Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICM2_LEIIN

TriTrypDb:

LINF_360017000

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4ICM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.381
CLV_NRD_NRD_1	138	140	PF00675	0.661
CLV_NRD_NRD_1	33	35	PF00675	0.706
CLV_PCSK_KEX2_1	33	35	PF00082	0.679
CLV_PCSK_SKI1_1	175	179	PF00082	0.630
CLV_PCSK_SKI1_1	67	71	PF00082	0.671
DEG_APCC_DBOX_1	8	16	PF00400	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_CKS1_1	117	122	PF01111	0.445
DOC_CYCLIN_RxL_1	171	182	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.621
DOC_MAPK_FxFP_2	156	159	PF00069	0.428
DOC_PP1_RVXF_1	251	257	PF00149	0.454
DOC_PP4_FxxP_1	156	159	PF00568	0.428
DOC_PP4_FxxP_1	300	303	PF00568	0.608
DOC_USP7_MATH_1	22	26	PF00917	0.383
DOC_USP7_MATH_1	284	288	PF00917	0.606
DOC_USP7_MATH_1	292	296	PF00917	0.629
DOC_USP7_MATH_1	5	9	PF00917	0.616
DOC_USP7_UBL2_3	218	222	PF12436	0.438
DOC_WW_Pin1_4	116	121	PF00397	0.436
LIG_14-3-3_CanoR_1	180	184	PF00244	0.394
LIG_14-3-3_CanoR_1	201	206	PF00244	0.434
LIG_14-3-3_CanoR_1	240	244	PF00244	0.398
LIG_14-3-3_CanoR_1	245	254	PF00244	0.357
LIG_14-3-3_CanoR_1	274	280	PF00244	0.643
LIG_14-3-3_CanoR_1	283	292	PF00244	0.640
LIG_14-3-3_CanoR_1	3	12	PF00244	0.744
LIG_BRCT_BRCA1_1	64	68	PF00533	0.413
LIG_deltaCOP1_diTrp_1	149	156	PF00928	0.422
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.428
LIG_deltaCOP1_diTrp_1	305	313	PF00928	0.610
LIG_deltaCOP1_diTrp_1	324	334	PF00928	0.703
LIG_eIF4E_1	291	297	PF01652	0.616
LIG_FHA_1	266	272	PF00498	0.388
LIG_FHA_2	189	195	PF00498	0.424
LIG_FHA_2	57	63	PF00498	0.432
LIG_LIR_Apic_2	130	135	PF02991	0.406
LIG_LIR_Apic_2	154	159	PF02991	0.432
LIG_LIR_Apic_2	208	212	PF02991	0.414
LIG_LIR_Gen_1	191	200	PF02991	0.438
LIG_LIR_Gen_1	78	86	PF02991	0.455
LIG_LIR_Nem_3	127	132	PF02991	0.408
LIG_LIR_Nem_3	191	196	PF02991	0.428
LIG_LIR_Nem_3	224	229	PF02991	0.470
LIG_LIR_Nem_3	239	244	PF02991	0.354
LIG_LIR_Nem_3	78	82	PF02991	0.459
LIG_Pex14_1	47	51	PF04695	0.409
LIG_Pex14_2	262	266	PF04695	0.259
LIG_REV1ctd_RIR_1	66	72	PF16727	0.490
LIG_SH2_CRK	132	136	PF00017	0.404
LIG_SH2_GRB2like	336	339	PF00017	0.639
LIG_SH2_NCK_1	132	136	PF00017	0.404
LIG_SH2_STAT3	328	331	PF00017	0.706
LIG_SH2_STAT5	128	131	PF00017	0.419
LIG_SH2_STAT5	132	135	PF00017	0.396
LIG_SH2_STAT5	226	229	PF00017	0.504
LIG_SH2_STAT5	270	273	PF00017	0.384
LIG_SH3_3	204	210	PF00018	0.430
LIG_TRAF2_1	316	319	PF00917	0.610
LIG_TRAF2_1	59	62	PF00917	0.450
LIG_WRC_WIRS_1	41	46	PF05994	0.498
LIG_WW_1	211	214	PF00397	0.399
MOD_CDK_SPxK_1	116	122	PF00069	0.465
MOD_CK1_1	110	116	PF00069	0.576
MOD_CK1_1	18	24	PF00069	0.347
MOD_CK1_1	8	14	PF00069	0.796
MOD_CK2_1	233	239	PF00069	0.388
MOD_CK2_1	56	62	PF00069	0.448
MOD_CK2_1	85	91	PF00069	0.461
MOD_CMANNOS	183	186	PF00535	0.545
MOD_GlcNHglycan	17	20	PF01048	0.462
MOD_GlcNHglycan	25	28	PF01048	0.368
MOD_GSK3_1	18	25	PF00069	0.337
MOD_GSK3_1	184	191	PF00069	0.417
MOD_GSK3_1	239	246	PF00069	0.439
MOD_GSK3_1	4	11	PF00069	0.752
MOD_GSK3_1	52	59	PF00069	0.487
MOD_GSK3_1	87	94	PF00069	0.482
MOD_N-GLC_1	108	113	PF02516	0.681
MOD_NEK2_1	265	270	PF00069	0.365
MOD_NEK2_1	277	282	PF00069	0.589
MOD_PIKK_1	327	333	PF00454	0.627
MOD_PIKK_1	62	68	PF00454	0.432
MOD_PIKK_1	85	91	PF00454	0.551
MOD_PKA_2	179	185	PF00069	0.380
MOD_PKA_2	239	245	PF00069	0.412
MOD_PKA_2	56	62	PF00069	0.466
MOD_PKA_2	8	14	PF00069	0.711
MOD_Plk_1	107	113	PF00069	0.558
MOD_Plk_4	179	185	PF00069	0.380
MOD_Plk_4	239	245	PF00069	0.412
MOD_Plk_4	265	271	PF00069	0.374
MOD_ProDKin_1	116	122	PF00069	0.433
TRG_DiLeu_BaEn_1	230	235	PF01217	0.441
TRG_DiLeu_BaEn_2	257	263	PF01217	0.427
TRG_ENDOCYTIC_2	126	129	PF00928	0.428
TRG_ENDOCYTIC_2	226	229	PF00928	0.528
TRG_ENDOCYTIC_2	241	244	PF00928	0.318
TRG_ENDOCYTIC_2	36	39	PF00928	0.437
TRG_ENDOCYTIC_2	79	82	PF00928	0.457
TRG_ER_diArg_1	165	168	PF00400	0.482
TRG_ER_diArg_1	200	203	PF00400	0.434
TRG_ER_diArg_1	92	95	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P652	Leptomonas seymouri	86%	100%
A0A0S4JBL9	Bodo saltans	60%	100%
A0A1X0P846	Trypanosomatidae	74%	100%
A0A3S7XAH0	Leishmania donovani	100%	100%
A4HNX2	Leishmania braziliensis	86%	100%
D0A2T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1W4	Leishmania major	93%	100%
V5BZU2	Trypanosoma cruzi	70%	96%