LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein phosphatase 2C - putative
Species:
Leishmania infantum
UniProt:
A4ICL1_LEIIN
TriTrypDb:
LINF_360018100
Length:
584

Annotations

Annotations by Jardim et al.

Phosphatase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ICL1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICL1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016311 dephosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004721 phosphoprotein phosphatase activity 3 12
GO:0004722 protein serine/threonine phosphatase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0017018 myosin phosphatase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 296 300 PF00656 0.593
CLV_C14_Caspase3-7 336 340 PF00656 0.334
CLV_NRD_NRD_1 123 125 PF00675 0.500
CLV_NRD_NRD_1 143 145 PF00675 0.563
CLV_NRD_NRD_1 178 180 PF00675 0.491
CLV_NRD_NRD_1 321 323 PF00675 0.334
CLV_NRD_NRD_1 360 362 PF00675 0.417
CLV_NRD_NRD_1 492 494 PF00675 0.536
CLV_NRD_NRD_1 511 513 PF00675 0.458
CLV_PCSK_KEX2_1 142 144 PF00082 0.553
CLV_PCSK_KEX2_1 178 180 PF00082 0.512
CLV_PCSK_KEX2_1 189 191 PF00082 0.734
CLV_PCSK_KEX2_1 321 323 PF00082 0.334
CLV_PCSK_KEX2_1 360 362 PF00082 0.340
CLV_PCSK_KEX2_1 491 493 PF00082 0.537
CLV_PCSK_KEX2_1 510 512 PF00082 0.461
CLV_PCSK_KEX2_1 575 577 PF00082 0.530
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.578
CLV_PCSK_PC1ET2_1 575 577 PF00082 0.530
CLV_PCSK_SKI1_1 230 234 PF00082 0.619
CLV_PCSK_SKI1_1 260 264 PF00082 0.615
CLV_PCSK_SKI1_1 287 291 PF00082 0.435
CLV_PCSK_SKI1_1 517 521 PF00082 0.451
CLV_PCSK_SKI1_1 556 560 PF00082 0.589
CLV_PCSK_SKI1_1 572 576 PF00082 0.447
CLV_PCSK_SKI1_1 59 63 PF00082 0.651
CLV_Separin_Metazoa 553 557 PF03568 0.473
DEG_APCC_DBOX_1 12 20 PF00400 0.384
DEG_APCC_DBOX_1 522 530 PF00400 0.446
DEG_COP1_1 461 470 PF00400 0.468
DEG_Nend_UBRbox_1 1 4 PF02207 0.515
DOC_CYCLIN_RxL_1 408 417 PF00134 0.241
DOC_CYCLIN_yCln2_LP_2 14 20 PF00134 0.389
DOC_MAPK_DCC_7 13 21 PF00069 0.465
DOC_MAPK_gen_1 13 21 PF00069 0.400
DOC_MAPK_gen_1 302 310 PF00069 0.399
DOC_MAPK_MEF2A_6 13 21 PF00069 0.433
DOC_MAPK_MEF2A_6 302 310 PF00069 0.401
DOC_MAPK_RevD_3 131 144 PF00069 0.450
DOC_PIKK_1 399 406 PF02985 0.417
DOC_PP1_RVXF_1 210 217 PF00149 0.364
DOC_PP2B_LxvP_1 14 17 PF13499 0.364
DOC_PP2B_LxvP_1 416 419 PF13499 0.302
DOC_PP2B_PxIxI_1 16 22 PF00149 0.455
DOC_USP7_MATH_1 181 185 PF00917 0.588
DOC_USP7_MATH_1 206 210 PF00917 0.503
DOC_USP7_MATH_1 436 440 PF00917 0.289
DOC_WW_Pin1_4 199 204 PF00397 0.741
DOC_WW_Pin1_4 218 223 PF00397 0.257
DOC_WW_Pin1_4 240 245 PF00397 0.645
DOC_WW_Pin1_4 263 268 PF00397 0.514
DOC_WW_Pin1_4 310 315 PF00397 0.288
DOC_WW_Pin1_4 359 364 PF00397 0.380
DOC_WW_Pin1_4 60 65 PF00397 0.566
LIG_14-3-3_CanoR_1 144 154 PF00244 0.536
LIG_14-3-3_CanoR_1 230 240 PF00244 0.558
LIG_14-3-3_CanoR_1 316 324 PF00244 0.383
LIG_14-3-3_CanoR_1 412 417 PF00244 0.424
LIG_14-3-3_CanoR_1 523 529 PF00244 0.536
LIG_14-3-3_CanoR_1 59 64 PF00244 0.513
LIG_Actin_WH2_2 303 318 PF00022 0.410
LIG_APCC_ABBAyCdc20_2 143 149 PF00400 0.512
LIG_BRCT_BRCA1_1 279 283 PF00533 0.356
LIG_FHA_1 21 27 PF00498 0.440
LIG_FHA_1 303 309 PF00498 0.417
LIG_FHA_2 153 159 PF00498 0.430
LIG_FHA_2 331 337 PF00498 0.302
LIG_FHA_2 61 67 PF00498 0.571
LIG_FHA_2 92 98 PF00498 0.413
LIG_IBAR_NPY_1 341 343 PF08397 0.338
LIG_LIR_Apic_2 471 476 PF02991 0.401
LIG_LIR_Gen_1 567 577 PF02991 0.445
LIG_LIR_Nem_3 317 323 PF02991 0.329
LIG_LIR_Nem_3 36 41 PF02991 0.446
LIG_LIR_Nem_3 376 380 PF02991 0.335
LIG_LIR_Nem_3 567 573 PF02991 0.440
LIG_Pex14_2 430 434 PF04695 0.417
LIG_PTAP_UEV_1 578 583 PF05743 0.516
LIG_PTB_Apo_2 338 345 PF02174 0.334
LIG_PTB_Phospho_1 338 344 PF10480 0.334
LIG_Rb_LxCxE_1 243 261 PF01857 0.508
LIG_REV1ctd_RIR_1 168 176 PF16727 0.457
LIG_SH2_CRK 320 324 PF00017 0.417
LIG_SH2_GRB2like 343 346 PF00017 0.338
LIG_SH2_PTP2 18 21 PF00017 0.387
LIG_SH2_SRC 162 165 PF00017 0.385
LIG_SH2_SRC 18 21 PF00017 0.254
LIG_SH2_STAP1 162 166 PF00017 0.307
LIG_SH2_STAT5 105 108 PF00017 0.323
LIG_SH2_STAT5 18 21 PF00017 0.387
LIG_SH2_STAT5 480 483 PF00017 0.412
LIG_SH2_STAT5 93 96 PF00017 0.428
LIG_SH3_1 125 131 PF00018 0.473
LIG_SH3_1 200 206 PF00018 0.547
LIG_SH3_1 576 582 PF00018 0.473
LIG_SH3_3 125 131 PF00018 0.540
LIG_SH3_3 177 183 PF00018 0.477
LIG_SH3_3 200 206 PF00018 0.695
LIG_SH3_3 443 449 PF00018 0.366
LIG_SH3_3 558 564 PF00018 0.469
LIG_SH3_3 576 582 PF00018 0.473
LIG_SUMO_SIM_anti_2 525 530 PF11976 0.422
LIG_SUMO_SIM_par_1 305 311 PF11976 0.395
LIG_SUMO_SIM_par_1 367 373 PF11976 0.337
LIG_TRAF2_1 185 188 PF00917 0.547
LIG_TRAF2_1 205 208 PF00917 0.584
LIG_TYR_ITIM 16 21 PF00017 0.459
LIG_UBA3_1 10 15 PF00899 0.449
LIG_UBA3_1 368 375 PF00899 0.400
LIG_WRC_WIRS_1 35 40 PF05994 0.359
MOD_CDC14_SPxK_1 243 246 PF00782 0.558
MOD_CDC14_SPxK_1 313 316 PF00782 0.217
MOD_CDK_SPxK_1 240 246 PF00069 0.542
MOD_CDK_SPxK_1 310 316 PF00069 0.217
MOD_CK1_1 111 117 PF00069 0.350
MOD_CK1_1 152 158 PF00069 0.470
MOD_CK1_1 463 469 PF00069 0.645
MOD_CK2_1 152 158 PF00069 0.440
MOD_CK2_1 182 188 PF00069 0.634
MOD_CK2_1 359 365 PF00069 0.393
MOD_CK2_1 399 405 PF00069 0.284
MOD_CK2_1 463 469 PF00069 0.567
MOD_CK2_1 91 97 PF00069 0.411
MOD_Cter_Amidation 176 179 PF01082 0.578
MOD_Cter_Amidation 358 361 PF01082 0.350
MOD_GlcNHglycan 149 152 PF01048 0.603
MOD_GlcNHglycan 164 167 PF01048 0.466
MOD_GlcNHglycan 184 187 PF01048 0.780
MOD_GlcNHglycan 207 211 PF01048 0.420
MOD_GlcNHglycan 216 219 PF01048 0.364
MOD_GlcNHglycan 458 461 PF01048 0.560
MOD_GlcNHglycan 462 465 PF01048 0.514
MOD_GlcNHglycan 579 582 PF01048 0.678
MOD_GSK3_1 111 118 PF00069 0.343
MOD_GSK3_1 145 152 PF00069 0.563
MOD_GSK3_1 214 221 PF00069 0.462
MOD_GSK3_1 298 305 PF00069 0.468
MOD_GSK3_1 306 313 PF00069 0.383
MOD_GSK3_1 456 463 PF00069 0.668
MOD_GSK3_1 65 72 PF00069 0.664
MOD_GSK3_1 96 103 PF00069 0.381
MOD_NEK2_1 101 106 PF00069 0.364
MOD_NEK2_1 216 221 PF00069 0.320
MOD_NEK2_1 29 34 PF00069 0.549
MOD_NEK2_1 48 53 PF00069 0.305
MOD_NEK2_1 89 94 PF00069 0.418
MOD_NEK2_2 351 356 PF00069 0.308
MOD_PIKK_1 71 77 PF00454 0.504
MOD_PKA_2 315 321 PF00069 0.326
MOD_PKA_2 522 528 PF00069 0.520
MOD_Plk_1 302 308 PF00069 0.417
MOD_Plk_1 330 336 PF00069 0.302
MOD_Plk_1 398 404 PF00069 0.290
MOD_Plk_1 436 442 PF00069 0.479
MOD_Plk_1 501 507 PF00069 0.401
MOD_Plk_1 96 102 PF00069 0.472
MOD_Plk_2-3 399 405 PF00069 0.334
MOD_Plk_4 111 117 PF00069 0.315
MOD_Plk_4 149 155 PF00069 0.494
MOD_Plk_4 220 226 PF00069 0.438
MOD_Plk_4 504 510 PF00069 0.489
MOD_Plk_4 524 530 PF00069 0.472
MOD_Plk_4 97 103 PF00069 0.440
MOD_ProDKin_1 199 205 PF00069 0.729
MOD_ProDKin_1 218 224 PF00069 0.268
MOD_ProDKin_1 240 246 PF00069 0.651
MOD_ProDKin_1 263 269 PF00069 0.503
MOD_ProDKin_1 310 316 PF00069 0.288
MOD_ProDKin_1 359 365 PF00069 0.380
MOD_ProDKin_1 60 66 PF00069 0.572
MOD_SUMO_rev_2 362 369 PF00179 0.337
TRG_DiLeu_BaEn_1 149 154 PF01217 0.469
TRG_DiLeu_BaEn_1 258 263 PF01217 0.560
TRG_DiLeu_BaEn_2 96 102 PF01217 0.472
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.512
TRG_ENDOCYTIC_2 18 21 PF00928 0.454
TRG_ENDOCYTIC_2 320 323 PF00928 0.442
TRG_ENDOCYTIC_2 343 346 PF00928 0.407
TRG_ER_diArg_1 142 144 PF00400 0.557
TRG_ER_diArg_1 178 180 PF00400 0.595
TRG_ER_diArg_1 320 322 PF00400 0.331
TRG_ER_diArg_1 490 493 PF00400 0.480
TRG_ER_diArg_1 509 512 PF00400 0.501
TRG_NES_CRM1_1 404 417 PF08389 0.241
TRG_Pf-PMV_PEXEL_1 121 126 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 378 383 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 412 417 PF00026 0.290
TRG_Pf-PMV_PEXEL_1 46 50 PF00026 0.547
TRG_Pf-PMV_PEXEL_1 492 496 PF00026 0.406

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Q6 Leptomonas seymouri 62% 100%
A0A0S4IM91 Bodo saltans 29% 100%
A0A0S4IRQ5 Bodo saltans 29% 100%
A0A1X0P810 Trypanosomatidae 44% 98%
A0A3S7XAR2 Leishmania donovani 99% 100%
A4HNY3 Leishmania braziliensis 81% 100%
D0A2U9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 98%
E9ASP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q4Q1V3 Leishmania major 96% 100%
V5BZP6 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS