Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICL2_LEIIN

TriTrypDb:

LINF_360018000

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.636
CLV_C14_Caspase3-7	343	347	PF00656	0.604
CLV_C14_Caspase3-7	360	364	PF00656	0.605
CLV_NRD_NRD_1	388	390	PF00675	0.516
CLV_NRD_NRD_1	451	453	PF00675	0.646
CLV_PCSK_KEX2_1	388	390	PF00082	0.516
CLV_PCSK_SKI1_1	333	337	PF00082	0.615
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DEG_SPOP_SBC_1	286	290	PF00917	0.571
DOC_CKS1_1	233	238	PF01111	0.638
DOC_CKS1_1	382	387	PF01111	0.656
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.589
DOC_MAPK_MEF2A_6	130	139	PF00069	0.644
DOC_PP1_RVXF_1	331	338	PF00149	0.615
DOC_USP7_MATH_1	286	290	PF00917	0.661
DOC_USP7_MATH_1	322	326	PF00917	0.554
DOC_USP7_MATH_1	338	342	PF00917	0.562
DOC_USP7_MATH_1	344	348	PF00917	0.623
DOC_USP7_MATH_1	54	58	PF00917	0.598
DOC_USP7_UBL2_3	136	140	PF12436	0.568
DOC_WW_Pin1_4	179	184	PF00397	0.717
DOC_WW_Pin1_4	187	192	PF00397	0.636
DOC_WW_Pin1_4	232	237	PF00397	0.635
DOC_WW_Pin1_4	255	260	PF00397	0.633
DOC_WW_Pin1_4	34	39	PF00397	0.649
DOC_WW_Pin1_4	369	374	PF00397	0.775
DOC_WW_Pin1_4	381	386	PF00397	0.684
LIG_14-3-3_CanoR_1	113	119	PF00244	0.576
LIG_14-3-3_CanoR_1	249	254	PF00244	0.617
LIG_14-3-3_CanoR_1	271	275	PF00244	0.594
LIG_14-3-3_CanoR_1	389	399	PF00244	0.599
LIG_14-3-3_CanoR_1	440	448	PF00244	0.687
LIG_14-3-3_CanoR_1	452	456	PF00244	0.557
LIG_14-3-3_CanoR_1	7	13	PF00244	0.710
LIG_Actin_WH2_2	257	273	PF00022	0.596
LIG_APCC_ABBA_1	297	302	PF00400	0.574
LIG_BIR_III_2	195	199	PF00653	0.631
LIG_BRCT_BRCA1_1	256	260	PF00533	0.642
LIG_BRCT_BRCA1_1	265	269	PF00533	0.545
LIG_BRCT_BRCA1_1	280	284	PF00533	0.503
LIG_CSL_BTD_1	180	183	PF09270	0.568
LIG_FHA_1	165	171	PF00498	0.640
LIG_FHA_1	23	29	PF00498	0.581
LIG_FHA_1	233	239	PF00498	0.638
LIG_FHA_1	316	322	PF00498	0.633
LIG_FHA_1	405	411	PF00498	0.515
LIG_FHA_1	46	52	PF00498	0.618
LIG_FHA_1	8	14	PF00498	0.704
LIG_FHA_2	107	113	PF00498	0.588
LIG_FHA_2	161	167	PF00498	0.605
LIG_FHA_2	365	371	PF00498	0.660
LIG_FHA_2	391	397	PF00498	0.562
LIG_GBD_Chelix_1	237	245	PF00786	0.600
LIG_LIR_Apic_2	224	229	PF02991	0.578
LIG_LIR_Gen_1	251	260	PF02991	0.591
LIG_LIR_Gen_1	415	425	PF02991	0.489
LIG_LIR_Nem_3	251	256	PF02991	0.597
LIG_LIR_Nem_3	415	420	PF02991	0.494
LIG_LIR_Nem_3	482	487	PF02991	0.538
LIG_Pex14_1	92	96	PF04695	0.562
LIG_Pex14_2	177	181	PF04695	0.652
LIG_RPA_C_Insects	69	84	PF08784	0.489
LIG_SH2_CRK	247	251	PF00017	0.560
LIG_SH2_CRK	484	488	PF00017	0.499
LIG_SH2_NCK_1	247	251	PF00017	0.616
LIG_SH2_NCK_1	96	100	PF00017	0.523
LIG_SH2_SRC	96	99	PF00017	0.665
LIG_SH2_STAP1	96	100	PF00017	0.662
LIG_SH2_STAT3	107	110	PF00017	0.561
LIG_SH2_STAT5	107	110	PF00017	0.611
LIG_SH2_STAT5	226	229	PF00017	0.614
LIG_SH2_STAT5	247	250	PF00017	0.615
LIG_SH2_STAT5	428	431	PF00017	0.562
LIG_SH3_1	230	236	PF00018	0.637
LIG_SH3_3	136	142	PF00018	0.689
LIG_SH3_3	167	173	PF00018	0.599
LIG_SH3_3	217	223	PF00018	0.643
LIG_SH3_3	230	236	PF00018	0.548
LIG_SH3_3	370	376	PF00018	0.704
LIG_SH3_3	379	385	PF00018	0.598
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.635
LIG_TRAF2_1	367	370	PF00917	0.675
LIG_TRAF2_1	454	457	PF00917	0.549
LIG_TYR_ITIM	245	250	PF00017	0.555
LIG_WRC_WIRS_1	250	255	PF05994	0.563
MOD_CDK_SPxxK_3	381	388	PF00069	0.546
MOD_CK1_1	117	123	PF00069	0.695
MOD_CK1_1	160	166	PF00069	0.595
MOD_CK1_1	224	230	PF00069	0.641
MOD_CK1_1	231	237	PF00069	0.598
MOD_CK1_1	252	258	PF00069	0.644
MOD_CK1_1	263	269	PF00069	0.534
MOD_CK1_1	287	293	PF00069	0.608
MOD_CK1_1	357	363	PF00069	0.667
MOD_CK1_1	57	63	PF00069	0.737
MOD_CK2_1	106	112	PF00069	0.617
MOD_CK2_1	311	317	PF00069	0.637
MOD_CK2_1	322	328	PF00069	0.553
MOD_CK2_1	337	343	PF00069	0.531
MOD_CK2_1	364	370	PF00069	0.659
MOD_CK2_1	390	396	PF00069	0.567
MOD_CK2_1	412	418	PF00069	0.518
MOD_CK2_1	451	457	PF00069	0.562
MOD_CK2_1	50	56	PF00069	0.657
MOD_GlcNHglycan	176	180	PF01048	0.659
MOD_GlcNHglycan	223	226	PF01048	0.636
MOD_GlcNHglycan	260	263	PF01048	0.637
MOD_GlcNHglycan	324	327	PF01048	0.639
MOD_GlcNHglycan	355	359	PF01048	0.632
MOD_GlcNHglycan	414	417	PF01048	0.541
MOD_GlcNHglycan	424	428	PF01048	0.480
MOD_GlcNHglycan	493	496	PF01048	0.590
MOD_GlcNHglycan	52	55	PF01048	0.590
MOD_GlcNHglycan	59	62	PF01048	0.561
MOD_GlcNHglycan	92	95	PF01048	0.709
MOD_GSK3_1	160	167	PF00069	0.715
MOD_GSK3_1	171	178	PF00069	0.664
MOD_GSK3_1	2	9	PF00069	0.610
MOD_GSK3_1	224	231	PF00069	0.646
MOD_GSK3_1	245	252	PF00069	0.602
MOD_GSK3_1	254	261	PF00069	0.570
MOD_GSK3_1	265	272	PF00069	0.455
MOD_GSK3_1	311	318	PF00069	0.636
MOD_GSK3_1	333	340	PF00069	0.639
MOD_GSK3_1	377	384	PF00069	0.680
MOD_GSK3_1	41	48	PF00069	0.784
MOD_GSK3_1	412	419	PF00069	0.695
MOD_GSK3_1	50	57	PF00069	0.631
MOD_GSK3_1	84	91	PF00069	0.776
MOD_N-GLC_1	363	368	PF02516	0.708
MOD_N-GLC_1	391	396	PF02516	0.483
MOD_N-GLC_1	72	77	PF02516	0.584
MOD_NEK2_1	116	121	PF00069	0.663
MOD_NEK2_1	177	182	PF00069	0.737
MOD_NEK2_1	237	242	PF00069	0.624
MOD_NEK2_1	245	250	PF00069	0.580
MOD_NEK2_1	254	259	PF00069	0.532
MOD_NEK2_1	260	265	PF00069	0.518
MOD_NEK2_1	269	274	PF00069	0.485
MOD_NEK2_1	278	283	PF00069	0.466
MOD_NEK2_1	284	289	PF00069	0.527
MOD_NEK2_1	311	316	PF00069	0.637
MOD_NEK2_1	337	342	PF00069	0.562
MOD_NEK2_1	41	46	PF00069	0.741
MOD_NEK2_1	429	434	PF00069	0.560
MOD_NEK2_1	462	467	PF00069	0.550
MOD_PIKK_1	106	112	PF00454	0.560
MOD_PIKK_1	278	284	PF00454	0.632
MOD_PIKK_1	457	463	PF00454	0.510
MOD_PKA_2	105	111	PF00069	0.598
MOD_PKA_2	22	28	PF00069	0.658
MOD_PKA_2	248	254	PF00069	0.616
MOD_PKA_2	270	276	PF00069	0.585
MOD_PKA_2	344	350	PF00069	0.584
MOD_PKA_2	451	457	PF00069	0.613
MOD_PKA_2	6	12	PF00069	0.634
MOD_Plk_1	165	171	PF00069	0.623
MOD_Plk_1	201	207	PF00069	0.634
MOD_Plk_1	333	339	PF00069	0.640
MOD_Plk_1	391	397	PF00069	0.468
MOD_Plk_1	41	47	PF00069	0.697
MOD_Plk_1	423	429	PF00069	0.628
MOD_Plk_1	457	463	PF00069	0.589
MOD_Plk_1	72	78	PF00069	0.601
MOD_Plk_2-3	27	33	PF00069	0.644
MOD_Plk_4	145	151	PF00069	0.578
MOD_Plk_4	202	208	PF00069	0.634
MOD_Plk_4	249	255	PF00069	0.626
MOD_Plk_4	311	317	PF00069	0.592
MOD_Plk_4	416	422	PF00069	0.567
MOD_ProDKin_1	179	185	PF00069	0.715
MOD_ProDKin_1	187	193	PF00069	0.638
MOD_ProDKin_1	232	238	PF00069	0.635
MOD_ProDKin_1	255	261	PF00069	0.633
MOD_ProDKin_1	34	40	PF00069	0.649
MOD_ProDKin_1	369	375	PF00069	0.774
MOD_ProDKin_1	381	387	PF00069	0.680
TRG_DiLeu_BaEn_1	405	410	PF01217	0.535
TRG_DiLeu_BaEn_2	475	481	PF01217	0.554
TRG_DiLeu_BaEn_4	457	463	PF01217	0.510
TRG_DiLeu_LyEn_5	349	354	PF01217	0.645
TRG_ENDOCYTIC_2	247	250	PF00928	0.559
TRG_ENDOCYTIC_2	428	431	PF00928	0.584
TRG_ENDOCYTIC_2	484	487	PF00928	0.716
TRG_ER_diArg_1	466	469	PF00400	0.537
TRG_NES_CRM1_1	461	476	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAI1	Leishmania donovani	99%	100%
A4HNY2	Leishmania braziliensis	53%	100%
E9ASP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1V4	Leishmania major	82%	100%