Meiosis recombination protein SPO11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICI5_LEIIN

TriTrypDb:

LINF_360035700

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

A4ICI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICI5

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003916	DNA topoisomerase activity	3	11
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	11
GO:0005488	binding	1	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016853	isomerase activity	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000166	nucleotide binding	3	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.521
CLV_NRD_NRD_1	111	113	PF00675	0.517
CLV_NRD_NRD_1	330	332	PF00675	0.382
CLV_PCSK_KEX2_1	111	113	PF00082	0.517
CLV_PCSK_KEX2_1	159	161	PF00082	0.537
CLV_PCSK_KEX2_1	330	332	PF00082	0.382
CLV_PCSK_KEX2_1	451	453	PF00082	0.399
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.393
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.492
CLV_PCSK_PC7_1	326	332	PF00082	0.433
CLV_PCSK_SKI1_1	191	195	PF00082	0.597
CLV_PCSK_SKI1_1	223	227	PF00082	0.339
CLV_PCSK_SKI1_1	25	29	PF00082	0.351
CLV_PCSK_SKI1_1	284	288	PF00082	0.517
CLV_PCSK_SKI1_1	336	340	PF00082	0.349
CLV_PCSK_SKI1_1	400	404	PF00082	0.425
CLV_PCSK_SKI1_1	488	492	PF00082	0.442
DEG_APCC_DBOX_1	325	333	PF00400	0.306
DEG_APCC_DBOX_1	482	490	PF00400	0.348
DEG_SCF_FBW7_1	207	212	PF00400	0.354
DEG_SCF_FBW7_1	8	15	PF00400	0.421
DOC_CKS1_1	114	119	PF01111	0.603
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.450
DOC_MAPK_DCC_7	398	407	PF00069	0.418
DOC_MAPK_gen_1	159	167	PF00069	0.378
DOC_MAPK_gen_1	398	407	PF00069	0.418
DOC_MAPK_gen_1	498	507	PF00069	0.438
DOC_MAPK_JIP1_4	281	287	PF00069	0.406
DOC_MAPK_MEF2A_6	336	345	PF00069	0.279
DOC_MAPK_MEF2A_6	398	407	PF00069	0.418
DOC_MAPK_NFAT4_5	400	408	PF00069	0.403
DOC_PP2B_LxvP_1	14	17	PF13499	0.422
DOC_PP2B_LxvP_1	145	148	PF13499	0.456
DOC_PP4_FxxP_1	187	190	PF00568	0.498
DOC_USP7_MATH_1	20	24	PF00917	0.418
DOC_USP7_MATH_1	221	225	PF00917	0.441
DOC_USP7_MATH_1	245	249	PF00917	0.568
DOC_USP7_MATH_1	370	374	PF00917	0.615
DOC_USP7_MATH_1	460	464	PF00917	0.577
DOC_USP7_MATH_1	465	469	PF00917	0.638
DOC_WW_Pin1_4	113	118	PF00397	0.619
DOC_WW_Pin1_4	186	191	PF00397	0.448
DOC_WW_Pin1_4	205	210	PF00397	0.609
DOC_WW_Pin1_4	303	308	PF00397	0.503
DOC_WW_Pin1_4	366	371	PF00397	0.643
DOC_WW_Pin1_4	381	386	PF00397	0.725
DOC_WW_Pin1_4	387	392	PF00397	0.553
DOC_WW_Pin1_4	77	82	PF00397	0.585
DOC_WW_Pin1_4	8	13	PF00397	0.516
LIG_14-3-3_CanoR_1	105	110	PF00244	0.398
LIG_14-3-3_CanoR_1	152	158	PF00244	0.385
LIG_14-3-3_CanoR_1	25	35	PF00244	0.459
LIG_14-3-3_CanoR_1	483	487	PF00244	0.387
LIG_14-3-3_CanoR_1	87	94	PF00244	0.473
LIG_Actin_WH2_2	437	453	PF00022	0.474
LIG_BRCT_BRCA1_1	416	420	PF00533	0.543
LIG_BRCT_BRCA1_1	426	430	PF00533	0.623
LIG_BRCT_BRCA1_1	529	533	PF00533	0.385
LIG_CaM_IQ_9	444	460	PF13499	0.422
LIG_CAP-Gly_1	526	533	PF01302	0.351
LIG_Clathr_ClatBox_1	285	289	PF01394	0.355
LIG_EH1_1	97	105	PF00400	0.398
LIG_eIF4E_1	140	146	PF01652	0.370
LIG_FHA_1	125	131	PF00498	0.553
LIG_FHA_1	229	235	PF00498	0.382
LIG_FHA_1	252	258	PF00498	0.402
LIG_FHA_1	394	400	PF00498	0.441
LIG_FHA_1	477	483	PF00498	0.488
LIG_FHA_1	9	15	PF00498	0.421
LIG_FHA_1	95	101	PF00498	0.392
LIG_FHA_2	132	138	PF00498	0.348
LIG_FHA_2	44	50	PF00498	0.516
LIG_FHA_2	441	447	PF00498	0.356
LIG_FHA_2	514	520	PF00498	0.368
LIG_GBD_Chelix_1	226	234	PF00786	0.446
LIG_LIR_Apic_2	137	143	PF02991	0.468
LIG_LIR_Apic_2	184	190	PF02991	0.445
LIG_LIR_Apic_2	364	370	PF02991	0.524
LIG_LIR_Gen_1	115	125	PF02991	0.496
LIG_LIR_Gen_1	309	315	PF02991	0.555
LIG_LIR_Nem_3	115	121	PF02991	0.631
LIG_LIR_Nem_3	280	286	PF02991	0.545
LIG_LIR_Nem_3	309	313	PF02991	0.575
LIG_LIR_Nem_3	317	323	PF02991	0.461
LIG_LIR_Nem_3	381	386	PF02991	0.591
LIG_LIR_Nem_3	97	101	PF02991	0.452
LIG_LYPXL_yS_3	320	323	PF13949	0.466
LIG_MYND_1	12	16	PF01753	0.422
LIG_PDZ_Class_3	528	533	PF00595	0.573
LIG_Pex14_1	416	420	PF04695	0.449
LIG_Pex14_2	70	74	PF04695	0.421
LIG_SH2_CRK	118	122	PF00017	0.551
LIG_SH2_CRK	140	144	PF00017	0.489
LIG_SH2_CRK	283	287	PF00017	0.490
LIG_SH2_CRK	310	314	PF00017	0.516
LIG_SH2_NCK_1	255	259	PF00017	0.452
LIG_SH2_PTP2	342	345	PF00017	0.376
LIG_SH2_STAP1	310	314	PF00017	0.357
LIG_SH2_STAT3	55	58	PF00017	0.484
LIG_SH2_STAT3	99	102	PF00017	0.472
LIG_SH2_STAT5	211	214	PF00017	0.356
LIG_SH2_STAT5	34	37	PF00017	0.365
LIG_SH2_STAT5	342	345	PF00017	0.376
LIG_SH2_STAT5	99	102	PF00017	0.399
LIG_SH3_3	14	20	PF00018	0.553
LIG_SH3_3	508	514	PF00018	0.412
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.433
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.405
LIG_SUMO_SIM_par_1	230	236	PF11976	0.405
LIG_SUMO_SIM_par_1	239	244	PF11976	0.336
LIG_SUMO_SIM_par_1	284	289	PF11976	0.319
LIG_WRC_WIRS_1	380	385	PF05994	0.588
MOD_CDC14_SPxK_1	80	83	PF00782	0.544
MOD_CDK_SPK_2	186	191	PF00069	0.448
MOD_CDK_SPxK_1	77	83	PF00069	0.530
MOD_CK1_1	15	21	PF00069	0.476
MOD_CK1_1	256	262	PF00069	0.447
MOD_CK1_1	381	387	PF00069	0.630
MOD_CK1_1	393	399	PF00069	0.390
MOD_CK1_1	470	476	PF00069	0.524
MOD_CK2_1	460	466	PF00069	0.444
MOD_CK2_1	513	519	PF00069	0.412
MOD_CK2_1	58	64	PF00069	0.456
MOD_GlcNHglycan	242	246	PF01048	0.473
MOD_GlcNHglycan	247	250	PF01048	0.378
MOD_GlcNHglycan	303	306	PF01048	0.508
MOD_GlcNHglycan	386	389	PF01048	0.666
MOD_GlcNHglycan	392	395	PF01048	0.553
MOD_GlcNHglycan	426	429	PF01048	0.590
MOD_GlcNHglycan	462	465	PF01048	0.607
MOD_GlcNHglycan	469	472	PF01048	0.627
MOD_GSK3_1	116	123	PF00069	0.631
MOD_GSK3_1	182	189	PF00069	0.565
MOD_GSK3_1	205	212	PF00069	0.622
MOD_GSK3_1	241	248	PF00069	0.475
MOD_GSK3_1	249	256	PF00069	0.482
MOD_GSK3_1	297	304	PF00069	0.452
MOD_GSK3_1	36	43	PF00069	0.493
MOD_GSK3_1	366	373	PF00069	0.588
MOD_GSK3_1	410	417	PF00069	0.449
MOD_GSK3_1	465	472	PF00069	0.622
MOD_GSK3_1	8	15	PF00069	0.512
MOD_NEK2_1	216	221	PF00069	0.503
MOD_NEK2_1	253	258	PF00069	0.356
MOD_NEK2_1	301	306	PF00069	0.517
MOD_NEK2_1	314	319	PF00069	0.293
MOD_NEK2_1	361	366	PF00069	0.566
MOD_NEK2_1	41	46	PF00069	0.720
MOD_NEK2_1	414	419	PF00069	0.585
MOD_NEK2_1	434	439	PF00069	0.603
MOD_OFUCOSY	411	418	PF10250	0.397
MOD_PIKK_1	371	377	PF00454	0.620
MOD_PIKK_1	434	440	PF00454	0.562
MOD_PK_1	452	458	PF00069	0.372
MOD_PKA_2	104	110	PF00069	0.390
MOD_PKA_2	151	157	PF00069	0.439
MOD_PKA_2	212	218	PF00069	0.441
MOD_PKA_2	245	251	PF00069	0.464
MOD_PKA_2	36	42	PF00069	0.510
MOD_PKA_2	482	488	PF00069	0.336
MOD_PKA_2	86	92	PF00069	0.469
MOD_Plk_2-3	131	137	PF00069	0.416
MOD_Plk_4	116	122	PF00069	0.587
MOD_Plk_4	182	188	PF00069	0.563
MOD_Plk_4	221	227	PF00069	0.360
MOD_Plk_4	354	360	PF00069	0.343
MOD_Plk_4	410	416	PF00069	0.491
MOD_Plk_4	452	458	PF00069	0.457
MOD_Plk_4	513	519	PF00069	0.412
MOD_Plk_4	94	100	PF00069	0.456
MOD_ProDKin_1	113	119	PF00069	0.623
MOD_ProDKin_1	186	192	PF00069	0.453
MOD_ProDKin_1	205	211	PF00069	0.593
MOD_ProDKin_1	303	309	PF00069	0.506
MOD_ProDKin_1	366	372	PF00069	0.649
MOD_ProDKin_1	381	387	PF00069	0.724
MOD_ProDKin_1	77	83	PF00069	0.592
MOD_ProDKin_1	8	14	PF00069	0.518
MOD_SUMO_for_1	501	504	PF00179	0.456
TRG_DiLeu_BaEn_1	64	69	PF01217	0.439
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.421
TRG_ENDOCYTIC_2	118	121	PF00928	0.637
TRG_ENDOCYTIC_2	283	286	PF00928	0.495
TRG_ENDOCYTIC_2	310	313	PF00928	0.541
TRG_ENDOCYTIC_2	320	323	PF00928	0.423
TRG_ENDOCYTIC_2	342	345	PF00928	0.427
TRG_ER_diArg_1	110	112	PF00400	0.454
TRG_ER_diArg_1	329	331	PF00400	0.382
TRG_ER_diArg_1	498	501	PF00400	0.539
TRG_NES_CRM1_1	57	73	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M4	Leptomonas seymouri	41%	100%
A0A1X0NL58	Trypanosomatidae	31%	100%
A0A3R7LIJ3	Trypanosoma rangeli	31%	100%
A0A3S7XAZ9	Leishmania donovani	100%	100%
A4HPE4	Leishmania braziliensis	79%	100%
D0A3F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1E2	Leishmania major	91%	100%
V5BPV6	Trypanosoma cruzi	31%	100%