Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICI8_LEIIN

TriTrypDb:

LINF_360036000

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.581
CLV_NRD_NRD_1	306	308	PF00675	0.445
CLV_NRD_NRD_1	394	396	PF00675	0.628
CLV_NRD_NRD_1	561	563	PF00675	0.747
CLV_PCSK_KEX2_1	254	256	PF00082	0.414
CLV_PCSK_KEX2_1	306	308	PF00082	0.445
CLV_PCSK_KEX2_1	394	396	PF00082	0.628
CLV_PCSK_KEX2_1	561	563	PF00082	0.747
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.414
CLV_PCSK_SKI1_1	221	225	PF00082	0.403
CLV_PCSK_SKI1_1	255	259	PF00082	0.394
CLV_PCSK_SKI1_1	284	288	PF00082	0.427
CLV_PCSK_SKI1_1	310	314	PF00082	0.383
CLV_PCSK_SKI1_1	363	367	PF00082	0.619
CLV_PCSK_SKI1_1	595	599	PF00082	0.686
CLV_Separin_Metazoa	218	222	PF03568	0.462
CLV_Separin_Metazoa	327	331	PF03568	0.669
DEG_APCC_DBOX_1	254	262	PF00400	0.392
DEG_APCC_DBOX_1	283	291	PF00400	0.425
DEG_SCF_FBW7_1	74	79	PF00400	0.567
DEG_SPOP_SBC_1	246	250	PF00917	0.616
DEG_SPOP_SBC_1	347	351	PF00917	0.637
DOC_CYCLIN_RxL_1	218	228	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.461
DOC_MAPK_DCC_7	194	203	PF00069	0.432
DOC_MAPK_gen_1	194	203	PF00069	0.420
DOC_MAPK_gen_1	254	260	PF00069	0.412
DOC_MAPK_gen_1	281	290	PF00069	0.421
DOC_MAPK_gen_1	306	314	PF00069	0.539
DOC_MAPK_gen_1	487	495	PF00069	0.584
DOC_MAPK_MEF2A_6	159	166	PF00069	0.409
DOC_MAPK_MEF2A_6	194	203	PF00069	0.427
DOC_MAPK_MEF2A_6	281	290	PF00069	0.421
DOC_MAPK_MEF2A_6	487	495	PF00069	0.600
DOC_PP1_RVXF_1	200	207	PF00149	0.376
DOC_PP1_RVXF_1	66	73	PF00149	0.598
DOC_PP2B_LxvP_1	321	324	PF13499	0.416
DOC_PP4_FxxP_1	9	12	PF00568	0.436
DOC_USP7_MATH_1	111	115	PF00917	0.652
DOC_USP7_MATH_1	124	128	PF00917	0.701
DOC_USP7_MATH_1	170	174	PF00917	0.413
DOC_USP7_MATH_1	175	179	PF00917	0.396
DOC_USP7_MATH_1	18	22	PF00917	0.640
DOC_USP7_MATH_1	205	209	PF00917	0.394
DOC_USP7_MATH_1	234	238	PF00917	0.611
DOC_USP7_MATH_1	246	250	PF00917	0.486
DOC_USP7_MATH_1	33	37	PF00917	0.299
DOC_USP7_MATH_1	347	351	PF00917	0.539
DOC_USP7_MATH_1	469	473	PF00917	0.726
DOC_USP7_MATH_1	578	582	PF00917	0.632
DOC_WW_Pin1_4	120	125	PF00397	0.635
DOC_WW_Pin1_4	146	151	PF00397	0.714
DOC_WW_Pin1_4	296	301	PF00397	0.518
DOC_WW_Pin1_4	363	368	PF00397	0.731
DOC_WW_Pin1_4	370	375	PF00397	0.632
DOC_WW_Pin1_4	427	432	PF00397	0.558
DOC_WW_Pin1_4	617	622	PF00397	0.556
DOC_WW_Pin1_4	72	77	PF00397	0.586
LIG_14-3-3_CanoR_1	153	157	PF00244	0.710
LIG_14-3-3_CanoR_1	221	227	PF00244	0.388
LIG_14-3-3_CanoR_1	337	341	PF00244	0.614
LIG_14-3-3_CanoR_1	346	353	PF00244	0.558
LIG_14-3-3_CanoR_1	384	390	PF00244	0.712
LIG_14-3-3_CanoR_1	561	568	PF00244	0.756
LIG_14-3-3_CanoR_1	595	601	PF00244	0.684
LIG_14-3-3_CanoR_1	633	637	PF00244	0.485
LIG_BRCT_BRCA1_1	349	353	PF00533	0.657
LIG_Clathr_ClatBox_1	183	187	PF01394	0.544
LIG_deltaCOP1_diTrp_1	602	606	PF00928	0.710
LIG_eIF4E_1	282	288	PF01652	0.417
LIG_FHA_1	198	204	PF00498	0.381
LIG_FHA_1	270	276	PF00498	0.441
LIG_FHA_1	278	284	PF00498	0.421
LIG_FHA_1	42	48	PF00498	0.383
LIG_FHA_1	519	525	PF00498	0.619
LIG_FHA_1	55	61	PF00498	0.519
LIG_FHA_1	618	624	PF00498	0.541
LIG_FHA_2	111	117	PF00498	0.760
LIG_FHA_2	260	266	PF00498	0.568
LIG_FHA_2	349	355	PF00498	0.670
LIG_FHA_2	76	82	PF00498	0.438
LIG_LIR_Gen_1	209	220	PF02991	0.500
LIG_LIR_Gen_1	423	431	PF02991	0.483
LIG_LIR_Gen_1	586	597	PF02991	0.747
LIG_LIR_Nem_3	209	215	PF02991	0.510
LIG_LIR_Nem_3	423	427	PF02991	0.504
LIG_LIR_Nem_3	536	540	PF02991	0.707
LIG_LIR_Nem_3	586	592	PF02991	0.753
LIG_LIR_Nem_3	609	615	PF02991	0.524
LIG_NRBOX	179	185	PF00104	0.527
LIG_NRBOX	282	288	PF00104	0.417
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.538
LIG_Pex14_2	9	13	PF04695	0.444
LIG_PTB_Apo_2	250	257	PF02174	0.415
LIG_PTB_Apo_2	531	538	PF02174	0.556
LIG_PTB_Apo_2	591	598	PF02174	0.639
LIG_PTB_Phospho_1	531	537	PF10480	0.557
LIG_SH2_CRK	212	216	PF00017	0.563
LIG_SH2_CRK	32	36	PF00017	0.383
LIG_SH2_CRK	488	492	PF00017	0.642
LIG_SH2_GRB2like	537	540	PF00017	0.674
LIG_SH2_NCK_1	32	36	PF00017	0.369
LIG_SH2_NCK_1	344	348	PF00017	0.670
LIG_SH2_STAP1	212	216	PF00017	0.563
LIG_SH2_STAP1	540	544	PF00017	0.624
LIG_SH2_STAT5	229	232	PF00017	0.423
LIG_SH2_STAT5	282	285	PF00017	0.417
LIG_SH2_STAT5	588	591	PF00017	0.646
LIG_SH2_STAT5	69	72	PF00017	0.457
LIG_SH3_3	193	199	PF00018	0.450
LIG_SH3_3	425	431	PF00018	0.486
LIG_SH3_3	61	67	PF00018	0.500
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.411
LIG_SUMO_SIM_par_1	256	262	PF11976	0.510
LIG_SUMO_SIM_par_1	271	276	PF11976	0.381
LIG_SUMO_SIM_par_1	44	52	PF11976	0.411
LIG_SUMO_SIM_par_1	613	620	PF11976	0.697
LIG_TRAF2_1	113	116	PF00917	0.696
LIG_TRAF2_1	324	327	PF00917	0.617
LIG_TRAF2_1	454	457	PF00917	0.624
LIG_TYR_ITIM	623	628	PF00017	0.499
LIG_UBA3_1	59	68	PF00899	0.495
LIG_WRC_WIRS_1	421	426	PF05994	0.514
MOD_CDK_SPK_2	72	77	PF00069	0.586
MOD_CDK_SPxxK_3	146	153	PF00069	0.616
MOD_CDK_SPxxK_3	363	370	PF00069	0.727
MOD_CK1_1	102	108	PF00069	0.630
MOD_CK1_1	120	126	PF00069	0.661
MOD_CK1_1	149	155	PF00069	0.790
MOD_CK1_1	345	351	PF00069	0.630
MOD_CK1_1	373	379	PF00069	0.677
MOD_CK1_1	388	394	PF00069	0.705
MOD_CK1_1	408	414	PF00069	0.761
MOD_CK1_1	460	466	PF00069	0.717
MOD_CK1_1	530	536	PF00069	0.625
MOD_CK1_1	546	552	PF00069	0.642
MOD_CK1_1	563	569	PF00069	0.513
MOD_CK2_1	109	115	PF00069	0.755
MOD_CK2_1	120	126	PF00069	0.570
MOD_CK2_1	265	271	PF00069	0.441
MOD_CK2_1	348	354	PF00069	0.662
MOD_CK2_1	471	477	PF00069	0.642
MOD_CK2_1	596	602	PF00069	0.626
MOD_CK2_1	75	81	PF00069	0.568
MOD_DYRK1A_RPxSP_1	370	374	PF00069	0.661
MOD_GlcNHglycan	101	104	PF01048	0.711
MOD_GlcNHglycan	115	120	PF01048	0.529
MOD_GlcNHglycan	139	142	PF01048	0.671
MOD_GlcNHglycan	171	175	PF01048	0.419
MOD_GlcNHglycan	177	180	PF01048	0.391
MOD_GlcNHglycan	236	239	PF01048	0.501
MOD_GlcNHglycan	275	278	PF01048	0.437
MOD_GlcNHglycan	412	415	PF01048	0.776
MOD_GlcNHglycan	417	420	PF01048	0.607
MOD_GlcNHglycan	459	462	PF01048	0.701
MOD_GlcNHglycan	471	474	PF01048	0.546
MOD_GlcNHglycan	51	54	PF01048	0.667
MOD_GlcNHglycan	639	642	PF01048	0.547
MOD_GSK3_1	111	118	PF00069	0.736
MOD_GSK3_1	120	127	PF00069	0.709
MOD_GSK3_1	132	139	PF00069	0.574
MOD_GSK3_1	18	25	PF00069	0.578
MOD_GSK3_1	224	231	PF00069	0.392
MOD_GSK3_1	240	247	PF00069	0.532
MOD_GSK3_1	261	268	PF00069	0.447
MOD_GSK3_1	269	276	PF00069	0.432
MOD_GSK3_1	336	343	PF00069	0.669
MOD_GSK3_1	345	352	PF00069	0.607
MOD_GSK3_1	366	373	PF00069	0.690
MOD_GSK3_1	397	404	PF00069	0.814
MOD_GSK3_1	457	464	PF00069	0.721
MOD_GSK3_1	526	533	PF00069	0.619
MOD_GSK3_1	539	546	PF00069	0.689
MOD_GSK3_1	54	61	PF00069	0.544
MOD_GSK3_1	72	79	PF00069	0.457
MOD_N-GLC_1	533	538	PF02516	0.673
MOD_NEK2_1	151	156	PF00069	0.636
MOD_NEK2_1	206	211	PF00069	0.480
MOD_NEK2_1	224	229	PF00069	0.396
MOD_NEK2_1	269	274	PF00069	0.450
MOD_NEK2_1	275	280	PF00069	0.446
MOD_NEK2_1	328	333	PF00069	0.677
MOD_NEK2_1	340	345	PF00069	0.526
MOD_NEK2_1	353	358	PF00069	0.688
MOD_NEK2_1	459	464	PF00069	0.714
MOD_NEK2_1	49	54	PF00069	0.619
MOD_NEK2_1	527	532	PF00069	0.636
MOD_NEK2_1	560	565	PF00069	0.703
MOD_NEK2_1	577	582	PF00069	0.518
MOD_NEK2_1	59	64	PF00069	0.490
MOD_NEK2_1	632	637	PF00069	0.634
MOD_NEK2_1	92	97	PF00069	0.635
MOD_NEK2_1	99	104	PF00069	0.677
MOD_NEK2_2	124	129	PF00069	0.723
MOD_NEK2_2	506	511	PF00069	0.657
MOD_NEK2_2	540	545	PF00069	0.643
MOD_PIKK_1	139	145	PF00454	0.763
MOD_PIKK_1	373	379	PF00454	0.704
MOD_PKA_2	1	7	PF00069	0.487
MOD_PKA_2	152	158	PF00069	0.682
MOD_PKA_2	290	296	PF00069	0.481
MOD_PKA_2	336	342	PF00069	0.660
MOD_PKA_2	345	351	PF00069	0.606
MOD_PKA_2	560	566	PF00069	0.733
MOD_PKA_2	632	638	PF00069	0.490
MOD_Plk_1	353	359	PF00069	0.688
MOD_Plk_1	527	533	PF00069	0.742
MOD_Plk_2-3	265	271	PF00069	0.436
MOD_Plk_4	1	7	PF00069	0.480
MOD_Plk_4	225	231	PF00069	0.392
MOD_Plk_4	247	253	PF00069	0.606
MOD_Plk_4	265	271	PF00069	0.359
MOD_Plk_4	310	316	PF00069	0.383
MOD_Plk_4	336	342	PF00069	0.619
MOD_Plk_4	461	467	PF00069	0.645
MOD_Plk_4	471	477	PF00069	0.557
MOD_Plk_4	527	533	PF00069	0.626
MOD_Plk_4	632	638	PF00069	0.504
MOD_ProDKin_1	120	126	PF00069	0.635
MOD_ProDKin_1	146	152	PF00069	0.712
MOD_ProDKin_1	296	302	PF00069	0.523
MOD_ProDKin_1	363	369	PF00069	0.732
MOD_ProDKin_1	370	376	PF00069	0.630
MOD_ProDKin_1	427	433	PF00069	0.553
MOD_ProDKin_1	617	623	PF00069	0.549
MOD_ProDKin_1	72	78	PF00069	0.575
MOD_SUMO_rev_2	417	424	PF00179	0.602
TRG_ENDOCYTIC_2	212	215	PF00928	0.574
TRG_ENDOCYTIC_2	32	35	PF00928	0.383
TRG_ENDOCYTIC_2	479	482	PF00928	0.541
TRG_ENDOCYTIC_2	488	491	PF00928	0.611
TRG_ENDOCYTIC_2	625	628	PF00928	0.495
TRG_ENDOCYTIC_2	69	72	PF00928	0.606
TRG_ER_diArg_1	305	307	PF00400	0.475
TRG_ER_diArg_1	329	332	PF00400	0.550
TRG_ER_diArg_1	560	562	PF00400	0.718
TRG_NES_CRM1_1	420	433	PF08389	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B6	Leptomonas seymouri	55%	98%
A0A3Q8IJG0	Leishmania donovani	100%	100%
A4HPE7	Leishmania braziliensis	77%	100%
E9AT58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1D9	Leishmania major	95%	100%