LeishMANIAdb
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Mannosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase
Gene product:
GPI alpha-mannosyltransferase III
Species:
Leishmania infantum
UniProt:
A4ICL4_LEIIN
TriTrypDb:
LINF_360017800
Length:
626

Annotations

Annotations by Jardim et al.

GPI anchor biosynthesis, GPI alpha-mannosyltransferase III GPI10

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 7
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 12
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4ICL4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICL4

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 12
GO:0006505 GPI anchor metabolic process 6 12
GO:0006506 GPI anchor biosynthetic process 6 12
GO:0006629 lipid metabolic process 3 12
GO:0006643 membrane lipid metabolic process 4 12
GO:0006644 phospholipid metabolic process 4 12
GO:0006650 glycerophospholipid metabolic process 5 12
GO:0006661 phosphatidylinositol biosynthetic process 6 12
GO:0006664 glycolipid metabolic process 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0008610 lipid biosynthetic process 4 12
GO:0008654 phospholipid biosynthetic process 5 12
GO:0009058 biosynthetic process 2 12
GO:0009247 glycolipid biosynthetic process 5 12
GO:0009987 cellular process 1 12
GO:0019538 protein metabolic process 3 12
GO:0019637 organophosphate metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044255 cellular lipid metabolic process 3 12
GO:0045017 glycerolipid biosynthetic process 4 12
GO:0046467 membrane lipid biosynthetic process 4 12
GO:0046474 glycerophospholipid biosynthetic process 5 12
GO:0046486 glycerolipid metabolic process 4 12
GO:0046488 phosphatidylinositol metabolic process 6 12
GO:0071704 organic substance metabolic process 2 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901137 carbohydrate derivative biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901576 organic substance biosynthetic process 3 12
GO:1903509 liposaccharide metabolic process 4 12
Molecular functions
Term Name Level Count
GO:0000026 alpha-1,2-mannosyltransferase activity 6 12
GO:0000030 mannosyltransferase activity 5 12
GO:0003824 catalytic activity 1 12
GO:0004376 glycolipid mannosyltransferase activity 6 12
GO:0016740 transferase activity 2 12
GO:0016757 glycosyltransferase activity 3 12
GO:0016758 hexosyltransferase activity 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.332
CLV_NRD_NRD_1 131 133 PF00675 0.332
CLV_NRD_NRD_1 413 415 PF00675 0.329
CLV_NRD_NRD_1 427 429 PF00675 0.311
CLV_NRD_NRD_1 449 451 PF00675 0.465
CLV_NRD_NRD_1 593 595 PF00675 0.534
CLV_PCSK_FUR_1 410 414 PF00082 0.206
CLV_PCSK_KEX2_1 125 127 PF00082 0.305
CLV_PCSK_KEX2_1 131 133 PF00082 0.319
CLV_PCSK_KEX2_1 355 357 PF00082 0.392
CLV_PCSK_KEX2_1 412 414 PF00082 0.324
CLV_PCSK_KEX2_1 427 429 PF00082 0.309
CLV_PCSK_KEX2_1 449 451 PF00082 0.465
CLV_PCSK_KEX2_1 593 595 PF00082 0.594
CLV_PCSK_PC1ET2_1 355 357 PF00082 0.433
CLV_PCSK_PC7_1 351 357 PF00082 0.331
CLV_PCSK_SKI1_1 135 139 PF00082 0.309
CLV_PCSK_SKI1_1 17 21 PF00082 0.471
CLV_PCSK_SKI1_1 239 243 PF00082 0.285
CLV_PCSK_SKI1_1 268 272 PF00082 0.516
CLV_PCSK_SKI1_1 356 360 PF00082 0.397
CLV_PCSK_SKI1_1 427 431 PF00082 0.302
CLV_PCSK_SKI1_1 513 517 PF00082 0.558
CLV_PCSK_SKI1_1 52 56 PF00082 0.527
CLV_PCSK_SKI1_1 554 558 PF00082 0.538
CLV_Separin_Metazoa 555 559 PF03568 0.260
DEG_APCC_DBOX_1 16 24 PF00400 0.407
DEG_APCC_DBOX_1 496 504 PF00400 0.304
DEG_APCC_DBOX_1 553 561 PF00400 0.264
DEG_Nend_UBRbox_2 1 3 PF02207 0.497
DEG_SPOP_SBC_1 141 145 PF00917 0.509
DOC_CDC14_PxL_1 359 367 PF14671 0.395
DOC_CDC14_PxL_1 380 388 PF14671 0.454
DOC_CDC14_PxL_1 76 84 PF14671 0.337
DOC_CKS1_1 270 275 PF01111 0.279
DOC_CKS1_1 476 481 PF01111 0.271
DOC_CYCLIN_RxL_1 234 246 PF00134 0.560
DOC_CYCLIN_RxL_1 424 433 PF00134 0.540
DOC_CYCLIN_yCln2_LP_2 586 592 PF00134 0.362
DOC_MAPK_DCC_7 377 387 PF00069 0.265
DOC_MAPK_gen_1 410 420 PF00069 0.533
DOC_MAPK_gen_1 526 536 PF00069 0.404
DOC_MAPK_gen_1 593 599 PF00069 0.324
DOC_MAPK_MEF2A_6 17 25 PF00069 0.370
DOC_MAPK_MEF2A_6 27 34 PF00069 0.293
DOC_MAPK_NFAT4_5 17 25 PF00069 0.443
DOC_MAPK_NFAT4_5 27 35 PF00069 0.409
DOC_PP1_RVXF_1 266 272 PF00149 0.358
DOC_PP1_RVXF_1 375 382 PF00149 0.345
DOC_PP1_RVXF_1 488 494 PF00149 0.366
DOC_PP2B_LxvP_1 418 421 PF13499 0.540
DOC_PP4_FxxP_1 138 141 PF00568 0.504
DOC_PP4_FxxP_1 381 384 PF00568 0.376
DOC_PP4_FxxP_1 77 80 PF00568 0.427
DOC_USP7_MATH_1 13 17 PF00917 0.481
DOC_USP7_MATH_1 141 145 PF00917 0.518
DOC_USP7_MATH_1 419 423 PF00917 0.517
DOC_USP7_MATH_1 621 625 PF00917 0.440
DOC_USP7_MATH_1 67 71 PF00917 0.304
DOC_WW_Pin1_4 153 158 PF00397 0.483
DOC_WW_Pin1_4 269 274 PF00397 0.254
DOC_WW_Pin1_4 36 41 PF00397 0.279
DOC_WW_Pin1_4 475 480 PF00397 0.276
LIG_14-3-3_CanoR_1 135 141 PF00244 0.406
LIG_14-3-3_CanoR_1 213 221 PF00244 0.289
LIG_14-3-3_CanoR_1 27 31 PF00244 0.413
LIG_14-3-3_CanoR_1 412 417 PF00244 0.519
LIG_14-3-3_CanoR_1 427 433 PF00244 0.511
LIG_14-3-3_CanoR_1 513 522 PF00244 0.341
LIG_14-3-3_CanoR_1 57 63 PF00244 0.340
LIG_Actin_WH2_2 390 408 PF00022 0.376
LIG_BRCT_BRCA1_1 186 190 PF00533 0.329
LIG_BRCT_BRCA1_1 338 342 PF00533 0.504
LIG_BRCT_BRCA1_1 436 440 PF00533 0.337
LIG_BRCT_BRCA1_1 69 73 PF00533 0.322
LIG_CSL_BTD_1 313 316 PF09270 0.415
LIG_eIF4E_1 380 386 PF01652 0.415
LIG_FHA_1 154 160 PF00498 0.530
LIG_FHA_1 27 33 PF00498 0.434
LIG_FHA_1 362 368 PF00498 0.406
LIG_FHA_1 397 403 PF00498 0.336
LIG_FHA_1 439 445 PF00498 0.396
LIG_FHA_1 576 582 PF00498 0.373
LIG_FHA_2 143 149 PF00498 0.512
LIG_FHA_2 85 91 PF00498 0.559
LIG_IRF3_LxIS_1 383 390 PF10401 0.376
LIG_LIR_Apic_2 70 74 PF02991 0.392
LIG_LIR_Apic_2 8 13 PF02991 0.445
LIG_LIR_Gen_1 16 26 PF02991 0.279
LIG_LIR_Gen_1 180 189 PF02991 0.327
LIG_LIR_Gen_1 215 226 PF02991 0.376
LIG_LIR_Gen_1 272 282 PF02991 0.332
LIG_LIR_Gen_1 375 386 PF02991 0.315
LIG_LIR_Gen_1 478 488 PF02991 0.289
LIG_LIR_Gen_1 609 619 PF02991 0.335
LIG_LIR_Nem_3 16 21 PF02991 0.430
LIG_LIR_Nem_3 170 174 PF02991 0.304
LIG_LIR_Nem_3 180 184 PF02991 0.285
LIG_LIR_Nem_3 186 192 PF02991 0.306
LIG_LIR_Nem_3 197 202 PF02991 0.197
LIG_LIR_Nem_3 215 221 PF02991 0.276
LIG_LIR_Nem_3 262 266 PF02991 0.265
LIG_LIR_Nem_3 272 277 PF02991 0.253
LIG_LIR_Nem_3 286 291 PF02991 0.206
LIG_LIR_Nem_3 375 381 PF02991 0.328
LIG_LIR_Nem_3 454 459 PF02991 0.315
LIG_LIR_Nem_3 463 469 PF02991 0.340
LIG_LIR_Nem_3 478 484 PF02991 0.297
LIG_LIR_Nem_3 48 54 PF02991 0.254
LIG_LIR_Nem_3 609 615 PF02991 0.394
LIG_LIR_Nem_3 70 76 PF02991 0.317
LIG_MLH1_MIPbox_1 186 190 PF16413 0.329
LIG_NRBOX 18 24 PF00104 0.411
LIG_NRBOX 187 193 PF00104 0.283
LIG_Pex14_2 310 314 PF04695 0.415
LIG_Pex14_2 342 346 PF04695 0.351
LIG_Pex14_2 430 434 PF04695 0.427
LIG_Pex14_2 73 77 PF04695 0.398
LIG_SH2_CRK 181 185 PF00017 0.283
LIG_SH2_CRK 266 270 PF00017 0.340
LIG_SH2_CRK 274 278 PF00017 0.340
LIG_SH2_CRK 476 480 PF00017 0.252
LIG_SH2_CRK 51 55 PF00017 0.279
LIG_SH2_CRK 592 596 PF00017 0.404
LIG_SH2_GRB2like 181 184 PF00017 0.295
LIG_SH2_NCK_1 181 185 PF00017 0.340
LIG_SH2_PTP2 71 74 PF00017 0.415
LIG_SH2_STAT5 263 266 PF00017 0.307
LIG_SH2_STAT5 281 284 PF00017 0.307
LIG_SH2_STAT5 297 300 PF00017 0.267
LIG_SH2_STAT5 380 383 PF00017 0.415
LIG_SH2_STAT5 527 530 PF00017 0.317
LIG_SH2_STAT5 612 615 PF00017 0.352
LIG_SH2_STAT5 71 74 PF00017 0.374
LIG_SH3_3 267 273 PF00018 0.275
LIG_SH3_3 288 294 PF00018 0.315
LIG_SH3_3 296 302 PF00018 0.254
LIG_SH3_3 310 316 PF00018 0.248
LIG_SH3_3 357 363 PF00018 0.395
LIG_SH3_3 563 569 PF00018 0.401
LIG_SUMO_SIM_anti_2 390 396 PF11976 0.427
LIG_SUMO_SIM_anti_2 441 446 PF11976 0.379
LIG_SUMO_SIM_par_1 165 170 PF11976 0.339
LIG_SUMO_SIM_par_1 363 370 PF11976 0.376
LIG_SUMO_SIM_par_1 384 391 PF11976 0.384
LIG_TRAF2_1 604 607 PF00917 0.383
LIG_TRFH_1 380 384 PF08558 0.412
LIG_TYR_ITIM 264 269 PF00017 0.298
LIG_TYR_ITIM 49 54 PF00017 0.254
LIG_UBA3_1 556 562 PF00899 0.268
LIG_UBA3_1 81 85 PF00899 0.453
LIG_WRC_WIRS_1 602 607 PF05994 0.328
MOD_CK1_1 130 136 PF00069 0.551
MOD_CK1_1 144 150 PF00069 0.479
MOD_CK1_1 400 406 PF00069 0.555
MOD_CK1_1 422 428 PF00069 0.392
MOD_CK1_1 617 623 PF00069 0.460
MOD_CK2_1 142 148 PF00069 0.562
MOD_CK2_1 36 42 PF00069 0.258
MOD_CK2_1 366 372 PF00069 0.368
MOD_CK2_1 601 607 PF00069 0.416
MOD_GlcNHglycan 132 135 PF01048 0.335
MOD_GlcNHglycan 138 141 PF01048 0.264
MOD_GlcNHglycan 254 257 PF01048 0.390
MOD_GlcNHglycan 330 333 PF01048 0.342
MOD_GlcNHglycan 342 345 PF01048 0.351
MOD_GlcNHglycan 402 405 PF01048 0.345
MOD_GlcNHglycan 421 424 PF01048 0.229
MOD_GlcNHglycan 436 439 PF01048 0.316
MOD_GlcNHglycan 503 506 PF01048 0.587
MOD_GSK3_1 136 143 PF00069 0.515
MOD_GSK3_1 155 162 PF00069 0.493
MOD_GSK3_1 173 180 PF00069 0.254
MOD_GSK3_1 190 197 PF00069 0.215
MOD_GSK3_1 26 33 PF00069 0.376
MOD_GSK3_1 336 343 PF00069 0.553
MOD_GSK3_1 396 403 PF00069 0.390
MOD_GSK3_1 430 437 PF00069 0.423
MOD_GSK3_1 617 624 PF00069 0.444
MOD_GSK3_1 84 91 PF00069 0.415
MOD_NEK2_1 142 147 PF00069 0.530
MOD_NEK2_1 173 178 PF00069 0.397
MOD_NEK2_1 190 195 PF00069 0.185
MOD_NEK2_1 212 217 PF00069 0.268
MOD_NEK2_1 283 288 PF00069 0.342
MOD_NEK2_1 30 35 PF00069 0.336
MOD_NEK2_1 330 335 PF00069 0.513
MOD_NEK2_1 342 347 PF00069 0.559
MOD_NEK2_1 366 371 PF00069 0.368
MOD_NEK2_1 387 392 PF00069 0.376
MOD_NEK2_1 396 401 PF00069 0.386
MOD_NEK2_1 405 410 PF00069 0.495
MOD_NEK2_1 430 435 PF00069 0.331
MOD_NEK2_1 575 580 PF00069 0.308
MOD_NEK2_1 84 89 PF00069 0.375
MOD_NEK2_2 337 342 PF00069 0.549
MOD_PIKK_1 507 513 PF00454 0.396
MOD_PKA_1 412 418 PF00069 0.406
MOD_PKA_2 130 136 PF00069 0.543
MOD_PKA_2 212 218 PF00069 0.276
MOD_PKA_2 26 32 PF00069 0.376
MOD_PKA_2 412 418 PF00069 0.515
MOD_PKA_2 617 623 PF00069 0.403
MOD_PKB_1 410 418 PF00069 0.434
MOD_Plk_1 110 116 PF00069 0.540
MOD_Plk_4 110 116 PF00069 0.372
MOD_Plk_4 184 190 PF00069 0.307
MOD_Plk_4 337 343 PF00069 0.559
MOD_Plk_4 361 367 PF00069 0.334
MOD_Plk_4 388 394 PF00069 0.384
MOD_Plk_4 451 457 PF00069 0.324
MOD_Plk_4 91 97 PF00069 0.519
MOD_ProDKin_1 153 159 PF00069 0.483
MOD_ProDKin_1 269 275 PF00069 0.254
MOD_ProDKin_1 36 42 PF00069 0.279
MOD_ProDKin_1 475 481 PF00069 0.276
MOD_SUMO_for_1 561 564 PF00179 0.328
MOD_SUMO_rev_2 369 376 PF00179 0.411
TRG_DiLeu_BaEn_2 185 191 PF01217 0.298
TRG_DiLeu_BaLyEn_6 381 386 PF01217 0.376
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.412
TRG_ENDOCYTIC_2 181 184 PF00928 0.302
TRG_ENDOCYTIC_2 199 202 PF00928 0.207
TRG_ENDOCYTIC_2 266 269 PF00928 0.279
TRG_ENDOCYTIC_2 274 277 PF00928 0.279
TRG_ENDOCYTIC_2 288 291 PF00928 0.224
TRG_ENDOCYTIC_2 295 298 PF00928 0.258
TRG_ENDOCYTIC_2 368 371 PF00928 0.301
TRG_ENDOCYTIC_2 380 383 PF00928 0.276
TRG_ENDOCYTIC_2 51 54 PF00928 0.254
TRG_ENDOCYTIC_2 527 530 PF00928 0.310
TRG_ENDOCYTIC_2 592 595 PF00928 0.334
TRG_ENDOCYTIC_2 612 615 PF00928 0.164
TRG_ER_diArg_1 124 126 PF00400 0.406
TRG_ER_diArg_1 410 413 PF00400 0.510
TRG_ER_diArg_1 426 428 PF00400 0.514
TRG_ER_diArg_1 448 450 PF00400 0.295
TRG_ER_diArg_1 497 500 PF00400 0.422
TRG_ER_diArg_1 592 594 PF00400 0.320
TRG_NES_CRM1_1 489 501 PF08389 0.361
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.248

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Q8 Leptomonas seymouri 56% 100%
A0A0S4J7A7 Bodo saltans 28% 100%
A0A1X0P926 Trypanosomatidae 33% 100%
A0A3Q8IJ48 Leishmania donovani 99% 100%
A0A422NTW3 Trypanosoma rangeli 32% 100%
A4HNY0 Leishmania braziliensis 70% 100%
D0A2U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9ASP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
P30777 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P86935 Trypanosoma brucei brucei 34% 100%
P86936 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 34% 100%
Q4Q1V6 Leishmania major 88% 100%
Q4V7R2 Xenopus laevis 24% 100%
Q6CN76 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 22% 100%
Q6FTY5 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 24% 100%
Q94A15 Arabidopsis thaliana 25% 100%
Q9JJQ0 Mus musculus 26% 100%
Q9USN0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q9VZM5 Drosophila melanogaster 27% 100%
V5DRF7 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS