Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICK7_LEIIN

TriTrypDb:

LINF_360018600

Length:

193

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.520
CLV_NRD_NRD_1	111	113	PF00675	0.445
CLV_NRD_NRD_1	121	123	PF00675	0.455
CLV_NRD_NRD_1	30	32	PF00675	0.598
CLV_PCSK_KEX2_1	103	105	PF00082	0.529
CLV_PCSK_KEX2_1	12	14	PF00082	0.623
CLV_PCSK_KEX2_1	121	123	PF00082	0.538
CLV_PCSK_KEX2_1	157	159	PF00082	0.541
CLV_PCSK_KEX2_1	24	26	PF00082	0.548
CLV_PCSK_KEX2_1	30	32	PF00082	0.589
CLV_PCSK_KEX2_1	45	47	PF00082	0.661
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.611
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.538
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.384
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.658
CLV_PCSK_SKI1_1	103	107	PF00082	0.498
CLV_PCSK_SKI1_1	12	16	PF00082	0.556
CLV_PCSK_SKI1_1	24	28	PF00082	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.572
DOC_MAPK_RevD_3	139	153	PF00069	0.505
DOC_PP2B_LxvP_1	26	29	PF13499	0.610
DOC_USP7_UBL2_3	153	157	PF12436	0.442
DOC_WW_Pin1_4	12	17	PF00397	0.591
DOC_WW_Pin1_4	45	50	PF00397	0.585
DOC_WW_Pin1_4	91	96	PF00397	0.621
LIG_14-3-3_CanoR_1	25	29	PF00244	0.517
LIG_14-3-3_CanoR_1	54	60	PF00244	0.512
LIG_AP2alpha_2	37	39	PF02296	0.508
LIG_FHA_1	169	175	PF00498	0.590
LIG_FHA_1	42	48	PF00498	0.581
LIG_FHA_1	54	60	PF00498	0.385
LIG_FHA_2	113	119	PF00498	0.561
LIG_FHA_2	13	19	PF00498	0.515
LIG_LIR_Apic_2	161	166	PF02991	0.484
LIG_LIR_Gen_1	3	10	PF02991	0.570
LIG_LIR_Nem_3	3	8	PF02991	0.569
LIG_SH2_CRK	126	130	PF00017	0.516
LIG_SH2_CRK	5	9	PF00017	0.539
LIG_SH2_NCK_1	5	9	PF00017	0.453
LIG_SH2_STAP1	160	164	PF00017	0.518
LIG_SH2_STAP1	60	64	PF00017	0.518
LIG_SH2_STAT5	163	166	PF00017	0.493
LIG_SH2_STAT5	60	63	PF00017	0.462
LIG_SH3_1	89	95	PF00018	0.442
LIG_SH3_3	89	95	PF00018	0.473
MOD_CK1_1	53	59	PF00069	0.481
MOD_CK2_1	112	118	PF00069	0.570
MOD_Cter_Amidation	10	13	PF01082	0.473
MOD_GlcNHglycan	89	92	PF01048	0.539
MOD_GSK3_1	164	171	PF00069	0.525
MOD_GSK3_1	41	48	PF00069	0.530
MOD_GSK3_1	83	90	PF00069	0.536
MOD_LATS_1	22	28	PF00433	0.405
MOD_N-GLC_1	130	135	PF02516	0.698
MOD_NEK2_1	159	164	PF00069	0.593
MOD_NEK2_1	186	191	PF00069	0.711
MOD_NEK2_1	87	92	PF00069	0.577
MOD_PIKK_1	58	64	PF00454	0.482
MOD_PKA_1	112	118	PF00069	0.604
MOD_PKA_1	152	158	PF00069	0.406
MOD_PKA_1	24	30	PF00069	0.575
MOD_PKA_2	127	133	PF00069	0.639
MOD_PKA_2	24	30	PF00069	0.501
MOD_PKA_2	53	59	PF00069	0.527
MOD_PKA_2	83	89	PF00069	0.507
MOD_Plk_1	98	104	PF00069	0.499
MOD_Plk_4	159	165	PF00069	0.542
MOD_Plk_4	83	89	PF00069	0.672
MOD_ProDKin_1	12	18	PF00069	0.584
MOD_ProDKin_1	45	51	PF00069	0.578
MOD_ProDKin_1	91	97	PF00069	0.616
MOD_SUMO_rev_2	108	115	PF00179	0.631
TRG_ENDOCYTIC_2	146	149	PF00928	0.396
TRG_ENDOCYTIC_2	5	8	PF00928	0.574
TRG_ER_diArg_1	102	104	PF00400	0.467
TRG_ER_diArg_1	120	122	PF00400	0.398
TRG_ER_diArg_1	29	31	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	27%	100%
A0A0N1HS21	Leptomonas seymouri	49%	98%
A0A0S4IZ88	Bodo saltans	23%	99%
A0A1X0P828	Trypanosomatidae	32%	100%
A0A3R7K1K7	Trypanosoma rangeli	34%	100%
A0A3S7XAJ8	Leishmania donovani	99%	100%
A0A422NMA5	Trypanosoma rangeli	28%	100%
A4HQ43	Leishmania braziliensis	27%	100%
D0A2V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ADW1	Leishmania major	27%	98%
E9AIX6	Leishmania braziliensis	76%	100%
E9ASP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ATW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
P17960	Trypanosoma brucei brucei	33%	100%