Separase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICH0_LEIIN

TriTrypDb:

LINF_360034200

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0070390	transcription export complex 2	3	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A4ICH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICH0

Function

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Biological processes
Term	Name	Level	Count
GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	6	1
GO:0000973	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006354	DNA-templated transcription elongation	6	1
GO:0006368	transcription elongation by RNA polymerase II	7	1
GO:0006405	RNA export from nucleus	5	12
GO:0006406	mRNA export from nucleus	6	12
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.456
CLV_NRD_NRD_1	120	122	PF00675	0.497
CLV_NRD_NRD_1	235	237	PF00675	0.336
CLV_NRD_NRD_1	256	258	PF00675	0.336
CLV_NRD_NRD_1	328	330	PF00675	0.483
CLV_NRD_NRD_1	375	377	PF00675	0.499
CLV_NRD_NRD_1	421	423	PF00675	0.401
CLV_PCSK_KEX2_1	255	257	PF00082	0.344
CLV_PCSK_KEX2_1	375	377	PF00082	0.499
CLV_PCSK_KEX2_1	421	423	PF00082	0.399

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTB0	Leptomonas seymouri	71%	100%
A0A0S4J9T0	Bodo saltans	41%	99%
A0A1X0NKD6	Trypanosomatidae	45%	100%
A0A3R7LU45	Trypanosoma rangeli	43%	100%
A0A3S7XAY0	Leishmania donovani	100%	100%
A4HPD0	Leishmania braziliensis	90%	100%
D0A3J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9AT41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q1F7	Leishmania major	97%	100%
V5BKA5	Trypanosoma cruzi	43%	100%

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