PKD_channel domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICI9_LEIIN

TriTrypDb:

LINF_360036100

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Phosphorylation

Promastigote/Amastigote: 328

Expansion

Sequence features

A4ICI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.622
CLV_C14_Caspase3-7	322	326	PF00656	0.678
CLV_C14_Caspase3-7	328	332	PF00656	0.638
CLV_C14_Caspase3-7	428	432	PF00656	0.710
CLV_C14_Caspase3-7	504	508	PF00656	0.711
CLV_NRD_NRD_1	12	14	PF00675	0.343
CLV_NRD_NRD_1	181	183	PF00675	0.548
CLV_NRD_NRD_1	264	266	PF00675	0.315
CLV_NRD_NRD_1	473	475	PF00675	0.525
CLV_PCSK_FUR_1	467	471	PF00082	0.536
CLV_PCSK_KEX2_1	12	14	PF00082	0.384
CLV_PCSK_KEX2_1	320	322	PF00082	0.549
CLV_PCSK_KEX2_1	469	471	PF00082	0.525
CLV_PCSK_KEX2_1	472	474	PF00082	0.533
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.464
CLV_PCSK_PC7_1	467	473	PF00082	0.539
CLV_PCSK_SKI1_1	12	16	PF00082	0.395
CLV_PCSK_SKI1_1	167	171	PF00082	0.559
CLV_PCSK_SKI1_1	247	251	PF00082	0.405
CLV_PCSK_SKI1_1	255	259	PF00082	0.355
CLV_PCSK_SKI1_1	309	313	PF00082	0.431
DEG_APCC_DBOX_1	11	19	PF00400	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DOC_CKS1_1	5	10	PF01111	0.577
DOC_CYCLIN_RxL_1	10	21	PF00134	0.585
DOC_CYCLIN_RxL_1	252	262	PF00134	0.598
DOC_MAPK_FxFP_2	3	6	PF00069	0.535
DOC_MAPK_gen_1	130	139	PF00069	0.579
DOC_MAPK_MEF2A_6	133	141	PF00069	0.584
DOC_PIKK_1	579	586	PF02985	0.703
DOC_PP1_RVXF_1	11	18	PF00149	0.589
DOC_PP4_FxxP_1	3	6	PF00568	0.560
DOC_PP4_FxxP_1	370	373	PF00568	0.679
DOC_USP7_MATH_1	243	247	PF00917	0.607
DOC_USP7_UBL2_3	255	259	PF12436	0.596
DOC_USP7_UBL2_3	277	281	PF12436	0.631
DOC_WW_Pin1_4	4	9	PF00397	0.574
DOC_WW_Pin1_4	431	436	PF00397	0.737
DOC_WW_Pin1_4	511	516	PF00397	0.750
LIG_14-3-3_CanoR_1	182	187	PF00244	0.300
LIG_14-3-3_CanoR_1	283	289	PF00244	0.630
LIG_14-3-3_CanoR_1	44	50	PF00244	0.299
LIG_AP2alpha_1	374	378	PF02296	0.681
LIG_APCC_ABBA_1	234	239	PF00400	0.594
LIG_BRCT_BRCA1_1	245	249	PF00533	0.570
LIG_BRCT_BRCA1_1	515	519	PF00533	0.698
LIG_Clathr_ClatBox_1	107	111	PF01394	0.352
LIG_Clathr_ClatBox_1	65	69	PF01394	0.356
LIG_CSL_BTD_1	432	435	PF09270	0.737
LIG_deltaCOP1_diTrp_1	241	249	PF00928	0.566
LIG_DLG_GKlike_1	182	189	PF00625	0.295
LIG_EH1_1	141	149	PF00400	0.506
LIG_EH1_1	151	159	PF00400	0.360
LIG_eIF4E_1	53	59	PF01652	0.390
LIG_FHA_1	26	32	PF00498	0.424
LIG_FHA_1	83	89	PF00498	0.357
LIG_FHA_2	182	188	PF00498	0.483
LIG_FHA_2	320	326	PF00498	0.658
LIG_FHA_2	442	448	PF00498	0.850
LIG_FHA_2	52	58	PF00498	0.402
LIG_GBD_Chelix_1	582	590	PF00786	0.489
LIG_Integrin_RGD_1	474	476	PF01839	0.511
LIG_LIR_Apic_2	367	373	PF02991	0.683
LIG_LIR_Apic_2	447	452	PF02991	0.723
LIG_LIR_Apic_2	509	515	PF02991	0.689
LIG_LIR_Gen_1	111	120	PF02991	0.360
LIG_LIR_Gen_1	184	194	PF02991	0.379
LIG_LIR_Gen_1	195	205	PF02991	0.258
LIG_LIR_Gen_1	287	296	PF02991	0.552
LIG_LIR_Gen_1	313	323	PF02991	0.598
LIG_LIR_Gen_1	39	50	PF02991	0.397
LIG_LIR_LC3C_4	33	36	PF02991	0.336
LIG_LIR_Nem_3	111	115	PF02991	0.360
LIG_LIR_Nem_3	16	22	PF02991	0.519
LIG_LIR_Nem_3	184	189	PF02991	0.360
LIG_LIR_Nem_3	192	197	PF02991	0.296
LIG_LIR_Nem_3	202	208	PF02991	0.229
LIG_LIR_Nem_3	287	291	PF02991	0.644
LIG_LIR_Nem_3	293	299	PF02991	0.597
LIG_LIR_Nem_3	313	319	PF02991	0.584
LIG_LIR_Nem_3	367	372	PF02991	0.663
LIG_LIR_Nem_3	39	45	PF02991	0.356
LIG_MLH1_MIPbox_1	515	519	PF16413	0.698
LIG_NRBOX	109	115	PF00104	0.384
LIG_Pex14_2	108	112	PF04695	0.360
LIG_Pex14_2	370	374	PF04695	0.677
LIG_PTB_Apo_2	329	336	PF02174	0.648
LIG_PTB_Apo_2	368	375	PF02174	0.659
LIG_PTB_Apo_2	67	74	PF02174	0.344
LIG_PTB_Phospho_1	67	73	PF10480	0.340
LIG_SH2_CRK	288	292	PF00017	0.626
LIG_SH2_CRK	42	46	PF00017	0.321
LIG_SH2_CRK	449	453	PF00017	0.793
LIG_SH2_CRK	512	516	PF00017	0.656
LIG_SH2_GRB2like	53	56	PF00017	0.382
LIG_SH2_NCK_1	449	453	PF00017	0.793
LIG_SH2_NCK_1	512	516	PF00017	0.656
LIG_SH2_SRC	449	452	PF00017	0.752
LIG_SH2_STAP1	152	156	PF00017	0.398
LIG_SH2_STAP1	186	190	PF00017	0.387
LIG_SH2_STAT5	103	106	PF00017	0.360
LIG_SH2_STAT5	125	128	PF00017	0.590
LIG_SH2_STAT5	218	221	PF00017	0.390
LIG_SH2_STAT5	227	230	PF00017	0.616
LIG_SH2_STAT5	377	380	PF00017	0.685
LIG_SH2_STAT5	42	45	PF00017	0.306
LIG_SH2_STAT5	512	515	PF00017	0.753
LIG_SH2_STAT5	518	521	PF00017	0.696
LIG_SH2_STAT5	527	530	PF00017	0.635
LIG_SH2_STAT5	53	56	PF00017	0.380
LIG_SH3_1	5	11	PF00018	0.581
LIG_SH3_2	8	13	PF14604	0.582
LIG_SH3_3	134	140	PF00018	0.587
LIG_SH3_3	201	207	PF00018	0.338
LIG_SH3_3	448	454	PF00018	0.719
LIG_SH3_3	487	493	PF00018	0.737
LIG_SH3_3	5	11	PF00018	0.539
LIG_SH3_4	255	262	PF00018	0.591
LIG_SH3_5	373	377	PF00018	0.681
LIG_Sin3_3	296	303	PF02671	0.600
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.343
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.376
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.291
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.327
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.345
LIG_SUMO_SIM_par_1	33	40	PF11976	0.327
LIG_SUMO_SIM_par_1	395	401	PF11976	0.715
LIG_SUMO_SIM_par_1	61	69	PF11976	0.356
LIG_SUMO_SIM_par_1	84	89	PF11976	0.374
LIG_TRAF2_1	398	401	PF00917	0.747
LIG_TRAF2_1	434	437	PF00917	0.782
LIG_TRFH_1	418	422	PF08558	0.732
LIG_Vh1_VBS_1	17	35	PF01044	0.483
MOD_CK1_1	48	54	PF00069	0.369
MOD_CK2_1	181	187	PF00069	0.475
MOD_CK2_1	226	232	PF00069	0.480
MOD_CK2_1	395	401	PF00069	0.746
MOD_CK2_1	431	437	PF00069	0.772
MOD_CK2_1	441	447	PF00069	0.839
MOD_CK2_1	556	562	PF00069	0.735
MOD_GlcNHglycan	219	222	PF01048	0.320
MOD_GlcNHglycan	534	537	PF01048	0.569
MOD_GlcNHglycan	540	543	PF01048	0.602
MOD_GSK3_1	142	149	PF00069	0.519
MOD_GSK3_1	36	43	PF00069	0.364
MOD_GSK3_1	455	462	PF00069	0.773
MOD_GSK3_1	556	563	PF00069	0.731
MOD_GSK3_1	69	76	PF00069	0.411
MOD_GSK3_1	82	89	PF00069	0.335
MOD_N-GLC_1	123	128	PF02516	0.332
MOD_N-GLC_1	251	256	PF02516	0.413
MOD_N-GLC_1	325	330	PF02516	0.472
MOD_N-GLC_1	69	74	PF02516	0.545
MOD_NEK2_1	123	128	PF00069	0.532
MOD_NEK2_1	181	186	PF00069	0.394
MOD_NEK2_1	208	213	PF00069	0.384
MOD_NEK2_1	25	30	PF00069	0.376
MOD_NEK2_1	250	255	PF00069	0.619
MOD_NEK2_1	319	324	PF00069	0.708
MOD_NEK2_1	341	346	PF00069	0.647
MOD_NEK2_1	441	446	PF00069	0.753
MOD_NEK2_1	45	50	PF00069	0.359
MOD_NEK2_1	532	537	PF00069	0.763
MOD_NEK2_1	549	554	PF00069	0.695
MOD_NEK2_1	97	102	PF00069	0.318
MOD_PIKK_1	146	152	PF00454	0.360
MOD_PIKK_1	325	331	PF00454	0.669
MOD_PIKK_1	455	461	PF00454	0.731
MOD_PKA_1	182	188	PF00069	0.300
MOD_PKA_2	181	187	PF00069	0.388
MOD_PKA_2	43	49	PF00069	0.298
MOD_PKA_2	560	566	PF00069	0.720
MOD_PKA_2	82	88	PF00069	0.345
MOD_PKB_1	564	572	PF00069	0.687
MOD_Plk_1	325	331	PF00069	0.672
MOD_Plk_1	69	75	PF00069	0.399
MOD_Plk_2-3	395	401	PF00069	0.725
MOD_Plk_2-3	584	590	PF00069	0.723
MOD_Plk_4	18	24	PF00069	0.506
MOD_Plk_4	30	36	PF00069	0.324
MOD_Plk_4	48	54	PF00069	0.298
MOD_ProDKin_1	4	10	PF00069	0.576
MOD_ProDKin_1	431	437	PF00069	0.736
MOD_ProDKin_1	511	517	PF00069	0.751
MOD_SUMO_for_1	190	193	PF00179	0.338
TRG_DiLeu_BaEn_1	111	116	PF01217	0.343
TRG_DiLeu_BaEn_2	244	250	PF01217	0.564
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.600
TRG_ENDOCYTIC_2	186	189	PF00928	0.380
TRG_ENDOCYTIC_2	197	200	PF00928	0.247
TRG_ENDOCYTIC_2	205	208	PF00928	0.226
TRG_ENDOCYTIC_2	288	291	PF00928	0.563
TRG_ENDOCYTIC_2	42	45	PF00928	0.335
TRG_ENDOCYTIC_2	95	98	PF00928	0.345
TRG_ER_diArg_1	11	13	PF00400	0.589
TRG_ER_diArg_1	467	470	PF00400	0.718
TRG_ER_diArg_1	471	474	PF00400	0.727
TRG_ER_diArg_1	545	548	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M6	Leptomonas seymouri	58%	98%
A0A3Q8IW35	Leishmania donovani	100%	100%
A4HPE8	Leishmania braziliensis	74%	99%
E9AT59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1D8	Leishmania major	93%	100%
V5BFT0	Trypanosoma cruzi	36%	100%