J domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein - putative

Species:

Leishmania infantum

UniProt:

A4ICK3_LEIIN

TriTrypDb:

LINF_360019000

Length:

315

Annotations

LeishMANIAdb annotations

Apparently a chaperone for some membrane-associated process unique to Kinetoplastids.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4ICK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.680
CLV_NRD_NRD_1	114	116	PF00675	0.522
CLV_NRD_NRD_1	140	142	PF00675	0.399
CLV_NRD_NRD_1	297	299	PF00675	0.428
CLV_NRD_NRD_1	4	6	PF00675	0.560
CLV_PCSK_FUR_1	55	59	PF00082	0.439
CLV_PCSK_KEX2_1	114	116	PF00082	0.587
CLV_PCSK_KEX2_1	139	141	PF00082	0.403
CLV_PCSK_KEX2_1	4	6	PF00082	0.560
CLV_PCSK_KEX2_1	57	59	PF00082	0.405
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.422
CLV_PCSK_SKI1_1	272	276	PF00082	0.397
CLV_PCSK_SKI1_1	299	303	PF00082	0.427
CLV_PCSK_SKI1_1	30	34	PF00082	0.491
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.607
DOC_MAPK_gen_1	139	146	PF00069	0.599
DOC_MAPK_MEF2A_6	239	248	PF00069	0.593
DOC_PP1_RVXF_1	40	46	PF00149	0.573
DOC_PP2B_LxvP_1	279	282	PF13499	0.627
DOC_PP4_FxxP_1	277	280	PF00568	0.623
DOC_USP7_MATH_1	202	206	PF00917	0.484
DOC_USP7_MATH_1	69	73	PF00917	0.741
DOC_USP7_MATH_1	94	98	PF00917	0.526
DOC_WW_Pin1_4	6	11	PF00397	0.721
LIG_14-3-3_CanoR_1	121	128	PF00244	0.758
LIG_14-3-3_CanoR_1	139	147	PF00244	0.603
LIG_14-3-3_CanoR_1	263	269	PF00244	0.636
LIG_14-3-3_CanoR_1	305	312	PF00244	0.686
LIG_14-3-3_CterR_2	310	315	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BRCT_BRCA1_1	119	123	PF00533	0.703
LIG_BRCT_BRCA1_1	35	39	PF00533	0.660
LIG_CtBP_PxDLS_1	282	286	PF00389	0.526
LIG_FHA_1	276	282	PF00498	0.573
LIG_FHA_2	211	217	PF00498	0.625
LIG_FHA_2	250	256	PF00498	0.644
LIG_FHA_2	48	54	PF00498	0.699
LIG_LIR_Apic_2	275	280	PF02991	0.625
LIG_LIR_Gen_1	92	102	PF02991	0.590
LIG_LIR_Nem_3	100	105	PF02991	0.530
LIG_LIR_Nem_3	158	164	PF02991	0.354
LIG_LIR_Nem_3	92	98	PF02991	0.598
LIG_MAD2	61	69	PF02301	0.579
LIG_Pex14_2	128	132	PF04695	0.693
LIG_Pex14_2	191	195	PF04695	0.437
LIG_SH2_CRK	102	106	PF00017	0.628
LIG_SH2_CRK	60	64	PF00017	0.561
LIG_SH2_NCK_1	102	106	PF00017	0.582
LIG_SH2_STAT5	177	180	PF00017	0.393
LIG_SUMO_SIM_par_1	299	304	PF11976	0.632
LIG_TRAF2_1	213	216	PF00917	0.645
MOD_CK1_1	17	23	PF00069	0.745
MOD_CK1_1	266	272	PF00069	0.477
MOD_CK1_1	72	78	PF00069	0.689
MOD_CK2_1	19	25	PF00069	0.641
MOD_CK2_1	210	216	PF00069	0.470
MOD_CK2_1	34	40	PF00069	0.507
MOD_CK2_1	47	53	PF00069	0.547
MOD_CK2_1	94	100	PF00069	0.406
MOD_Cter_Amidation	112	115	PF01082	0.649
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	123	126	PF01048	0.680
MOD_GlcNHglycan	17	20	PF01048	0.711
MOD_GlcNHglycan	307	310	PF01048	0.583
MOD_GlcNHglycan	70	74	PF01048	0.616
MOD_GlcNHglycan	86	90	PF01048	0.711
MOD_GSK3_1	117	124	PF00069	0.659
MOD_GSK3_1	15	22	PF00069	0.738
MOD_GSK3_1	164	171	PF00069	0.532
MOD_GSK3_1	262	269	PF00069	0.545
MOD_GSK3_1	68	75	PF00069	0.675
MOD_N-GLC_1	117	122	PF02516	0.728
MOD_N-GLC_1	168	173	PF02516	0.602
MOD_N-GLC_1	283	288	PF02516	0.387
MOD_N-GLC_2	229	231	PF02516	0.367
MOD_NEK2_2	202	207	PF00069	0.526
MOD_NEK2_2	94	99	PF00069	0.428
MOD_PIKK_1	139	145	PF00454	0.610
MOD_PIKK_1	17	23	PF00454	0.693
MOD_PKA_1	139	145	PF00069	0.610
MOD_PKA_2	139	145	PF00069	0.546
MOD_PKA_2	262	268	PF00069	0.575
MOD_Plk_1	168	174	PF00069	0.604
MOD_Plk_1	283	289	PF00069	0.591
MOD_Plk_1	303	309	PF00069	0.439
MOD_Plk_2-3	210	216	PF00069	0.575
MOD_Plk_2-3	49	55	PF00069	0.626
MOD_ProDKin_1	6	12	PF00069	0.671
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.615
TRG_ENDOCYTIC_2	102	105	PF00928	0.410
TRG_ENDOCYTIC_2	60	63	PF00928	0.453
TRG_ER_diArg_1	139	141	PF00400	0.593
TRG_ER_diArg_1	4	6	PF00400	0.763
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P358	Leptomonas seymouri	58%	85%
A0A0S4IZF1	Bodo saltans	29%	100%
A0A1X0P876	Trypanosomatidae	43%	97%
A0A3R7N2F8	Trypanosoma rangeli	40%	100%
A0A3S7XAJ1	Leishmania donovani	100%	70%
A4HNZ0	Leishmania braziliensis	74%	100%
D0A2V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9ASQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1U3	Leishmania major	96%	100%
V5BUV1	Trypanosoma cruzi	40%	97%