	PF00069	0.471
MOD_Plk_4	485	491	PF00069	0.490
MOD_Plk_4	512	518	PF00069	0.521
MOD_ProDKin_1	189	195	PF00069	0.411
MOD_ProDKin_1	458	464	PF00069	0.636
MOD_ProDKin_1	469	475	PF00069	0.799
TRG_DiLeu_BaEn_1	153	158	PF01217	0.513
TRG_DiLeu_BaEn_1	392	397	PF01217	0.439
TRG_DiLeu_BaEn_1	436	441	PF01217	0.364
TRG_DiLeu_BaEn_2	40	46	PF01217	0.407
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.491
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.563
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.648
TRG_ENDOCYTIC_2	188	191	PF00928	0.411
TRG_ENDOCYTIC_2	395	398	PF00928	0.445
TRG_ENDOCYTIC_2	424	427	PF00928	0.525
TRG_ER_diArg_1	144	147	PF00400	0.411
TRG_ER_diArg_1	385	387	PF00400	0.656
TRG_ER_diArg_1	523	525	PF00400	0.603
TRG_ER_diArg_1	534	537	PF00400	0.592
TRG_NLS_MonoCore_2	144	149	PF00514	0.513
TRG_NLS_MonoCore_2	462	467	PF00514	0.670
TRG_NLS_MonoExtC_3	532	537	PF00514	0.590
TRG_NLS_MonoExtN_4	142	149	PF00514	0.513
TRG_NLS_MonoExtN_4	460	467	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U4	Leptomonas seymouri	53%	99%
A0A3S7XAH4	Leishmania donovani	99%	100%
A4HNX1	Leishmania braziliensis	73%	100%
E9ASN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q1W5	Leishmania major	90%	100%