Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide acetyltransferase precursor - putative

Species:

Leishmania infantum

UniProt:

A4ICH2_LEIIN

TriTrypDb:

LINF_360034400

Length:

463

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, dihydrolipoamide acetyltransferase E3

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	1
GO:0020023	kinetoplast	2	1
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045254	pyruvate dehydrogenase complex	4	11
GO:0098798	mitochondrial protein-containing complex	2	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICH2

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006084	acetyl-CoA metabolic process	5	11
GO:0006085	acetyl-CoA biosynthetic process	6	11
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	11
GO:0006090	pyruvate metabolic process	7	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006637	acyl-CoA metabolic process	4	11
GO:0006725	cellular aromatic compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	3	2
GO:0016407	acetyltransferase activity	5	2
GO:0016417	S-acyltransferase activity	5	2
GO:0016418	S-acetyltransferase activity	6	2
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.250
CLV_NRD_NRD_1	4	6	PF00675	0.483
CLV_PCSK_KEX2_1	243	245	PF00082	0.289
CLV_PCSK_KEX2_1	3	5	PF00082	0.490
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.309
CLV_PCSK_SKI1_1	17	21	PF00082	0.441
CLV_PCSK_SKI1_1	78	82	PF00082	0.414
CLV_PCSK_SKI1_1	9	13	PF00082	0.572
DEG_Kelch_Keap1_1	412	417	PF01344	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.557

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV8	Leptomonas seymouri	80%	100%
A0A0N1PBB0	Leptomonas seymouri	29%	81%
A0A0S4JC61	Bodo saltans	59%	99%
A0A0S4JS90	Bodo saltans	27%	100%
A0A1X0NKN9	Trypanosomatidae	65%	98%
A0A1X0P2L7	Trypanosomatidae	24%	93%
A0A3Q8IJE7	Leishmania donovani	100%	100%
A0A3S5H5G3	Leishmania donovani	25%	97%
A0A3S5ISA9	Trypanosoma rangeli	25%	100%
A4H464	Leishmania braziliensis	25%	100%

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