Putative acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acid phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4ICF3_LEIIN

TriTrypDb:

LINF_360032100

Length:

445

Annotations

Annotations by Jardim et al.

Acidocalcisome, acid phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.358
CLV_NRD_NRD_1	16	18	PF00675	0.654
CLV_NRD_NRD_1	192	194	PF00675	0.405
CLV_NRD_NRD_1	51	53	PF00675	0.462
CLV_PCSK_KEX2_1	16	18	PF00082	0.654
CLV_PCSK_KEX2_1	192	194	PF00082	0.389
CLV_PCSK_KEX2_1	204	206	PF00082	0.404
CLV_PCSK_KEX2_1	92	94	PF00082	0.317
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.565
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.433
CLV_PCSK_PC7_1	200	206	PF00082	0.417
CLV_PCSK_SKI1_1	217	221	PF00082	0.476
CLV_PCSK_SKI1_1	255	259	PF00082	0.545
CLV_PCSK_SKI1_1	297	301	PF00082	0.475
CLV_PCSK_SKI1_1	332	336	PF00082	0.352
CLV_PCSK_SKI1_1	53	57	PF00082	0.525
CLV_PCSK_SKI1_1	59	63	PF00082	0.485
DEG_APCC_DBOX_1	296	304	PF00400	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.726
DOC_CKS1_1	387	392	PF01111	0.342
DOC_MAPK_gen_1	258	267	PF00069	0.475
DOC_MAPK_MEF2A_6	270	278	PF00069	0.378
DOC_MAPK_MEF2A_6	380	387	PF00069	0.305
DOC_USP7_MATH_1	357	361	PF00917	0.347
DOC_USP7_UBL2_3	49	53	PF12436	0.593
DOC_WW_Pin1_4	259	264	PF00397	0.376
DOC_WW_Pin1_4	308	313	PF00397	0.577
DOC_WW_Pin1_4	386	391	PF00397	0.332
LIG_14-3-3_CanoR_1	142	150	PF00244	0.338
LIG_14-3-3_CanoR_1	270	275	PF00244	0.337
LIG_14-3-3_CanoR_1	384	388	PF00244	0.377
LIG_14-3-3_CanoR_1	5	12	PF00244	0.753
LIG_Actin_WH2_2	239	257	PF00022	0.527
LIG_AP2alpha_1	155	159	PF02296	0.322
LIG_APCC_ABBA_1	172	177	PF00400	0.390
LIG_APCC_ABBA_1	367	372	PF00400	0.493
LIG_CSL_BTD_1	387	390	PF09270	0.381
LIG_DLG_GKlike_1	270	277	PF00625	0.345
LIG_FHA_1	213	219	PF00498	0.502
LIG_FHA_1	394	400	PF00498	0.422
LIG_FHA_1	439	445	PF00498	0.648
LIG_FHA_1	61	67	PF00498	0.357
LIG_FHA_2	20	26	PF00498	0.728
LIG_FHA_2	239	245	PF00498	0.367
LIG_FHA_2	319	325	PF00498	0.432
LIG_FHA_2	46	52	PF00498	0.567
LIG_LIR_Apic_2	228	232	PF02991	0.356
LIG_LIR_Gen_1	126	135	PF02991	0.430
LIG_LIR_Gen_1	203	213	PF02991	0.502
LIG_LIR_Gen_1	234	243	PF02991	0.399
LIG_LIR_Gen_1	289	296	PF02991	0.332
LIG_LIR_Gen_1	379	390	PF02991	0.435
LIG_LIR_Gen_1	424	435	PF02991	0.411
LIG_LIR_LC3C_4	63	67	PF02991	0.433
LIG_LIR_Nem_3	109	115	PF02991	0.381
LIG_LIR_Nem_3	203	209	PF02991	0.552
LIG_LIR_Nem_3	234	239	PF02991	0.446
LIG_LIR_Nem_3	289	293	PF02991	0.343
LIG_LIR_Nem_3	379	385	PF02991	0.386
LIG_LIR_Nem_3	386	391	PF02991	0.346
LIG_LIR_Nem_3	424	430	PF02991	0.370
LIG_PCNA_PIPBox_1	275	284	PF02747	0.388
LIG_PCNA_yPIPBox_3	270	282	PF02747	0.386
LIG_Pex14_2	155	159	PF04695	0.333
LIG_Pex14_2	171	175	PF04695	0.238
LIG_Pex14_2	338	342	PF04695	0.358
LIG_Rb_pABgroove_1	276	284	PF01858	0.327
LIG_SH2_CRK	236	240	PF00017	0.419
LIG_SH2_CRK	391	395	PF00017	0.523
LIG_SH2_GRB2like	206	209	PF00017	0.410
LIG_SH2_NCK_1	346	350	PF00017	0.429
LIG_SH2_PTP2	229	232	PF00017	0.554
LIG_SH2_PTP2	382	385	PF00017	0.323
LIG_SH2_SRC	164	167	PF00017	0.535
LIG_SH2_SRC	236	239	PF00017	0.488
LIG_SH2_STAP1	374	378	PF00017	0.449
LIG_SH2_STAP1	94	98	PF00017	0.334
LIG_SH2_STAT3	433	436	PF00017	0.590
LIG_SH2_STAT5	115	118	PF00017	0.291
LIG_SH2_STAT5	134	137	PF00017	0.437
LIG_SH2_STAT5	164	167	PF00017	0.552
LIG_SH2_STAT5	183	186	PF00017	0.463
LIG_SH2_STAT5	229	232	PF00017	0.544
LIG_SH2_STAT5	238	241	PF00017	0.285
LIG_SH2_STAT5	328	331	PF00017	0.359
LIG_SH2_STAT5	382	385	PF00017	0.336
LIG_SH2_STAT5	395	398	PF00017	0.402
LIG_SH2_STAT5	415	418	PF00017	0.218
LIG_SH3_3	135	141	PF00018	0.297
LIG_SH3_3	163	169	PF00018	0.407
LIG_SH3_3	26	32	PF00018	0.558
LIG_SH3_3	290	296	PF00018	0.349
LIG_SH3_3	73	79	PF00018	0.297
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.357
LIG_TRAF2_1	321	324	PF00917	0.437
LIG_TRAF2_1	434	437	PF00917	0.596
LIG_TRAF2_2	312	317	PF00917	0.672
LIG_TYR_ITSM	387	394	PF00017	0.437
MOD_CK1_1	21	27	PF00069	0.756
MOD_CK1_1	42	48	PF00069	0.565
MOD_CK2_1	19	25	PF00069	0.789
MOD_CK2_1	318	324	PF00069	0.479
MOD_CK2_1	45	51	PF00069	0.551
MOD_GlcNHglycan	13	16	PF01048	0.743
MOD_GlcNHglycan	145	148	PF01048	0.297
MOD_GlcNHglycan	7	10	PF01048	0.717
MOD_GlcNHglycan	95	99	PF01048	0.421
MOD_GSK3_1	173	180	PF00069	0.441
MOD_GSK3_1	19	26	PF00069	0.717
MOD_GSK3_1	299	306	PF00069	0.493
MOD_GSK3_1	318	325	PF00069	0.399
MOD_GSK3_1	372	379	PF00069	0.583
MOD_GSK3_1	393	400	PF00069	0.422
MOD_GSK3_1	419	426	PF00069	0.341
MOD_N-GLC_1	195	200	PF02516	0.449
MOD_N-GLC_1	270	275	PF02516	0.345
MOD_N-GLC_1	303	308	PF02516	0.517
MOD_N-GLC_1	36	41	PF02516	0.557
MOD_N-GLC_1	376	381	PF02516	0.587
MOD_N-GLC_1	45	50	PF02516	0.526
MOD_NEK2_1	265	270	PF00069	0.509
MOD_NEK2_1	303	308	PF00069	0.483
MOD_NEK2_1	318	323	PF00069	0.408
MOD_NEK2_1	60	65	PF00069	0.353
MOD_NEK2_2	398	403	PF00069	0.420
MOD_PIKK_1	36	42	PF00454	0.519
MOD_PKA_2	383	389	PF00069	0.374
MOD_PKA_2	419	425	PF00069	0.389
MOD_Plk_1	270	276	PF00069	0.344
MOD_Plk_1	303	309	PF00069	0.561
MOD_Plk_1	323	329	PF00069	0.379
MOD_Plk_1	376	382	PF00069	0.560
MOD_Plk_4	286	292	PF00069	0.468
MOD_Plk_4	323	329	PF00069	0.412
MOD_Plk_4	358	364	PF00069	0.357
MOD_ProDKin_1	259	265	PF00069	0.369
MOD_ProDKin_1	308	314	PF00069	0.579
MOD_ProDKin_1	386	392	PF00069	0.339
MOD_SUMO_rev_2	406	413	PF00179	0.455
MOD_SUMO_rev_2	45	55	PF00179	0.562
TRG_ENDOCYTIC_2	120	123	PF00928	0.313
TRG_ENDOCYTIC_2	206	209	PF00928	0.510
TRG_ENDOCYTIC_2	236	239	PF00928	0.372
TRG_ENDOCYTIC_2	290	293	PF00928	0.330
TRG_ENDOCYTIC_2	382	385	PF00928	0.342
TRG_ENDOCYTIC_2	391	394	PF00928	0.398
TRG_ER_diArg_1	191	193	PF00400	0.417
TRG_NES_CRM1_1	264	275	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN6	Leptomonas seymouri	76%	97%
A0A0S4JT27	Bodo saltans	52%	100%
A0A1X0P7L7	Trypanosomatidae	59%	92%
A0A3S7XAY1	Leishmania donovani	100%	100%
A0A422NCB6	Trypanosoma rangeli	59%	97%
A4HPB3	Leishmania braziliensis	82%	100%
D0A3C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AT24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1H4	Leishmania major	96%	100%
V5BCK5	Trypanosoma cruzi	62%	98%