LeishMANIAdb
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Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Gene product:
dihydrolipoamide acetyltransferase precursor - putative
Species:
Leishmania infantum
UniProt:
A4ICH2_LEIIN
TriTrypDb:
LINF_360034400
Length:
463

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, dihydrolipoamide acetyltransferase E3

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 8
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 11
GO:0045254 pyruvate dehydrogenase complex 4 11
GO:1902494 catalytic complex 2 11
GO:1990204 oxidoreductase complex 3 11
GO:0005739 mitochondrion 5 1
GO:0005967 mitochondrial pyruvate dehydrogenase complex 3 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICH2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICH2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006084 acetyl-CoA metabolic process 5 11
GO:0006085 acetyl-CoA biosynthetic process 6 11
GO:0006086 acetyl-CoA biosynthetic process from pyruvate 7 11
GO:0006090 pyruvate metabolic process 7 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006163 purine nucleotide metabolic process 5 11
GO:0006164 purine nucleotide biosynthetic process 6 11
GO:0006637 acyl-CoA metabolic process 4 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006753 nucleoside phosphate metabolic process 4 11
GO:0006790 sulfur compound metabolic process 3 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009117 nucleotide metabolic process 5 11
GO:0009150 purine ribonucleotide metabolic process 6 11
GO:0009152 purine ribonucleotide biosynthetic process 7 11
GO:0009165 nucleotide biosynthetic process 6 11
GO:0009259 ribonucleotide metabolic process 5 11
GO:0009260 ribonucleotide biosynthetic process 6 11
GO:0009987 cellular process 1 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019693 ribose phosphate metabolic process 4 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0032787 monocarboxylic acid metabolic process 6 11
GO:0033865 nucleoside bisphosphate metabolic process 5 11
GO:0033866 nucleoside bisphosphate biosynthetic process 6 11
GO:0033875 ribonucleoside bisphosphate metabolic process 6 11
GO:0034030 ribonucleoside bisphosphate biosynthetic process 7 11
GO:0034032 purine nucleoside bisphosphate metabolic process 5 11
GO:0034033 purine nucleoside bisphosphate biosynthetic process 6 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0035383 thioester metabolic process 3 11
GO:0035384 thioester biosynthetic process 4 11
GO:0043436 oxoacid metabolic process 4 11
GO:0043603 amide metabolic process 3 11
GO:0043604 amide biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0044272 sulfur compound biosynthetic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046390 ribose phosphate biosynthetic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071616 acyl-CoA biosynthetic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0072521 purine-containing compound metabolic process 4 11
GO:0072522 purine-containing compound biosynthetic process 5 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901137 carbohydrate derivative biosynthetic process 4 11
GO:1901293 nucleoside phosphate biosynthetic process 5 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity 3 2
GO:0016407 acetyltransferase activity 5 2
GO:0016417 S-acyltransferase activity 5 2
GO:0016418 S-acetyltransferase activity 6 2
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 2
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 154 156 PF00675 0.250
CLV_NRD_NRD_1 4 6 PF00675 0.483
CLV_PCSK_KEX2_1 243 245 PF00082 0.289
CLV_PCSK_KEX2_1 3 5 PF00082 0.490
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.309
CLV_PCSK_SKI1_1 17 21 PF00082 0.441
CLV_PCSK_SKI1_1 78 82 PF00082 0.414
CLV_PCSK_SKI1_1 9 13 PF00082 0.572
DEG_Kelch_Keap1_1 412 417 PF01344 0.388
DEG_Nend_Nbox_1 1 3 PF02207 0.557
DOC_CKS1_1 10 15 PF01111 0.466
DOC_CKS1_1 325 330 PF01111 0.289
DOC_CKS1_1 331 336 PF01111 0.289
DOC_CYCLIN_yClb3_PxF_3 223 229 PF00134 0.617
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.628
DOC_MAPK_DCC_7 17 26 PF00069 0.418
DOC_MAPK_MEF2A_6 314 323 PF00069 0.273
DOC_MAPK_RevD_3 230 244 PF00069 0.220
DOC_PP2B_LxvP_1 210 213 PF13499 0.627
DOC_PP2B_LxvP_1 251 254 PF13499 0.317
DOC_USP7_MATH_1 186 190 PF00917 0.489
DOC_USP7_MATH_1 399 403 PF00917 0.332
DOC_USP7_MATH_1 63 67 PF00917 0.326
DOC_USP7_UBL2_3 352 356 PF12436 0.289
DOC_WW_Pin1_4 131 136 PF00397 0.593
DOC_WW_Pin1_4 148 153 PF00397 0.425
DOC_WW_Pin1_4 19 24 PF00397 0.376
DOC_WW_Pin1_4 219 224 PF00397 0.554
DOC_WW_Pin1_4 27 32 PF00397 0.251
DOC_WW_Pin1_4 324 329 PF00397 0.289
DOC_WW_Pin1_4 330 335 PF00397 0.289
DOC_WW_Pin1_4 9 14 PF00397 0.575
LIG_14-3-3_CanoR_1 177 183 PF00244 0.516
LIG_14-3-3_CanoR_1 314 320 PF00244 0.255
LIG_APCC_ABBAyCdc20_2 100 106 PF00400 0.513
LIG_BRCT_BRCA1_1 430 434 PF00533 0.317
LIG_FHA_1 316 322 PF00498 0.289
LIG_FHA_1 327 333 PF00498 0.270
LIG_FHA_1 349 355 PF00498 0.348
LIG_FHA_1 370 376 PF00498 0.289
LIG_FHA_1 385 391 PF00498 0.289
LIG_FHA_1 419 425 PF00498 0.401
LIG_FHA_1 90 96 PF00498 0.332
LIG_FHA_2 177 183 PF00498 0.488
LIG_FHA_2 283 289 PF00498 0.298
LIG_LIR_Gen_1 53 63 PF02991 0.290
LIG_LIR_Gen_1 73 83 PF02991 0.103
LIG_LIR_Nem_3 53 58 PF02991 0.290
LIG_LIR_Nem_3 73 79 PF02991 0.103
LIG_MYND_1 27 31 PF01753 0.289
LIG_PDZ_Class_2 458 463 PF00595 0.289
LIG_Pex14_1 308 312 PF04695 0.332
LIG_Pex14_1 447 451 PF04695 0.289
LIG_Pex14_2 430 434 PF04695 0.289
LIG_REV1ctd_RIR_1 73 82 PF16727 0.401
LIG_SH2_GRB2like 67 70 PF00017 0.309
LIG_SH2_NCK_1 316 320 PF00017 0.332
LIG_SH2_NCK_1 67 71 PF00017 0.309
LIG_SH2_SRC 67 70 PF00017 0.309
LIG_SH2_STAP1 153 157 PF00017 0.516
LIG_SH2_STAT5 257 260 PF00017 0.289
LIG_SH2_STAT5 289 292 PF00017 0.278
LIG_SH3_3 124 130 PF00018 0.668
LIG_SH3_3 195 201 PF00018 0.659
LIG_SH3_3 210 216 PF00018 0.600
LIG_SH3_3 221 227 PF00018 0.505
LIG_SH3_3 322 328 PF00018 0.289
LIG_SH3_3 45 51 PF00018 0.330
LIG_SH3_3 7 13 PF00018 0.622
LIG_SUMO_SIM_par_1 139 144 PF11976 0.524
LIG_SUMO_SIM_par_1 317 322 PF11976 0.309
LIG_SUMO_SIM_par_1 343 348 PF11976 0.362
LIG_SUMO_SIM_par_1 396 402 PF11976 0.277
LIG_SxIP_EBH_1 17 30 PF03271 0.309
LIG_TRAF2_1 122 125 PF00917 0.701
LIG_TRAF2_1 70 73 PF00917 0.351
LIG_TRAF2_1 83 86 PF00917 0.292
LIG_UBA3_1 267 272 PF00899 0.332
MOD_CDK_SPxxK_3 148 155 PF00069 0.436
MOD_CDK_SPxxK_3 330 337 PF00069 0.289
MOD_CK1_1 348 354 PF00069 0.388
MOD_CK1_1 412 418 PF00069 0.317
MOD_CK2_1 191 197 PF00069 0.608
MOD_CK2_1 79 85 PF00069 0.403
MOD_GlcNHglycan 143 146 PF01048 0.599
MOD_GlcNHglycan 165 168 PF01048 0.270
MOD_GlcNHglycan 188 191 PF01048 0.555
MOD_GlcNHglycan 193 196 PF01048 0.601
MOD_GlcNHglycan 401 404 PF01048 0.332
MOD_GlcNHglycan 430 433 PF01048 0.381
MOD_GlcNHglycan 81 84 PF01048 0.440
MOD_GSK3_1 186 193 PF00069 0.536
MOD_GSK3_1 232 239 PF00069 0.339
MOD_GSK3_1 315 322 PF00069 0.311
MOD_GSK3_1 326 333 PF00069 0.269
MOD_GSK3_1 359 366 PF00069 0.332
MOD_GSK3_1 369 376 PF00069 0.247
MOD_GSK3_1 5 12 PF00069 0.581
MOD_N-GLC_1 161 166 PF02516 0.260
MOD_N-GLC_1 304 309 PF02516 0.289
MOD_N-GLC_1 428 433 PF02516 0.220
MOD_N-GLC_1 68 73 PF02516 0.309
MOD_NEK2_1 245 250 PF00069 0.300
MOD_NEK2_1 378 383 PF00069 0.300
MOD_NEK2_1 418 423 PF00069 0.380
MOD_NEK2_2 233 238 PF00069 0.362
MOD_PKA_2 176 182 PF00069 0.483
MOD_PKB_1 3 11 PF00069 0.612
MOD_Plk_1 161 167 PF00069 0.460
MOD_Plk_1 304 310 PF00069 0.305
MOD_Plk_1 319 325 PF00069 0.289
MOD_Plk_1 84 90 PF00069 0.335
MOD_Plk_2-3 68 74 PF00069 0.309
MOD_Plk_4 457 463 PF00069 0.289
MOD_ProDKin_1 131 137 PF00069 0.593
MOD_ProDKin_1 148 154 PF00069 0.425
MOD_ProDKin_1 19 25 PF00069 0.378
MOD_ProDKin_1 219 225 PF00069 0.550
MOD_ProDKin_1 27 33 PF00069 0.251
MOD_ProDKin_1 324 330 PF00069 0.289
MOD_ProDKin_1 9 15 PF00069 0.573
MOD_SUMO_for_1 410 413 PF00179 0.342
MOD_SUMO_rev_2 346 354 PF00179 0.289
TRG_ENDOCYTIC_2 256 259 PF00928 0.273
TRG_ENDOCYTIC_2 316 319 PF00928 0.289
TRG_ER_diArg_1 2 5 PF00400 0.554
TRG_Pf-PMV_PEXEL_1 342 346 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHV8 Leptomonas seymouri 80% 100%
A0A0N1PBB0 Leptomonas seymouri 29% 81%
A0A0S4JC61 Bodo saltans 59% 99%
A0A0S4JS90 Bodo saltans 27% 100%
A0A1X0NKN9 Trypanosomatidae 65% 98%
A0A1X0P2L7 Trypanosomatidae 24% 93%
A0A3Q8IJE7 Leishmania donovani 100% 100%
A0A3S5H5G3 Leishmania donovani 25% 97%
A0A3S5ISA9 Trypanosoma rangeli 25% 100%
A4H464 Leishmania braziliensis 25% 100%
A4HPD2 Leishmania braziliensis 84% 100%
C9ZPW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
D0A3J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AG63 Leishmania infantum 25% 97%
E9AKC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AT43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
G0S4X6 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 41% 100%
O00330 Homo sapiens 37% 92%
O31550 Bacillus subtilis (strain 168) 31% 100%
O59816 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 96%
O66119 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 36% 100%
O94681 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
P06959 Escherichia coli (strain K12) 33% 73%
P08461 Rattus norvegicus 43% 73%
P09062 Pseudomonas putida 28% 100%
P0AFG6 Escherichia coli (strain K12) 29% 100%
P0AFG7 Escherichia coli O157:H7 29% 100%
P10515 Homo sapiens 41% 72%
P10802 Azotobacter vinelandii 29% 73%
P11181 Bos taurus 26% 96%
P11182 Homo sapiens 25% 96%
P11961 Geobacillus stearothermophilus 31% 100%
P12695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 96%
P16263 Bacillus subtilis (strain 168) 30% 100%
P19262 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P20285 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 39% 100%
P20708 Azotobacter vinelandii 28% 100%
P21883 Bacillus subtilis (strain 168) 31% 100%
P22439 Bos taurus 37% 92%
P35489 Acholeplasma laidlawii 29% 85%
P36413 Dictyostelium discoideum 38% 73%
P37942 Bacillus subtilis (strain 168) 33% 100%
P45118 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 32% 82%
P45302 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 27% 100%
P52993 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 32% 100%
P53395 Mus musculus 26% 96%
P57302 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 25% 100%
P57389 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 22% 100%
P65635 Staphylococcus aureus (strain Mu50 / ATCC 700699) 33% 100%
P65636 Staphylococcus aureus (strain N315) 33% 100%
Q0WQF7 Arabidopsis thaliana 38% 73%
Q19749 Caenorhabditis elegans 41% 91%
Q1RHI5 Rickettsia bellii (strain RML369-C) 28% 100%
Q1RJT3 Rickettsia bellii (strain RML369-C) 38% 100%
Q23571 Caenorhabditis elegans 24% 100%
Q2FH26 Staphylococcus aureus (strain USA300) 29% 100%
Q2FYM2 Staphylococcus aureus (strain NCTC 8325 / PS 47) 29% 100%
Q2YY06 Staphylococcus aureus (strain bovine RF122 / ET3-1) 29% 100%
Q49110 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) 30% 100%
Q49XM4 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 29% 100%
Q4L6C3 Staphylococcus haemolyticus (strain JCSC1435) 27% 100%
Q4Q1F5 Leishmania major 97% 100%
Q4QJI5 Leishmania major 24% 100%
Q4UKI7 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 28% 100%
Q4ULG1 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 33% 100%
Q59098 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 32% 84%
Q59638 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 30% 85%
Q59821 Staphylococcus aureus 33% 100%
Q5HG07 Staphylococcus aureus (strain COL) 29% 100%
Q5HGY9 Staphylococcus aureus (strain COL) 33% 100%
Q5HPC7 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 27% 100%
Q5HQ74 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 30% 100%
Q5M729 Arabidopsis thaliana 41% 86%
Q68WK6 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 33% 100%
Q68XI8 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 28% 100%
Q6ABX9 Leifsonia xyli subsp. xyli (strain CTCB07) 26% 100%
Q6FYD4 Bartonella quintana (strain Toulouse) 28% 100%
Q6G9E9 Staphylococcus aureus (strain MSSA476) 29% 100%
Q6GAB9 Staphylococcus aureus (strain MSSA476) 33% 100%
Q6GGZ6 Staphylococcus aureus (strain MRSA252) 28% 100%
Q6GHZ0 Staphylococcus aureus (strain MRSA252) 33% 100%
Q7A5N4 Staphylococcus aureus (strain N315) 29% 100%
Q89AJ6 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 23% 100%
Q89AQ9 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 23% 100%
Q8BKZ9 Mus musculus 37% 92%
Q8BMF4 Mus musculus 43% 72%
Q8CSL9 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 27% 100%
Q8CT13 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 30% 100%
Q8GCY1 Bartonella vinsonii subsp. berkhoffii 27% 100%
Q8K9T8 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 25% 100%
Q8NNJ2 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 30% 69%
Q8NWR7 Staphylococcus aureus (strain MW2) 29% 100%
Q8NX76 Staphylococcus aureus (strain MW2) 33% 100%
Q8RWN9 Arabidopsis thaliana 40% 86%
Q92HK7 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 35% 100%
Q92J43 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 29% 100%
Q99U75 Staphylococcus aureus (strain Mu50 / ATCC 700699) 29% 100%
Q9C8P0 Arabidopsis thaliana 31% 100%
Q9I1M0 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 28% 100%
Q9I3D2 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 29% 100%
Q9M7Z1 Arabidopsis thaliana 23% 96%
Q9R9N3 Rhizobium meliloti (strain 1021) 39% 100%
Q9SQI8 Arabidopsis thaliana 32% 96%
Q9ZD20 Rickettsia prowazekii (strain Madrid E) 32% 100%
Q9ZDY4 Rickettsia prowazekii (strain Madrid E) 27% 100%
V5BFP9 Trypanosoma cruzi 63% 98%
V5BJF4 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS