LeishMANIAdb
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Putative DEAD/DEAH box helicase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative DEAD/DEAH box helicase
Gene product:
ATP-dependent DEAD/H RNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4ICF9_LEIIN
TriTrypDb:
LINF_360032700 *
Length:
598

Annotations

Annotations by Jardim et al.

Helicases, DEAD/DEAH box helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 3
Forrest at al. (metacyclic) no yes: 5
Forrest at al. (procyclic) no yes: 5
Silverman et al. no yes: 0
Pissara et al. no yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 22
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 3
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005634 nucleus 5 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0034399 nuclear periphery 2 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097165 nuclear stress granule 4 1
GO:0099080 supramolecular complex 2 1

Expansion

Sequence features

A4ICF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF9

Function

Biological processes
Term Name Level Count
GO:0002183 cytoplasmic translational initiation 4 1
GO:0006412 translation 4 1
GO:0006413 translational initiation 3 1
GO:0006518 peptide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 2
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:0000027 ribosomal large subunit assembly 7 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1902775 mitochondrial large ribosomal subunit assembly 8 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 24
GO:0003676 nucleic acid binding 3 24
GO:0003824 catalytic activity 1 24
GO:0004386 helicase activity 2 24
GO:0005488 binding 1 24
GO:0005524 ATP binding 5 24
GO:0017076 purine nucleotide binding 4 24
GO:0030554 adenyl nucleotide binding 5 24
GO:0032553 ribonucleotide binding 3 24
GO:0032555 purine ribonucleotide binding 4 24
GO:0032559 adenyl ribonucleotide binding 5 24
GO:0035639 purine ribonucleoside triphosphate binding 4 24
GO:0036094 small molecule binding 2 24
GO:0043167 ion binding 2 24
GO:0043168 anion binding 3 24
GO:0097159 organic cyclic compound binding 2 24
GO:0097367 carbohydrate derivative binding 2 24
GO:0140640 catalytic activity, acting on a nucleic acid 2 24
GO:0140657 ATP-dependent activity 1 24
GO:1901265 nucleoside phosphate binding 3 24
GO:1901363 heterocyclic compound binding 2 24
GO:0003724 RNA helicase activity 3 9
GO:0003743 translation initiation factor activity 4 9
GO:0008135 translation factor activity, RNA binding 3 9
GO:0008186 ATP-dependent activity, acting on RNA 2 9
GO:0016787 hydrolase activity 2 13
GO:0045182 translation regulator activity 1 9
GO:0090079 translation regulator activity, nucleic acid binding 2 9
GO:0140098 catalytic activity, acting on RNA 3 9
GO:0003723 RNA binding 4 3
GO:0016462 pyrophosphatase activity 5 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 112 114 PF00675 0.288
CLV_NRD_NRD_1 166 168 PF00675 0.237
CLV_NRD_NRD_1 221 223 PF00675 0.264
CLV_NRD_NRD_1 253 255 PF00675 0.281
CLV_NRD_NRD_1 288 290 PF00675 0.172
CLV_NRD_NRD_1 33 35 PF00675 0.358
CLV_NRD_NRD_1 564 566 PF00675 0.595
CLV_NRD_NRD_1 581 583 PF00675 0.732
CLV_PCSK_FUR_1 562 566 PF00082 0.494
CLV_PCSK_KEX2_1 112 114 PF00082 0.247
CLV_PCSK_KEX2_1 166 168 PF00082 0.237
CLV_PCSK_KEX2_1 288 290 PF00082 0.218
CLV_PCSK_KEX2_1 35 37 PF00082 0.345
CLV_PCSK_KEX2_1 564 566 PF00082 0.602
CLV_PCSK_KEX2_1 581 583 PF00082 0.641
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.334
CLV_PCSK_PC7_1 162 168 PF00082 0.277
CLV_PCSK_SKI1_1 277 281 PF00082 0.215
CLV_PCSK_SKI1_1 292 296 PF00082 0.205
CLV_PCSK_SKI1_1 309 313 PF00082 0.381
CLV_PCSK_SKI1_1 317 321 PF00082 0.321
CLV_PCSK_SKI1_1 38 42 PF00082 0.444
CLV_PCSK_SKI1_1 520 524 PF00082 0.302
CLV_PCSK_SKI1_1 55 59 PF00082 0.180
DEG_APCC_DBOX_1 221 229 PF00400 0.436
DEG_APCC_DBOX_1 24 32 PF00400 0.288
DEG_APCC_DBOX_1 316 324 PF00400 0.336
DEG_APCC_DBOX_1 373 381 PF00400 0.452
DEG_SPOP_SBC_1 361 365 PF00917 0.446
DOC_CYCLIN_RxL_1 288 298 PF00134 0.401
DOC_CYCLIN_RxL_1 307 315 PF00134 0.349
DOC_CYCLIN_yClb1_LxF_4 290 295 PF00134 0.375
DOC_CYCLIN_yCln2_LP_2 323 329 PF00134 0.567
DOC_CYCLIN_yCln2_LP_2 535 538 PF00134 0.380
DOC_MAPK_gen_1 162 171 PF00069 0.421
DOC_MAPK_gen_1 285 295 PF00069 0.418
DOC_MAPK_JIP1_4 289 295 PF00069 0.403
DOC_PP1_RVXF_1 290 296 PF00149 0.371
DOC_PP1_RVXF_1 376 383 PF00149 0.345
DOC_PP1_RVXF_1 390 396 PF00149 0.238
DOC_PP1_RVXF_1 405 412 PF00149 0.482
DOC_PP1_RVXF_1 467 474 PF00149 0.395
DOC_PP1_SILK_1 21 26 PF00149 0.309
DOC_PP2B_LxvP_1 323 326 PF13499 0.403
DOC_PP2B_LxvP_1 535 538 PF13499 0.342
DOC_PP4_FxxP_1 147 150 PF00568 0.453
DOC_PP4_FxxP_1 513 516 PF00568 0.282
DOC_PP4_FxxP_1 557 560 PF00568 0.424
DOC_USP7_MATH_1 148 152 PF00917 0.492
DOC_USP7_MATH_1 160 164 PF00917 0.515
DOC_USP7_MATH_1 332 336 PF00917 0.487
DOC_USP7_MATH_1 441 445 PF00917 0.420
DOC_USP7_MATH_1 544 548 PF00917 0.367
DOC_USP7_MATH_1 569 573 PF00917 0.542
DOC_WW_Pin1_4 17 22 PF00397 0.433
DOC_WW_Pin1_4 235 240 PF00397 0.493
DOC_WW_Pin1_4 342 347 PF00397 0.640
DOC_WW_Pin1_4 38 43 PF00397 0.379
DOC_WW_Pin1_4 570 575 PF00397 0.542
LIG_14-3-3_CanoR_1 248 254 PF00244 0.440
LIG_14-3-3_CanoR_1 454 462 PF00244 0.500
LIG_Actin_WH2_2 69 84 PF00022 0.414
LIG_AP2alpha_1 548 552 PF02296 0.432
LIG_APCC_ABBA_1 128 133 PF00400 0.477
LIG_BRCT_BRCA1_1 196 200 PF00533 0.414
LIG_BRCT_BRCA1_1 314 318 PF00533 0.300
LIG_EH1_1 206 214 PF00400 0.403
LIG_eIF4E_1 71 77 PF01652 0.477
LIG_FHA_1 397 403 PF00498 0.463
LIG_FHA_1 457 463 PF00498 0.474
LIG_FHA_1 571 577 PF00498 0.616
LIG_FHA_2 484 490 PF00498 0.458
LIG_FHA_2 95 101 PF00498 0.451
LIG_LIR_Apic_2 145 150 PF02991 0.453
LIG_LIR_Apic_2 512 516 PF02991 0.276
LIG_LIR_Apic_2 555 560 PF02991 0.421
LIG_LIR_Gen_1 12 21 PF02991 0.500
LIG_LIR_Gen_1 315 326 PF02991 0.372
LIG_LIR_Gen_1 547 556 PF02991 0.505
LIG_LIR_Nem_3 12 16 PF02991 0.412
LIG_LIR_Nem_3 197 203 PF02991 0.516
LIG_LIR_Nem_3 315 321 PF02991 0.326
LIG_LIR_Nem_3 472 476 PF02991 0.395
LIG_LIR_Nem_3 53 57 PF02991 0.469
LIG_LIR_Nem_3 547 551 PF02991 0.541
LIG_NRBOX 75 81 PF00104 0.477
LIG_OCRL_FandH_1 199 211 PF00620 0.403
LIG_PCNA_PIPBox_1 588 597 PF02747 0.498
LIG_Pex14_2 548 552 PF04695 0.432
LIG_PTB_Apo_2 551 558 PF02174 0.460
LIG_SH2_CRK 37 41 PF00017 0.486
LIG_SH2_CRK 482 486 PF00017 0.451
LIG_SH2_CRK 73 77 PF00017 0.477
LIG_SH2_NCK_1 482 486 PF00017 0.451
LIG_SH2_SRC 71 74 PF00017 0.506
LIG_SH2_STAP1 73 77 PF00017 0.477
LIG_SH2_STAT3 528 531 PF00017 0.451
LIG_SH2_STAT3 543 546 PF00017 0.337
LIG_SH2_STAT5 131 134 PF00017 0.403
LIG_SH2_STAT5 224 227 PF00017 0.466
LIG_SH2_STAT5 420 423 PF00017 0.434
LIG_SH2_STAT5 478 481 PF00017 0.439
LIG_SH2_STAT5 509 512 PF00017 0.272
LIG_SH2_STAT5 528 531 PF00017 0.490
LIG_SH2_STAT5 71 74 PF00017 0.441
LIG_SH3_2 560 565 PF14604 0.511
LIG_SH3_3 175 181 PF00018 0.470
LIG_SH3_3 182 188 PF00018 0.513
LIG_SH3_3 233 239 PF00018 0.522
LIG_SH3_3 284 290 PF00018 0.520
LIG_SH3_3 343 349 PF00018 0.696
LIG_SH3_3 557 563 PF00018 0.449
LIG_SUMO_SIM_par_1 14 20 PF11976 0.395
LIG_SUMO_SIM_par_1 48 53 PF11976 0.414
LIG_TRAF2_1 217 220 PF00917 0.416
LIG_TYR_ITIM 302 307 PF00017 0.321
LIG_TYR_ITIM 52 57 PF00017 0.477
LIG_UBA3_1 242 250 PF00899 0.403
LIG_UBA3_1 279 285 PF00899 0.431
LIG_UBA3_1 76 82 PF00899 0.477
LIG_WRC_WIRS_1 115 120 PF05994 0.403
LIG_WRC_WIRS_1 510 515 PF05994 0.342
LIG_WW_3 536 540 PF00397 0.307
MOD_CDC14_SPxK_1 345 348 PF00782 0.493
MOD_CDK_SPxK_1 342 348 PF00069 0.492
MOD_CK1_1 194 200 PF00069 0.415
MOD_CK1_1 238 244 PF00069 0.403
MOD_CK1_1 336 342 PF00069 0.562
MOD_CK1_1 439 445 PF00069 0.424
MOD_CK2_1 132 138 PF00069 0.451
MOD_CK2_1 148 154 PF00069 0.420
MOD_CK2_1 174 180 PF00069 0.405
MOD_CK2_1 213 219 PF00069 0.409
MOD_CK2_1 441 447 PF00069 0.465
MOD_CK2_1 483 489 PF00069 0.440
MOD_DYRK1A_RPxSP_1 38 42 PF00069 0.312
MOD_GlcNHglycan 150 153 PF01048 0.192
MOD_GlcNHglycan 196 199 PF01048 0.202
MOD_GlcNHglycan 216 219 PF01048 0.241
MOD_GlcNHglycan 443 446 PF01048 0.249
MOD_GSK3_1 19 26 PF00069 0.419
MOD_GSK3_1 332 339 PF00069 0.627
MOD_GSK3_1 360 367 PF00069 0.530
MOD_GSK3_1 432 439 PF00069 0.401
MOD_GSK3_1 452 459 PF00069 0.483
MOD_GSK3_1 461 468 PF00069 0.467
MOD_GSK3_1 483 490 PF00069 0.422
MOD_N-GLC_1 432 437 PF02516 0.306
MOD_N-GLC_1 570 575 PF02516 0.701
MOD_NEK2_1 174 179 PF00069 0.462
MOD_NEK2_1 295 300 PF00069 0.466
MOD_NEK2_1 337 342 PF00069 0.494
MOD_NEK2_1 362 367 PF00069 0.489
MOD_NEK2_1 396 401 PF00069 0.482
MOD_NEK2_1 411 416 PF00069 0.451
MOD_NEK2_1 452 457 PF00069 0.496
MOD_NEK2_1 552 557 PF00069 0.419
MOD_NEK2_2 509 514 PF00069 0.253
MOD_PIKK_1 191 197 PF00454 0.405
MOD_PIKK_1 23 29 PF00454 0.309
MOD_PIKK_1 427 433 PF00454 0.498
MOD_PKA_2 213 219 PF00069 0.408
MOD_Plk_1 132 138 PF00069 0.456
MOD_Plk_1 432 438 PF00069 0.524
MOD_Plk_2-3 483 489 PF00069 0.422
MOD_Plk_4 114 120 PF00069 0.403
MOD_Plk_4 19 25 PF00069 0.427
MOD_Plk_4 238 244 PF00069 0.411
MOD_Plk_4 255 261 PF00069 0.490
MOD_Plk_4 457 463 PF00069 0.493
MOD_Plk_4 509 515 PF00069 0.310
MOD_Plk_4 544 550 PF00069 0.394
MOD_Plk_4 552 558 PF00069 0.406
MOD_Plk_4 72 78 PF00069 0.405
MOD_ProDKin_1 17 23 PF00069 0.435
MOD_ProDKin_1 235 241 PF00069 0.493
MOD_ProDKin_1 342 348 PF00069 0.640
MOD_ProDKin_1 38 44 PF00069 0.285
MOD_ProDKin_1 570 576 PF00069 0.544
TRG_DiLeu_BaEn_1 180 185 PF01217 0.395
TRG_DiLeu_BaLyEn_6 289 294 PF01217 0.395
TRG_ENDOCYTIC_2 131 134 PF00928 0.403
TRG_ENDOCYTIC_2 304 307 PF00928 0.295
TRG_ENDOCYTIC_2 37 40 PF00928 0.437
TRG_ENDOCYTIC_2 511 514 PF00928 0.301
TRG_ENDOCYTIC_2 54 57 PF00928 0.549
TRG_ENDOCYTIC_2 73 76 PF00928 0.487
TRG_ER_diArg_1 287 289 PF00400 0.372
TRG_ER_diArg_1 34 37 PF00400 0.399
TRG_ER_diArg_1 538 541 PF00400 0.356
TRG_ER_diArg_1 562 565 PF00400 0.637
TRG_ER_diArg_1 580 582 PF00400 0.637
TRG_NLS_MonoExtN_4 34 39 PF00514 0.339
TRG_Pf-PMV_PEXEL_1 201 206 PF00026 0.330

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWK5 Leptomonas seymouri 20% 76%
A0A0N1I1U1 Leptomonas seymouri 23% 77%
A0A0N1I458 Leptomonas seymouri 73% 100%
A0A0N1I5R1 Leptomonas seymouri 20% 75%
A0A0N1I7N1 Leptomonas seymouri 24% 96%
A0A0S4IX79 Bodo saltans 24% 82%
A0A0S4JPF4 Bodo saltans 39% 86%
A0A1X0P7J3 Trypanosomatidae 56% 86%
A0A3Q8ID91 Leishmania donovani 26% 100%
A0A3Q8IEU7 Leishmania donovani 25% 100%
A0A3Q8IF94 Leishmania donovani 26% 97%
A0A3Q8IG57 Leishmania donovani 100% 76%
A0A3S5H4X0 Leishmania donovani 27% 100%
A1D405 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 25% 100%
A4HGR1 Leishmania braziliensis 27% 100%
A4HK20 Leishmania braziliensis 26% 100%
A4HPB9 Leishmania braziliensis 88% 100%
A4HRK0 Leishmania infantum 27% 100%
A4I3T6 Leishmania infantum 26% 100%
A4I7K4 Leishmania infantum 26% 100%
A4IAT7 Leishmania infantum 25% 100%
A7EML8 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 25% 100%
B1KQF6 Shewanella woodyi (strain ATCC 51908 / MS32) 22% 100%
C9ZNU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 93%
D0A127 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 100%
D0A3C9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 87%
E9AEL4 Leishmania major 25% 100%
E9AJG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AT30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B028 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B2G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B5S5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
O13370 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 94%
O62591 Leishmania major 27% 100%
Q0DB53 Oryza sativa subsp. japonica 26% 99%
Q1DMX8 Coccidioides immitis (strain RS) 26% 73%
Q1E1N5 Coccidioides immitis (strain RS) 25% 100%
Q25225 Leishmania braziliensis 26% 100%
Q2UH00 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 26% 74%
Q3MSQ8 Pelophylax lessonae 23% 83%
Q4I7F9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 25% 83%
Q4JG17 Penaeus vannamei 25% 85%
Q4Q1G8 Leishmania major 95% 100%
Q4Q5P5 Leishmania major 26% 100%
Q4Q858 Leishmania major 26% 100%
Q4R5S7 Macaca fascicularis 23% 82%
Q4WJE9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 100%
Q53RK8 Oryza sativa subsp. japonica 26% 81%
Q5BCU6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 76%
Q5W5U4 Bos taurus 24% 82%
Q61496 Mus musculus 24% 85%
Q64060 Rattus norvegicus 23% 84%
Q6CXB7 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 23% 100%
Q6GWX0 Sus scrofa 24% 83%
Q6YS30 Oryza sativa subsp. japonica 23% 100%
Q7S5R1 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 97%
Q814I2 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 24% 100%
Q8TFK8 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 24% 97%
Q91372 Xenopus laevis 25% 85%
Q91VN6 Mus musculus 24% 96%
Q9NQI0 Homo sapiens 24% 83%
Q9UJV9 Homo sapiens 24% 96%
V5D8J9 Trypanosoma cruzi 57% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS