C2H2-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phytochelatin synthase - putative

Species:

Leishmania infantum

UniProt:

A4ICJ1_LEIIN

TriTrypDb:

LINF_360036300

Length:

1145

Annotations

LeishMANIAdb annotations

An expanding protein family in kinetoplastids with a fairly unique structure. Non-TM.

Annotations by Jardim et al.

Flagella, Flagellar Member 2 (FLAM2) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Show entries

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4ICJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICJ1

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.584
CLV_C14_Caspase3-7	781	785	PF00656	0.514
CLV_C14_Caspase3-7	800	804	PF00656	0.487
CLV_C14_Caspase3-7	866	870	PF00656	0.486
CLV_MEL_PAP_1	663	669	PF00089	0.419
CLV_NRD_NRD_1	174	176	PF00675	0.411
CLV_NRD_NRD_1	224	226	PF00675	0.400
CLV_NRD_NRD_1	29	31	PF00675	0.484
CLV_NRD_NRD_1	63	65	PF00675	0.655
CLV_NRD_NRD_1	665	667	PF00675	0.512

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS6	Leptomonas seymouri	79%	98%
A0A0S4JCR2	Bodo saltans	43%	96%
A0A1X0NM20	Trypanosomatidae	53%	95%
A0A1X0P7W8	Trypanosomatidae	23%	100%
A0A3R7LI08	Trypanosoma rangeli	51%	97%
A0A3S7WV43	Leishmania donovani	23%	78%
A0A3S7XB44	Leishmania donovani	100%	100%
A4HPF0	Leishmania braziliensis	92%	100%
D0A3F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
E9ARR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	78%

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