Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICL3_LEIIN

TriTrypDb:

LINF_360017900

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.504
CLV_C14_Caspase3-7	205	209	PF00656	0.619
CLV_PCSK_SKI1_1	113	117	PF00082	0.460
CLV_PCSK_SKI1_1	125	129	PF00082	0.440
CLV_PCSK_SKI1_1	211	215	PF00082	0.668
CLV_PCSK_SKI1_1	60	64	PF00082	0.488
DEG_SPOP_SBC_1	191	195	PF00917	0.655
DEG_SPOP_SBC_1	9	13	PF00917	0.627
DOC_USP7_MATH_1	107	111	PF00917	0.500
DOC_USP7_MATH_1	187	191	PF00917	0.698
DOC_USP7_MATH_1	9	13	PF00917	0.651
DOC_WW_Pin1_4	181	186	PF00397	0.733
DOC_WW_Pin1_4	2	7	PF00397	0.587
LIG_14-3-3_CanoR_1	188	196	PF00244	0.728
LIG_14-3-3_CanoR_1	245	250	PF00244	0.617
LIG_14-3-3_CanoR_1	7	16	PF00244	0.590
LIG_14-3-3_CanoR_1	82	88	PF00244	0.521
LIG_14-3-3_CanoR_1	91	97	PF00244	0.459
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	151	155	PF00533	0.495
LIG_DLG_GKlike_1	245	253	PF00625	0.505
LIG_FHA_1	191	197	PF00498	0.586
LIG_FHA_1	56	62	PF00498	0.438
LIG_FHA_1	84	90	PF00498	0.608
LIG_FHA_1	99	105	PF00498	0.445
LIG_FHA_2	169	175	PF00498	0.698
LIG_FHA_2	193	199	PF00498	0.605
LIG_FHA_2	218	224	PF00498	0.522
LIG_LIR_Gen_1	131	140	PF02991	0.419
LIG_LIR_Gen_1	167	175	PF02991	0.545
LIG_LIR_Gen_1	85	93	PF02991	0.519
LIG_LIR_Nem_3	131	137	PF02991	0.440
LIG_LIR_Nem_3	167	172	PF02991	0.574
LIG_LIR_Nem_3	220	225	PF02991	0.407
LIG_LIR_Nem_3	53	59	PF02991	0.400
LIG_LIR_Nem_3	85	90	PF02991	0.504
LIG_PCNA_PIPBox_1	112	121	PF02747	0.510
LIG_PCNA_PIPBox_1	240	249	PF02747	0.643
LIG_PCNA_yPIPBox_3	240	250	PF02747	0.636
LIG_SH2_CRK	222	226	PF00017	0.507
LIG_SH2_NCK_1	146	150	PF00017	0.367
LIG_SH2_STAP1	146	150	PF00017	0.367
LIG_SH2_STAP1	247	251	PF00017	0.514
LIG_SH2_STAP1	57	61	PF00017	0.537
LIG_SH2_STAT3	19	22	PF00017	0.595
LIG_SH2_STAT3	237	240	PF00017	0.596
LIG_SH2_STAT5	118	121	PF00017	0.476
LIG_SH2_STAT5	19	22	PF00017	0.549
LIG_SH2_STAT5	237	240	PF00017	0.504
LIG_SH2_STAT5	36	39	PF00017	0.438
LIG_SH2_STAT5	57	60	PF00017	0.512
LIG_SH3_3	236	242	PF00018	0.488
LIG_SUMO_SIM_anti_2	208	216	PF11976	0.472
LIG_TYR_ITSM	218	225	PF00017	0.512
MOD_CDK_SPK_2	2	7	PF00069	0.573
MOD_CDK_SPxxK_3	181	188	PF00069	0.621
MOD_CK1_1	138	144	PF00069	0.549
MOD_CK1_1	190	196	PF00069	0.601
MOD_CK1_1	48	54	PF00069	0.464
MOD_CK1_1	5	11	PF00069	0.604
MOD_CK1_1	85	91	PF00069	0.554
MOD_CK2_1	168	174	PF00069	0.690
MOD_GlcNHglycan	109	112	PF01048	0.477
MOD_GlcNHglycan	13	16	PF01048	0.656
MOD_GlcNHglycan	189	192	PF01048	0.684
MOD_GlcNHglycan	50	53	PF01048	0.489
MOD_GSK3_1	1	8	PF00069	0.628
MOD_GSK3_1	138	145	PF00069	0.462
MOD_GSK3_1	187	194	PF00069	0.646
MOD_GSK3_1	202	209	PF00069	0.579
MOD_N-GLC_1	156	161	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	106	111	PF00069	0.335
MOD_NEK2_1	150	155	PF00069	0.502
MOD_NEK2_1	229	234	PF00069	0.409
MOD_NEK2_1	50	55	PF00069	0.456
MOD_NEK2_1	98	103	PF00069	0.420
MOD_NEK2_2	168	173	PF00069	0.645
MOD_NEK2_2	45	50	PF00069	0.495
MOD_NEK2_2	55	60	PF00069	0.353
MOD_PIKK_1	179	185	PF00454	0.736
MOD_PIKK_1	92	98	PF00454	0.545
MOD_PKA_2	187	193	PF00069	0.757
MOD_PKB_1	80	88	PF00069	0.484
MOD_Plk_4	150	156	PF00069	0.559
MOD_Plk_4	217	223	PF00069	0.443
MOD_Plk_4	229	235	PF00069	0.406
MOD_Plk_4	45	51	PF00069	0.497
MOD_ProDKin_1	181	187	PF00069	0.732
MOD_ProDKin_1	2	8	PF00069	0.585
TRG_AP2beta_CARGO_1	167	176	PF09066	0.549
TRG_DiLeu_BaEn_1	210	215	PF01217	0.579
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.482
TRG_ENDOCYTIC_2	222	225	PF00928	0.503
TRG_ENDOCYTIC_2	246	249	PF00928	0.544
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB2	Leptomonas seymouri	51%	91%
A0A0S4JAI8	Bodo saltans	31%	100%
A0A1X0P886	Trypanosomatidae	37%	100%
A0A3S7XAI3	Leishmania donovani	100%	100%
D0A2U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ASP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1V5	Leishmania major	85%	100%
V5B9R5	Trypanosoma cruzi	36%	100%