EOG090X093U

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X093U

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICJ8_LEIIN

TriTrypDb:

LINF_360019900

Length:

605

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.580
CLV_NRD_NRD_1	13	15	PF00675	0.464
CLV_NRD_NRD_1	37	39	PF00675	0.457
CLV_NRD_NRD_1	41	43	PF00675	0.435
CLV_PCSK_FUR_1	38	42	PF00082	0.461
CLV_PCSK_KEX2_1	13	15	PF00082	0.464
CLV_PCSK_KEX2_1	225	227	PF00082	0.361
CLV_PCSK_KEX2_1	37	39	PF00082	0.458
CLV_PCSK_KEX2_1	40	42	PF00082	0.440
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.361
CLV_PCSK_PC7_1	37	43	PF00082	0.457
CLV_PCSK_SKI1_1	286	290	PF00082	0.342
CLV_PCSK_SKI1_1	330	334	PF00082	0.290
CLV_PCSK_SKI1_1	446	450	PF00082	0.443
CLV_PCSK_SKI1_1	466	470	PF00082	0.251
CLV_PCSK_SKI1_1	504	508	PF00082	0.490
CLV_Separin_Metazoa	229	233	PF03568	0.330
DEG_APCC_DBOX_1	592	600	PF00400	0.367
DEG_SPOP_SBC_1	55	59	PF00917	0.532
DOC_ANK_TNKS_1	267	274	PF00023	0.486
DOC_CYCLIN_RxL_1	274	283	PF00134	0.442
DOC_MAPK_gen_1	119	127	PF00069	0.386
DOC_MAPK_gen_1	232	239	PF00069	0.431
DOC_MAPK_gen_1	502	511	PF00069	0.397
DOC_MAPK_MEF2A_6	119	127	PF00069	0.386
DOC_MAPK_MEF2A_6	504	513	PF00069	0.523
DOC_MAPK_MEF2A_6	587	596	PF00069	0.404
DOC_PP1_RVXF_1	332	339	PF00149	0.260
DOC_PP1_RVXF_1	5	11	PF00149	0.477
DOC_PP2B_LxvP_1	88	91	PF13499	0.366
DOC_USP7_MATH_1	102	106	PF00917	0.497
DOC_USP7_MATH_1	537	541	PF00917	0.469
DOC_USP7_MATH_1	55	59	PF00917	0.609
DOC_WW_Pin1_4	155	160	PF00397	0.387
DOC_WW_Pin1_4	530	535	PF00397	0.581
LIG_14-3-3_CanoR_1	106	114	PF00244	0.417
LIG_14-3-3_CanoR_1	17	25	PF00244	0.504
LIG_14-3-3_CanoR_1	234	240	PF00244	0.330
LIG_14-3-3_CanoR_1	277	282	PF00244	0.398
LIG_14-3-3_CanoR_1	31	36	PF00244	0.493
LIG_14-3-3_CanoR_1	593	597	PF00244	0.388
LIG_14-3-3_CanoR_1	7	11	PF00244	0.508
LIG_deltaCOP1_diTrp_1	305	311	PF00928	0.371
LIG_EH1_1	542	550	PF00400	0.457
LIG_eIF4E_1	543	549	PF01652	0.422
LIG_FHA_1	106	112	PF00498	0.445
LIG_FHA_1	14	20	PF00498	0.577
LIG_FHA_1	308	314	PF00498	0.344
LIG_FHA_1	31	37	PF00498	0.487
LIG_FHA_1	316	322	PF00498	0.318
LIG_FHA_1	331	337	PF00498	0.336
LIG_FHA_1	494	500	PF00498	0.367
LIG_FHA_1	523	529	PF00498	0.505
LIG_FHA_1	55	61	PF00498	0.600
LIG_FHA_2	111	117	PF00498	0.511
LIG_FHA_2	301	307	PF00498	0.446
LIG_FHA_2	403	409	PF00498	0.397
LIG_FHA_2	416	422	PF00498	0.405
LIG_IRF3_LxIS_1	589	595	PF10401	0.450
LIG_LIR_Gen_1	141	152	PF02991	0.340
LIG_LIR_Gen_1	211	222	PF02991	0.516
LIG_LIR_Gen_1	301	312	PF02991	0.361
LIG_LIR_Gen_1	470	478	PF02991	0.343
LIG_LIR_Nem_3	141	147	PF02991	0.336
LIG_LIR_Nem_3	166	172	PF02991	0.361
LIG_LIR_Nem_3	211	217	PF02991	0.540
LIG_LIR_Nem_3	301	307	PF02991	0.399
LIG_LIR_Nem_3	421	425	PF02991	0.355
LIG_LIR_Nem_3	470	475	PF02991	0.331
LIG_LIR_Nem_3	554	558	PF02991	0.463
LIG_LYPXL_S_1	451	455	PF13949	0.447
LIG_NRBOX	543	549	PF00104	0.364
LIG_NRBOX	557	563	PF00104	0.341
LIG_Pex14_1	308	312	PF04695	0.331
LIG_Pex14_2	304	308	PF04695	0.331
LIG_Pex14_2	467	471	PF04695	0.296
LIG_Rb_LxCxE_1	143	158	PF01857	0.425
LIG_SH2_CRK	144	148	PF00017	0.310
LIG_SH2_NCK_1	536	540	PF00017	0.397
LIG_SH2_STAT3	221	224	PF00017	0.550
LIG_SH2_STAT5	133	136	PF00017	0.361
LIG_SH2_STAT5	144	147	PF00017	0.270
LIG_SH2_STAT5	221	224	PF00017	0.535
LIG_SH2_STAT5	312	315	PF00017	0.372
LIG_SH2_STAT5	543	546	PF00017	0.422
LIG_SH3_3	178	184	PF00018	0.336
LIG_SH3_3	214	220	PF00018	0.593
LIG_SH3_3	289	295	PF00018	0.461
LIG_SH3_5	140	144	PF00018	0.360
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.347
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.453
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.422
LIG_SUMO_SIM_anti_2	525	530	PF11976	0.514
LIG_SUMO_SIM_par_1	176	182	PF11976	0.489
LIG_SUMO_SIM_par_1	277	283	PF11976	0.285
LIG_SUMO_SIM_par_1	405	412	PF11976	0.376
LIG_SxIP_EBH_1	94	106	PF03271	0.369
LIG_TRAF2_1	148	151	PF00917	0.435
LIG_TRAF2_1	171	174	PF00917	0.577
LIG_TYR_ITIM	553	558	PF00017	0.456
LIG_UBA3_1	278	286	PF00899	0.440
LIG_UBA3_1	320	328	PF00899	0.421
LIG_UBA3_1	547	556	PF00899	0.396
LIG_WRC_WIRS_1	111	116	PF05994	0.498
LIG_WW_3	10	14	PF00397	0.454
MOD_CK1_1	105	111	PF00069	0.445
MOD_CK1_1	204	210	PF00069	0.674
MOD_CK1_1	280	286	PF00069	0.382
MOD_CK1_1	352	358	PF00069	0.475
MOD_CK1_1	58	64	PF00069	0.515
MOD_CK2_1	110	116	PF00069	0.467
MOD_CK2_1	145	151	PF00069	0.504
MOD_CK2_1	384	390	PF00069	0.344
MOD_CK2_1	415	421	PF00069	0.396
MOD_CMANNOS	308	311	PF00535	0.368
MOD_GlcNHglycan	120	123	PF01048	0.578
MOD_GlcNHglycan	206	209	PF01048	0.676
MOD_GlcNHglycan	563	566	PF01048	0.452
MOD_GlcNHglycan	84	87	PF01048	0.488
MOD_GlcNHglycan	96	99	PF01048	0.367
MOD_GSK3_1	13	20	PF00069	0.461
MOD_GSK3_1	198	205	PF00069	0.695
MOD_GSK3_1	2	9	PF00069	0.490
MOD_GSK3_1	235	242	PF00069	0.405
MOD_GSK3_1	307	314	PF00069	0.443
MOD_GSK3_1	364	371	PF00069	0.491
MOD_GSK3_1	467	474	PF00069	0.325
MOD_GSK3_1	54	61	PF00069	0.589
MOD_GSK3_1	557	564	PF00069	0.362
MOD_GSK3_1	96	103	PF00069	0.560
MOD_N-GLC_1	155	160	PF02516	0.387
MOD_N-GLC_1	235	240	PF02516	0.374
MOD_N-GLC_1	364	369	PF02516	0.469
MOD_N-GLC_1	384	389	PF02516	0.201
MOD_N-GLC_1	415	420	PF02516	0.474
MOD_N-GLC_1	437	442	PF02516	0.424
MOD_N-GLC_1	530	535	PF02516	0.329
MOD_N-GLC_1	79	84	PF02516	0.495
MOD_NEK2_1	115	120	PF00069	0.458
MOD_NEK2_1	202	207	PF00069	0.613
MOD_NEK2_1	239	244	PF00069	0.495
MOD_NEK2_1	349	354	PF00069	0.395
MOD_NEK2_1	458	463	PF00069	0.388
MOD_NEK2_1	467	472	PF00069	0.323
MOD_NEK2_1	56	61	PF00069	0.542
MOD_NEK2_1	561	566	PF00069	0.424
MOD_NEK2_1	592	597	PF00069	0.345
MOD_NEK2_1	599	604	PF00069	0.356
MOD_NEK2_1	93	98	PF00069	0.348
MOD_PIKK_1	100	106	PF00454	0.383
MOD_PIKK_1	262	268	PF00454	0.373
MOD_PKA_1	13	19	PF00069	0.459
MOD_PKA_2	105	111	PF00069	0.442
MOD_PKA_2	13	19	PF00069	0.447
MOD_PKA_2	30	36	PF00069	0.460
MOD_PKA_2	458	464	PF00069	0.466
MOD_PKA_2	592	598	PF00069	0.390
MOD_PKA_2	6	12	PF00069	0.475
MOD_PKA_2	76	82	PF00069	0.417
MOD_PKB_1	40	48	PF00069	0.466
MOD_Plk_1	235	241	PF00069	0.380
MOD_Plk_1	300	306	PF00069	0.411
MOD_Plk_1	315	321	PF00069	0.264
MOD_Plk_1	364	370	PF00069	0.470
MOD_Plk_1	384	390	PF00069	0.206
MOD_Plk_1	415	421	PF00069	0.444
MOD_Plk_1	79	85	PF00069	0.519
MOD_Plk_2-3	300	306	PF00069	0.506
MOD_Plk_4	110	116	PF00069	0.495
MOD_Plk_4	235	241	PF00069	0.578
MOD_Plk_4	277	283	PF00069	0.361
MOD_Plk_4	307	313	PF00069	0.345
MOD_Plk_4	31	37	PF00069	0.439
MOD_Plk_4	364	370	PF00069	0.432
MOD_Plk_4	393	399	PF00069	0.444
MOD_Plk_4	402	408	PF00069	0.362
MOD_Plk_4	415	421	PF00069	0.405
MOD_Plk_4	458	464	PF00069	0.353
MOD_Plk_4	467	473	PF00069	0.315
MOD_Plk_4	557	563	PF00069	0.342
MOD_ProDKin_1	155	161	PF00069	0.391
MOD_ProDKin_1	530	536	PF00069	0.584
MOD_SUMO_for_1	398	401	PF00179	0.550
MOD_SUMO_rev_2	367	376	PF00179	0.345
TRG_DiLeu_BaEn_1	256	261	PF01217	0.468
TRG_ENDOCYTIC_2	144	147	PF00928	0.306
TRG_ENDOCYTIC_2	452	455	PF00928	0.450
TRG_ENDOCYTIC_2	555	558	PF00928	0.347
TRG_ER_diArg_1	12	14	PF00400	0.457
TRG_ER_diArg_1	231	234	PF00400	0.344
TRG_ER_diArg_1	36	38	PF00400	0.455
TRG_ER_diArg_1	39	42	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E7	Leptomonas seymouri	68%	100%
A0A0S4JC36	Bodo saltans	41%	100%
A0A1X0P7Z1	Trypanosomatidae	45%	100%
A0A3Q8IIW2	Leishmania donovani	99%	100%
A0A422MZU5	Trypanosoma rangeli	47%	100%
A4HNZ3	Leishmania braziliensis	79%	100%
A4HNZ7	Leishmania braziliensis	78%	100%
D0A2X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1T8	Leishmania major	92%	100%
V5BU60	Trypanosoma cruzi	47%	100%