LeishMANIAdb
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AAA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AAA domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICK6_LEIIN
TriTrypDb:
LINF_360018700 *
Length:
608

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0032797 SMN complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0120114 Sm-like protein family complex 2 1

Expansion

Sequence features

A4ICK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK6

Function

Biological processes
Term Name Level Count
GO:0000387 spliceosomal snRNP assembly 7 9
GO:0009987 cellular process 1 9
GO:0016043 cellular component organization 3 9
GO:0022607 cellular component assembly 4 9
GO:0022618 ribonucleoprotein complex assembly 6 9
GO:0043933 protein-containing complex organization 4 9
GO:0065003 protein-containing complex assembly 5 9
GO:0071826 ribonucleoprotein complex subunit organization 5 9
GO:0071840 cellular component organization or biogenesis 2 9
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 289 293 PF00656 0.718
CLV_C14_Caspase3-7 330 334 PF00656 0.524
CLV_C14_Caspase3-7 418 422 PF00656 0.718
CLV_C14_Caspase3-7 433 437 PF00656 0.667
CLV_C14_Caspase3-7 64 68 PF00656 0.499
CLV_NRD_NRD_1 20 22 PF00675 0.518
CLV_NRD_NRD_1 233 235 PF00675 0.673
CLV_NRD_NRD_1 25 27 PF00675 0.479
CLV_NRD_NRD_1 301 303 PF00675 0.676
CLV_NRD_NRD_1 354 356 PF00675 0.536
CLV_NRD_NRD_1 564 566 PF00675 0.514
CLV_NRD_NRD_1 580 582 PF00675 0.270
CLV_PCSK_FUR_1 299 303 PF00082 0.678
CLV_PCSK_FUR_1 352 356 PF00082 0.552
CLV_PCSK_KEX2_1 144 146 PF00082 0.661
CLV_PCSK_KEX2_1 148 150 PF00082 0.666
CLV_PCSK_KEX2_1 20 22 PF00082 0.518
CLV_PCSK_KEX2_1 24 26 PF00082 0.491
CLV_PCSK_KEX2_1 301 303 PF00082 0.691
CLV_PCSK_KEX2_1 352 354 PF00082 0.512
CLV_PCSK_KEX2_1 564 566 PF00082 0.534
CLV_PCSK_KEX2_1 580 582 PF00082 0.270
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.649
CLV_PCSK_PC1ET2_1 148 150 PF00082 0.651
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.512
CLV_PCSK_PC7_1 20 26 PF00082 0.515
CLV_PCSK_PC7_1 348 354 PF00082 0.569
CLV_PCSK_SKI1_1 145 149 PF00082 0.728
CLV_PCSK_SKI1_1 21 25 PF00082 0.518
CLV_PCSK_SKI1_1 481 485 PF00082 0.454
CLV_PCSK_SKI1_1 554 558 PF00082 0.577
CLV_Separin_Metazoa 314 318 PF03568 0.403
DEG_APCC_DBOX_1 480 488 PF00400 0.490
DEG_Nend_Nbox_1 1 3 PF02207 0.434
DEG_SCF_FBW7_1 171 178 PF00400 0.632
DEG_SIAH_1 205 213 PF03145 0.767
DEG_SPOP_SBC_1 175 179 PF00917 0.747
DOC_CYCLIN_yCln2_LP_2 517 523 PF00134 0.543
DOC_MAPK_FxFP_2 34 37 PF00069 0.461
DOC_MAPK_gen_1 253 263 PF00069 0.504
DOC_MAPK_gen_1 380 390 PF00069 0.482
DOC_MAPK_gen_1 580 587 PF00069 0.328
DOC_PP1_RVXF_1 188 195 PF00149 0.715
DOC_PP2B_LxvP_1 39 42 PF13499 0.510
DOC_PP2B_LxvP_1 517 520 PF13499 0.542
DOC_PP2B_PxIxI_1 110 116 PF00149 0.576
DOC_PP4_FxxP_1 34 37 PF00568 0.465
DOC_PP4_FxxP_1 489 492 PF00568 0.482
DOC_USP7_MATH_1 103 107 PF00917 0.675
DOC_USP7_MATH_1 147 151 PF00917 0.733
DOC_USP7_MATH_1 164 168 PF00917 0.653
DOC_USP7_MATH_1 175 179 PF00917 0.608
DOC_USP7_MATH_1 393 397 PF00917 0.450
DOC_USP7_MATH_1 401 405 PF00917 0.386
DOC_USP7_MATH_2 183 189 PF00917 0.676
DOC_USP7_UBL2_3 144 148 PF12436 0.759
DOC_USP7_UBL2_3 73 77 PF12436 0.592
DOC_WW_Pin1_4 107 112 PF00397 0.737
DOC_WW_Pin1_4 171 176 PF00397 0.663
DOC_WW_Pin1_4 202 207 PF00397 0.666
DOC_WW_Pin1_4 29 34 PF00397 0.472
DOC_WW_Pin1_4 51 56 PF00397 0.517
LIG_14-3-3_CanoR_1 279 286 PF00244 0.678
LIG_14-3-3_CanoR_1 383 390 PF00244 0.578
LIG_14-3-3_CanoR_1 481 487 PF00244 0.521
LIG_14-3-3_CanoR_1 500 505 PF00244 0.539
LIG_14-3-3_CanoR_1 538 544 PF00244 0.455
LIG_Actin_WH2_2 250 267 PF00022 0.522
LIG_Actin_WH2_2 58 75 PF00022 0.508
LIG_APCC_ABBAyCdc20_2 190 196 PF00400 0.672
LIG_BIR_III_2 567 571 PF00653 0.535
LIG_BRCT_BRCA1_1 242 246 PF00533 0.587
LIG_BRCT_BRCA1_1 395 399 PF00533 0.482
LIG_BRCT_BRCA1_1 79 83 PF00533 0.625
LIG_FHA_1 108 114 PF00498 0.760
LIG_FHA_1 119 125 PF00498 0.647
LIG_FHA_1 187 193 PF00498 0.741
LIG_FHA_1 205 211 PF00498 0.513
LIG_FHA_1 30 36 PF00498 0.636
LIG_FHA_1 499 505 PF00498 0.522
LIG_FHA_1 523 529 PF00498 0.512
LIG_FHA_1 551 557 PF00498 0.556
LIG_FHA_1 587 593 PF00498 0.345
LIG_FHA_2 429 435 PF00498 0.727
LIG_FHA_2 449 455 PF00498 0.675
LIG_FHA_2 54 60 PF00498 0.681
LIG_FHA_2 572 578 PF00498 0.482
LIG_LIR_Apic_2 32 37 PF02991 0.465
LIG_LIR_Gen_1 259 268 PF02991 0.506
LIG_LIR_Gen_1 485 492 PF02991 0.413
LIG_LIR_LC3C_4 121 126 PF02991 0.775
LIG_LIR_Nem_3 259 263 PF02991 0.528
LIG_LIR_Nem_3 303 307 PF02991 0.480
LIG_LIR_Nem_3 485 489 PF02991 0.413
LIG_LIR_Nem_3 603 608 PF02991 0.645
LIG_PCNA_PIPBox_1 480 489 PF02747 0.522
LIG_PCNA_yPIPBox_3 480 488 PF02747 0.523
LIG_Pex14_2 336 340 PF04695 0.510
LIG_Pex14_2 34 38 PF04695 0.477
LIG_PTAP_UEV_1 205 210 PF05743 0.774
LIG_REV1ctd_RIR_1 595 603 PF16727 0.537
LIG_SH2_CRK 347 351 PF00017 0.552
LIG_SH2_CRK 588 592 PF00017 0.429
LIG_SH2_GRB2like 370 373 PF00017 0.588
LIG_SH2_PTP2 260 263 PF00017 0.579
LIG_SH2_STAP1 588 592 PF00017 0.420
LIG_SH2_STAT5 2 5 PF00017 0.405
LIG_SH2_STAT5 260 263 PF00017 0.509
LIG_SH2_STAT5 370 373 PF00017 0.464
LIG_SH2_STAT5 45 48 PF00017 0.473
LIG_SH2_STAT5 573 576 PF00017 0.532
LIG_SH2_STAT5 588 591 PF00017 0.388
LIG_SH2_STAT5 71 74 PF00017 0.537
LIG_SH3_1 157 163 PF00018 0.584
LIG_SH3_1 25 31 PF00018 0.488
LIG_SH3_1 560 566 PF00018 0.555
LIG_SH3_3 157 163 PF00018 0.677
LIG_SH3_3 200 206 PF00018 0.689
LIG_SH3_3 25 31 PF00018 0.488
LIG_SH3_3 316 322 PF00018 0.570
LIG_SH3_3 353 359 PF00018 0.542
LIG_SH3_3 467 473 PF00018 0.599
LIG_SH3_3 517 523 PF00018 0.461
LIG_SH3_3 560 566 PF00018 0.555
LIG_SUMO_SIM_anti_2 119 128 PF11976 0.764
LIG_SUMO_SIM_anti_2 259 265 PF11976 0.565
LIG_SUMO_SIM_anti_2 589 595 PF11976 0.349
LIG_SUMO_SIM_par_1 582 589 PF11976 0.366
LIG_TRAF2_1 230 233 PF00917 0.639
LIG_TRAF2_1 452 455 PF00917 0.749
LIG_TRAF2_1 89 92 PF00917 0.681
LIG_WRC_WIRS_1 321 326 PF05994 0.401
LIG_WRC_WIRS_1 483 488 PF05994 0.412
LIG_WW_1 570 573 PF00397 0.530
LIG_WW_3 380 384 PF00397 0.404
MOD_CDC14_SPxK_1 54 57 PF00782 0.505
MOD_CDK_SPxK_1 51 57 PF00069 0.500
MOD_CK1_1 117 123 PF00069 0.727
MOD_CK1_1 16 22 PF00069 0.491
MOD_CK1_1 278 284 PF00069 0.545
MOD_CK1_1 29 35 PF00069 0.420
MOD_CK1_1 338 344 PF00069 0.460
MOD_CK1_1 391 397 PF00069 0.428
MOD_CK1_1 420 426 PF00069 0.700
MOD_CK1_1 437 443 PF00069 0.757
MOD_CK1_1 550 556 PF00069 0.579
MOD_CK2_1 227 233 PF00069 0.597
MOD_CK2_1 305 311 PF00069 0.508
MOD_CK2_1 428 434 PF00069 0.742
MOD_CK2_1 448 454 PF00069 0.679
MOD_CK2_1 493 499 PF00069 0.627
MOD_Cter_Amidation 74 77 PF01082 0.643
MOD_GlcNHglycan 121 124 PF01048 0.717
MOD_GlcNHglycan 151 154 PF01048 0.769
MOD_GlcNHglycan 289 292 PF01048 0.707
MOD_GlcNHglycan 340 343 PF01048 0.487
MOD_GlcNHglycan 390 393 PF01048 0.439
MOD_GlcNHglycan 395 398 PF01048 0.351
MOD_GlcNHglycan 436 439 PF01048 0.665
MOD_GlcNHglycan 466 469 PF01048 0.572
MOD_GlcNHglycan 514 517 PF01048 0.428
MOD_GlcNHglycan 549 552 PF01048 0.599
MOD_GSK3_1 103 110 PF00069 0.688
MOD_GSK3_1 113 120 PF00069 0.697
MOD_GSK3_1 147 154 PF00069 0.720
MOD_GSK3_1 171 178 PF00069 0.779
MOD_GSK3_1 181 188 PF00069 0.705
MOD_GSK3_1 198 205 PF00069 0.735
MOD_GSK3_1 393 400 PF00069 0.388
MOD_GSK3_1 426 433 PF00069 0.751
MOD_N-GLC_1 117 122 PF02516 0.706
MOD_N-GLC_1 171 176 PF02516 0.676
MOD_N-GLC_1 198 203 PF02516 0.707
MOD_N-GLC_1 293 298 PF02516 0.694
MOD_NEK2_1 198 203 PF00069 0.707
MOD_NEK2_1 275 280 PF00069 0.581
MOD_NEK2_1 315 320 PF00069 0.545
MOD_NEK2_1 388 393 PF00069 0.494
MOD_NEK2_1 399 404 PF00069 0.413
MOD_NEK2_1 532 537 PF00069 0.473
MOD_NEK2_1 556 561 PF00069 0.543
MOD_PIKK_1 278 284 PF00454 0.568
MOD_PK_1 500 506 PF00069 0.497
MOD_PKA_2 16 22 PF00069 0.491
MOD_PKA_2 278 284 PF00069 0.576
MOD_PKA_2 382 388 PF00069 0.587
MOD_PKA_2 426 432 PF00069 0.756
MOD_PKA_2 499 505 PF00069 0.553
MOD_PKB_1 149 157 PF00069 0.757
MOD_PKB_1 498 506 PF00069 0.526
MOD_Plk_1 247 253 PF00069 0.480
MOD_Plk_1 420 426 PF00069 0.670
MOD_Plk_1 91 97 PF00069 0.740
MOD_Plk_2-3 415 421 PF00069 0.644
MOD_Plk_4 166 172 PF00069 0.683
MOD_Plk_4 240 246 PF00069 0.548
MOD_Plk_4 482 488 PF00069 0.396
MOD_Plk_4 586 592 PF00069 0.343
MOD_Plk_4 91 97 PF00069 0.682
MOD_ProDKin_1 107 113 PF00069 0.740
MOD_ProDKin_1 171 177 PF00069 0.665
MOD_ProDKin_1 202 208 PF00069 0.663
MOD_ProDKin_1 29 35 PF00069 0.469
MOD_ProDKin_1 51 57 PF00069 0.520
MOD_SUMO_rev_2 230 236 PF00179 0.611
TRG_DiLeu_BaEn_1 311 316 PF01217 0.570
TRG_DiLeu_BaLyEn_6 345 350 PF01217 0.482
TRG_DiLeu_BaLyEn_6 402 407 PF01217 0.493
TRG_ENDOCYTIC_2 2 5 PF00928 0.405
TRG_ENDOCYTIC_2 260 263 PF00928 0.548
TRG_ENDOCYTIC_2 304 307 PF00928 0.560
TRG_ENDOCYTIC_2 347 350 PF00928 0.553
TRG_ENDOCYTIC_2 573 576 PF00928 0.404
TRG_ENDOCYTIC_2 588 591 PF00928 0.343
TRG_ENDOCYTIC_2 71 74 PF00928 0.626
TRG_ER_diArg_1 14 17 PF00400 0.477
TRG_ER_diArg_1 299 302 PF00400 0.707
TRG_ER_diArg_1 352 355 PF00400 0.552
TRG_ER_diArg_1 442 445 PF00400 0.778
TRG_ER_diArg_1 563 565 PF00400 0.504
TRG_ER_diArg_1 579 581 PF00400 0.256
TRG_NLS_MonoCore_2 141 146 PF00514 0.690
TRG_NLS_MonoExtC_3 23 28 PF00514 0.508
TRG_NLS_MonoExtN_4 140 147 PF00514 0.644
TRG_NLS_MonoExtN_4 21 28 PF00514 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC77 Leptomonas seymouri 48% 100%
A0A0S4IYS2 Bodo saltans 27% 100%
A0A1X0P8B5 Trypanosomatidae 31% 100%
A0A3Q8IJZ4 Leishmania donovani 100% 100%
A0A3R7RAQ0 Trypanosoma rangeli 32% 100%
A4HNY7 Leishmania braziliensis 77% 100%
D0A2V6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ASP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q1U6 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS