LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
transportin2-like protein
Species:
Leishmania infantum
UniProt:
A4ICH9_LEIIN
TriTrypDb:
LINF_360035100
Length:
938

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 5
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 12
GO:0005643 nuclear pore 3 1
GO:0032991 protein-containing complex 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4ICH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICH9

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0034504 protein localization to nucleus 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051169 nuclear transport 4 12
GO:0051170 import into nucleus 6 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 5
GO:0019899 enzyme binding 3 5
GO:0031267 small GTPase binding 5 5
GO:0051020 GTPase binding 4 5
GO:0005048 signal sequence binding 4 1
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0061608 nuclear import signal receptor activity 3 1
GO:0140104 molecular carrier activity 1 1
GO:0140142 nucleocytoplasmic carrier activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 181 187 PF00089 0.418
CLV_NRD_NRD_1 198 200 PF00675 0.356
CLV_PCSK_KEX2_1 525 527 PF00082 0.239
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.239
CLV_PCSK_SKI1_1 200 204 PF00082 0.393
CLV_PCSK_SKI1_1 353 357 PF00082 0.431
CLV_PCSK_SKI1_1 463 467 PF00082 0.350
CLV_PCSK_SKI1_1 631 635 PF00082 0.315
CLV_PCSK_SKI1_1 670 674 PF00082 0.476
CLV_PCSK_SKI1_1 755 759 PF00082 0.487
CLV_PCSK_SKI1_1 85 89 PF00082 0.468
CLV_PCSK_SKI1_1 928 932 PF00082 0.428
CLV_PCSK_SKI1_1 98 102 PF00082 0.348
DEG_APCC_DBOX_1 462 470 PF00400 0.529
DEG_APCC_DBOX_1 97 105 PF00400 0.383
DEG_Nend_Nbox_1 1 3 PF02207 0.580
DEG_SPOP_SBC_1 568 572 PF00917 0.497
DOC_CDC14_PxL_1 345 353 PF14671 0.417
DOC_CDC14_PxL_1 552 560 PF14671 0.497
DOC_CKS1_1 1 6 PF01111 0.549
DOC_MAPK_gen_1 111 121 PF00069 0.347
DOC_MAPK_gen_1 199 207 PF00069 0.454
DOC_MAPK_gen_1 372 381 PF00069 0.538
DOC_MAPK_gen_1 442 451 PF00069 0.465
DOC_MAPK_MEF2A_6 114 123 PF00069 0.339
DOC_MAPK_MEF2A_6 622 629 PF00069 0.464
DOC_PP4_FxxP_1 428 431 PF00568 0.497
DOC_USP7_MATH_1 100 104 PF00917 0.448
DOC_USP7_MATH_1 113 117 PF00917 0.340
DOC_USP7_MATH_1 125 129 PF00917 0.301
DOC_USP7_MATH_1 233 237 PF00917 0.455
DOC_USP7_MATH_1 739 743 PF00917 0.419
DOC_USP7_MATH_1 795 799 PF00917 0.437
DOC_USP7_MATH_1 802 806 PF00917 0.310
DOC_USP7_MATH_1 828 832 PF00917 0.435
DOC_USP7_MATH_1 900 904 PF00917 0.430
DOC_USP7_UBL2_3 384 388 PF12436 0.661
DOC_WW_Pin1_4 221 226 PF00397 0.389
DOC_WW_Pin1_4 274 279 PF00397 0.388
DOC_WW_Pin1_4 502 507 PF00397 0.497
LIG_14-3-3_CanoR_1 111 121 PF00244 0.411
LIG_14-3-3_CanoR_1 261 266 PF00244 0.398
LIG_14-3-3_CanoR_1 406 413 PF00244 0.439
LIG_14-3-3_CanoR_1 496 502 PF00244 0.506
LIG_14-3-3_CanoR_1 519 529 PF00244 0.464
LIG_14-3-3_CanoR_1 596 601 PF00244 0.501
LIG_14-3-3_CanoR_1 608 612 PF00244 0.445
LIG_14-3-3_CanoR_1 670 679 PF00244 0.485
LIG_14-3-3_CanoR_1 703 708 PF00244 0.491
LIG_Actin_WH2_2 447 465 PF00022 0.505
LIG_Actin_WH2_2 690 705 PF00022 0.417
LIG_Actin_WH2_2 723 740 PF00022 0.351
LIG_Actin_WH2_2 784 799 PF00022 0.441
LIG_APCC_ABBAyCdc20_2 804 810 PF00400 0.544
LIG_BRCT_BRCA1_1 46 50 PF00533 0.330
LIG_BRCT_BRCA1_1 804 808 PF00533 0.479
LIG_BRCT_BRCA1_1 811 815 PF00533 0.442
LIG_BRCT_BRCA1_1 873 877 PF00533 0.522
LIG_BRCT_BRCA1_1 902 906 PF00533 0.453
LIG_Clathr_ClatBox_1 835 839 PF01394 0.368
LIG_deltaCOP1_diTrp_1 699 707 PF00928 0.422
LIG_eIF4E_1 161 167 PF01652 0.301
LIG_eIF4E_1 210 216 PF01652 0.453
LIG_FHA_1 240 246 PF00498 0.321
LIG_FHA_1 318 324 PF00498 0.401
LIG_FHA_1 385 391 PF00498 0.691
LIG_FHA_1 52 58 PF00498 0.539
LIG_FHA_1 546 552 PF00498 0.497
LIG_FHA_1 569 575 PF00498 0.497
LIG_FHA_1 680 686 PF00498 0.363
LIG_FHA_1 688 694 PF00498 0.330
LIG_FHA_1 712 718 PF00498 0.504
LIG_FHA_1 756 762 PF00498 0.404
LIG_FHA_1 791 797 PF00498 0.516
LIG_FHA_1 856 862 PF00498 0.345
LIG_FHA_2 1 7 PF00498 0.425
LIG_FHA_2 125 131 PF00498 0.405
LIG_FHA_2 317 323 PF00498 0.433
LIG_FHA_2 590 596 PF00498 0.508
LIG_FHA_2 694 700 PF00498 0.378
LIG_LIR_Apic_2 704 710 PF02991 0.476
LIG_LIR_Gen_1 252 260 PF02991 0.463
LIG_LIR_Gen_1 268 278 PF02991 0.417
LIG_LIR_Gen_1 422 432 PF02991 0.497
LIG_LIR_Gen_1 471 477 PF02991 0.579
LIG_LIR_Gen_1 613 621 PF02991 0.377
LIG_LIR_Gen_1 677 688 PF02991 0.327
LIG_LIR_Gen_1 812 822 PF02991 0.395
LIG_LIR_Gen_1 831 838 PF02991 0.214
LIG_LIR_Nem_3 252 258 PF02991 0.457
LIG_LIR_Nem_3 268 273 PF02991 0.283
LIG_LIR_Nem_3 422 428 PF02991 0.498
LIG_LIR_Nem_3 471 476 PF02991 0.579
LIG_LIR_Nem_3 65 69 PF02991 0.340
LIG_LIR_Nem_3 658 663 PF02991 0.370
LIG_LIR_Nem_3 677 683 PF02991 0.212
LIG_LIR_Nem_3 831 835 PF02991 0.433
LIG_LIR_Nem_3 871 876 PF02991 0.418
LIG_LIR_Nem_3 933 937 PF02991 0.429
LIG_MLH1_MIPbox_1 811 815 PF16413 0.378
LIG_NRBOX 583 589 PF00104 0.557
LIG_NRBOX 732 738 PF00104 0.336
LIG_Pex14_2 203 207 PF04695 0.367
LIG_Pex14_2 873 877 PF04695 0.398
LIG_PTB_Apo_2 36 43 PF02174 0.408
LIG_SH2_CRK 30 34 PF00017 0.502
LIG_SH2_CRK 354 358 PF00017 0.402
LIG_SH2_CRK 69 73 PF00017 0.312
LIG_SH2_CRK 832 836 PF00017 0.546
LIG_SH2_GRB2like 284 287 PF00017 0.517
LIG_SH2_GRB2like 689 692 PF00017 0.397
LIG_SH2_NCK_1 210 214 PF00017 0.334
LIG_SH2_STAP1 284 288 PF00017 0.407
LIG_SH2_STAP1 616 620 PF00017 0.407
LIG_SH2_STAP1 689 693 PF00017 0.395
LIG_SH2_STAP1 832 836 PF00017 0.365
LIG_SH2_STAT3 161 164 PF00017 0.298
LIG_SH2_STAT3 784 787 PF00017 0.499
LIG_SH2_STAT3 885 888 PF00017 0.400
LIG_SH2_STAT3 935 938 PF00017 0.543
LIG_SH2_STAT5 161 164 PF00017 0.298
LIG_SH2_STAT5 165 168 PF00017 0.318
LIG_SH2_STAT5 2 5 PF00017 0.534
LIG_SH2_STAT5 269 272 PF00017 0.334
LIG_SH2_STAT5 284 287 PF00017 0.334
LIG_SH2_STAT5 616 619 PF00017 0.344
LIG_SH2_STAT5 620 623 PF00017 0.392
LIG_SH2_STAT5 689 692 PF00017 0.410
LIG_SH2_STAT5 814 817 PF00017 0.494
LIG_SH3_3 547 553 PF00018 0.489
LIG_SH3_3 863 869 PF00018 0.518
LIG_SH3_3 889 895 PF00018 0.442
LIG_Sin3_3 348 355 PF02671 0.388
LIG_SUMO_SIM_anti_2 570 579 PF11976 0.562
LIG_SUMO_SIM_anti_2 8 14 PF11976 0.479
LIG_SUMO_SIM_par_1 256 262 PF11976 0.397
LIG_SUMO_SIM_par_1 318 325 PF11976 0.427
LIG_SUMO_SIM_par_1 411 418 PF11976 0.497
LIG_SUMO_SIM_par_1 447 453 PF11976 0.506
LIG_SUMO_SIM_par_1 555 561 PF11976 0.461
LIG_SUMO_SIM_par_1 681 687 PF11976 0.335
LIG_TRAF2_1 358 361 PF00917 0.386
LIG_TRFH_1 345 349 PF08558 0.380
LIG_TYR_ITIM 352 357 PF00017 0.395
LIG_TYR_ITIM 537 542 PF00017 0.497
LIG_WRC_WIRS_1 416 421 PF05994 0.452
LIG_WRC_WIRS_1 901 906 PF05994 0.475
LIG_WRC_WIRS_1 931 936 PF05994 0.423
MOD_CDK_SPK_2 502 507 PF00069 0.461
MOD_CK1_1 231 237 PF00069 0.463
MOD_CK1_1 239 245 PF00069 0.447
MOD_CK1_1 417 423 PF00069 0.478
MOD_CK1_1 478 484 PF00069 0.495
MOD_CK1_1 495 501 PF00069 0.448
MOD_CK1_1 505 511 PF00069 0.522
MOD_CK1_1 687 693 PF00069 0.412
MOD_CK1_1 759 765 PF00069 0.464
MOD_CK1_1 855 861 PF00069 0.339
MOD_CK2_1 124 130 PF00069 0.406
MOD_CK2_1 240 246 PF00069 0.365
MOD_CK2_1 274 280 PF00069 0.517
MOD_CK2_1 355 361 PF00069 0.399
MOD_CK2_1 434 440 PF00069 0.497
MOD_CK2_1 589 595 PF00069 0.506
MOD_CK2_1 607 613 PF00069 0.424
MOD_CK2_1 693 699 PF00069 0.369
MOD_CK2_1 759 765 PF00069 0.547
MOD_CK2_1 915 921 PF00069 0.429
MOD_GlcNHglycan 115 118 PF01048 0.539
MOD_GlcNHglycan 134 137 PF01048 0.273
MOD_GlcNHglycan 251 255 PF01048 0.429
MOD_GlcNHglycan 291 294 PF01048 0.487
MOD_GlcNHglycan 303 306 PF01048 0.566
MOD_GlcNHglycan 337 340 PF01048 0.503
MOD_GlcNHglycan 407 410 PF01048 0.248
MOD_GlcNHglycan 532 535 PF01048 0.276
MOD_GlcNHglycan 560 563 PF01048 0.252
MOD_GlcNHglycan 686 689 PF01048 0.492
MOD_GlcNHglycan 711 714 PF01048 0.488
MOD_GlcNHglycan 741 744 PF01048 0.422
MOD_GlcNHglycan 797 800 PF01048 0.384
MOD_GlcNHglycan 815 818 PF01048 0.415
MOD_GlcNHglycan 82 85 PF01048 0.430
MOD_GlcNHglycan 873 876 PF01048 0.476
MOD_GlcNHglycan 878 881 PF01048 0.420
MOD_GSK3_1 121 128 PF00069 0.345
MOD_GSK3_1 231 238 PF00069 0.371
MOD_GSK3_1 295 302 PF00069 0.426
MOD_GSK3_1 373 380 PF00069 0.531
MOD_GSK3_1 384 391 PF00069 0.520
MOD_GSK3_1 401 408 PF00069 0.448
MOD_GSK3_1 414 421 PF00069 0.463
MOD_GSK3_1 497 504 PF00069 0.494
MOD_GSK3_1 515 522 PF00069 0.457
MOD_GSK3_1 568 575 PF00069 0.514
MOD_GSK3_1 642 649 PF00069 0.429
MOD_GSK3_1 687 694 PF00069 0.363
MOD_GSK3_1 711 718 PF00069 0.363
MOD_GSK3_1 755 762 PF00069 0.448
MOD_GSK3_1 786 793 PF00069 0.552
MOD_GSK3_1 809 816 PF00069 0.473
MOD_GSK3_1 848 855 PF00069 0.409
MOD_GSK3_1 871 878 PF00069 0.445
MOD_N-GLC_1 478 483 PF02516 0.261
MOD_N-GLC_1 502 507 PF02516 0.297
MOD_N-GLC_1 572 577 PF02516 0.266
MOD_N-GLC_1 655 660 PF02516 0.467
MOD_N-GLC_1 670 675 PF02516 0.459
MOD_N-GLC_2 456 458 PF02516 0.264
MOD_NEK2_1 183 188 PF00069 0.454
MOD_NEK2_1 228 233 PF00069 0.507
MOD_NEK2_1 245 250 PF00069 0.342
MOD_NEK2_1 316 321 PF00069 0.401
MOD_NEK2_1 335 340 PF00069 0.246
MOD_NEK2_1 343 348 PF00069 0.435
MOD_NEK2_1 405 410 PF00069 0.439
MOD_NEK2_1 45 50 PF00069 0.445
MOD_NEK2_1 450 455 PF00069 0.490
MOD_NEK2_1 515 520 PF00069 0.477
MOD_NEK2_1 558 563 PF00069 0.484
MOD_NEK2_1 612 617 PF00069 0.338
MOD_NEK2_1 684 689 PF00069 0.346
MOD_NEK2_1 702 707 PF00069 0.528
MOD_NEK2_1 716 721 PF00069 0.341
MOD_NEK2_1 749 754 PF00069 0.425
MOD_NEK2_1 808 813 PF00069 0.501
MOD_NEK2_1 930 935 PF00069 0.356
MOD_NEK2_2 401 406 PF00069 0.464
MOD_NEK2_2 642 647 PF00069 0.466
MOD_NEK2_2 73 78 PF00069 0.298
MOD_PIKK_1 183 189 PF00454 0.483
MOD_PIKK_1 839 845 PF00454 0.497
MOD_PK_1 299 305 PF00069 0.385
MOD_PK_1 596 602 PF00069 0.364
MOD_PKA_2 113 119 PF00069 0.458
MOD_PKA_2 183 189 PF00069 0.421
MOD_PKA_2 282 288 PF00069 0.403
MOD_PKA_2 373 379 PF00069 0.584
MOD_PKA_2 405 411 PF00069 0.445
MOD_PKA_2 495 501 PF00069 0.541
MOD_PKA_2 595 601 PF00069 0.406
MOD_PKA_2 607 613 PF00069 0.508
MOD_PKA_2 702 708 PF00069 0.483
MOD_PKB_1 372 380 PF00069 0.504
MOD_Plk_1 250 256 PF00069 0.349
MOD_Plk_1 374 380 PF00069 0.489
MOD_Plk_1 421 427 PF00069 0.508
MOD_Plk_1 572 578 PF00069 0.464
MOD_Plk_1 612 618 PF00069 0.335
MOD_Plk_1 655 661 PF00069 0.396
MOD_Plk_1 809 815 PF00069 0.416
MOD_Plk_1 848 854 PF00069 0.454
MOD_Plk_1 855 861 PF00069 0.355
MOD_Plk_2-3 211 217 PF00069 0.470
MOD_Plk_2-3 632 638 PF00069 0.308
MOD_Plk_4 139 145 PF00069 0.389
MOD_Plk_4 211 217 PF00069 0.470
MOD_Plk_4 240 246 PF00069 0.330
MOD_Plk_4 261 267 PF00069 0.411
MOD_Plk_4 45 51 PF00069 0.294
MOD_Plk_4 465 471 PF00069 0.467
MOD_Plk_4 497 503 PF00069 0.480
MOD_Plk_4 508 514 PF00069 0.464
MOD_Plk_4 572 578 PF00069 0.498
MOD_Plk_4 596 602 PF00069 0.493
MOD_Plk_4 607 613 PF00069 0.334
MOD_Plk_4 679 685 PF00069 0.380
MOD_Plk_4 693 699 PF00069 0.348
MOD_Plk_4 749 755 PF00069 0.402
MOD_Plk_4 8 14 PF00069 0.425
MOD_Plk_4 809 815 PF00069 0.512
MOD_Plk_4 900 906 PF00069 0.414
MOD_Plk_4 915 921 PF00069 0.312
MOD_Plk_4 930 936 PF00069 0.458
MOD_ProDKin_1 221 227 PF00069 0.379
MOD_ProDKin_1 274 280 PF00069 0.381
MOD_ProDKin_1 502 508 PF00069 0.497
MOD_SUMO_rev_2 147 157 PF00179 0.369
MOD_SUMO_rev_2 720 728 PF00179 0.485
TRG_DiLeu_BaEn_1 211 216 PF01217 0.464
TRG_DiLeu_BaEn_1 624 629 PF01217 0.522
TRG_DiLeu_BaEn_2 250 256 PF01217 0.399
TRG_DiLeu_BaEn_3 360 366 PF01217 0.383
TRG_DiLeu_BaLyEn_6 511 516 PF01217 0.541
TRG_DiLeu_BaLyEn_6 553 558 PF01217 0.461
TRG_DiLeu_BaLyEn_6 772 777 PF01217 0.406
TRG_ENDOCYTIC_2 269 272 PF00928 0.530
TRG_ENDOCYTIC_2 30 33 PF00928 0.435
TRG_ENDOCYTIC_2 354 357 PF00928 0.406
TRG_ENDOCYTIC_2 425 428 PF00928 0.541
TRG_ENDOCYTIC_2 539 542 PF00928 0.554
TRG_ENDOCYTIC_2 616 619 PF00928 0.362
TRG_ENDOCYTIC_2 69 72 PF00928 0.314
TRG_ENDOCYTIC_2 832 835 PF00928 0.554
TRG_ER_diArg_1 371 374 PF00400 0.490
TRG_NES_CRM1_1 921 936 PF08389 0.443
TRG_Pf-PMV_PEXEL_1 775 779 PF00026 0.490

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBU0 Leptomonas seymouri 67% 100%
A0A0S4JDM2 Bodo saltans 34% 100%
A0A1X0NKI1 Trypanosomatidae 45% 100%
A0A3Q8IR35 Leishmania donovani 100% 100%
A0A3R7N6Q2 Trypanosoma rangeli 44% 100%
A4HPD4 Leishmania braziliensis 87% 100%
D0A3J8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AT50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q1E8 Leishmania major 96% 100%
V5BFP7 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS