Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICF4_LEIIN

TriTrypDb:

LINF_360032200

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.543
CLV_NRD_NRD_1	140	142	PF00675	0.555
CLV_NRD_NRD_1	239	241	PF00675	0.582
CLV_NRD_NRD_1	47	49	PF00675	0.433
CLV_NRD_NRD_1	92	94	PF00675	0.482
CLV_PCSK_FUR_1	92	96	PF00082	0.538
CLV_PCSK_KEX2_1	139	141	PF00082	0.577
CLV_PCSK_KEX2_1	18	20	PF00082	0.457
CLV_PCSK_KEX2_1	47	49	PF00082	0.433
CLV_PCSK_KEX2_1	5	7	PF00082	0.426
CLV_PCSK_KEX2_1	92	94	PF00082	0.480
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.594
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.457
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.426
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.565
CLV_PCSK_SKI1_1	58	62	PF00082	0.547
CLV_Separin_Metazoa	23	27	PF03568	0.596
DEG_APCC_DBOX_1	5	13	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DOC_USP7_MATH_1	150	154	PF00917	0.530
DOC_USP7_MATH_1	175	179	PF00917	0.745
DOC_USP7_MATH_1	217	221	PF00917	0.785
DOC_USP7_MATH_1	32	36	PF00917	0.560
DOC_USP7_MATH_1	66	70	PF00917	0.360
DOC_USP7_UBL2_3	237	241	PF12436	0.592
DOC_USP7_UBL2_3	253	257	PF12436	0.547
DOC_WW_Pin1_4	128	133	PF00397	0.482
DOC_WW_Pin1_4	173	178	PF00397	0.574
DOC_WW_Pin1_4	28	33	PF00397	0.548
LIG_Actin_WH2_2	56	73	PF00022	0.545
LIG_BIR_III_4	41	45	PF00653	0.443
LIG_deltaCOP1_diTrp_1	107	117	PF00928	0.505
LIG_FHA_2	129	135	PF00498	0.521
LIG_FHA_2	15	21	PF00498	0.436
LIG_FHA_2	234	240	PF00498	0.630
LIG_LIR_Apic_2	73	79	PF02991	0.539
LIG_LIR_Gen_1	46	57	PF02991	0.568
LIG_LIR_Nem_3	46	52	PF02991	0.570
LIG_PROFILIN_1	227	233	PF00235	0.799
LIG_SH2_CRK	142	146	PF00017	0.510
LIG_SH2_NCK_1	142	146	PF00017	0.487
LIG_SH2_NCK_1	76	80	PF00017	0.544
LIG_SH2_SRC	165	168	PF00017	0.739
LIG_SH2_SRC	76	79	PF00017	0.548
LIG_SH2_SRC	88	91	PF00017	0.600
LIG_SH2_STAP1	142	146	PF00017	0.487
LIG_SH2_STAP1	84	88	PF00017	0.556
LIG_SH3_2	232	237	PF14604	0.649
LIG_SH3_3	224	230	PF00018	0.690
LIG_SUMO_SIM_par_1	59	65	PF11976	0.522
LIG_TRAF2_1	236	239	PF00917	0.606
MOD_CDK_SPK_2	128	133	PF00069	0.482
MOD_CK1_1	213	219	PF00069	0.784
MOD_CK2_1	14	20	PF00069	0.470
MOD_CK2_1	233	239	PF00069	0.639
MOD_GlcNHglycan	179	182	PF01048	0.727
MOD_GlcNHglycan	187	190	PF01048	0.669
MOD_GlcNHglycan	199	202	PF01048	0.474
MOD_GlcNHglycan	242	245	PF01048	0.561
MOD_GlcNHglycan	64	67	PF01048	0.409
MOD_GSK3_1	173	180	PF00069	0.560
MOD_GSK3_1	213	220	PF00069	0.775
MOD_GSK3_1	28	35	PF00069	0.528
MOD_GSK3_1	62	69	PF00069	0.523
MOD_N-GLC_1	26	31	PF02516	0.498
MOD_NEK2_1	118	123	PF00069	0.502
MOD_NEK2_1	135	140	PF00069	0.469
MOD_NEK2_1	70	75	PF00069	0.544
MOD_NEK2_2	66	71	PF00069	0.462
MOD_NEK2_2	82	87	PF00069	0.436
MOD_PKA_1	240	246	PF00069	0.571
MOD_PKA_2	213	219	PF00069	0.779
MOD_PKA_2	70	76	PF00069	0.547
MOD_Plk_1	71	77	PF00069	0.509
MOD_Plk_4	71	77	PF00069	0.545
MOD_ProDKin_1	128	134	PF00069	0.477
MOD_ProDKin_1	173	179	PF00069	0.577
MOD_ProDKin_1	28	34	PF00069	0.553
MOD_SUMO_rev_2	234	243	PF00179	0.604
MOD_SUMO_rev_2	37	46	PF00179	0.530
TRG_DiLeu_BaEn_1	20	25	PF01217	0.538
TRG_DiLeu_BaEn_4	101	107	PF01217	0.553
TRG_ENDOCYTIC_2	142	145	PF00928	0.467
TRG_ENDOCYTIC_2	49	52	PF00928	0.396
TRG_ER_diArg_1	114	117	PF00400	0.576
TRG_ER_diArg_1	140	142	PF00400	0.459
TRG_ER_diArg_1	25	28	PF00400	0.459
TRG_ER_diArg_1	47	49	PF00400	0.452
TRG_ER_diArg_1	92	95	PF00400	0.478
TRG_ER_diLys_1	253	258	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA6	Leptomonas seymouri	68%	92%
A0A0S4JT72	Bodo saltans	44%	100%
A0A3Q8IJE0	Leishmania donovani	100%	100%
A0A422NCV8	Trypanosoma rangeli	44%	93%
A4HPB4	Leishmania braziliensis	78%	100%
D0A3C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	96%
E9AT25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1H3	Leishmania major	92%	100%
V5D8K3	Trypanosoma cruzi	46%	97%