Membrane-bound acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase precursor

Species:

Leishmania infantum

UniProt:

A4ICG3_LEIIN

TriTrypDb:

LINF_360033500

Length:

514

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Annotations by Jardim et al.

Phosphatase, Membrane-bound acid phosphatase MBAP

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 4
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	29

Expansion

Sequence features

A4ICG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICG3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003993	acid phosphatase activity	6	2
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.236
CLV_C14_Caspase3-7	329	333	PF00656	0.394
CLV_NRD_NRD_1	2	4	PF00675	0.616
CLV_NRD_NRD_1	434	436	PF00675	0.490
CLV_PCSK_KEX2_1	2	4	PF00082	0.647
CLV_PCSK_KEX2_1	499	501	PF00082	0.358
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.419
CLV_PCSK_SKI1_1	125	129	PF00082	0.511
CLV_PCSK_SKI1_1	369	373	PF00082	0.565
CLV_PCSK_SKI1_1	502	506	PF00082	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_CDC14_PxL_1	224	232	PF14671	0.418
DOC_CYCLIN_RxL_1	122	132	PF00134	0.304
DOC_MAPK_gen_1	505	514	PF00069	0.635
DOC_MAPK_MEF2A_6	10	19	PF00069	0.545
DOC_PP1_RVXF_1	1	8	PF00149	0.628
DOC_PP2B_LxvP_1	25	28	PF13499	0.489
DOC_PP4_MxPP_1	315	318	PF00568	0.343
DOC_SPAK_OSR1_1	339	343	PF12202	0.209
DOC_USP7_MATH_1	129	133	PF00917	0.346
DOC_USP7_MATH_1	242	246	PF00917	0.313
DOC_USP7_MATH_1	334	338	PF00917	0.445
DOC_USP7_MATH_1	461	465	PF00917	0.450
DOC_USP7_MATH_1	470	474	PF00917	0.438
DOC_USP7_UBL2_3	499	503	PF12436	0.546
DOC_WW_Pin1_4	298	303	PF00397	0.298
DOC_WW_Pin1_4	396	401	PF00397	0.321
DOC_WW_Pin1_4	42	47	PF00397	0.258
DOC_WW_Pin1_4	466	471	PF00397	0.524
LIG_14-3-3_CanoR_1	109	117	PF00244	0.306
LIG_14-3-3_CanoR_1	390	400	PF00244	0.305
LIG_14-3-3_CanoR_1	81	91	PF00244	0.359
LIG_APCC_ABBA_1	382	387	PF00400	0.320
LIG_BIR_III_4	370	374	PF00653	0.419
LIG_BIR_III_4	419	423	PF00653	0.376
LIG_BRCT_BRCA1_1	131	135	PF00533	0.305
LIG_BRCT_BRCA1_1	193	197	PF00533	0.349
LIG_BRCT_BRCA1_1	243	247	PF00533	0.326
LIG_BRCT_BRCA1_1	336	340	PF00533	0.410
LIG_Clathr_ClatBox_1	179	183	PF01394	0.217
LIG_Clathr_ClatBox_1	411	415	PF01394	0.234
LIG_eIF4E_1	266	272	PF01652	0.347
LIG_eIF4E_1	405	411	PF01652	0.210
LIG_FHA_1	109	115	PF00498	0.339
LIG_FHA_1	219	225	PF00498	0.369
LIG_FHA_1	319	325	PF00498	0.321
LIG_FHA_1	356	362	PF00498	0.334
LIG_FHA_1	377	383	PF00498	0.326
LIG_FHA_1	401	407	PF00498	0.340
LIG_FHA_2	384	390	PF00498	0.295
LIG_GBD_Chelix_1	268	276	PF00786	0.482
LIG_LIR_Apic_2	403	408	PF02991	0.316
LIG_LIR_Gen_1	338	345	PF02991	0.386
LIG_LIR_Gen_1	386	396	PF02991	0.263
LIG_LIR_Nem_3	132	138	PF02991	0.332
LIG_LIR_Nem_3	338	344	PF02991	0.387
LIG_LIR_Nem_3	386	391	PF02991	0.284
LIG_LIR_Nem_3	496	501	PF02991	0.462
LIG_LIR_Nem_3	92	98	PF02991	0.390
LIG_LIR_Nem_3	99	103	PF02991	0.402
LIG_MLH1_MIPbox_1	131	135	PF16413	0.361
LIG_NRBOX	267	273	PF00104	0.347
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.222
LIG_PDZ_Class_2	509	514	PF00595	0.535
LIG_Pex14_2	319	323	PF04695	0.270
LIG_Pex14_2	60	64	PF04695	0.216
LIG_Pex14_2	96	100	PF04695	0.216
LIG_SH2_CRK	501	505	PF00017	0.617
LIG_SH2_PTP2	341	344	PF00017	0.370
LIG_SH2_SRC	291	294	PF00017	0.310
LIG_SH2_SRC	405	408	PF00017	0.310
LIG_SH2_SRC	448	451	PF00017	0.380
LIG_SH2_STAP1	291	295	PF00017	0.289
LIG_SH2_STAT3	67	70	PF00017	0.347
LIG_SH2_STAT5	107	110	PF00017	0.279
LIG_SH2_STAT5	201	204	PF00017	0.360
LIG_SH2_STAT5	341	344	PF00017	0.330
LIG_SH2_STAT5	376	379	PF00017	0.279
LIG_SH2_STAT5	405	408	PF00017	0.277
LIG_SH2_STAT5	448	451	PF00017	0.337
LIG_SH2_STAT5	79	82	PF00017	0.301
LIG_SH2_STAT5	84	87	PF00017	0.303
LIG_SH2_STAT5	95	98	PF00017	0.374
LIG_SH3_3	394	400	PF00018	0.259
LIG_SH3_3	464	470	PF00018	0.501
LIG_SH3_3	88	94	PF00018	0.356
LIG_Sin3_3	269	276	PF02671	0.202
LIG_SUMO_SIM_par_1	301	306	PF11976	0.364
LIG_SUMO_SIM_par_1	323	329	PF11976	0.305
LIG_TRAF2_1	164	167	PF00917	0.378
MOD_CK1_1	355	361	PF00069	0.348
MOD_CK1_1	439	445	PF00069	0.331
MOD_CK1_1	469	475	PF00069	0.435
MOD_CK1_1	506	512	PF00069	0.614
MOD_CK1_1	89	95	PF00069	0.377
MOD_CK2_1	307	313	PF00069	0.213
MOD_CK2_1	383	389	PF00069	0.375
MOD_GlcNHglycan	118	121	PF01048	0.505
MOD_GlcNHglycan	19	22	PF01048	0.607
MOD_GlcNHglycan	292	296	PF01048	0.526
MOD_GlcNHglycan	348	351	PF01048	0.570
MOD_GlcNHglycan	472	475	PF01048	0.626
MOD_GSK3_1	101	108	PF00069	0.287
MOD_GSK3_1	238	245	PF00069	0.301
MOD_GSK3_1	291	298	PF00069	0.293
MOD_GSK3_1	303	310	PF00069	0.278
MOD_GSK3_1	355	362	PF00069	0.359
MOD_GSK3_1	372	379	PF00069	0.300
MOD_GSK3_1	391	398	PF00069	0.258
MOD_GSK3_1	461	468	PF00069	0.442
MOD_GSK3_1	82	89	PF00069	0.360
MOD_N-GLC_1	101	106	PF02516	0.536
MOD_N-GLC_1	129	134	PF02516	0.562
MOD_N-GLC_1	199	204	PF02516	0.584
MOD_N-GLC_1	251	256	PF02516	0.540
MOD_N-GLC_1	355	360	PF02516	0.519
MOD_N-GLC_1	392	397	PF02516	0.444
MOD_N-GLC_1	423	428	PF02516	0.552
MOD_N-GLC_1	439	444	PF02516	0.575
MOD_N-GLC_1	461	466	PF02516	0.695
MOD_N-GLC_1	50	55	PF02516	0.534
MOD_N-GLC_2	381	383	PF02516	0.513
MOD_NEK2_1	103	108	PF00069	0.307
MOD_NEK2_1	148	153	PF00069	0.351
MOD_NEK2_1	271	276	PF00069	0.335
MOD_NEK2_1	303	308	PF00069	0.261
MOD_NEK2_1	359	364	PF00069	0.362
MOD_NEK2_1	391	396	PF00069	0.239
MOD_NEK2_2	199	204	PF00069	0.376
MOD_NEK2_2	400	405	PF00069	0.308
MOD_OFUCOSY	438	443	PF10250	0.527
MOD_PIKK_1	191	197	PF00454	0.222
MOD_PKA_2	108	114	PF00069	0.313
MOD_PKA_2	281	287	PF00069	0.420
MOD_PKA_2	82	88	PF00069	0.327
MOD_Plk_1	101	107	PF00069	0.307
MOD_Plk_1	199	205	PF00069	0.361
MOD_Plk_1	296	302	PF00069	0.296
MOD_Plk_1	308	314	PF00069	0.324
MOD_Plk_1	355	361	PF00069	0.309
MOD_Plk_1	423	429	PF00069	0.398
MOD_Plk_1	462	468	PF00069	0.467
MOD_Plk_1	50	56	PF00069	0.322
MOD_Plk_1	86	92	PF00069	0.357
MOD_Plk_2-3	326	332	PF00069	0.218
MOD_Plk_4	148	154	PF00069	0.297
MOD_Plk_4	372	378	PF00069	0.306
MOD_Plk_4	50	56	PF00069	0.327
MOD_Plk_4	96	102	PF00069	0.337
MOD_ProDKin_1	298	304	PF00069	0.298
MOD_ProDKin_1	396	402	PF00069	0.317
MOD_ProDKin_1	42	48	PF00069	0.258
MOD_ProDKin_1	466	472	PF00069	0.517
MOD_SUMO_for_1	164	167	PF00179	0.223
TRG_DiLeu_BaEn_1	144	149	PF01217	0.302
TRG_DiLeu_BaEn_4	144	150	PF01217	0.187
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.394
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.379
TRG_DiLeu_LyEn_5	225	230	PF01217	0.350
TRG_ENDOCYTIC_2	341	344	PF00928	0.347
TRG_ENDOCYTIC_2	501	504	PF00928	0.630
TRG_ER_diArg_1	1	3	PF00400	0.564
TRG_ER_diArg_1	157	160	PF00400	0.316
TRG_ER_diArg_1	203	206	PF00400	0.360
TRG_ER_diArg_1	80	83	PF00400	0.336
TRG_NES_CRM1_1	313	326	PF08389	0.295
TRG_NLS_MonoExtC_3	498	503	PF00514	0.478
TRG_NLS_MonoExtN_4	499	506	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	36%	90%
A0A0N1I756	Leptomonas seymouri	65%	99%
A0A0N1PEH4	Leptomonas seymouri	39%	100%
A0A0S4IRF5	Bodo saltans	26%	77%
A0A0S4IUV8	Bodo saltans	26%	100%
A0A0S4IV77	Bodo saltans	34%	99%
A0A0S4JEA9	Bodo saltans	24%	100%
A0A0S4JJK3	Bodo saltans	29%	100%
A0A0S4JW09	Bodo saltans	28%	100%
A0A1X0NNY4	Trypanosomatidae	36%	93%
A0A1X0NQL4	Trypanosomatidae	27%	94%
A0A1X0NY34	Trypanosomatidae	27%	100%
A0A1X0P7V5	Trypanosomatidae	40%	98%
A0A3Q8IR23	Leishmania donovani	38%	90%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	38%	99%
A0A3R7MHJ7	Trypanosoma rangeli	27%	100%
A0A3S5H827	Leishmania donovani	100%	100%
A0A3S7WXU0	Leishmania donovani	39%	97%
A0A3S7X1W4	Leishmania donovani	35%	94%
A4HCZ0	Leishmania braziliensis	39%	100%
A4HGW8	Leishmania braziliensis	36%	100%
A4HPC1	Leishmania braziliensis	70%	100%
A4HPC5	Leishmania braziliensis	38%	100%
A4HQG6	Leishmania braziliensis	39%	100%
A4HQG9	Leishmania braziliensis	38%	100%
A4I0H5	Leishmania infantum	39%	100%
A4I3Z8	Leishmania infantum	35%	100%
A4ICA5	Leishmania infantum	36%	100%
A4ICG5	Leishmania infantum	38%	90%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
P11117	Homo sapiens	27%	100%
P24638	Mus musculus	25%	100%
Q4Q0A9	Leishmania major	29%	100%
Q4Q1G2	Leishmania major	38%	100%
Q4Q1G4	Leishmania major	93%	100%
Q4Q7Z7	Leishmania major	34%	100%
Q4QB35	Leishmania major	39%	100%
Q5NVF6	Pongo abelii	26%	100%
V5BCI2	Trypanosoma cruzi	27%	100%
V5BK91	Trypanosoma cruzi	39%	100%
V5BL75	Trypanosoma cruzi	28%	100%