LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICL6_LEIIN
TriTrypDb:
LINF_360017600
Length:
335

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICL6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.428
CLV_NRD_NRD_1 267 269 PF00675 0.462
CLV_PCSK_KEX2_1 267 269 PF00082 0.368
CLV_PCSK_SKI1_1 268 272 PF00082 0.492
CLV_PCSK_SKI1_1 308 312 PF00082 0.409
DEG_Nend_Nbox_1 1 3 PF02207 0.572
DEG_SCF_FBW7_1 172 179 PF00400 0.554
DOC_CYCLIN_RxL_1 149 157 PF00134 0.416
DOC_CYCLIN_RxL_1 305 314 PF00134 0.361
DOC_MAPK_gen_1 267 275 PF00069 0.351
DOC_MAPK_gen_1 70 78 PF00069 0.421
DOC_MAPK_HePTP_8 265 277 PF00069 0.352
DOC_MAPK_MEF2A_6 142 151 PF00069 0.500
DOC_MAPK_MEF2A_6 268 277 PF00069 0.343
DOC_MAPK_MEF2A_6 70 78 PF00069 0.333
DOC_PP4_FxxP_1 79 82 PF00568 0.397
DOC_USP7_MATH_1 216 220 PF00917 0.404
DOC_USP7_MATH_1 237 241 PF00917 0.526
DOC_USP7_MATH_1 326 330 PF00917 0.615
DOC_USP7_MATH_1 82 86 PF00917 0.451
DOC_WW_Pin1_4 143 148 PF00397 0.419
DOC_WW_Pin1_4 154 159 PF00397 0.410
DOC_WW_Pin1_4 172 177 PF00397 0.491
DOC_WW_Pin1_4 28 33 PF00397 0.383
LIG_14-3-3_CanoR_1 51 55 PF00244 0.421
LIG_14-3-3_CanoR_1 6 10 PF00244 0.562
LIG_Actin_WH2_2 35 53 PF00022 0.369
LIG_APCC_ABBA_1 275 280 PF00400 0.422
LIG_BRCT_BRCA1_1 230 234 PF00533 0.488
LIG_Clathr_ClatBox_1 310 314 PF01394 0.362
LIG_FHA_1 100 106 PF00498 0.406
LIG_FHA_1 123 129 PF00498 0.353
LIG_FHA_1 144 150 PF00498 0.424
LIG_FHA_1 177 183 PF00498 0.648
LIG_FHA_1 39 45 PF00498 0.443
LIG_FHA_2 317 323 PF00498 0.522
LIG_LIR_Gen_1 219 229 PF02991 0.535
LIG_LIR_Gen_1 266 277 PF02991 0.352
LIG_LIR_Gen_1 37 45 PF02991 0.472
LIG_LIR_LC3C_4 125 129 PF02991 0.398
LIG_LIR_Nem_3 201 206 PF02991 0.462
LIG_LIR_Nem_3 219 224 PF02991 0.203
LIG_LIR_Nem_3 266 272 PF02991 0.350
LIG_LIR_Nem_3 37 42 PF02991 0.468
LIG_PCNA_yPIPBox_3 61 75 PF02747 0.436
LIG_REV1ctd_RIR_1 14 24 PF16727 0.456
LIG_RPA_C_Fungi 188 200 PF08784 0.321
LIG_SH2_SRC 75 78 PF00017 0.466
LIG_SH2_STAP1 101 105 PF00017 0.421
LIG_SH2_STAT5 101 104 PF00017 0.362
LIG_SH2_STAT5 75 78 PF00017 0.469
LIG_SH3_2 147 152 PF14604 0.450
LIG_SH3_3 144 150 PF00018 0.475
LIG_SH3_3 39 45 PF00018 0.427
LIG_SH3_3 71 77 PF00018 0.355
LIG_SUMO_SIM_anti_2 125 131 PF11976 0.422
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.442
LIG_SUMO_SIM_par_1 125 131 PF11976 0.393
LIG_SUMO_SIM_par_1 309 314 PF11976 0.351
LIG_SUMO_SIM_par_1 60 66 PF11976 0.384
LIG_TRFH_1 28 32 PF08558 0.421
LIG_WRC_WIRS_1 138 143 PF05994 0.447
LIG_WRC_WIRS_1 36 41 PF05994 0.552
MOD_CDK_SPxK_1 172 178 PF00069 0.553
MOD_CK1_1 230 236 PF00069 0.460
MOD_CK1_1 5 11 PF00069 0.493
MOD_CK1_1 85 91 PF00069 0.457
MOD_GlcNHglycan 179 182 PF01048 0.625
MOD_GlcNHglycan 303 306 PF01048 0.401
MOD_GlcNHglycan 54 57 PF01048 0.512
MOD_GSK3_1 118 125 PF00069 0.601
MOD_GSK3_1 162 169 PF00069 0.658
MOD_GSK3_1 172 179 PF00069 0.530
MOD_GSK3_1 233 240 PF00069 0.440
MOD_GSK3_1 297 304 PF00069 0.386
MOD_GSK3_1 326 333 PF00069 0.682
MOD_GSK3_1 5 12 PF00069 0.541
MOD_N-GLC_1 189 194 PF02516 0.482
MOD_N-GLC_1 227 232 PF02516 0.470
MOD_N-GLC_1 28 33 PF02516 0.461
MOD_N-GLC_1 297 302 PF02516 0.387
MOD_N-GLC_1 88 93 PF02516 0.475
MOD_N-GLC_2 207 209 PF02516 0.427
MOD_NEK2_1 177 182 PF00069 0.575
MOD_NEK2_1 189 194 PF00069 0.367
MOD_NEK2_1 2 7 PF00069 0.626
MOD_NEK2_1 50 55 PF00069 0.439
MOD_NEK2_1 9 14 PF00069 0.482
MOD_NEK2_2 107 112 PF00069 0.364
MOD_NEK2_2 137 142 PF00069 0.442
MOD_PIKK_1 162 168 PF00454 0.664
MOD_PKA_2 177 183 PF00069 0.738
MOD_PKA_2 5 11 PF00069 0.562
MOD_PKA_2 50 56 PF00069 0.414
MOD_Plk_1 227 233 PF00069 0.452
MOD_Plk_4 122 128 PF00069 0.372
MOD_Plk_4 181 187 PF00069 0.699
MOD_Plk_4 217 223 PF00069 0.334
MOD_Plk_4 38 44 PF00069 0.367
MOD_ProDKin_1 143 149 PF00069 0.415
MOD_ProDKin_1 154 160 PF00069 0.408
MOD_ProDKin_1 172 178 PF00069 0.494
MOD_ProDKin_1 28 34 PF00069 0.383
TRG_DiLeu_BaLyEn_6 184 189 PF01217 0.563
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.367
TRG_ENDOCYTIC_2 138 141 PF00928 0.436
TRG_ENDOCYTIC_2 203 206 PF00928 0.426
TRG_ENDOCYTIC_2 36 39 PF00928 0.443
TRG_ENDOCYTIC_2 75 78 PF00928 0.377
TRG_ER_diArg_1 267 269 PF00400 0.462
TRG_NES_CRM1_1 33 47 PF08389 0.361
TRG_Pf-PMV_PEXEL_1 204 208 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 48 52 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 61 66 PF00026 0.343

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC55 Leptomonas seymouri 41% 100%
A0A3S7XAI8 Leishmania donovani 100% 100%
A0A422NTW5 Trypanosoma rangeli 31% 100%
A4HNX8 Leishmania braziliensis 75% 100%
D0A2U4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ASN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q1V8 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS