Centrosomal protein POC5

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICH6_LEIIN

TriTrypDb:

LINF_360034800

Length:

339

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005814	centriole	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

A4ICH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICH6

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	9
GO:0009987	cellular process	1	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.551
CLV_NRD_NRD_1	110	112	PF00675	0.421
CLV_NRD_NRD_1	116	118	PF00675	0.452
CLV_NRD_NRD_1	120	122	PF00675	0.420
CLV_NRD_NRD_1	41	43	PF00675	0.472
CLV_NRD_NRD_1	63	65	PF00675	0.481
CLV_PCSK_FUR_1	117	121	PF00082	0.525
CLV_PCSK_FUR_1	150	154	PF00082	0.435
CLV_PCSK_KEX2_1	110	112	PF00082	0.434
CLV_PCSK_KEX2_1	116	118	PF00082	0.477
CLV_PCSK_KEX2_1	119	121	PF00082	0.462
CLV_PCSK_KEX2_1	152	154	PF00082	0.476
CLV_PCSK_KEX2_1	161	163	PF00082	0.465
CLV_PCSK_KEX2_1	40	42	PF00082	0.486
CLV_PCSK_KEX2_1	63	65	PF00082	0.458
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.440
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.518
CLV_PCSK_PC7_1	116	122	PF00082	0.597
CLV_PCSK_SKI1_1	195	199	PF00082	0.478
CLV_PCSK_SKI1_1	240	244	PF00082	0.674
DOC_MAPK_MEF2A_6	26	35	PF00069	0.489
DOC_PP4_FxxP_1	272	275	PF00568	0.532
DOC_USP7_MATH_1	268	272	PF00917	0.437
DOC_USP7_MATH_1	293	297	PF00917	0.695
DOC_USP7_MATH_1	300	304	PF00917	0.679
DOC_USP7_UBL2_3	157	161	PF12436	0.503
DOC_WW_Pin1_4	240	245	PF00397	0.609
DOC_WW_Pin1_4	275	280	PF00397	0.578
DOC_WW_Pin1_4	318	323	PF00397	0.633
LIG_14-3-3_CanoR_1	104	110	PF00244	0.519
LIG_14-3-3_CanoR_1	238	243	PF00244	0.653
LIG_14-3-3_CanoR_1	291	300	PF00244	0.746
LIG_BIR_III_4	267	271	PF00653	0.502
LIG_BRCT_BRCA1_1	302	306	PF00533	0.654
LIG_eIF4E_1	139	145	PF01652	0.375
LIG_EVH1_2	322	326	PF00568	0.592
LIG_FHA_1	41	47	PF00498	0.442
LIG_LIR_Apic_2	271	275	PF02991	0.403
LIG_LIR_Nem_3	278	284	PF02991	0.539
LIG_SH2_STAT3	176	179	PF00017	0.501
LIG_SH2_STAT5	281	284	PF00017	0.542
LIG_SH2_STAT5	38	41	PF00017	0.454
LIG_SH3_2	322	327	PF14604	0.641
LIG_SH3_3	319	325	PF00018	0.739
LIG_SUMO_SIM_anti_2	29	37	PF11976	0.482
LIG_TRAF2_1	50	53	PF00917	0.447
LIG_TRAF2_1	73	76	PF00917	0.620
MOD_CK1_1	232	238	PF00069	0.682
MOD_CK1_1	250	256	PF00069	0.730
MOD_CK1_1	314	320	PF00069	0.579
MOD_CK1_1	330	336	PF00069	0.613
MOD_CK2_1	186	192	PF00069	0.460
MOD_DYRK1A_RPxSP_1	240	244	PF00069	0.608
MOD_GlcNHglycan	287	290	PF01048	0.623
MOD_GlcNHglycan	295	298	PF01048	0.713
MOD_GlcNHglycan	300	303	PF01048	0.662
MOD_GlcNHglycan	313	316	PF01048	0.632
MOD_GSK3_1	234	241	PF00069	0.598
MOD_GSK3_1	246	253	PF00069	0.553
MOD_GSK3_1	314	321	PF00069	0.684
MOD_GSK3_1	327	334	PF00069	0.555
MOD_LATS_1	236	242	PF00433	0.602
MOD_NEK2_1	105	110	PF00069	0.569
MOD_NEK2_1	247	252	PF00069	0.719
MOD_NEK2_1	329	334	PF00069	0.671
MOD_NEK2_2	268	273	PF00069	0.429
MOD_PIKK_1	40	46	PF00454	0.441
MOD_PK_1	238	244	PF00069	0.674
MOD_PKA_1	40	46	PF00069	0.441
MOD_PKA_2	232	238	PF00069	0.619
MOD_PKA_2	285	291	PF00069	0.580
MOD_PKA_2	40	46	PF00069	0.514
MOD_Plk_1	186	192	PF00069	0.458
MOD_Plk_1	247	253	PF00069	0.670
MOD_Plk_1	8	14	PF00069	0.510
MOD_Plk_4	268	274	PF00069	0.448
MOD_Plk_4	8	14	PF00069	0.554
MOD_ProDKin_1	240	246	PF00069	0.608
MOD_ProDKin_1	275	281	PF00069	0.584
MOD_ProDKin_1	318	324	PF00069	0.634
MOD_SUMO_for_1	4	7	PF00179	0.615
MOD_SUMO_for_1	50	53	PF00179	0.508
TRG_ER_diArg_1	109	111	PF00400	0.468
TRG_ER_diArg_1	115	117	PF00400	0.453
TRG_ER_diArg_1	119	121	PF00400	0.425
TRG_ER_diArg_1	39	42	PF00400	0.503
TRG_ER_diArg_1	63	65	PF00400	0.523
TRG_NES_CRM1_1	92	103	PF08389	0.427
TRG_NLS_Bipartite_1	63	85	PF00514	0.512
TRG_NLS_MonoExtN_4	78	85	PF00514	0.461
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V9	Leptomonas seymouri	51%	99%
A0A3Q8IKC6	Leishmania donovani	100%	100%
A4HPD7	Leishmania braziliensis	81%	100%
D0A3J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	93%
E9AT47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1F1	Leishmania major	95%	100%
V5BK99	Trypanosoma cruzi	28%	90%