LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICI7_LEIIN
TriTrypDb:
LINF_360035900
Length:
875

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICI7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICI7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.617
CLV_C14_Caspase3-7 177 181 PF00656 0.650
CLV_C14_Caspase3-7 279 283 PF00656 0.635
CLV_C14_Caspase3-7 352 356 PF00656 0.637
CLV_C14_Caspase3-7 607 611 PF00656 0.611
CLV_NRD_NRD_1 116 118 PF00675 0.499
CLV_NRD_NRD_1 127 129 PF00675 0.578
CLV_NRD_NRD_1 17 19 PF00675 0.555
CLV_NRD_NRD_1 284 286 PF00675 0.604
CLV_NRD_NRD_1 64 66 PF00675 0.677
CLV_NRD_NRD_1 640 642 PF00675 0.428
CLV_NRD_NRD_1 707 709 PF00675 0.428
CLV_NRD_NRD_1 73 75 PF00675 0.412
CLV_PCSK_KEX2_1 116 118 PF00082 0.499
CLV_PCSK_KEX2_1 127 129 PF00082 0.578
CLV_PCSK_KEX2_1 17 19 PF00082 0.555
CLV_PCSK_KEX2_1 236 238 PF00082 0.619
CLV_PCSK_KEX2_1 284 286 PF00082 0.604
CLV_PCSK_KEX2_1 294 296 PF00082 0.619
CLV_PCSK_KEX2_1 64 66 PF00082 0.575
CLV_PCSK_KEX2_1 640 642 PF00082 0.464
CLV_PCSK_KEX2_1 707 709 PF00082 0.428
CLV_PCSK_KEX2_1 73 75 PF00082 0.488
CLV_PCSK_PC1ET2_1 236 238 PF00082 0.619
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.613
CLV_PCSK_SKI1_1 117 121 PF00082 0.458
CLV_PCSK_SKI1_1 17 21 PF00082 0.533
CLV_PCSK_SKI1_1 36 40 PF00082 0.443
CLV_PCSK_SKI1_1 384 388 PF00082 0.568
CLV_PCSK_SKI1_1 641 645 PF00082 0.400
CLV_PCSK_SKI1_1 695 699 PF00082 0.359
CLV_PCSK_SKI1_1 74 78 PF00082 0.476
CLV_PCSK_SKI1_1 802 806 PF00082 0.387
DEG_Nend_Nbox_1 1 3 PF02207 0.527
DOC_CKS1_1 343 348 PF01111 0.616
DOC_CYCLIN_RxL_1 381 391 PF00134 0.562
DOC_CYCLIN_RxL_1 846 857 PF00134 0.357
DOC_CYCLIN_yClb5_NLxxxL_5 846 855 PF00134 0.371
DOC_CYCLIN_yCln2_LP_2 648 654 PF00134 0.338
DOC_CYCLIN_yCln2_LP_2 669 675 PF00134 0.446
DOC_CYCLIN_yCln2_LP_2 722 728 PF00134 0.369
DOC_CYCLIN_yCln2_LP_2 812 818 PF00134 0.573
DOC_MAPK_gen_1 124 133 PF00069 0.584
DOC_MAPK_gen_1 236 243 PF00069 0.655
DOC_MAPK_gen_1 640 648 PF00069 0.396
DOC_MAPK_gen_1 95 104 PF00069 0.543
DOC_MAPK_MEF2A_6 236 245 PF00069 0.553
DOC_MAPK_MEF2A_6 640 648 PF00069 0.393
DOC_MAPK_MEF2A_6 95 104 PF00069 0.543
DOC_MAPK_NFAT4_5 641 649 PF00069 0.392
DOC_PP1_RVXF_1 307 313 PF00149 0.629
DOC_PP1_RVXF_1 474 481 PF00149 0.406
DOC_PP1_RVXF_1 767 774 PF00149 0.480
DOC_PP2B_LxvP_1 337 340 PF13499 0.693
DOC_PP2B_LxvP_1 648 651 PF13499 0.381
DOC_PP2B_LxvP_1 669 672 PF13499 0.428
DOC_PP2B_LxvP_1 853 856 PF13499 0.373
DOC_USP7_MATH_1 138 142 PF00917 0.577
DOC_USP7_MATH_1 196 200 PF00917 0.788
DOC_USP7_MATH_1 210 214 PF00917 0.682
DOC_USP7_MATH_1 227 231 PF00917 0.524
DOC_USP7_MATH_1 403 407 PF00917 0.549
DOC_USP7_MATH_1 410 414 PF00917 0.459
DOC_USP7_MATH_1 522 526 PF00917 0.585
DOC_USP7_MATH_1 57 61 PF00917 0.615
DOC_USP7_MATH_1 728 732 PF00917 0.490
DOC_USP7_MATH_1 76 80 PF00917 0.504
DOC_WW_Pin1_4 342 347 PF00397 0.622
DOC_WW_Pin1_4 36 41 PF00397 0.554
DOC_WW_Pin1_4 401 406 PF00397 0.635
DOC_WW_Pin1_4 456 461 PF00397 0.495
DOC_WW_Pin1_4 498 503 PF00397 0.651
DOC_WW_Pin1_4 505 510 PF00397 0.621
DOC_WW_Pin1_4 53 58 PF00397 0.663
LIG_14-3-3_CanoR_1 132 139 PF00244 0.608
LIG_14-3-3_CanoR_1 148 153 PF00244 0.621
LIG_14-3-3_CanoR_1 17 22 PF00244 0.480
LIG_14-3-3_CanoR_1 237 245 PF00244 0.651
LIG_14-3-3_CanoR_1 265 270 PF00244 0.627
LIG_14-3-3_CanoR_1 284 290 PF00244 0.686
LIG_14-3-3_CanoR_1 342 346 PF00244 0.634
LIG_14-3-3_CanoR_1 400 407 PF00244 0.626
LIG_14-3-3_CanoR_1 491 495 PF00244 0.541
LIG_14-3-3_CanoR_1 626 632 PF00244 0.521
LIG_14-3-3_CanoR_1 64 70 PF00244 0.693
LIG_14-3-3_CanoR_1 688 694 PF00244 0.345
LIG_14-3-3_CanoR_1 707 711 PF00244 0.439
LIG_14-3-3_CanoR_1 74 84 PF00244 0.462
LIG_APCC_ABBA_1 215 220 PF00400 0.606
LIG_APCC_ABBA_1 773 778 PF00400 0.426
LIG_APCC_ABBA_1 808 813 PF00400 0.377
LIG_BIR_III_4 280 284 PF00653 0.635
LIG_Clathr_ClatBox_1 184 188 PF01394 0.669
LIG_CtBP_PxDLS_1 684 688 PF00389 0.386
LIG_deltaCOP1_diTrp_1 768 776 PF00928 0.414
LIG_EVH1_1 337 341 PF00568 0.657
LIG_FHA_1 165 171 PF00498 0.670
LIG_FHA_1 37 43 PF00498 0.649
LIG_FHA_1 381 387 PF00498 0.548
LIG_FHA_1 457 463 PF00498 0.446
LIG_FHA_1 857 863 PF00498 0.388
LIG_FHA_2 163 169 PF00498 0.663
LIG_FHA_2 18 24 PF00498 0.464
LIG_FHA_2 181 187 PF00498 0.636
LIG_FHA_2 355 361 PF00498 0.622
LIG_FHA_2 456 462 PF00498 0.496
LIG_FHA_2 514 520 PF00498 0.618
LIG_FHA_2 542 548 PF00498 0.644
LIG_FHA_2 605 611 PF00498 0.646
LIG_FHA_2 855 861 PF00498 0.466
LIG_Integrin_RGD_1 570 572 PF01839 0.544
LIG_LIR_Apic_2 404 410 PF02991 0.518
LIG_LIR_Gen_1 213 220 PF02991 0.644
LIG_LIR_Gen_1 3 13 PF02991 0.540
LIG_LIR_Gen_1 485 495 PF02991 0.404
LIG_LIR_Gen_1 689 698 PF02991 0.336
LIG_LIR_Gen_1 768 777 PF02991 0.459
LIG_LIR_Gen_1 822 833 PF02991 0.379
LIG_LIR_Nem_3 192 198 PF02991 0.667
LIG_LIR_Nem_3 213 218 PF02991 0.644
LIG_LIR_Nem_3 3 8 PF02991 0.530
LIG_LIR_Nem_3 472 478 PF02991 0.387
LIG_LIR_Nem_3 485 490 PF02991 0.366
LIG_LIR_Nem_3 619 625 PF02991 0.536
LIG_LIR_Nem_3 689 693 PF02991 0.330
LIG_LIR_Nem_3 757 761 PF02991 0.455
LIG_LIR_Nem_3 768 773 PF02991 0.384
LIG_LIR_Nem_3 822 828 PF02991 0.375
LIG_LIR_Nem_3 88 93 PF02991 0.517
LIG_LYPXL_yS_3 195 198 PF13949 0.590
LIG_NRP_CendR_1 872 875 PF00754 0.442
LIG_Pex14_2 623 627 PF04695 0.405
LIG_Pex14_2 761 765 PF04695 0.344
LIG_REV1ctd_RIR_1 84 90 PF16727 0.599
LIG_SH2_CRK 407 411 PF00017 0.635
LIG_SH2_CRK 475 479 PF00017 0.375
LIG_SH2_CRK 5 9 PF00017 0.531
LIG_SH2_CRK 675 679 PF00017 0.429
LIG_SH2_CRK 690 694 PF00017 0.329
LIG_SH2_CRK 93 97 PF00017 0.453
LIG_SH2_NCK_1 5 9 PF00017 0.531
LIG_SH2_PTP2 487 490 PF00017 0.445
LIG_SH2_PTP2 825 828 PF00017 0.367
LIG_SH2_SRC 660 663 PF00017 0.414
LIG_SH2_STAP1 448 452 PF00017 0.390
LIG_SH2_STAP1 5 9 PF00017 0.538
LIG_SH2_STAP1 690 694 PF00017 0.329
LIG_SH2_STAT3 844 847 PF00017 0.445
LIG_SH2_STAT5 15 18 PF00017 0.522
LIG_SH2_STAT5 24 27 PF00017 0.476
LIG_SH2_STAT5 487 490 PF00017 0.445
LIG_SH2_STAT5 593 596 PF00017 0.747
LIG_SH2_STAT5 622 625 PF00017 0.419
LIG_SH2_STAT5 690 693 PF00017 0.363
LIG_SH2_STAT5 825 828 PF00017 0.367
LIG_SH2_STAT5 844 847 PF00017 0.445
LIG_SH3_3 170 176 PF00018 0.647
LIG_SH3_3 272 278 PF00018 0.725
LIG_SH3_3 335 341 PF00018 0.642
LIG_SH3_3 344 350 PF00018 0.655
LIG_SH3_3 35 41 PF00018 0.575
LIG_SH3_3 556 562 PF00018 0.684
LIG_SH3_3 579 585 PF00018 0.625
LIG_SH3_3 722 728 PF00018 0.345
LIG_SH3_CIN85_PxpxPR_1 271 276 PF14604 0.592
LIG_SUMO_SIM_par_1 182 188 PF11976 0.641
LIG_SUMO_SIM_par_1 683 689 PF11976 0.374
LIG_SUMO_SIM_par_1 830 837 PF11976 0.545
LIG_SUMO_SIM_par_1 851 860 PF11976 0.363
LIG_TRAF2_1 20 23 PF00917 0.473
LIG_TRAF2_1 247 250 PF00917 0.626
LIG_TRAF2_1 618 621 PF00917 0.546
LIG_TYR_ITIM 673 678 PF00017 0.474
LIG_UBA3_1 845 849 PF00899 0.375
LIG_WW_3 339 343 PF00397 0.628
MOD_CDC14_SPxK_1 501 504 PF00782 0.555
MOD_CDK_SPxK_1 498 504 PF00069 0.544
MOD_CDK_SPxxK_3 401 408 PF00069 0.621
MOD_CK1_1 126 132 PF00069 0.586
MOD_CK1_1 141 147 PF00069 0.610
MOD_CK1_1 155 161 PF00069 0.599
MOD_CK1_1 190 196 PF00069 0.610
MOD_CK1_1 213 219 PF00069 0.794
MOD_CK1_1 298 304 PF00069 0.632
MOD_CK1_1 374 380 PF00069 0.550
MOD_CK1_1 396 402 PF00069 0.679
MOD_CK1_1 49 55 PF00069 0.591
MOD_CK1_1 508 514 PF00069 0.651
MOD_CK1_1 686 692 PF00069 0.385
MOD_CK1_1 796 802 PF00069 0.605
MOD_CK1_1 836 842 PF00069 0.363
MOD_CK1_1 854 860 PF00069 0.465
MOD_CK2_1 162 168 PF00069 0.722
MOD_CK2_1 17 23 PF00069 0.473
MOD_CK2_1 354 360 PF00069 0.622
MOD_CK2_1 455 461 PF00069 0.398
MOD_CK2_1 513 519 PF00069 0.572
MOD_CK2_1 531 537 PF00069 0.507
MOD_CK2_1 541 547 PF00069 0.612
MOD_CK2_1 615 621 PF00069 0.608
MOD_CK2_1 854 860 PF00069 0.467
MOD_CMANNOS 767 770 PF00535 0.404
MOD_Cter_Amidation 282 285 PF01082 0.586
MOD_GlcNHglycan 128 131 PF01048 0.585
MOD_GlcNHglycan 133 136 PF01048 0.608
MOD_GlcNHglycan 154 157 PF01048 0.613
MOD_GlcNHglycan 188 192 PF01048 0.586
MOD_GlcNHglycan 198 201 PF01048 0.669
MOD_GlcNHglycan 208 211 PF01048 0.536
MOD_GlcNHglycan 220 224 PF01048 0.538
MOD_GlcNHglycan 300 303 PF01048 0.745
MOD_GlcNHglycan 315 320 PF01048 0.618
MOD_GlcNHglycan 376 379 PF01048 0.575
MOD_GlcNHglycan 418 421 PF01048 0.534
MOD_GlcNHglycan 471 474 PF01048 0.525
MOD_GlcNHglycan 492 495 PF01048 0.479
MOD_GlcNHglycan 53 56 PF01048 0.611
MOD_GlcNHglycan 533 536 PF01048 0.539
MOD_GlcNHglycan 59 62 PF01048 0.573
MOD_GlcNHglycan 680 683 PF01048 0.383
MOD_GlcNHglycan 714 717 PF01048 0.541
MOD_GSK3_1 140 147 PF00069 0.643
MOD_GSK3_1 148 155 PF00069 0.693
MOD_GSK3_1 164 171 PF00069 0.681
MOD_GSK3_1 190 197 PF00069 0.601
MOD_GSK3_1 202 209 PF00069 0.667
MOD_GSK3_1 232 239 PF00069 0.555
MOD_GSK3_1 370 377 PF00069 0.610
MOD_GSK3_1 386 393 PF00069 0.497
MOD_GSK3_1 399 406 PF00069 0.529
MOD_GSK3_1 49 56 PF00069 0.626
MOD_GSK3_1 498 505 PF00069 0.772
MOD_GSK3_1 513 520 PF00069 0.521
MOD_N-GLC_1 712 717 PF02516 0.502
MOD_N-GLC_2 611 613 PF02516 0.569
MOD_NEK2_1 218 223 PF00069 0.602
MOD_NEK2_1 386 391 PF00069 0.598
MOD_NEK2_1 418 423 PF00069 0.639
MOD_NEK2_1 644 649 PF00069 0.410
MOD_NEK2_1 75 80 PF00069 0.697
MOD_NEK2_1 804 809 PF00069 0.486
MOD_NEK2_1 851 856 PF00069 0.370
MOD_NEK2_2 706 711 PF00069 0.404
MOD_OFUCOSY 596 603 PF10250 0.622
MOD_PIKK_1 162 168 PF00454 0.669
MOD_PIKK_1 283 289 PF00454 0.682
MOD_PIKK_1 522 528 PF00454 0.561
MOD_PIKK_1 616 622 PF00454 0.531
MOD_PIKK_1 836 842 PF00454 0.488
MOD_PK_1 148 154 PF00069 0.692
MOD_PKA_1 17 23 PF00069 0.531
MOD_PKA_1 236 242 PF00069 0.618
MOD_PKA_1 64 70 PF00069 0.536
MOD_PKA_2 123 129 PF00069 0.586
MOD_PKA_2 131 137 PF00069 0.583
MOD_PKA_2 152 158 PF00069 0.662
MOD_PKA_2 17 23 PF00069 0.473
MOD_PKA_2 174 180 PF00069 0.570
MOD_PKA_2 210 216 PF00069 0.750
MOD_PKA_2 218 224 PF00069 0.607
MOD_PKA_2 227 233 PF00069 0.620
MOD_PKA_2 236 242 PF00069 0.607
MOD_PKA_2 283 289 PF00069 0.598
MOD_PKA_2 298 304 PF00069 0.697
MOD_PKA_2 305 311 PF00069 0.681
MOD_PKA_2 341 347 PF00069 0.633
MOD_PKA_2 368 374 PF00069 0.611
MOD_PKA_2 380 386 PF00069 0.544
MOD_PKA_2 399 405 PF00069 0.579
MOD_PKA_2 490 496 PF00069 0.552
MOD_PKA_2 627 633 PF00069 0.512
MOD_PKA_2 63 69 PF00069 0.726
MOD_PKA_2 706 712 PF00069 0.426
MOD_PKB_1 295 303 PF00069 0.625
MOD_Plk_1 11 17 PF00069 0.549
MOD_Plk_1 168 174 PF00069 0.629
MOD_Plk_1 213 219 PF00069 0.603
MOD_Plk_1 354 360 PF00069 0.618
MOD_Plk_1 365 371 PF00069 0.650
MOD_Plk_1 550 556 PF00069 0.680
MOD_Plk_1 712 718 PF00069 0.495
MOD_Plk_1 728 734 PF00069 0.443
MOD_Plk_1 771 777 PF00069 0.586
MOD_Plk_2-3 180 186 PF00069 0.636
MOD_Plk_2-3 541 547 PF00069 0.649
MOD_Plk_4 11 17 PF00069 0.531
MOD_Plk_4 180 186 PF00069 0.689
MOD_Plk_4 463 469 PF00069 0.404
MOD_Plk_4 627 633 PF00069 0.565
MOD_Plk_4 689 695 PF00069 0.359
MOD_Plk_4 700 706 PF00069 0.411
MOD_Plk_4 729 735 PF00069 0.437
MOD_Plk_4 793 799 PF00069 0.459
MOD_ProDKin_1 342 348 PF00069 0.620
MOD_ProDKin_1 36 42 PF00069 0.560
MOD_ProDKin_1 401 407 PF00069 0.623
MOD_ProDKin_1 456 462 PF00069 0.486
MOD_ProDKin_1 498 504 PF00069 0.654
MOD_ProDKin_1 505 511 PF00069 0.621
MOD_ProDKin_1 53 59 PF00069 0.662
MOD_SUMO_for_1 28 31 PF00179 0.520
TRG_DiLeu_BaEn_1 249 254 PF01217 0.576
TRG_DiLeu_BaEn_1 729 734 PF01217 0.436
TRG_DiLeu_BaEn_1 823 828 PF01217 0.399
TRG_ENDOCYTIC_2 195 198 PF00928 0.590
TRG_ENDOCYTIC_2 475 478 PF00928 0.369
TRG_ENDOCYTIC_2 487 490 PF00928 0.372
TRG_ENDOCYTIC_2 5 8 PF00928 0.530
TRG_ENDOCYTIC_2 675 678 PF00928 0.455
TRG_ENDOCYTIC_2 690 693 PF00928 0.362
TRG_ENDOCYTIC_2 825 828 PF00928 0.367
TRG_ENDOCYTIC_2 93 96 PF00928 0.449
TRG_ER_diArg_1 115 117 PF00400 0.496
TRG_ER_diArg_1 16 18 PF00400 0.584
TRG_ER_diArg_1 309 312 PF00400 0.733
TRG_ER_diArg_1 63 65 PF00400 0.715
TRG_ER_diArg_1 73 75 PF00400 0.480
TRG_NES_CRM1_1 94 108 PF08389 0.543
TRG_Pf-PMV_PEXEL_1 116 121 PF00026 0.550
TRG_Pf-PMV_PEXEL_1 311 315 PF00026 0.607

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P794 Leptomonas seymouri 53% 100%
A0A3Q8INY8 Leishmania donovani 100% 100%
A4HPE6 Leishmania braziliensis 80% 100%
E9AT57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q1E0 Leishmania major 90% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS