Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICK5_LEIIN

TriTrypDb:

LINF_360018800

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.551
CLV_MEL_PAP_1	145	151	PF00089	0.577
CLV_NRD_NRD_1	176	178	PF00675	0.491
CLV_NRD_NRD_1	190	192	PF00675	0.432
CLV_NRD_NRD_1	210	212	PF00675	0.439
CLV_PCSK_FUR_1	208	212	PF00082	0.591
CLV_PCSK_KEX2_1	176	178	PF00082	0.488
CLV_PCSK_KEX2_1	190	192	PF00082	0.439
CLV_PCSK_KEX2_1	208	210	PF00082	0.443
CLV_PCSK_SKI1_1	185	189	PF00082	0.596
CLV_PCSK_SKI1_1	193	197	PF00082	0.364
CLV_PCSK_SKI1_1	217	221	PF00082	0.546
CLV_PCSK_SKI1_1	230	234	PF00082	0.381
CLV_PCSK_SKI1_1	241	245	PF00082	0.596
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_CYCLIN_RxL_1	190	199	PF00134	0.613
DOC_CYCLIN_yClb5_NLxxxL_5	14	21	PF00134	0.447
DOC_MAPK_MEF2A_6	14	21	PF00069	0.337
DOC_MIT_MIM_1	179	191	PF04212	0.503
DOC_PP2B_LxvP_1	106	109	PF13499	0.335
DOC_USP7_MATH_1	112	116	PF00917	0.546
DOC_USP7_MATH_1	126	130	PF00917	0.577
DOC_USP7_MATH_1	161	165	PF00917	0.678
DOC_WW_Pin1_4	135	140	PF00397	0.627
DOC_WW_Pin1_4	157	162	PF00397	0.660
DOC_WW_Pin1_4	163	168	PF00397	0.505
DOC_WW_Pin1_4	251	256	PF00397	0.700
LIG_14-3-3_CanoR_1	116	121	PF00244	0.659
LIG_14-3-3_CanoR_1	135	139	PF00244	0.607
LIG_14-3-3_CanoR_1	148	155	PF00244	0.679
LIG_14-3-3_CanoR_1	185	190	PF00244	0.556
LIG_14-3-3_CanoR_1	208	214	PF00244	0.616
LIG_Actin_WH2_2	57	75	PF00022	0.344
LIG_APCC_ABBA_1	64	69	PF00400	0.355
LIG_FHA_1	213	219	PF00498	0.538
LIG_Integrin_isoDGR_2	133	135	PF01839	0.546
LIG_LIR_Gen_1	57	67	PF02991	0.473
LIG_LIR_Gen_1	85	94	PF02991	0.335
LIG_LIR_Nem_3	214	219	PF02991	0.528
LIG_LIR_Nem_3	237	243	PF02991	0.481
LIG_LIR_Nem_3	85	89	PF02991	0.335
LIG_Rb_LxCxE_1	214	231	PF01857	0.518
LIG_Rb_LxCxE_1	23	45	PF01857	0.305
LIG_SH2_CRK	216	220	PF00017	0.523
LIG_SH2_CRK	86	90	PF00017	0.335
LIG_SH2_SRC	67	70	PF00017	0.335
LIG_SH2_STAP1	67	71	PF00017	0.335
LIG_SH2_STAP1	86	90	PF00017	0.335
LIG_SH2_STAT3	90	93	PF00017	0.335
LIG_SH2_STAT5	90	93	PF00017	0.355
LIG_SH3_2	109	114	PF14604	0.603
LIG_SH3_3	105	111	PF00018	0.354
LIG_SH3_3	52	58	PF00018	0.432
LIG_SH3_3	88	94	PF00018	0.338
LIG_TRAF2_1	236	239	PF00917	0.473
LIG_TYR_ITIM	65	70	PF00017	0.383
LIG_WW_3	107	111	PF00397	0.508
MOD_CDC14_SPxK_1	166	169	PF00782	0.568
MOD_CDK_SPxK_1	163	169	PF00069	0.593
MOD_CDK_SPxxK_3	135	142	PF00069	0.666
MOD_CK1_1	115	121	PF00069	0.699
MOD_CK1_1	143	149	PF00069	0.710
MOD_CK1_1	212	218	PF00069	0.597
MOD_DYRK1A_RPxSP_1	135	139	PF00069	0.566
MOD_GlcNHglycan	123	126	PF01048	0.671
MOD_GlcNHglycan	142	145	PF01048	0.734
MOD_GlcNHglycan	149	152	PF01048	0.688
MOD_GlcNHglycan	44	48	PF01048	0.423
MOD_GSK3_1	112	119	PF00069	0.587
MOD_GSK3_1	140	147	PF00069	0.651
MOD_GSK3_1	157	164	PF00069	0.621
MOD_GSK3_1	20	27	PF00069	0.414
MOD_GSK3_1	72	79	PF00069	0.447
MOD_NEK2_1	120	125	PF00069	0.728
MOD_NEK2_1	72	77	PF00069	0.487
MOD_NEK2_2	126	131	PF00069	0.585
MOD_PIKK_1	225	231	PF00454	0.600
MOD_PIKK_1	93	99	PF00454	0.447
MOD_PKA_1	209	215	PF00069	0.617
MOD_PKA_2	115	121	PF00069	0.754
MOD_PKA_2	134	140	PF00069	0.432
MOD_PKA_2	147	153	PF00069	0.676
MOD_PKA_2	209	215	PF00069	0.617
MOD_PKA_2	72	78	PF00069	0.480
MOD_PKB_1	114	122	PF00069	0.745
MOD_Plk_4	60	66	PF00069	0.438
MOD_ProDKin_1	135	141	PF00069	0.624
MOD_ProDKin_1	157	163	PF00069	0.659
MOD_ProDKin_1	251	257	PF00069	0.739
TRG_DiLeu_BaEn_1	214	219	PF01217	0.567
TRG_DiLeu_BaEn_1	246	251	PF01217	0.614
TRG_DiLeu_BaEn_3	238	244	PF01217	0.561
TRG_DiLeu_LyEn_5	214	219	PF01217	0.567
TRG_ENDOCYTIC_2	216	219	PF00928	0.527
TRG_ENDOCYTIC_2	67	70	PF00928	0.398
TRG_ENDOCYTIC_2	86	89	PF00928	0.335
TRG_ER_diArg_1	189	191	PF00400	0.539
TRG_ER_diArg_1	208	211	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R9	Leptomonas seymouri	50%	93%
A0A0S4J2G2	Bodo saltans	41%	100%
A0A1X0P9F2	Trypanosomatidae	44%	100%
A0A3Q8IH20	Leishmania donovani	100%	100%
A0A422N0I0	Trypanosoma rangeli	44%	100%
A4HNY8	Leishmania braziliensis	76%	100%
E9ASQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1U5	Leishmania major	90%	100%
V5BQB2	Trypanosoma cruzi	40%	100%