LeishMANIAdb
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Putative Transitional endoplasmic reticulum ATPase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative Transitional endoplasmic reticulum ATPase
Gene product:
Transitional endoplasmic reticulum ATPase - putative
Species:
Leishmania infantum
UniProt:
A4ICJ9_LEIIN
TriTrypDb:
LINF_360019800 *
Length:
690

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Metal Binding, Transitional endoplasmic reticulum ATPase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0016020 membrane 2 1
GO:0032991 protein-containing complex 1 1
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098552 side of membrane 2 1
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane 4 1
GO:0098562 cytoplasmic side of membrane 3 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICJ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICJ9

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006950 response to stress 2 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 3
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0022402 cell cycle process 2 1
GO:0022411 cellular component disassembly 4 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0030970 retrograde protein transport, ER to cytosol 5 1
GO:0032527 protein exit from endoplasmic reticulum 5 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0033036 macromolecule localization 2 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0050896 response to stimulus 1 1
GO:0051179 localization 1 1
GO:0051228 mitotic spindle disassembly 5 1
GO:0051230 spindle disassembly 4 1
GO:0051234 establishment of localization 2 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051716 cellular response to stimulus 2 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0071712 ER-associated misfolded protein catabolic process 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097352 autophagosome maturation 6 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903008 organelle disassembly 5 1
GO:1903047 mitotic cell cycle process 3 1
GO:1903513 endoplasmic reticulum to cytosol transport 4 1
GO:0051301 cell division 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016462 pyrophosphatase activity 5 9
GO:0016787 hydrolase activity 2 9
GO:0016817 hydrolase activity, acting on acid anhydrides 3 9
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 9
GO:0016887 ATP hydrolysis activity 7 9
GO:0017076 purine nucleotide binding 4 9
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:0005515 protein binding 2 1
GO:0031593 polyubiquitin modification-dependent protein binding 4 1
GO:0042802 identical protein binding 3 1
GO:0140030 modification-dependent protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.567
CLV_C14_Caspase3-7 226 230 PF00656 0.292
CLV_C14_Caspase3-7 473 477 PF00656 0.292
CLV_C14_Caspase3-7 500 504 PF00656 0.292
CLV_C14_Caspase3-7 639 643 PF00656 0.391
CLV_NRD_NRD_1 254 256 PF00675 0.292
CLV_NRD_NRD_1 555 557 PF00675 0.390
CLV_NRD_NRD_1 637 639 PF00675 0.441
CLV_NRD_NRD_1 646 648 PF00675 0.425
CLV_NRD_NRD_1 80 82 PF00675 0.293
CLV_PCSK_KEX2_1 254 256 PF00082 0.292
CLV_PCSK_KEX2_1 35 37 PF00082 0.316
CLV_PCSK_KEX2_1 382 384 PF00082 0.364
CLV_PCSK_KEX2_1 637 639 PF00082 0.441
CLV_PCSK_KEX2_1 646 648 PF00082 0.425
CLV_PCSK_KEX2_1 80 82 PF00082 0.316
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.316
CLV_PCSK_PC1ET2_1 382 384 PF00082 0.364
CLV_PCSK_SKI1_1 135 139 PF00082 0.316
CLV_PCSK_SKI1_1 282 286 PF00082 0.388
CLV_PCSK_SKI1_1 294 298 PF00082 0.272
CLV_PCSK_SKI1_1 408 412 PF00082 0.292
CLV_PCSK_SKI1_1 420 424 PF00082 0.292
CLV_PCSK_SKI1_1 456 460 PF00082 0.292
CLV_PCSK_SKI1_1 509 513 PF00082 0.292
DEG_APCC_DBOX_1 103 111 PF00400 0.402
DEG_APCC_DBOX_1 319 327 PF00400 0.391
DEG_COP1_1 613 624 PF00400 0.428
DOC_CKS1_1 365 370 PF01111 0.422
DOC_MAPK_gen_1 11 19 PF00069 0.544
DOC_MAPK_gen_1 232 239 PF00069 0.316
DOC_MAPK_gen_1 254 265 PF00069 0.292
DOC_MAPK_gen_1 282 292 PF00069 0.404
DOC_MAPK_gen_1 35 42 PF00069 0.311
DOC_MAPK_gen_1 51 61 PF00069 0.232
DOC_MAPK_gen_1 529 539 PF00069 0.292
DOC_MAPK_gen_1 77 87 PF00069 0.316
DOC_MAPK_MEF2A_6 258 267 PF00069 0.292
DOC_MAPK_MEF2A_6 463 471 PF00069 0.273
DOC_MAPK_MEF2A_6 532 541 PF00069 0.292
DOC_MAPK_MEF2A_6 54 63 PF00069 0.292
DOC_MAPK_MEF2A_6 80 87 PF00069 0.316
DOC_PP1_RVXF_1 148 155 PF00149 0.292
DOC_PP1_RVXF_1 406 413 PF00149 0.352
DOC_PP4_FxxP_1 125 128 PF00568 0.292
DOC_PP4_FxxP_1 412 415 PF00568 0.292
DOC_PP4_MxPP_1 404 407 PF00568 0.455
DOC_USP7_MATH_1 148 152 PF00917 0.316
DOC_USP7_MATH_1 296 300 PF00917 0.316
DOC_USP7_MATH_1 559 563 PF00917 0.445
DOC_USP7_MATH_1 636 640 PF00917 0.443
DOC_USP7_MATH_1 674 678 PF00917 0.766
DOC_WW_Pin1_4 165 170 PF00397 0.303
DOC_WW_Pin1_4 212 217 PF00397 0.123
DOC_WW_Pin1_4 364 369 PF00397 0.437
DOC_WW_Pin1_4 402 407 PF00397 0.404
DOC_WW_Pin1_4 555 560 PF00397 0.382
LIG_14-3-3_CanoR_1 56 60 PF00244 0.348
LIG_14-3-3_CanoR_1 637 645 PF00244 0.420
LIG_Actin_WH2_2 345 363 PF00022 0.463
LIG_BIR_II_1 1 5 PF00653 0.609
LIG_BIR_III_3 1 5 PF00653 0.618
LIG_BIR_III_4 3 7 PF00653 0.630
LIG_BRCT_BRCA1_1 150 154 PF00533 0.316
LIG_BRCT_BRCA1_1 298 302 PF00533 0.432
LIG_BRCT_BRCA1_1 657 661 PF00533 0.558
LIG_CaM_IQ_9 341 356 PF13499 0.391
LIG_Clathr_ClatBox_1 107 111 PF01394 0.391
LIG_CSL_BTD_1 197 200 PF09270 0.369
LIG_deltaCOP1_diTrp_1 394 399 PF00928 0.391
LIG_FHA_1 116 122 PF00498 0.309
LIG_FHA_1 269 275 PF00498 0.470
LIG_FHA_1 330 336 PF00498 0.246
LIG_FHA_1 365 371 PF00498 0.405
LIG_FHA_1 45 51 PF00498 0.292
LIG_FHA_1 56 62 PF00498 0.274
LIG_FHA_1 88 94 PF00498 0.292
LIG_FHA_2 224 230 PF00498 0.292
LIG_FHA_2 361 367 PF00498 0.453
LIG_FHA_2 498 504 PF00498 0.292
LIG_Integrin_RGD_1 44 46 PF01839 0.292
LIG_LIR_Apic_2 123 128 PF02991 0.292
LIG_LIR_Apic_2 194 200 PF02991 0.351
LIG_LIR_Gen_1 120 130 PF02991 0.292
LIG_LIR_Gen_1 163 172 PF02991 0.272
LIG_LIR_Nem_3 120 125 PF02991 0.292
LIG_LIR_Nem_3 132 137 PF02991 0.292
LIG_LIR_Nem_3 151 157 PF02991 0.175
LIG_LIR_Nem_3 163 167 PF02991 0.256
LIG_MAD2 92 100 PF02301 0.205
LIG_PCNA_yPIPBox_3 218 228 PF02747 0.123
LIG_SH2_CRK 134 138 PF00017 0.292
LIG_SH2_CRK 164 168 PF00017 0.292
LIG_SH2_CRK 413 417 PF00017 0.292
LIG_SH2_PTP2 538 541 PF00017 0.292
LIG_SH2_SRC 193 196 PF00017 0.490
LIG_SH2_STAP1 193 197 PF00017 0.333
LIG_SH2_STAT5 129 132 PF00017 0.292
LIG_SH2_STAT5 164 167 PF00017 0.292
LIG_SH2_STAT5 538 541 PF00017 0.292
LIG_SH3_3 16 22 PF00018 0.364
LIG_SH3_3 362 368 PF00018 0.446
LIG_SH3_3 386 392 PF00018 0.359
LIG_SH3_3 519 525 PF00018 0.323
LIG_SUMO_SIM_anti_2 235 241 PF11976 0.334
LIG_SUMO_SIM_anti_2 321 327 PF11976 0.391
LIG_SUMO_SIM_anti_2 334 339 PF11976 0.391
LIG_SUMO_SIM_anti_2 546 552 PF11976 0.348
LIG_SUMO_SIM_par_1 155 160 PF11976 0.292
LIG_SUMO_SIM_par_1 222 229 PF11976 0.316
LIG_SUMO_SIM_par_1 329 336 PF11976 0.246
LIG_TRAF2_1 219 222 PF00917 0.123
LIG_TYR_ITIM 191 196 PF00017 0.492
LIG_TYR_ITIM 536 541 PF00017 0.292
LIG_UBA3_1 224 232 PF00899 0.320
LIG_UBA3_1 276 282 PF00899 0.377
LIG_UBA3_1 536 544 PF00899 0.308
LIG_WW_3 215 219 PF00397 0.123
MOD_CDC14_SPxK_1 215 218 PF00782 0.123
MOD_CDC14_SPxK_1 405 408 PF00782 0.392
MOD_CDK_SPxK_1 212 218 PF00069 0.123
MOD_CDK_SPxK_1 402 408 PF00069 0.401
MOD_CK1_1 168 174 PF00069 0.316
MOD_CK1_1 28 34 PF00069 0.388
MOD_CK2_1 360 366 PF00069 0.474
MOD_Cter_Amidation 51 54 PF01082 0.292
MOD_GlcNHglycan 357 360 PF01048 0.488
MOD_GlcNHglycan 576 579 PF01048 0.292
MOD_GlcNHglycan 580 584 PF01048 0.292
MOD_GlcNHglycan 676 679 PF01048 0.686
MOD_GSK3_1 168 175 PF00069 0.391
MOD_GSK3_1 360 367 PF00069 0.478
MOD_GSK3_1 474 481 PF00069 0.364
MOD_GSK3_1 551 558 PF00069 0.444
MOD_GSK3_1 570 577 PF00069 0.133
MOD_GSK3_1 651 658 PF00069 0.498
MOD_N-GLC_1 115 120 PF02516 0.292
MOD_NEK2_1 130 135 PF00069 0.325
MOD_NEK2_1 240 245 PF00069 0.301
MOD_NEK2_1 352 357 PF00069 0.455
MOD_NEK2_1 360 365 PF00069 0.476
MOD_NEK2_1 650 655 PF00069 0.430
MOD_NEK2_1 661 666 PF00069 0.594
MOD_NEK2_1 87 92 PF00069 0.285
MOD_PIKK_1 232 238 PF00454 0.325
MOD_PIKK_1 341 347 PF00454 0.388
MOD_PIKK_1 360 366 PF00454 0.355
MOD_PKA_2 360 366 PF00069 0.480
MOD_PKA_2 55 61 PF00069 0.292
MOD_PKA_2 593 599 PF00069 0.292
MOD_PKA_2 636 642 PF00069 0.420
MOD_Plk_1 110 116 PF00069 0.395
MOD_Plk_1 25 31 PF00069 0.298
MOD_Plk_1 329 335 PF00069 0.278
MOD_Plk_2-3 321 327 PF00069 0.292
MOD_Plk_2-3 329 335 PF00069 0.292
MOD_Plk_4 139 145 PF00069 0.432
MOD_Plk_4 168 174 PF00069 0.292
MOD_Plk_4 223 229 PF00069 0.292
MOD_Plk_4 25 31 PF00069 0.315
MOD_Plk_4 321 327 PF00069 0.274
MOD_Plk_4 418 424 PF00069 0.287
MOD_Plk_4 44 50 PF00069 0.162
MOD_Plk_4 442 448 PF00069 0.292
MOD_ProDKin_1 165 171 PF00069 0.303
MOD_ProDKin_1 212 218 PF00069 0.123
MOD_ProDKin_1 364 370 PF00069 0.426
MOD_ProDKin_1 402 408 PF00069 0.401
MOD_ProDKin_1 555 561 PF00069 0.377
MOD_SUMO_for_1 381 384 PF00179 0.356
MOD_SUMO_rev_2 151 157 PF00179 0.316
MOD_SUMO_rev_2 600 609 PF00179 0.348
TRG_DiLeu_BaEn_1 384 389 PF01217 0.355
TRG_ENDOCYTIC_2 134 137 PF00928 0.292
TRG_ENDOCYTIC_2 164 167 PF00928 0.292
TRG_ENDOCYTIC_2 193 196 PF00928 0.490
TRG_ENDOCYTIC_2 538 541 PF00928 0.276
TRG_ENDOCYTIC_2 648 651 PF00928 0.415
TRG_ER_diArg_1 253 255 PF00400 0.292
TRG_ER_diArg_1 645 647 PF00400 0.530
TRG_NES_CRM1_1 331 346 PF08389 0.292
TRG_NLS_Bipartite_1 35 57 PF00514 0.316
TRG_NLS_MonoExtN_4 51 57 PF00514 0.292
TRG_Pf-PMV_PEXEL_1 383 387 PF00026 0.365
TRG_Pf-PMV_PEXEL_1 493 497 PF00026 0.292

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3G0 Leptomonas seymouri 88% 87%
A0A0S4JI00 Bodo saltans 71% 94%
A0A1X0P870 Trypanosomatidae 82% 88%
A0A3Q8IQP5 Leishmania donovani 97% 88%
A0A3R7M9L0 Trypanosoma rangeli 82% 88%
A0A3S7X0L3 Leishmania donovani 44% 100%
A4HFM9 Leishmania braziliensis 44% 100%
A4HNZ5 Leishmania braziliensis 93% 88%
A4I2Q7 Leishmania infantum 44% 100%
C9ZR48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 87%
D4A2B7 Rattus norvegicus 37% 92%
E9AD83 Leishmania major 44% 100%
E9AZ07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
O14325 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 89%
O15381 Homo sapiens 39% 81%
O60058 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 85%
P25694 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 59% 83%
P54609 Arabidopsis thaliana 63% 85%
P54774 Glycine max 64% 86%
P54811 Caenorhabditis elegans 70% 85%
P54812 Caenorhabditis elegans 70% 85%
Q07844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 82%
Q4Q1T9 Leishmania major 96% 88%
Q5AWS6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 65% 84%
Q7KN62 Drosophila melanogaster 70% 86%
Q8SSJ5 Encephalitozoon cuniculi (strain GB-M1) 62% 88%
Q96372 Capsicum annuum 69% 86%
Q9DBY8 Mus musculus 39% 81%
Q9LZF6 Arabidopsis thaliana 64% 85%
Q9P3A7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 85%
Q9SCN8 Arabidopsis thaliana 62% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS