LeishMANIAdb
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Putative N-acetyltransferase subunit Nat1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative N-acetyltransferase subunit Nat1
Gene product:
N-acetyltransferase subunit Nat1 - putative
Species:
Leishmania infantum
UniProt:
A4ICK2_LEIIN
TriTrypDb:
LINF_360019100
Length:
711

Annotations

Annotations by Jardim et al.

Transferases, N-acetyltransferase subunit Nat1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICK2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK2

Function

Biological processes
Term Name Level Count
GO:0006473 protein acetylation 6 1
GO:0006474 N-terminal protein amino acid acetylation 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0017196 N-terminal peptidyl-methionine acetylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018206 peptidyl-methionine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0031365 N-terminal protein amino acid modification 5 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 176 180 PF00656 0.417
CLV_C14_Caspase3-7 254 258 PF00656 0.509
CLV_C14_Caspase3-7 692 696 PF00656 0.470
CLV_NRD_NRD_1 265 267 PF00675 0.217
CLV_NRD_NRD_1 390 392 PF00675 0.309
CLV_NRD_NRD_1 440 442 PF00675 0.284
CLV_NRD_NRD_1 505 507 PF00675 0.249
CLV_NRD_NRD_1 539 541 PF00675 0.223
CLV_PCSK_KEX2_1 104 106 PF00082 0.396
CLV_PCSK_KEX2_1 243 245 PF00082 0.248
CLV_PCSK_KEX2_1 302 304 PF00082 0.223
CLV_PCSK_KEX2_1 390 392 PF00082 0.309
CLV_PCSK_KEX2_1 440 442 PF00082 0.284
CLV_PCSK_KEX2_1 505 507 PF00082 0.291
CLV_PCSK_KEX2_1 539 541 PF00082 0.241
CLV_PCSK_KEX2_1 605 607 PF00082 0.234
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.396
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.248
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.309
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.234
CLV_PCSK_SKI1_1 101 105 PF00082 0.291
CLV_PCSK_SKI1_1 139 143 PF00082 0.363
CLV_PCSK_SKI1_1 224 228 PF00082 0.234
CLV_PCSK_SKI1_1 290 294 PF00082 0.281
CLV_PCSK_SKI1_1 303 307 PF00082 0.161
CLV_PCSK_SKI1_1 382 386 PF00082 0.272
CLV_PCSK_SKI1_1 452 456 PF00082 0.223
CLV_PCSK_SKI1_1 560 564 PF00082 0.264
CLV_PCSK_SKI1_1 605 609 PF00082 0.264
CLV_PCSK_SKI1_1 658 662 PF00082 0.351
CLV_PCSK_SKI1_1 664 668 PF00082 0.330
CLV_Separin_Metazoa 115 119 PF03568 0.457
DEG_APCC_DBOX_1 302 310 PF00400 0.406
DEG_SCF_FBW7_2 406 413 PF00400 0.434
DOC_CKS1_1 321 326 PF01111 0.509
DOC_CYCLIN_RxL_1 101 110 PF00134 0.396
DOC_CYCLIN_RxL_1 437 446 PF00134 0.403
DOC_CYCLIN_RxL_1 49 60 PF00134 0.350
DOC_CYCLIN_RxL_1 655 665 PF00134 0.279
DOC_MAPK_gen_1 101 109 PF00069 0.396
DOC_MAPK_gen_1 558 565 PF00069 0.458
DOC_MAPK_gen_1 673 682 PF00069 0.527
DOC_MAPK_MEF2A_6 676 684 PF00069 0.427
DOC_PP1_RVXF_1 103 110 PF00149 0.396
DOC_PP4_FxxP_1 321 324 PF00568 0.509
DOC_PP4_FxxP_1 473 476 PF00568 0.464
DOC_USP7_MATH_1 143 147 PF00917 0.476
DOC_USP7_MATH_1 487 491 PF00917 0.423
DOC_USP7_MATH_1 637 641 PF00917 0.434
DOC_USP7_UBL2_3 293 297 PF12436 0.458
DOC_USP7_UBL2_3 560 564 PF12436 0.448
DOC_USP7_UBL2_3 608 612 PF12436 0.500
DOC_WW_Pin1_4 320 325 PF00397 0.493
DOC_WW_Pin1_4 406 411 PF00397 0.423
LIG_14-3-3_CanoR_1 105 110 PF00244 0.396
LIG_14-3-3_CanoR_1 33 41 PF00244 0.472
LIG_14-3-3_CanoR_1 539 544 PF00244 0.434
LIG_14-3-3_CanoR_1 664 670 PF00244 0.476
LIG_Actin_WH2_2 261 277 PF00022 0.528
LIG_BIR_II_1 1 5 PF00653 0.586
LIG_Clathr_ClatBox_1 414 418 PF01394 0.509
LIG_Clathr_ClatBox_1 516 520 PF01394 0.509
LIG_deltaCOP1_diTrp_1 129 133 PF00928 0.320
LIG_FHA_1 112 118 PF00498 0.424
LIG_FHA_1 221 227 PF00498 0.493
LIG_FHA_1 321 327 PF00498 0.455
LIG_FHA_1 407 413 PF00498 0.427
LIG_FHA_1 467 473 PF00498 0.492
LIG_FHA_1 643 649 PF00498 0.446
LIG_FHA_1 675 681 PF00498 0.414
LIG_FHA_2 484 490 PF00498 0.427
LIG_FHA_2 690 696 PF00498 0.532
LIG_GBD_Chelix_1 701 709 PF00786 0.277
LIG_Integrin_RGD_1 506 508 PF01839 0.294
LIG_KLC1_Yacidic_2 413 418 PF13176 0.509
LIG_LIR_Apic_2 271 276 PF02991 0.509
LIG_LIR_Gen_1 242 253 PF02991 0.423
LIG_LIR_Gen_1 281 292 PF02991 0.448
LIG_LIR_Gen_1 332 342 PF02991 0.444
LIG_LIR_Gen_1 352 361 PF02991 0.483
LIG_LIR_Gen_1 365 373 PF02991 0.394
LIG_LIR_Gen_1 572 578 PF02991 0.424
LIG_LIR_Gen_1 593 604 PF02991 0.528
LIG_LIR_Gen_1 63 74 PF02991 0.490
LIG_LIR_Nem_3 129 133 PF02991 0.320
LIG_LIR_Nem_3 242 248 PF02991 0.423
LIG_LIR_Nem_3 281 287 PF02991 0.465
LIG_LIR_Nem_3 332 337 PF02991 0.444
LIG_LIR_Nem_3 365 369 PF02991 0.413
LIG_LIR_Nem_3 531 536 PF02991 0.434
LIG_LIR_Nem_3 572 576 PF02991 0.431
LIG_LIR_Nem_3 593 599 PF02991 0.528
LIG_LIR_Nem_3 629 634 PF02991 0.400
LIG_LIR_Nem_3 63 69 PF02991 0.449
LIG_NRBOX 512 518 PF00104 0.509
LIG_NRBOX 705 711 PF00104 0.280
LIG_PALB2_WD40_1 542 550 PF16756 0.448
LIG_PCNA_TLS_4 267 274 PF02747 0.509
LIG_Pex14_1 380 384 PF04695 0.423
LIG_Pex14_2 561 565 PF04695 0.509
LIG_PTB_Apo_2 22 29 PF02174 0.466
LIG_PTB_Apo_2 371 378 PF02174 0.431
LIG_PTB_Apo_2 532 539 PF02174 0.434
LIG_PTB_Phospho_1 22 28 PF10480 0.465
LIG_PTB_Phospho_1 371 377 PF10480 0.471
LIG_REV1ctd_RIR_1 559 566 PF16727 0.434
LIG_SH2_CRK 573 577 PF00017 0.464
LIG_SH2_GRB2like 23 26 PF00017 0.521
LIG_SH2_GRB2like 448 451 PF00017 0.423
LIG_SH2_NCK_1 653 657 PF00017 0.456
LIG_SH2_PTP2 245 248 PF00017 0.472
LIG_SH2_SRC 245 248 PF00017 0.472
LIG_SH2_SRC 341 344 PF00017 0.509
LIG_SH2_SRC 448 451 PF00017 0.423
LIG_SH2_STAP1 28 32 PF00017 0.383
LIG_SH2_STAP1 280 284 PF00017 0.509
LIG_SH2_STAP1 495 499 PF00017 0.423
LIG_SH2_STAP1 653 657 PF00017 0.269
LIG_SH2_STAT5 245 248 PF00017 0.472
LIG_SH2_STAT5 273 276 PF00017 0.509
LIG_SH2_STAT5 280 283 PF00017 0.475
LIG_SH2_STAT5 325 328 PF00017 0.509
LIG_SH2_STAT5 341 344 PF00017 0.484
LIG_SH2_STAT5 377 380 PF00017 0.459
LIG_SH2_STAT5 401 404 PF00017 0.471
LIG_SH2_STAT5 416 419 PF00017 0.423
LIG_SH2_STAT5 448 451 PF00017 0.423
LIG_SH2_STAT5 457 460 PF00017 0.423
LIG_SH2_STAT5 484 487 PF00017 0.434
LIG_SH2_STAT5 509 512 PF00017 0.427
LIG_SH2_STAT5 536 539 PF00017 0.509
LIG_SH2_STAT5 615 618 PF00017 0.352
LIG_SH2_STAT5 634 637 PF00017 0.330
LIG_SH2_STAT5 653 656 PF00017 0.270
LIG_SH2_STAT5 689 692 PF00017 0.532
LIG_SH3_3 586 592 PF00018 0.464
LIG_SH3_5 296 300 PF00018 0.426
LIG_SUMO_SIM_anti_2 411 416 PF11976 0.448
LIG_SUMO_SIM_par_1 182 189 PF11976 0.440
LIG_SUMO_SIM_par_1 215 223 PF11976 0.522
LIG_SUMO_SIM_par_1 644 651 PF11976 0.411
LIG_UBA3_1 329 338 PF00899 0.281
LIG_UBA3_1 414 421 PF00899 0.275
LIG_WRC_WIRS_1 381 386 PF05994 0.353
LIG_WRC_WIRS_1 46 51 PF05994 0.461
MOD_CK1_1 3 9 PF00069 0.554
MOD_CK1_1 332 338 PF00069 0.275
MOD_CK1_1 477 483 PF00069 0.131
MOD_CK1_1 644 650 PF00069 0.470
MOD_CK1_1 665 671 PF00069 0.273
MOD_CK2_1 21 27 PF00069 0.508
MOD_CK2_1 483 489 PF00069 0.319
MOD_CK2_1 705 711 PF00069 0.372
MOD_GlcNHglycan 121 124 PF01048 0.372
MOD_GlcNHglycan 2 5 PF01048 0.641
MOD_GlcNHglycan 200 203 PF01048 0.396
MOD_GlcNHglycan 510 513 PF01048 0.275
MOD_GlcNHglycan 8 11 PF01048 0.512
MOD_GSK3_1 139 146 PF00069 0.471
MOD_GSK3_1 247 254 PF00069 0.402
MOD_GSK3_1 332 339 PF00069 0.275
MOD_GSK3_1 380 387 PF00069 0.386
MOD_GSK3_1 483 490 PF00069 0.281
MOD_GSK3_1 637 644 PF00069 0.426
MOD_GSK3_1 683 690 PF00069 0.474
MOD_N-GLC_1 406 411 PF02516 0.384
MOD_N-GLC_1 674 679 PF02516 0.385
MOD_N-GLC_2 526 528 PF02516 0.396
MOD_NEK2_1 161 166 PF00069 0.444
MOD_NEK2_1 384 389 PF00069 0.312
MOD_NEK2_1 688 693 PF00069 0.458
MOD_NEK2_2 143 148 PF00069 0.517
MOD_NEK2_2 65 70 PF00069 0.461
MOD_PIKK_1 487 493 PF00454 0.275
MOD_PIKK_1 638 644 PF00454 0.355
MOD_PKA_1 539 545 PF00069 0.291
MOD_PKA_2 32 38 PF00069 0.462
MOD_PKA_2 389 395 PF00069 0.422
MOD_PKA_2 539 545 PF00069 0.291
MOD_PKA_2 638 644 PF00069 0.394
MOD_Plk_1 364 370 PF00069 0.310
MOD_Plk_1 466 472 PF00069 0.351
MOD_Plk_4 173 179 PF00069 0.417
MOD_Plk_4 329 335 PF00069 0.287
MOD_Plk_4 336 342 PF00069 0.256
MOD_Plk_4 474 480 PF00069 0.305
MOD_Plk_4 705 711 PF00069 0.472
MOD_Plk_4 76 82 PF00069 0.443
MOD_ProDKin_1 320 326 PF00069 0.374
MOD_ProDKin_1 406 412 PF00069 0.275
MOD_SUMO_rev_2 216 226 PF00179 0.320
MOD_SUMO_rev_2 358 366 PF00179 0.394
MOD_SUMO_rev_2 597 607 PF00179 0.295
TRG_DiLeu_BaEn_1 222 227 PF01217 0.360
TRG_DiLeu_BaLyEn_6 656 661 PF01217 0.374
TRG_ENDOCYTIC_2 245 248 PF00928 0.275
TRG_ENDOCYTIC_2 284 287 PF00928 0.291
TRG_ENDOCYTIC_2 573 576 PF00928 0.275
TRG_ENDOCYTIC_2 66 69 PF00928 0.442
TRG_ER_diArg_1 389 391 PF00400 0.396
TRG_ER_diArg_1 440 442 PF00400 0.360
TRG_ER_diArg_1 504 506 PF00400 0.375
TRG_ER_diArg_1 538 540 PF00400 0.275
TRG_ER_diArg_1 671 674 PF00400 0.489
TRG_NES_CRM1_1 508 520 PF08389 0.396
TRG_Pf-PMV_PEXEL_1 105 110 PF00026 0.396
TRG_Pf-PMV_PEXEL_1 440 445 PF00026 0.275

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2R8 Leptomonas seymouri 79% 100%
A0A0S4IZ29 Bodo saltans 53% 100%
A0A1X0P802 Trypanosomatidae 56% 100%
A0A3S7XAS1 Leishmania donovani 99% 100%
A0A422N0I1 Trypanosoma rangeli 60% 100%
A4HNZ1 Leishmania braziliensis 91% 100%
D0A2V9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9ASQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O74985 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 98%
P12945 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 83%
Q4Q1U2 Leishmania major 96% 100%
Q5R4J9 Pongo abelii 29% 82%
Q6N069 Homo sapiens 30% 82%
Q80UM3 Mus musculus 29% 82%
Q8VZM1 Arabidopsis thaliana 29% 79%
Q9BXJ9 Homo sapiens 29% 82%
Q9DBB4 Mus musculus 30% 82%
Q9Y7X2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
V5DRE7 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS