PARP-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICK1_LEIIN

TriTrypDb:

LINF_360019200

Length:

286

Annotations

Annotations by Jardim et al.

Polymerase, Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4ICK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICK1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.686
CLV_C14_Caspase3-7	262	266	PF00656	0.764
CLV_NRD_NRD_1	201	203	PF00675	0.750
CLV_NRD_NRD_1	283	285	PF00675	0.694
CLV_NRD_NRD_1	43	45	PF00675	0.512
CLV_PCSK_KEX2_1	195	197	PF00082	0.681
CLV_PCSK_KEX2_1	282	284	PF00082	0.648
CLV_PCSK_KEX2_1	42	44	PF00082	0.517
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.681
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.648
DOC_MAPK_gen_1	70	79	PF00069	0.561
DOC_MAPK_MEF2A_6	44	53	PF00069	0.489
DOC_USP7_MATH_1	111	115	PF00917	0.551
DOC_USP7_MATH_1	156	160	PF00917	0.353
DOC_USP7_MATH_1	176	180	PF00917	0.792
DOC_USP7_MATH_1	188	192	PF00917	0.725
DOC_USP7_MATH_1	267	271	PF00917	0.775
DOC_USP7_MATH_1	61	65	PF00917	0.508
DOC_USP7_UBL2_3	173	177	PF12436	0.754
DOC_USP7_UBL2_3	278	282	PF12436	0.682
DOC_USP7_UBL2_3	70	74	PF12436	0.512
LIG_14-3-3_CanoR_1	13	23	PF00244	0.504
LIG_14-3-3_CanoR_1	245	251	PF00244	0.511
LIG_14-3-3_CanoR_1	42	51	PF00244	0.664
LIG_Actin_WH2_2	17	32	PF00022	0.475
LIG_APCC_ABBA_1	84	89	PF00400	0.543
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BRCT_BRCA1_1	18	22	PF00533	0.477
LIG_deltaCOP1_diTrp_1	93	97	PF00928	0.561
LIG_FHA_1	144	150	PF00498	0.583
LIG_FHA_1	79	85	PF00498	0.522
LIG_FHA_2	244	250	PF00498	0.531
LIG_FHA_2	253	259	PF00498	0.531
LIG_FHA_2	260	266	PF00498	0.706
LIG_LIR_Gen_1	2	8	PF02991	0.442
LIG_LIR_Nem_3	19	24	PF02991	0.412
LIG_LIR_Nem_3	2	6	PF02991	0.450
LIG_LIR_Nem_3	248	254	PF02991	0.563
LIG_LIR_Nem_3	94	100	PF02991	0.490
LIG_MLH1_MIPbox_1	18	22	PF16413	0.477
LIG_SH2_PTP2	3	6	PF00017	0.443
LIG_SH2_STAP1	224	228	PF00017	0.619
LIG_SH2_STAT5	254	257	PF00017	0.561
LIG_SH2_STAT5	3	6	PF00017	0.443
LIG_SH3_1	195	201	PF00018	0.644
LIG_SH3_2	197	202	PF14604	0.772
LIG_SH3_3	194	200	PF00018	0.741
LIG_SH3_3	232	238	PF00018	0.304
LIG_SH3_3	80	86	PF00018	0.506
LIG_SH3_4	173	180	PF00018	0.704
LIG_SH3_4	278	285	PF00018	0.683
LIG_SH3_CIN85_PxpxPR_1	197	202	PF14604	0.694
LIG_SxIP_EBH_1	199	211	PF03271	0.573
LIG_TRAF2_1	220	223	PF00917	0.624
LIG_TRAF2_1	246	249	PF00917	0.591
LIG_WW_3	199	203	PF00397	0.699
MOD_CK1_1	158	164	PF00069	0.577
MOD_CK1_1	169	175	PF00069	0.651
MOD_CK1_1	218	224	PF00069	0.607
MOD_CK1_1	270	276	PF00069	0.690
MOD_CK1_1	64	70	PF00069	0.514
MOD_CK2_1	156	162	PF00069	0.356
MOD_CK2_1	188	194	PF00069	0.702
MOD_CK2_1	243	249	PF00069	0.531
MOD_Cter_Amidation	68	71	PF01082	0.361
MOD_GlcNHglycan	113	116	PF01048	0.402
MOD_GlcNHglycan	16	19	PF01048	0.474
MOD_GlcNHglycan	178	181	PF01048	0.787
MOD_GlcNHglycan	188	191	PF01048	0.534
MOD_GlcNHglycan	273	276	PF01048	0.685
MOD_GlcNHglycan	45	48	PF01048	0.596
MOD_GlcNHglycan	57	60	PF01048	0.276
MOD_GSK3_1	106	113	PF00069	0.536
MOD_GSK3_1	12	19	PF00069	0.472
MOD_GSK3_1	267	274	PF00069	0.736
MOD_LATS_1	250	256	PF00433	0.591
MOD_N-GLC_1	259	264	PF02516	0.785
MOD_N-GLC_1	64	69	PF02516	0.391
MOD_NEK2_1	16	21	PF00069	0.474
MOD_NEK2_1	22	27	PF00069	0.440
MOD_OFUCOSY	63	68	PF10250	0.331
MOD_PKA_1	43	49	PF00069	0.544
MOD_PKA_2	111	117	PF00069	0.551
MOD_PKA_2	12	18	PF00069	0.471
MOD_PKA_2	201	207	PF00069	0.700
MOD_PKA_2	244	250	PF00069	0.511
MOD_PKA_2	43	49	PF00069	0.702
MOD_Plk_1	144	150	PF00069	0.554
MOD_Plk_4	144	150	PF00069	0.531
TRG_ENDOCYTIC_2	3	6	PF00928	0.443
TRG_ER_diArg_1	42	44	PF00400	0.514
TRG_NLS_MonoCore_2	281	286	PF00514	0.693
TRG_NLS_MonoExtN_4	200	206	PF00514	0.687
TRG_NLS_MonoExtN_4	279	286	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA52	Leptomonas seymouri	73%	100%
A0A0S4J2P2	Bodo saltans	39%	100%
A0A1X0P7R0	Trypanosomatidae	42%	100%
A0A3S5H819	Leishmania donovani	100%	100%
A4HNZ2	Leishmania braziliensis	74%	100%
D0A369	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1U1	Leishmania major	90%	100%