Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

The ARF-like 2 binding protein BART - putative

Species:

Leishmania infantum

UniProt:

A4ICJ6_LEIIN

TriTrypDb:

LINF_360020200

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0097546	ciliary base	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4ICJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.530
CLV_NRD_NRD_1	435	437	PF00675	0.454
CLV_NRD_NRD_1	445	447	PF00675	0.511
CLV_PCSK_KEX2_1	120	122	PF00082	0.264
CLV_PCSK_KEX2_1	178	180	PF00082	0.565
CLV_PCSK_KEX2_1	377	379	PF00082	0.583
CLV_PCSK_KEX2_1	435	437	PF00082	0.454
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.330
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.531
CLV_PCSK_SKI1_1	5	9	PF00082	0.369
CLV_PCSK_SKI1_1	99	103	PF00082	0.345
DEG_SPOP_SBC_1	413	417	PF00917	0.521
DOC_CKS1_1	20	25	PF01111	0.459
DOC_CYCLIN_RxL_1	115	126	PF00134	0.532
DOC_MAPK_gen_1	120	127	PF00069	0.459
DOC_MAPK_gen_1	178	185	PF00069	0.588
DOC_MAPK_MEF2A_6	120	127	PF00069	0.465
DOC_MAPK_MEF2A_6	178	185	PF00069	0.535
DOC_MAPK_NFAT4_5	120	128	PF00069	0.459
DOC_PP2B_LxvP_1	264	267	PF13499	0.421
DOC_PP4_FxxP_1	284	287	PF00568	0.656
DOC_PP4_FxxP_1	291	294	PF00568	0.645
DOC_USP7_MATH_1	132	136	PF00917	0.508
DOC_USP7_MATH_1	307	311	PF00917	0.594
DOC_USP7_MATH_1	321	325	PF00917	0.615
DOC_USP7_MATH_1	334	338	PF00917	0.567
DOC_USP7_MATH_1	341	345	PF00917	0.457
DOC_USP7_MATH_1	413	417	PF00917	0.664
DOC_USP7_MATH_1	425	429	PF00917	0.695
DOC_USP7_MATH_1	445	449	PF00917	0.418
DOC_USP7_MATH_1	77	81	PF00917	0.488
DOC_USP7_MATH_1	86	90	PF00917	0.428
DOC_USP7_UBL2_3	99	103	PF12436	0.457
DOC_WW_Pin1_4	14	19	PF00397	0.442
DOC_WW_Pin1_4	152	157	PF00397	0.667
DOC_WW_Pin1_4	283	288	PF00397	0.749
DOC_WW_Pin1_4	344	349	PF00397	0.562
DOC_WW_Pin1_4	360	365	PF00397	0.669
LIG_14-3-3_CanoR_1	113	118	PF00244	0.494
LIG_14-3-3_CanoR_1	5	14	PF00244	0.488
LIG_14-3-3_CterR_2	446	450	PF00244	0.598
LIG_Actin_WH2_2	164	180	PF00022	0.481
LIG_FHA_1	114	120	PF00498	0.530
LIG_FHA_1	338	344	PF00498	0.594
LIG_FHA_1	428	434	PF00498	0.488
LIG_FHA_1	59	65	PF00498	0.442
LIG_FHA_1	6	12	PF00498	0.541
LIG_FHA_2	20	26	PF00498	0.484
LIG_FHA_2	369	375	PF00498	0.556
LIG_FHA_2	71	77	PF00498	0.483
LIG_GBD_Chelix_1	433	441	PF00786	0.511
LIG_Integrin_RGD_1	438	440	PF01839	0.587
LIG_LIR_Apic_2	17	23	PF02991	0.442
LIG_LIR_Apic_2	283	287	PF02991	0.631
LIG_LIR_Apic_2	288	294	PF02991	0.621
LIG_LIR_Gen_1	109	119	PF02991	0.463
LIG_LIR_Gen_1	44	52	PF02991	0.489
LIG_LIR_LC3C_4	80	84	PF02991	0.416
LIG_LIR_Nem_3	109	114	PF02991	0.483
LIG_LIR_Nem_3	44	48	PF02991	0.462
LIG_PCNA_PIPBox_1	398	407	PF02747	0.505
LIG_PCNA_yPIPBox_3	392	405	PF02747	0.486
LIG_PTAP_UEV_1	347	352	PF05743	0.593
LIG_SH2_CRK	45	49	PF00017	0.462
LIG_SH2_STAT5	45	48	PF00017	0.484
LIG_SH3_1	345	351	PF00018	0.599
LIG_SH3_3	284	290	PF00018	0.642
LIG_SH3_3	310	316	PF00018	0.574
LIG_SH3_3	317	323	PF00018	0.618
LIG_SH3_3	330	336	PF00018	0.561
LIG_SH3_3	345	351	PF00018	0.509
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.560
LIG_TRAF2_1	147	150	PF00917	0.564
LIG_TRAF2_1	371	374	PF00917	0.547
LIG_TRAF2_1	396	399	PF00917	0.531
LIG_TYR_ITIM	43	48	PF00017	0.505
LIG_WRC_WIRS_1	401	406	PF05994	0.501
MOD_CK1_1	286	292	PF00069	0.737
MOD_CK1_1	337	343	PF00069	0.627
MOD_CK1_1	344	350	PF00069	0.617
MOD_CK1_1	36	42	PF00069	0.553
MOD_CK1_1	409	415	PF00069	0.556
MOD_CK1_1	58	64	PF00069	0.488
MOD_CK1_1	70	76	PF00069	0.408
MOD_CK1_1	85	91	PF00069	0.493
MOD_CK2_1	144	150	PF00069	0.573
MOD_CK2_1	234	240	PF00069	0.500
MOD_CK2_1	368	374	PF00069	0.563
MOD_CK2_1	393	399	PF00069	0.531
MOD_CK2_1	70	76	PF00069	0.495
MOD_GlcNHglycan	14	17	PF01048	0.288
MOD_GlcNHglycan	146	149	PF01048	0.539
MOD_GlcNHglycan	309	312	PF01048	0.603
MOD_GlcNHglycan	348	351	PF01048	0.672
MOD_GlcNHglycan	360	363	PF01048	0.611
MOD_GlcNHglycan	416	419	PF01048	0.620
MOD_GlcNHglycan	84	87	PF01048	0.260
MOD_GSK3_1	1	8	PF00069	0.499
MOD_GSK3_1	109	116	PF00069	0.548
MOD_GSK3_1	335	342	PF00069	0.645
MOD_GSK3_1	407	414	PF00069	0.572
MOD_GSK3_1	78	85	PF00069	0.471
MOD_GSK3_1	86	93	PF00069	0.551
MOD_N-GLC_1	109	114	PF02516	0.306
MOD_N-GLC_1	36	41	PF02516	0.343
MOD_N-GLC_1	406	411	PF02516	0.599
MOD_N-GLC_2	31	33	PF02516	0.325
MOD_NEK2_1	1	6	PF00069	0.444
MOD_NEK2_1	420	425	PF00069	0.634
MOD_NEK2_1	43	48	PF00069	0.494
MOD_NEK2_1	55	60	PF00069	0.442
MOD_NEK2_1	78	83	PF00069	0.599
MOD_PIKK_1	227	233	PF00454	0.478
MOD_PIKK_1	253	259	PF00454	0.516
MOD_PKA_2	393	399	PF00069	0.531
MOD_Plk_1	109	115	PF00069	0.506
MOD_Plk_1	181	187	PF00069	0.490
MOD_Plk_1	43	49	PF00069	0.459
MOD_Plk_4	113	119	PF00069	0.534
MOD_Plk_4	400	406	PF00069	0.502
MOD_Plk_4	43	49	PF00069	0.501
MOD_Plk_4	55	61	PF00069	0.469
MOD_Plk_4	78	84	PF00069	0.489
MOD_ProDKin_1	14	20	PF00069	0.442
MOD_ProDKin_1	152	158	PF00069	0.661
MOD_ProDKin_1	283	289	PF00069	0.746
MOD_ProDKin_1	344	350	PF00069	0.560
MOD_ProDKin_1	360	366	PF00069	0.667
TRG_ENDOCYTIC_2	45	48	PF00928	0.462
TRG_ER_diArg_1	177	179	PF00400	0.546
TRG_ER_diArg_1	435	438	PF00400	0.456
TRG_NES_CRM1_1	57	72	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F6	Leptomonas seymouri	48%	100%
A0A0S4JFM0	Bodo saltans	32%	100%
A0A3R7MMF8	Trypanosoma rangeli	32%	100%
A0A3S7XAM0	Leishmania donovani	100%	100%
A4HP00	Leishmania braziliensis	68%	100%
E9ASR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4Q1T6	Leishmania major	87%	98%
V5DL00	Trypanosoma cruzi	34%	100%