Putative membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2 - putative

Species:

Leishmania infantum

UniProt:

A4ICG5_LEIIN

TriTrypDb:

LINF_360033700

Length:

571

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Annotations by Jardim et al.

Phosphatase, membrane-bound acid phosphatase 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 43, no: 4
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	34
GO:0110165	cellular anatomical entity	1	34

Expansion

Sequence features

A4ICG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICG5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003993	acid phosphatase activity	6	3
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.631
CLV_C14_Caspase3-7	497	501	PF00656	0.393
CLV_NRD_NRD_1	537	539	PF00675	0.440
CLV_PCSK_KEX2_1	251	253	PF00082	0.592
CLV_PCSK_KEX2_1	397	399	PF00082	0.580
CLV_PCSK_KEX2_1	535	537	PF00082	0.430
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.416
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.556
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.469
CLV_PCSK_SKI1_1	137	141	PF00082	0.533
CLV_PCSK_SKI1_1	177	181	PF00082	0.569
CLV_PCSK_SKI1_1	222	226	PF00082	0.544
CLV_PCSK_SKI1_1	251	255	PF00082	0.545
CLV_PCSK_SKI1_1	398	402	PF00082	0.630
CLV_PCSK_SKI1_1	565	569	PF00082	0.607
DOC_CDC14_PxL_1	237	245	PF14671	0.408
DOC_CKS1_1	431	436	PF01111	0.345
DOC_CYCLIN_RxL_1	217	226	PF00134	0.382
DOC_MAPK_gen_1	249	258	PF00069	0.329
DOC_MAPK_gen_1	535	544	PF00069	0.678
DOC_MAPK_MEF2A_6	537	546	PF00069	0.515
DOC_PP1_RVXF_1	396	403	PF00149	0.430
DOC_PP1_RVXF_1	4	10	PF00149	0.678
DOC_PP4_FxxP_1	108	111	PF00568	0.322
DOC_PP4_MxPP_1	326	329	PF00568	0.379
DOC_USP7_MATH_1	141	145	PF00917	0.337
DOC_USP7_MATH_1	510	514	PF00917	0.427
DOC_USP7_UBL2_3	397	401	PF12436	0.267
DOC_WW_Pin1_4	102	107	PF00397	0.361
DOC_WW_Pin1_4	319	324	PF00397	0.296
DOC_WW_Pin1_4	356	361	PF00397	0.379
DOC_WW_Pin1_4	430	435	PF00397	0.417
DOC_WW_Pin1_4	69	74	PF00397	0.423
LIG_14-3-3_CanoR_1	121	129	PF00244	0.333
LIG_14-3-3_CanoR_1	252	257	PF00244	0.305
LIG_14-3-3_CanoR_1	444	453	PF00244	0.341
LIG_14-3-3_CanoR_1	545	551	PF00244	0.719
LIG_14-3-3_CanoR_1	6	16	PF00244	0.432
LIG_14-3-3_CanoR_1	95	100	PF00244	0.372
LIG_APCC_ABBA_1	390	395	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BIR_III_4	378	382	PF00653	0.455
LIG_BIR_III_4	407	411	PF00653	0.388
LIG_BRCT_BRCA1_1	104	108	PF00533	0.370
LIG_deltaCOP1_diTrp_1	365	372	PF00928	0.333
LIG_FHA_1	121	127	PF00498	0.341
LIG_FHA_1	155	161	PF00498	0.303
LIG_FHA_1	186	192	PF00498	0.305
LIG_FHA_1	252	258	PF00498	0.355
LIG_FHA_1	296	302	PF00498	0.308
LIG_FHA_1	434	440	PF00498	0.495
LIG_FHA_1	526	532	PF00498	0.490
LIG_FHA_1	547	553	PF00498	0.718
LIG_FHA_1	63	69	PF00498	0.434
LIG_FHA_1	8	14	PF00498	0.523
LIG_FHA_2	150	156	PF00498	0.349
LIG_FHA_2	214	220	PF00498	0.330
LIG_FHA_2	221	227	PF00498	0.325
LIG_FHA_2	315	321	PF00498	0.340
LIG_FHA_2	360	366	PF00498	0.483
LIG_FHA_2	478	484	PF00498	0.556
LIG_FHA_2	495	501	PF00498	0.431
LIG_LIR_Apic_2	105	111	PF02991	0.327
LIG_LIR_Gen_1	144	154	PF02991	0.359
LIG_LIR_Gen_1	165	173	PF02991	0.371
LIG_LIR_Gen_1	194	203	PF02991	0.381
LIG_LIR_Gen_1	244	253	PF02991	0.357
LIG_LIR_Nem_3	144	150	PF02991	0.315
LIG_LIR_Nem_3	165	171	PF02991	0.325
LIG_LIR_Nem_3	194	198	PF02991	0.376
LIG_LIR_Nem_3	244	250	PF02991	0.345
LIG_LIR_Nem_3	395	399	PF02991	0.330
LIG_LIR_Nem_3	78	82	PF02991	0.406
LIG_LYPXL_yS_3	240	243	PF13949	0.412
LIG_PDZ_Class_3	566	571	PF00595	0.808
LIG_Pex14_1	168	172	PF04695	0.366
LIG_Pex14_2	135	139	PF04695	0.395
LIG_Pex14_2	364	368	PF04695	0.453
LIG_Rb_pABgroove_1	219	227	PF01858	0.394
LIG_SH2_CRK	147	151	PF00017	0.370
LIG_SH2_CRK	431	435	PF00017	0.474
LIG_SH2_GRB2like	173	176	PF00017	0.379
LIG_SH2_PTP2	348	351	PF00017	0.386
LIG_SH2_SRC	206	209	PF00017	0.226
LIG_SH2_SRC	260	263	PF00017	0.381
LIG_SH2_STAP1	113	117	PF00017	0.320
LIG_SH2_STAP1	260	264	PF00017	0.333
LIG_SH2_STAT3	413	416	PF00017	0.265
LIG_SH2_STAT5	210	213	PF00017	0.360
LIG_SH2_STAT5	348	351	PF00017	0.327
LIG_SH2_STAT5	411	414	PF00017	0.353
LIG_SH2_STAT5	543	546	PF00017	0.620
LIG_SH2_STAT5	76	79	PF00017	0.331
LIG_SH3_3	100	106	PF00018	0.368
LIG_SH3_3	180	186	PF00018	0.343
LIG_SH3_3	422	428	PF00018	0.415
LIG_TRAF2_1	480	483	PF00917	0.410
LIG_TRAF2_2	356	361	PF00917	0.424
LIG_UBA3_1	224	232	PF00899	0.405
LIG_WRC_WIRS_1	514	519	PF05994	0.418
MOD_CDK_SPxxK_3	356	363	PF00069	0.416
MOD_CK1_1	101	107	PF00069	0.385
MOD_CK1_1	120	126	PF00069	0.348
MOD_CK1_1	359	365	PF00069	0.439
MOD_CK1_1	471	477	PF00069	0.447
MOD_CK1_1	513	519	PF00069	0.486
MOD_CK2_1	149	155	PF00069	0.373
MOD_CK2_1	209	215	PF00069	0.417
MOD_CK2_1	359	365	PF00069	0.445
MOD_CK2_1	477	483	PF00069	0.538
MOD_CK2_1	545	551	PF00069	0.696
MOD_GlcNHglycan	130	133	PF01048	0.519
MOD_GlcNHglycan	304	307	PF01048	0.543
MOD_GlcNHglycan	447	450	PF01048	0.596
MOD_GlcNHglycan	482	487	PF01048	0.737
MOD_GlcNHglycan	504	507	PF01048	0.732
MOD_GlcNHglycan	57	60	PF01048	0.598
MOD_GSK3_1	149	156	PF00069	0.321
MOD_GSK3_1	209	216	PF00069	0.335
MOD_GSK3_1	302	309	PF00069	0.320
MOD_GSK3_1	477	484	PF00069	0.515
MOD_GSK3_1	494	501	PF00069	0.611
MOD_GSK3_1	63	70	PF00069	0.425
MOD_GSK3_1	91	98	PF00069	0.363
MOD_N-GLC_1	141	146	PF02516	0.532
MOD_N-GLC_1	264	269	PF02516	0.535
MOD_N-GLC_1	63	68	PF02516	0.620
MOD_N-GLC_2	389	391	PF02516	0.568
MOD_NEK2_1	160	165	PF00069	0.357
MOD_NEK2_1	171	176	PF00069	0.359
MOD_NEK2_1	302	307	PF00069	0.360
MOD_NEK2_1	445	450	PF00069	0.408
MOD_NEK2_1	498	503	PF00069	0.548
MOD_NEK2_1	7	12	PF00069	0.464
MOD_NEK2_1	91	96	PF00069	0.341
MOD_NEK2_2	220	225	PF00069	0.378
MOD_OFUCOSY	468	475	PF10250	0.650
MOD_PIKK_1	162	168	PF00454	0.391
MOD_PKA_1	251	257	PF00069	0.216
MOD_PKA_1	494	500	PF00069	0.425
MOD_PKA_2	120	126	PF00069	0.341
MOD_PKA_2	251	257	PF00069	0.352
MOD_PKA_2	498	504	PF00069	0.570
MOD_PKA_2	544	550	PF00069	0.656
MOD_PKB_1	93	101	PF00069	0.408
MOD_Plk_1	141	147	PF00069	0.382
MOD_Plk_1	307	313	PF00069	0.325
MOD_Plk_2-3	415	421	PF00069	0.275
MOD_Plk_4	142	148	PF00069	0.350
MOD_Plk_4	252	258	PF00069	0.306
MOD_Plk_4	98	104	PF00069	0.347
MOD_ProDKin_1	102	108	PF00069	0.361
MOD_ProDKin_1	319	325	PF00069	0.296
MOD_ProDKin_1	356	362	PF00069	0.381
MOD_ProDKin_1	430	436	PF00069	0.420
MOD_ProDKin_1	69	75	PF00069	0.417
MOD_SUMO_rev_2	359	364	PF00179	0.297
MOD_SUMO_rev_2	487	497	PF00179	0.433
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.325
TRG_ENDOCYTIC_2	147	150	PF00928	0.346
TRG_ENDOCYTIC_2	240	243	PF00928	0.382
TRG_ENDOCYTIC_2	299	302	PF00928	0.377
TRG_ENDOCYTIC_2	348	351	PF00928	0.368
TRG_ENDOCYTIC_2	411	414	PF00928	0.363
TRG_ENDOCYTIC_2	543	546	PF00928	0.692
TRG_ER_diArg_1	536	538	PF00400	0.633
TRG_ER_diArg_1	92	95	PF00400	0.370
TRG_NES_CRM1_1	324	337	PF08389	0.394
TRG_NLS_MonoCore_2	534	539	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	63%	100%
A0A0N1I756	Leptomonas seymouri	40%	100%
A0A0N1PEH4	Leptomonas seymouri	38%	100%
A0A0S4IRF5	Bodo saltans	23%	85%
A0A0S4IV77	Bodo saltans	36%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	25%	100%
A0A0S4JW09	Bodo saltans	30%	100%
A0A1X0NNY4	Trypanosomatidae	34%	100%
A0A1X0NQL4	Trypanosomatidae	30%	100%
A0A1X0NY34	Trypanosomatidae	24%	100%
A0A1X0P7V5	Trypanosomatidae	45%	100%
A0A3Q8IR23	Leishmania donovani	100%	100%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	42%	100%
A0A3R7MHJ7	Trypanosoma rangeli	30%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	51%	100%
A0A3S7X1W4	Leishmania donovani	46%	100%
A4HCZ0	Leishmania braziliensis	50%	100%
A4HGW8	Leishmania braziliensis	46%	100%
A4HPC1	Leishmania braziliensis	40%	100%
A4HPC5	Leishmania braziliensis	81%	100%
A4HQG6	Leishmania braziliensis	37%	100%
A4HQG9	Leishmania braziliensis	36%	100%
A4I0H5	Leishmania infantum	51%	100%
A4I3Z8	Leishmania infantum	47%	100%
A4ICA5	Leishmania infantum	36%	100%
A4ICG3	Leishmania infantum	38%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q0A9	Leishmania major	27%	91%
Q4Q1G2	Leishmania major	94%	100%
Q4Q1G4	Leishmania major	39%	100%
Q4Q7Z7	Leishmania major	47%	100%
Q4QB35	Leishmania major	50%	100%
V5BCI2	Trypanosoma cruzi	26%	100%
V5BIM1	Trypanosoma cruzi	24%	100%
V5BK91	Trypanosoma cruzi	41%	100%
V5BL75	Trypanosoma cruzi	30%	100%