LeishMANIAdb
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Ch36-1990 protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ch36-1990 protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICM1_LEIIN
TriTrypDb:
LINF_360017100
Length:
455

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 6
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICM1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICM1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 326 330 PF00656 0.409
CLV_NRD_NRD_1 270 272 PF00675 0.450
CLV_PCSK_KEX2_1 270 272 PF00082 0.436
CLV_PCSK_SKI1_1 234 238 PF00082 0.452
CLV_PCSK_SKI1_1 6 10 PF00082 0.648
CLV_PCSK_SKI1_1 90 94 PF00082 0.528
DEG_APCC_DBOX_1 233 241 PF00400 0.422
DEG_Nend_UBRbox_3 1 3 PF02207 0.537
DEG_SPOP_SBC_1 52 56 PF00917 0.407
DOC_CDC14_PxL_1 136 144 PF14671 0.423
DOC_CYCLIN_RxL_1 333 344 PF00134 0.374
DOC_CYCLIN_yCln2_LP_2 390 396 PF00134 0.434
DOC_CYCLIN_yCln2_LP_2 92 98 PF00134 0.471
DOC_MAPK_DCC_7 195 203 PF00069 0.415
DOC_MAPK_HePTP_8 192 204 PF00069 0.372
DOC_MAPK_HePTP_8 350 362 PF00069 0.398
DOC_MAPK_MEF2A_6 195 204 PF00069 0.413
DOC_MAPK_MEF2A_6 338 347 PF00069 0.359
DOC_MAPK_MEF2A_6 353 362 PF00069 0.285
DOC_PP2B_LxvP_1 92 95 PF13499 0.501
DOC_PP4_FxxP_1 178 181 PF00568 0.420
DOC_PP4_FxxP_1 30 33 PF00568 0.430
DOC_USP7_MATH_1 149 153 PF00917 0.445
DOC_USP7_MATH_1 215 219 PF00917 0.573
DOC_USP7_MATH_1 327 331 PF00917 0.410
DOC_USP7_MATH_1 341 345 PF00917 0.322
DOC_USP7_MATH_1 53 57 PF00917 0.463
DOC_WW_Pin1_4 151 156 PF00397 0.439
DOC_WW_Pin1_4 81 86 PF00397 0.491
LIG_14-3-3_CanoR_1 189 199 PF00244 0.438
LIG_14-3-3_CanoR_1 223 233 PF00244 0.385
LIG_14-3-3_CanoR_1 425 431 PF00244 0.452
LIG_14-3-3_CanoR_1 6 11 PF00244 0.522
LIG_BIR_III_4 43 47 PF00653 0.375
LIG_BRCT_BRCA1_1 161 165 PF00533 0.374
LIG_BRCT_BRCA1_1 38 42 PF00533 0.317
LIG_Clathr_ClatBox_1 360 364 PF01394 0.399
LIG_EH1_1 272 280 PF00400 0.441
LIG_eIF4E_1 273 279 PF01652 0.425
LIG_FHA_1 118 124 PF00498 0.412
LIG_FHA_1 243 249 PF00498 0.436
LIG_FHA_1 407 413 PF00498 0.377
LIG_FHA_2 191 197 PF00498 0.480
LIG_FHA_2 418 424 PF00498 0.486
LIG_FHA_2 52 58 PF00498 0.443
LIG_FHA_2 82 88 PF00498 0.533
LIG_LIR_Apic_2 28 33 PF02991 0.448
LIG_LIR_Gen_1 384 394 PF02991 0.422
LIG_LIR_Gen_1 39 50 PF02991 0.420
LIG_LIR_LC3C_4 359 362 PF02991 0.400
LIG_LIR_Nem_3 168 174 PF02991 0.433
LIG_LIR_Nem_3 28 34 PF02991 0.600
LIG_LIR_Nem_3 373 377 PF02991 0.447
LIG_LIR_Nem_3 384 390 PF02991 0.324
LIG_LIR_Nem_3 39 45 PF02991 0.373
LIG_LYPXL_yS_3 139 142 PF13949 0.420
LIG_MYND_3 435 439 PF01753 0.426
LIG_PDZ_Class_3 450 455 PF00595 0.608
LIG_Pex14_2 399 403 PF04695 0.452
LIG_SH2_CRK 397 401 PF00017 0.431
LIG_SH2_GRB2like 396 399 PF00017 0.397
LIG_SH2_STAT5 147 150 PF00017 0.354
LIG_SH2_STAT5 153 156 PF00017 0.355
LIG_SH2_STAT5 158 161 PF00017 0.302
LIG_SH2_STAT5 374 377 PF00017 0.428
LIG_SH3_3 134 140 PF00018 0.429
LIG_SH3_3 219 225 PF00018 0.444
LIG_SH3_3 308 314 PF00018 0.418
LIG_SUMO_SIM_anti_2 359 364 PF11976 0.407
LIG_SUMO_SIM_par_1 296 302 PF11976 0.430
LIG_SUMO_SIM_par_1 338 344 PF11976 0.372
LIG_SUMO_SIM_par_1 359 364 PF11976 0.363
LIG_SxIP_EBH_1 424 437 PF03271 0.443
LIG_TRAF2_1 286 289 PF00917 0.396
LIG_UBA3_1 386 395 PF00899 0.420
LIG_WRC_WIRS_1 400 405 PF05994 0.417
MOD_CK1_1 113 119 PF00069 0.418
MOD_CK1_1 25 31 PF00069 0.398
MOD_CK2_1 191 197 PF00069 0.451
MOD_CK2_1 229 235 PF00069 0.524
MOD_CK2_1 51 57 PF00069 0.432
MOD_CK2_1 81 87 PF00069 0.510
MOD_GlcNHglycan 24 27 PF01048 0.445
MOD_GlcNHglycan 325 328 PF01048 0.432
MOD_GlcNHglycan 329 332 PF01048 0.401
MOD_GlcNHglycan 403 406 PF01048 0.414
MOD_GlcNHglycan 69 72 PF01048 0.612
MOD_GSK3_1 106 113 PF00069 0.440
MOD_GSK3_1 147 154 PF00069 0.363
MOD_GSK3_1 238 245 PF00069 0.491
MOD_GSK3_1 323 330 PF00069 0.426
MOD_N-GLC_1 181 186 PF02516 0.433
MOD_N-GLC_1 190 195 PF02516 0.335
MOD_NEK2_1 159 164 PF00069 0.427
MOD_NEK2_1 239 244 PF00069 0.386
MOD_NEK2_1 323 328 PF00069 0.411
MOD_NEK2_1 34 39 PF00069 0.391
MOD_NEK2_1 399 404 PF00069 0.418
MOD_NEK2_1 8 13 PF00069 0.459
MOD_NEK2_2 341 346 PF00069 0.288
MOD_PIKK_1 159 165 PF00454 0.363
MOD_PIKK_1 255 261 PF00454 0.383
MOD_PIKK_1 406 412 PF00454 0.376
MOD_PKA_2 445 451 PF00069 0.513
MOD_Plk_1 181 187 PF00069 0.415
MOD_Plk_4 181 187 PF00069 0.486
MOD_Plk_4 356 362 PF00069 0.531
MOD_Plk_4 426 432 PF00069 0.438
MOD_ProDKin_1 151 157 PF00069 0.435
MOD_ProDKin_1 81 87 PF00069 0.504
MOD_SUMO_for_1 253 256 PF00179 0.496
MOD_SUMO_for_1 436 439 PF00179 0.569
TRG_DiLeu_BaEn_1 197 202 PF01217 0.372
TRG_DiLeu_BaEn_2 234 240 PF01217 0.423
TRG_ENDOCYTIC_2 139 142 PF00928 0.367
TRG_ENDOCYTIC_2 158 161 PF00928 0.219
TRG_ENDOCYTIC_2 374 377 PF00928 0.402
TRG_ENDOCYTIC_2 396 399 PF00928 0.489
TRG_ER_diArg_1 270 272 PF00400 0.431
TRG_NLS_MonoExtN_4 314 319 PF00514 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Q9 Leptomonas seymouri 54% 88%
A0A0S4JAW3 Bodo saltans 27% 100%
A4HNX3 Leishmania braziliensis 77% 100%
E9ASN3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
H2ALR9 Leishmania donovani 99% 100%
Q4Q1W3 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS