Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICK4_LEIIN

TriTrypDb:

LINF_360018900

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.514
CLV_MEL_PAP_1	133	139	PF00089	0.523
CLV_NRD_NRD_1	146	148	PF00675	0.488
CLV_NRD_NRD_1	151	153	PF00675	0.489
CLV_NRD_NRD_1	17	19	PF00675	0.694
CLV_NRD_NRD_1	206	208	PF00675	0.607
CLV_NRD_NRD_1	233	235	PF00675	0.616
CLV_NRD_NRD_1	342	344	PF00675	0.628
CLV_NRD_NRD_1	80	82	PF00675	0.627
CLV_PCSK_KEX2_1	145	147	PF00082	0.496
CLV_PCSK_KEX2_1	17	19	PF00082	0.694
CLV_PCSK_KEX2_1	206	208	PF00082	0.584
CLV_PCSK_KEX2_1	233	235	PF00082	0.571
CLV_PCSK_KEX2_1	342	344	PF00082	0.611
CLV_PCSK_KEX2_1	80	82	PF00082	0.769
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.611
CLV_PCSK_SKI1_1	185	189	PF00082	0.443
DEG_SPOP_SBC_1	295	299	PF00917	0.616
DEG_SPOP_SBC_1	306	310	PF00917	0.520
DOC_CKS1_1	86	91	PF01111	0.637
DOC_CKS1_1	92	97	PF01111	0.552
DOC_MAPK_gen_1	152	160	PF00069	0.455
DOC_MAPK_gen_1	17	27	PF00069	0.611
DOC_MAPK_MEF2A_6	153	162	PF00069	0.367
DOC_MAPK_RevD_3	133	146	PF00069	0.445
DOC_PP1_RVXF_1	191	197	PF00149	0.412
DOC_USP7_MATH_1	295	299	PF00917	0.665
DOC_USP7_MATH_1	38	42	PF00917	0.626
DOC_USP7_MATH_1	397	401	PF00917	0.590
DOC_USP7_MATH_1	55	59	PF00917	0.586
DOC_USP7_MATH_1	8	12	PF00917	0.560
DOC_USP7_UBL2_3	36	40	PF12436	0.643
DOC_WW_Pin1_4	205	210	PF00397	0.509
DOC_WW_Pin1_4	248	253	PF00397	0.446
DOC_WW_Pin1_4	332	337	PF00397	0.611
DOC_WW_Pin1_4	356	361	PF00397	0.678
DOC_WW_Pin1_4	56	61	PF00397	0.707
DOC_WW_Pin1_4	79	84	PF00397	0.711
DOC_WW_Pin1_4	85	90	PF00397	0.650
DOC_WW_Pin1_4	91	96	PF00397	0.551
DOC_WW_Pin1_4	99	104	PF00397	0.642
LIG_14-3-3_CanoR_1	136	142	PF00244	0.587
LIG_14-3-3_CanoR_1	17	27	PF00244	0.638
LIG_14-3-3_CanoR_1	185	191	PF00244	0.443
LIG_14-3-3_CanoR_1	218	224	PF00244	0.476
LIG_14-3-3_CanoR_1	233	241	PF00244	0.389
LIG_14-3-3_CanoR_1	259	268	PF00244	0.523
LIG_14-3-3_CanoR_1	30	38	PF00244	0.587
LIG_14-3-3_CanoR_1	305	314	PF00244	0.698
LIG_14-3-3_CanoR_1	343	349	PF00244	0.694
LIG_14-3-3_CanoR_1	61	65	PF00244	0.617
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_2	285	289	PF00653	0.618
LIG_FHA_1	261	267	PF00498	0.426
LIG_FHA_1	307	313	PF00498	0.622
LIG_FHA_1	66	72	PF00498	0.631
LIG_FHA_1	80	86	PF00498	0.612
LIG_FHA_2	235	241	PF00498	0.536
LIG_FHA_2	365	371	PF00498	0.702
LIG_FHA_2	381	387	PF00498	0.460
LIG_FHA_2	46	52	PF00498	0.722
LIG_FHA_2	86	92	PF00498	0.599
LIG_LIR_Gen_1	245	255	PF02991	0.536
LIG_LIR_Gen_1	45	55	PF02991	0.562
LIG_LIR_Gen_1	5	12	PF02991	0.529
LIG_LIR_Gen_1	59	69	PF02991	0.475
LIG_LIR_Nem_3	231	235	PF02991	0.474
LIG_LIR_Nem_3	245	250	PF02991	0.461
LIG_LIR_Nem_3	45	50	PF02991	0.576
LIG_LIR_Nem_3	5	9	PF02991	0.637
LIG_LIR_Nem_3	59	65	PF02991	0.630
LIG_PDZ_Class_2	417	422	PF00595	0.461
LIG_SH2_NCK_1	406	410	PF00017	0.419
LIG_SH2_NCK_1	47	51	PF00017	0.600
LIG_SH2_SRC	406	409	PF00017	0.425
LIG_SH2_STAP1	23	27	PF00017	0.666
LIG_SH2_STAP1	406	410	PF00017	0.438
LIG_SH2_STAT5	47	50	PF00017	0.602
LIG_SH3_3	287	293	PF00018	0.650
LIG_SH3_3	68	74	PF00018	0.663
LIG_SH3_5	19	23	PF00018	0.526
LIG_TRAF2_1	163	166	PF00917	0.359
LIG_WW_3	102	106	PF00397	0.514
MOD_CDK_SPK_2	56	61	PF00069	0.605
MOD_CDK_SPK_2	85	90	PF00069	0.621
MOD_CDK_SPxK_1	99	105	PF00069	0.521
MOD_CDK_SPxxK_3	356	363	PF00069	0.565
MOD_CK1_1	2	8	PF00069	0.610
MOD_CK1_1	21	27	PF00069	0.490
MOD_CK1_1	236	242	PF00069	0.485
MOD_CK1_1	260	266	PF00069	0.429
MOD_CK1_1	308	314	PF00069	0.618
MOD_CK1_1	395	401	PF00069	0.516
MOD_CK1_1	411	417	PF00069	0.434
MOD_CK1_1	43	49	PF00069	0.715
MOD_CK2_1	234	240	PF00069	0.629
MOD_CK2_1	356	362	PF00069	0.683
MOD_CK2_1	364	370	PF00069	0.638
MOD_CK2_1	401	407	PF00069	0.594
MOD_CK2_1	45	51	PF00069	0.683
MOD_GlcNHglycan	123	126	PF01048	0.551
MOD_GlcNHglycan	214	217	PF01048	0.584
MOD_GlcNHglycan	219	222	PF01048	0.464
MOD_GlcNHglycan	244	247	PF01048	0.532
MOD_GlcNHglycan	302	305	PF01048	0.675
MOD_GlcNHglycan	318	321	PF01048	0.501
MOD_GlcNHglycan	396	400	PF01048	0.485
MOD_GlcNHglycan	42	45	PF01048	0.645
MOD_GSK3_1	108	115	PF00069	0.606
MOD_GSK3_1	121	128	PF00069	0.480
MOD_GSK3_1	296	303	PF00069	0.634
MOD_GSK3_1	304	311	PF00069	0.684
MOD_GSK3_1	38	45	PF00069	0.668
MOD_GSK3_1	397	404	PF00069	0.595
MOD_GSK3_1	56	63	PF00069	0.669
MOD_GSK3_1	99	106	PF00069	0.700
MOD_N-GLC_1	280	285	PF02516	0.524
MOD_N-GLC_1	316	321	PF02516	0.657
MOD_N-GLC_1	356	361	PF02516	0.647
MOD_NEK2_1	186	191	PF00069	0.390
MOD_NEK2_1	300	305	PF00069	0.640
MOD_NEK2_1	316	321	PF00069	0.504
MOD_NEK2_2	296	301	PF00069	0.550
MOD_PIKK_1	260	266	PF00454	0.429
MOD_PK_1	344	350	PF00069	0.534
MOD_PKA_1	233	239	PF00069	0.524
MOD_PKA_1	344	350	PF00069	0.611
MOD_PKA_2	135	141	PF00069	0.580
MOD_PKA_2	217	223	PF00069	0.480
MOD_PKA_2	233	239	PF00069	0.441
MOD_PKA_2	300	306	PF00069	0.655
MOD_PKA_2	60	66	PF00069	0.604
MOD_Plk_1	181	187	PF00069	0.552
MOD_Plk_1	21	27	PF00069	0.458
MOD_Plk_4	308	314	PF00069	0.680
MOD_Plk_4	344	350	PF00069	0.613
MOD_Plk_4	401	407	PF00069	0.526
MOD_Plk_4	408	414	PF00069	0.441
MOD_ProDKin_1	205	211	PF00069	0.507
MOD_ProDKin_1	248	254	PF00069	0.460
MOD_ProDKin_1	332	338	PF00069	0.609
MOD_ProDKin_1	356	362	PF00069	0.683
MOD_ProDKin_1	56	62	PF00069	0.710
MOD_ProDKin_1	79	85	PF00069	0.712
MOD_ProDKin_1	91	97	PF00069	0.552
MOD_ProDKin_1	99	105	PF00069	0.643
MOD_SUMO_rev_2	28	38	PF00179	0.478
TRG_DiLeu_BaEn_1	182	187	PF01217	0.470
TRG_DiLeu_LyEn_5	182	187	PF01217	0.444
TRG_ENDOCYTIC_2	47	50	PF00928	0.574
TRG_ENDOCYTIC_2	6	9	PF00928	0.640
TRG_ER_diArg_1	145	147	PF00400	0.632
TRG_ER_diArg_1	16	18	PF00400	0.659
TRG_ER_diArg_1	232	234	PF00400	0.557
TRG_ER_diArg_1	416	419	PF00400	0.445
TRG_NLS_MonoExtN_4	342	347	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ64	Leptomonas seymouri	32%	100%
A0A3S7XAJ3	Leishmania donovani	99%	100%
A4HNY9	Leishmania braziliensis	58%	100%
E9ASQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1U4	Leishmania major	83%	100%