Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4ICF8_LEIIN

TriTrypDb:

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.567
CLV_NRD_NRD_1	342	344	PF00675	0.642
CLV_PCSK_KEX2_1	256	258	PF00082	0.567
CLV_PCSK_KEX2_1	341	343	PF00082	0.682
CLV_PCSK_SKI1_1	202	206	PF00082	0.528
CLV_PCSK_SKI1_1	250	254	PF00082	0.512
CLV_PCSK_SKI1_1	256	260	PF00082	0.516
CLV_PCSK_SKI1_1	296	300	PF00082	0.701
CLV_PCSK_SKI1_1	306	310	PF00082	0.545
CLV_PCSK_SKI1_1	342	346	PF00082	0.690
CLV_PCSK_SKI1_1	61	65	PF00082	0.645
DEG_APCC_DBOX_1	201	209	PF00400	0.538
DOC_CYCLIN_RxL_1	199	206	PF00134	0.532
DOC_CYCLIN_RxL_1	290	302	PF00134	0.613
DOC_CYCLIN_RxL_1	339	348	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.722
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.560
DOC_MAPK_DCC_7	188	198	PF00069	0.683
DOC_MAPK_gen_1	88	97	PF00069	0.453
DOC_MAPK_MEF2A_6	91	99	PF00069	0.449
DOC_PP2B_LxvP_1	187	190	PF13499	0.741
DOC_PP2B_LxvP_1	79	82	PF13499	0.493
DOC_PP4_FxxP_1	28	31	PF00568	0.598
DOC_PP4_FxxP_1	325	328	PF00568	0.603
DOC_USP7_MATH_1	182	186	PF00917	0.713
DOC_USP7_MATH_1	66	70	PF00917	0.500
DOC_WW_Pin1_4	177	182	PF00397	0.686
DOC_WW_Pin1_4	237	242	PF00397	0.665
DOC_WW_Pin1_4	289	294	PF00397	0.676
LIG_14-3-3_CanoR_1	88	94	PF00244	0.398
LIG_14-3-3_CanoR_1	9	17	PF00244	0.441
LIG_BRCT_BRCA1_1	205	209	PF00533	0.426
LIG_FHA_1	128	134	PF00498	0.541
LIG_FHA_1	66	72	PF00498	0.441
LIG_FHA_1	90	96	PF00498	0.444
LIG_FHA_2	3	9	PF00498	0.665
LIG_FHA_2	55	61	PF00498	0.581
LIG_LIR_Apic_2	322	328	PF02991	0.614
LIG_LIR_Gen_1	16	25	PF02991	0.455
LIG_LIR_Gen_1	327	337	PF02991	0.577
LIG_LIR_Gen_1	37	45	PF02991	0.549
LIG_LIR_Gen_1	75	86	PF02991	0.472
LIG_LIR_Nem_3	16	20	PF02991	0.409
LIG_LIR_Nem_3	327	333	PF02991	0.681
LIG_LIR_Nem_3	37	42	PF02991	0.547
LIG_LIR_Nem_3	49	53	PF02991	0.467
LIG_LIR_Nem_3	75	81	PF02991	0.421
LIG_LIR_Nem_3	92	96	PF02991	0.441
LIG_LIR_Nem_3	98	102	PF02991	0.466
LIG_NRP_CendR_1	349	350	PF00754	0.755
LIG_Pex14_2	24	28	PF04695	0.537
LIG_Pex14_2	39	43	PF04695	0.474
LIG_SH2_CRK	17	21	PF00017	0.544
LIG_SH2_STAP1	17	21	PF00017	0.475
LIG_SH2_STAT3	102	105	PF00017	0.505
LIG_SH2_STAT3	266	269	PF00017	0.703
LIG_SH2_STAT5	266	269	PF00017	0.682
LIG_SH2_STAT5	50	53	PF00017	0.522
LIG_SH2_STAT5	78	81	PF00017	0.469
LIG_SH3_1	108	114	PF00018	0.700
LIG_SH3_3	108	114	PF00018	0.700
LIG_SH3_3	175	181	PF00018	0.663
LIG_SH3_3	187	193	PF00018	0.545
LIG_SH3_3	59	65	PF00018	0.560
LIG_SUMO_SIM_par_1	194	199	PF11976	0.553
LIG_SUMO_SIM_par_1	68	76	PF11976	0.566
LIG_TRAF2_1	314	317	PF00917	0.742
LIG_WRC_WIRS_1	96	101	PF05994	0.419
MOD_CDK_SPxxK_3	289	296	PF00069	0.679
MOD_CK1_1	116	122	PF00069	0.686
MOD_CK1_1	155	161	PF00069	0.646
MOD_CK1_1	218	224	PF00069	0.750
MOD_CK2_1	129	135	PF00069	0.773
MOD_CK2_1	165	171	PF00069	0.761
MOD_CK2_1	2	8	PF00069	0.580
MOD_CK2_1	218	224	PF00069	0.586
MOD_CK2_1	242	248	PF00069	0.495
MOD_CK2_1	43	49	PF00069	0.500
MOD_CK2_1	54	60	PF00069	0.347
MOD_CK2_1	77	83	PF00069	0.488
MOD_GlcNHglycan	140	143	PF01048	0.797
MOD_GlcNHglycan	167	170	PF01048	0.774
MOD_GlcNHglycan	213	216	PF01048	0.663
MOD_GlcNHglycan	217	220	PF01048	0.715
MOD_GlcNHglycan	237	240	PF01048	0.647
MOD_GlcNHglycan	273	276	PF01048	0.553
MOD_GlcNHglycan	277	280	PF01048	0.517
MOD_GlcNHglycan	311	314	PF01048	0.623
MOD_GlcNHglycan	75	78	PF01048	0.456
MOD_GSK3_1	116	123	PF00069	0.736
MOD_GSK3_1	129	136	PF00069	0.654
MOD_GSK3_1	152	159	PF00069	0.673
MOD_GSK3_1	173	180	PF00069	0.782
MOD_GSK3_1	211	218	PF00069	0.688
MOD_GSK3_1	271	278	PF00069	0.536
MOD_GSK3_1	73	80	PF00069	0.558
MOD_N-GLC_1	309	314	PF02516	0.637
MOD_NEK2_1	133	138	PF00069	0.741
MOD_NEK2_1	152	157	PF00069	0.578
MOD_NEK2_1	203	208	PF00069	0.544
MOD_NEK2_1	299	304	PF00069	0.534
MOD_NEK2_1	309	314	PF00069	0.595
MOD_NEK2_1	43	48	PF00069	0.438
MOD_NEK2_1	72	77	PF00069	0.441
MOD_NEK2_1	95	100	PF00069	0.411
MOD_NEK2_2	320	325	PF00069	0.604
MOD_PIKK_1	101	107	PF00454	0.518
MOD_PIKK_1	158	164	PF00454	0.739
MOD_PKA_1	256	262	PF00069	0.660
MOD_PKA_2	2	8	PF00069	0.580
MOD_PKA_2	256	262	PF00069	0.660
MOD_PKA_2	32	38	PF00069	0.541
MOD_Plk_1	134	140	PF00069	0.606
MOD_Plk_1	43	49	PF00069	0.508
MOD_Plk_2-3	32	38	PF00069	0.501
MOD_Plk_4	129	135	PF00069	0.732
MOD_Plk_4	320	326	PF00069	0.634
MOD_Plk_4	95	101	PF00069	0.398
MOD_ProDKin_1	177	183	PF00069	0.687
MOD_ProDKin_1	237	243	PF00069	0.656
MOD_ProDKin_1	289	295	PF00069	0.675
MOD_SUMO_rev_2	245	252	PF00179	0.622
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.630
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.683
TRG_ENDOCYTIC_2	17	20	PF00928	0.405
TRG_ENDOCYTIC_2	21	24	PF00928	0.397
TRG_ENDOCYTIC_2	78	81	PF00928	0.543
TRG_ER_diArg_1	255	257	PF00400	0.649
TRG_ER_diArg_1	331	334	PF00400	0.582
TRG_ER_diArg_1	341	343	PF00400	0.581
TRG_NES_CRM1_1	19	32	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y4	Leptomonas seymouri	48%	100%
A0A3S7XB07	Leishmania donovani	99%	100%
A4HPB8	Leishmania braziliensis	81%	100%
E9AT29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1G9	Leishmania major	93%	100%