Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit b-like protein

Species:

Leishmania infantum

UniProt:

A4ICF6_LEIIN

TriTrypDb:

LINF_360032400

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	7
GO:0000417	HIR complex	2	1
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4ICF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006325	chromatin organization	4	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.550
CLV_C14_Caspase3-7	386	390	PF00656	0.426
CLV_C14_Caspase3-7	80	84	PF00656	0.489
CLV_NRD_NRD_1	277	279	PF00675	0.438
CLV_NRD_NRD_1	284	286	PF00675	0.365
CLV_NRD_NRD_1	301	303	PF00675	0.280
CLV_NRD_NRD_1	469	471	PF00675	0.461
CLV_NRD_NRD_1	591	593	PF00675	0.744
CLV_NRD_NRD_1	615	617	PF00675	0.603
CLV_NRD_NRD_1	618	620	PF00675	0.597
CLV_PCSK_FUR_1	467	471	PF00082	0.518
CLV_PCSK_FUR_1	616	620	PF00082	0.586
CLV_PCSK_KEX2_1	277	279	PF00082	0.432
CLV_PCSK_KEX2_1	301	303	PF00082	0.300
CLV_PCSK_KEX2_1	371	373	PF00082	0.726
CLV_PCSK_KEX2_1	469	471	PF00082	0.467
CLV_PCSK_KEX2_1	618	620	PF00082	0.618
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.511
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.618
CLV_PCSK_SKI1_1	189	193	PF00082	0.304
CLV_PCSK_SKI1_1	208	212	PF00082	0.136
CLV_PCSK_SKI1_1	419	423	PF00082	0.310
CLV_PCSK_SKI1_1	510	514	PF00082	0.417
CLV_PCSK_SKI1_1	76	80	PF00082	0.219
CLV_Separin_Fungi	573	579	PF03568	0.471
DEG_SPOP_SBC_1	446	450	PF00917	0.729
DOC_CYCLIN_yClb1_LxF_4	331	337	PF00134	0.372
DOC_MAPK_gen_1	116	124	PF00069	0.430
DOC_MAPK_gen_1	566	574	PF00069	0.500
DOC_MAPK_MEF2A_6	566	574	PF00069	0.476
DOC_PP1_RVXF_1	241	248	PF00149	0.283
DOC_PP1_RVXF_1	299	306	PF00149	0.405
DOC_PP1_RVXF_1	417	424	PF00149	0.293
DOC_PP2B_LxvP_1	312	315	PF13499	0.364
DOC_PP2B_LxvP_1	422	425	PF13499	0.329
DOC_PP4_FxxP_1	427	430	PF00568	0.369
DOC_USP7_MATH_1	152	156	PF00917	0.590
DOC_USP7_MATH_1	158	162	PF00917	0.659
DOC_USP7_MATH_1	556	560	PF00917	0.547
DOC_USP7_MATH_1	576	580	PF00917	0.336
DOC_USP7_MATH_1	629	633	PF00917	0.576
DOC_WW_Pin1_4	126	131	PF00397	0.344
DOC_WW_Pin1_4	303	308	PF00397	0.330
DOC_WW_Pin1_4	551	556	PF00397	0.527
LIG_14-3-3_CanoR_1	116	122	PF00244	0.414
LIG_14-3-3_CanoR_1	252	258	PF00244	0.335
LIG_14-3-3_CanoR_1	413	422	PF00244	0.372
LIG_14-3-3_CanoR_1	500	507	PF00244	0.359
LIG_14-3-3_CanoR_1	510	517	PF00244	0.315
LIG_14-3-3_CanoR_1	569	575	PF00244	0.444
LIG_AP2alpha_2	248	250	PF02296	0.320
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_deltaCOP1_diTrp_1	248	257	PF00928	0.323
LIG_deltaCOP1_diTrp_1	40	45	PF00928	0.477
LIG_FHA_1	190	196	PF00498	0.513
LIG_FHA_1	249	255	PF00498	0.448
LIG_FHA_1	328	334	PF00498	0.564
LIG_FHA_1	36	42	PF00498	0.355
LIG_FHA_1	524	530	PF00498	0.285
LIG_FHA_1	60	66	PF00498	0.426
LIG_FHA_2	172	178	PF00498	0.513
LIG_FHA_2	4	10	PF00498	0.603
LIG_FHA_2	622	628	PF00498	0.575
LIG_FHA_2	64	70	PF00498	0.485
LIG_FHA_2	78	84	PF00498	0.433
LIG_LIR_Gen_1	248	257	PF02991	0.449
LIG_LIR_Gen_1	502	512	PF02991	0.358
LIG_LIR_Gen_1	530	538	PF02991	0.286
LIG_LIR_Nem_3	119	124	PF02991	0.347
LIG_LIR_Nem_3	183	188	PF02991	0.366
LIG_LIR_Nem_3	248	253	PF02991	0.360
LIG_LIR_Nem_3	299	303	PF02991	0.307
LIG_LIR_Nem_3	502	507	PF02991	0.361
LIG_LIR_Nem_3	530	535	PF02991	0.286
LIG_NRBOX	559	565	PF00104	0.519
LIG_PDZ_Class_1	646	651	PF00595	0.562
LIG_Pex14_1	423	427	PF04695	0.324
LIG_Pex14_2	253	257	PF04695	0.411
LIG_SH2_CRK	300	304	PF00017	0.372
LIG_SH2_CRK	316	320	PF00017	0.432
LIG_SH2_PTP2	532	535	PF00017	0.284
LIG_SH2_STAP1	199	203	PF00017	0.451
LIG_SH2_STAP1	525	529	PF00017	0.390
LIG_SH2_STAT5	209	212	PF00017	0.419
LIG_SH2_STAT5	291	294	PF00017	0.402
LIG_SH2_STAT5	396	399	PF00017	0.287
LIG_SH2_STAT5	493	496	PF00017	0.319
LIG_SH2_STAT5	525	528	PF00017	0.284
LIG_SH2_STAT5	532	535	PF00017	0.298
LIG_SH2_STAT5	550	553	PF00017	0.403
LIG_SH3_2	30	35	PF14604	0.422
LIG_SH3_3	27	33	PF00018	0.480
LIG_SH3_3	625	631	PF00018	0.645
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.345
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.664
LIG_TRAF2_1	7	10	PF00917	0.519
LIG_TYR_ITIM	298	303	PF00017	0.452
LIG_TYR_ITIM	314	319	PF00017	0.235
LIG_UBA3_1	333	342	PF00899	0.553
LIG_WRC_WIRS_1	254	259	PF05994	0.304
MOD_CDK_SPxxK_3	551	558	PF00069	0.528
MOD_CK1_1	166	172	PF00069	0.702
MOD_CK1_1	175	181	PF00069	0.370
MOD_CK1_1	204	210	PF00069	0.275
MOD_CK1_1	259	265	PF00069	0.453
MOD_CK1_1	3	9	PF00069	0.604
MOD_CK1_1	358	364	PF00069	0.675
MOD_CK1_1	499	505	PF00069	0.387
MOD_CK1_1	59	65	PF00069	0.441
MOD_CK2_1	158	164	PF00069	0.612
MOD_CK2_1	3	9	PF00069	0.604
MOD_CK2_1	57	63	PF00069	0.589
MOD_CMANNOS	247	250	PF00535	0.309
MOD_Cter_Amidation	368	371	PF01082	0.512
MOD_GlcNHglycan	136	139	PF01048	0.283
MOD_GlcNHglycan	154	157	PF01048	0.486
MOD_GlcNHglycan	168	171	PF01048	0.572
MOD_GlcNHglycan	174	177	PF01048	0.580
MOD_GlcNHglycan	203	206	PF01048	0.312
MOD_GlcNHglycan	211	214	PF01048	0.388
MOD_GlcNHglycan	258	261	PF01048	0.377
MOD_GlcNHglycan	365	369	PF01048	0.619
MOD_GlcNHglycan	551	554	PF01048	0.469
MOD_GlcNHglycan	583	586	PF01048	0.608
MOD_GlcNHglycan	624	627	PF01048	0.702
MOD_GSK3_1	122	129	PF00069	0.415
MOD_GSK3_1	159	166	PF00069	0.707
MOD_GSK3_1	171	178	PF00069	0.529
MOD_GSK3_1	189	196	PF00069	0.388
MOD_GSK3_1	292	299	PF00069	0.414
MOD_GSK3_1	343	350	PF00069	0.611
MOD_GSK3_1	354	361	PF00069	0.610
MOD_GSK3_1	438	445	PF00069	0.725
MOD_GSK3_1	491	498	PF00069	0.474
MOD_GSK3_1	515	522	PF00069	0.371
MOD_GSK3_1	577	584	PF00069	0.571
MOD_GSK3_1	59	66	PF00069	0.435
MOD_LATS_1	508	514	PF00433	0.359
MOD_NEK2_1	117	122	PF00069	0.467
MOD_NEK2_1	134	139	PF00069	0.199
MOD_NEK2_1	171	176	PF00069	0.521
MOD_NEK2_1	224	229	PF00069	0.376
MOD_NEK2_1	232	237	PF00069	0.369
MOD_NEK2_1	253	258	PF00069	0.345
MOD_NEK2_1	264	269	PF00069	0.284
MOD_NEK2_1	447	452	PF00069	0.547
MOD_NEK2_1	538	543	PF00069	0.454
MOD_NEK2_1	57	62	PF00069	0.449
MOD_NEK2_2	343	348	PF00069	0.390
MOD_PIKK_1	438	444	PF00454	0.574
MOD_PIKK_1	455	461	PF00454	0.533
MOD_PKA_2	117	123	PF00069	0.436
MOD_PKA_2	347	353	PF00069	0.436
MOD_PKA_2	499	505	PF00069	0.373
MOD_PKA_2	577	583	PF00069	0.567
MOD_Plk_1	343	349	PF00069	0.497
MOD_Plk_1	355	361	PF00069	0.547
MOD_Plk_1	519	525	PF00069	0.407
MOD_Plk_4	117	123	PF00069	0.417
MOD_Plk_4	215	221	PF00069	0.256
MOD_Plk_4	259	265	PF00069	0.394
MOD_Plk_4	629	635	PF00069	0.550
MOD_ProDKin_1	126	132	PF00069	0.342
MOD_ProDKin_1	303	309	PF00069	0.328
MOD_ProDKin_1	551	557	PF00069	0.526
MOD_SUMO_for_1	270	273	PF00179	0.548
MOD_SUMO_for_1	7	10	PF00179	0.519
MOD_SUMO_rev_2	137	144	PF00179	0.319
MOD_SUMO_rev_2	178	187	PF00179	0.538
TRG_DiLeu_BaEn_1	50	55	PF01217	0.549
TRG_DiLeu_BaEn_4	50	56	PF01217	0.463
TRG_ENDOCYTIC_2	188	191	PF00928	0.256
TRG_ENDOCYTIC_2	300	303	PF00928	0.372
TRG_ENDOCYTIC_2	316	319	PF00928	0.414
TRG_ENDOCYTIC_2	532	535	PF00928	0.284
TRG_ER_diArg_1	277	279	PF00400	0.476
TRG_ER_diArg_1	300	302	PF00400	0.298
TRG_ER_diArg_1	34	37	PF00400	0.359
TRG_ER_diArg_1	467	470	PF00400	0.565
TRG_NLS_MonoCore_2	615	620	PF00514	0.556
TRG_NLS_MonoExtC_3	615	620	PF00514	0.556
TRG_NLS_MonoExtN_4	616	621	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.329
TRG_PTS2	1	45	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV3	Leptomonas seymouri	62%	95%
A0A1X0P8Z1	Trypanosomatidae	47%	100%
A0A3S7XAX4	Leishmania donovani	100%	100%
A0A422NCI3	Trypanosoma rangeli	48%	100%
A4HPB6	Leishmania braziliensis	78%	100%
D0A3C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AT27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O13985	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q4Q1H1	Leishmania major	90%	100%
V5BH36	Trypanosoma cruzi	48%	100%