LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICF2_LEIIN
TriTrypDb:
LINF_360032000
Length:
706

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICF2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 302 306 PF00656 0.590
CLV_C14_Caspase3-7 323 327 PF00656 0.679
CLV_NRD_NRD_1 106 108 PF00675 0.438
CLV_NRD_NRD_1 349 351 PF00675 0.720
CLV_NRD_NRD_1 360 362 PF00675 0.557
CLV_NRD_NRD_1 385 387 PF00675 0.606
CLV_NRD_NRD_1 420 422 PF00675 0.697
CLV_NRD_NRD_1 488 490 PF00675 0.522
CLV_PCSK_KEX2_1 106 108 PF00082 0.438
CLV_PCSK_KEX2_1 385 387 PF00082 0.606
CLV_PCSK_KEX2_1 392 394 PF00082 0.480
CLV_PCSK_KEX2_1 420 422 PF00082 0.694
CLV_PCSK_KEX2_1 488 490 PF00082 0.522
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.336
CLV_PCSK_PC7_1 381 387 PF00082 0.573
CLV_PCSK_SKI1_1 119 123 PF00082 0.362
CLV_PCSK_SKI1_1 371 375 PF00082 0.524
CLV_PCSK_SKI1_1 386 390 PF00082 0.418
CLV_PCSK_SKI1_1 451 455 PF00082 0.511
CLV_PCSK_SKI1_1 526 530 PF00082 0.539
CLV_PCSK_SKI1_1 558 562 PF00082 0.583
CLV_PCSK_SKI1_1 582 586 PF00082 0.409
CLV_Separin_Metazoa 523 527 PF03568 0.435
DEG_APCC_DBOX_1 525 533 PF00400 0.469
DEG_APCC_DBOX_1 581 589 PF00400 0.409
DEG_Nend_Nbox_1 1 3 PF02207 0.442
DOC_ANK_TNKS_1 270 277 PF00023 0.569
DOC_CYCLIN_yCln2_LP_2 498 504 PF00134 0.502
DOC_MAPK_gen_1 134 143 PF00069 0.459
DOC_MAPK_gen_1 392 399 PF00069 0.381
DOC_MAPK_gen_1 655 665 PF00069 0.483
DOC_MAPK_MEF2A_6 137 145 PF00069 0.426
DOC_MAPK_MEF2A_6 477 486 PF00069 0.446
DOC_MAPK_MEF2A_6 582 590 PF00069 0.520
DOC_PP1_RVXF_1 364 371 PF00149 0.503
DOC_PP1_RVXF_1 384 391 PF00149 0.539
DOC_PP2B_LxvP_1 79 82 PF13499 0.580
DOC_PP4_FxxP_1 445 448 PF00568 0.526
DOC_USP7_MATH_1 205 209 PF00917 0.568
DOC_USP7_MATH_1 315 319 PF00917 0.670
DOC_USP7_MATH_1 331 335 PF00917 0.542
DOC_USP7_MATH_1 502 506 PF00917 0.379
DOC_USP7_MATH_1 55 59 PF00917 0.526
DOC_USP7_MATH_1 74 78 PF00917 0.486
DOC_USP7_UBL2_3 362 366 PF12436 0.526
DOC_WW_Pin1_4 223 228 PF00397 0.578
DOC_WW_Pin1_4 259 264 PF00397 0.378
DOC_WW_Pin1_4 265 270 PF00397 0.501
DOC_WW_Pin1_4 404 409 PF00397 0.576
DOC_WW_Pin1_4 454 459 PF00397 0.685
DOC_WW_Pin1_4 558 563 PF00397 0.757
DOC_WW_Pin1_4 88 93 PF00397 0.677
LIG_14-3-3_CanoR_1 111 117 PF00244 0.470
LIG_14-3-3_CanoR_1 22 26 PF00244 0.569
LIG_14-3-3_CanoR_1 220 226 PF00244 0.580
LIG_14-3-3_CanoR_1 385 391 PF00244 0.444
LIG_14-3-3_CanoR_1 451 459 PF00244 0.498
LIG_14-3-3_CanoR_1 517 521 PF00244 0.523
LIG_14-3-3_CanoR_1 618 622 PF00244 0.437
LIG_14-3-3_CanoR_1 633 639 PF00244 0.523
LIG_BIR_III_2 305 309 PF00653 0.674
LIG_CtBP_PxDLS_1 458 462 PF00389 0.551
LIG_FHA_1 341 347 PF00498 0.585
LIG_FHA_1 454 460 PF00498 0.520
LIG_FHA_1 506 512 PF00498 0.441
LIG_FHA_1 58 64 PF00498 0.536
LIG_FHA_1 593 599 PF00498 0.409
LIG_FHA_1 640 646 PF00498 0.423
LIG_FHA_1 675 681 PF00498 0.640
LIG_FHA_2 321 327 PF00498 0.677
LIG_LIR_Apic_2 644 650 PF02991 0.532
LIG_LIR_Gen_1 463 468 PF02991 0.601
LIG_LIR_Nem_3 235 240 PF02991 0.405
LIG_LIR_Nem_3 24 28 PF02991 0.578
LIG_LIR_Nem_3 463 467 PF02991 0.621
LIG_LIR_Nem_3 620 624 PF02991 0.573
LIG_LYPXL_yS_3 670 673 PF13949 0.492
LIG_NRBOX 584 590 PF00104 0.515
LIG_PCNA_yPIPBox_3 172 184 PF02747 0.418
LIG_SH2_NCK_1 298 302 PF00017 0.564
LIG_SH2_NCK_1 536 540 PF00017 0.438
LIG_SH2_SRC 298 301 PF00017 0.564
LIG_SH2_SRC 536 539 PF00017 0.554
LIG_SH2_STAP1 254 258 PF00017 0.475
LIG_SH2_STAP1 479 483 PF00017 0.525
LIG_SH2_STAT5 131 134 PF00017 0.465
LIG_SH2_STAT5 170 173 PF00017 0.467
LIG_SH2_STAT5 237 240 PF00017 0.398
LIG_SH2_STAT5 68 71 PF00017 0.365
LIG_SH3_3 333 339 PF00018 0.598
LIG_SH3_3 440 446 PF00018 0.513
LIG_SH3_3 89 95 PF00018 0.584
LIG_Sin3_3 480 487 PF02671 0.347
LIG_SUMO_SIM_anti_2 512 517 PF11976 0.524
LIG_SUMO_SIM_par_1 454 463 PF11976 0.619
LIG_SUMO_SIM_par_1 58 66 PF11976 0.523
LIG_TRAF2_1 623 626 PF00917 0.553
LIG_TRFH_1 259 263 PF08558 0.441
LIG_UBA3_1 28 32 PF00899 0.583
LIG_WRC_WIRS_1 461 466 PF05994 0.612
MOD_CDC14_SPxK_1 268 271 PF00782 0.565
MOD_CDC14_SPxK_1 91 94 PF00782 0.691
MOD_CDK_SPK_2 404 409 PF00069 0.576
MOD_CDK_SPxK_1 265 271 PF00069 0.529
MOD_CDK_SPxK_1 88 94 PF00069 0.682
MOD_CK1_1 162 168 PF00069 0.555
MOD_CK1_1 208 214 PF00069 0.572
MOD_CK1_1 24 30 PF00069 0.423
MOD_CK1_1 265 271 PF00069 0.624
MOD_CK1_1 430 436 PF00069 0.695
MOD_CK1_1 460 466 PF00069 0.614
MOD_CK1_1 505 511 PF00069 0.424
MOD_CK1_1 632 638 PF00069 0.510
MOD_CK1_1 641 647 PF00069 0.479
MOD_CK1_1 8 14 PF00069 0.559
MOD_CK2_1 102 108 PF00069 0.518
MOD_CK2_1 112 118 PF00069 0.345
MOD_CK2_1 374 380 PF00069 0.525
MOD_Cter_Amidation 418 421 PF01082 0.633
MOD_GlcNHglycan 161 164 PF01048 0.525
MOD_GlcNHglycan 207 210 PF01048 0.438
MOD_GlcNHglycan 255 258 PF01048 0.404
MOD_GlcNHglycan 309 312 PF01048 0.692
MOD_GlcNHglycan 326 329 PF01048 0.562
MOD_GlcNHglycan 416 419 PF01048 0.531
MOD_GlcNHglycan 436 439 PF01048 0.534
MOD_GlcNHglycan 474 477 PF01048 0.559
MOD_GlcNHglycan 651 654 PF01048 0.411
MOD_GlcNHglycan 76 79 PF01048 0.464
MOD_GSK3_1 179 186 PF00069 0.405
MOD_GSK3_1 223 230 PF00069 0.590
MOD_GSK3_1 320 327 PF00069 0.651
MOD_GSK3_1 426 433 PF00069 0.638
MOD_GSK3_1 453 460 PF00069 0.622
MOD_GSK3_1 466 473 PF00069 0.487
MOD_GSK3_1 5 12 PF00069 0.538
MOD_GSK3_1 505 512 PF00069 0.590
MOD_GSK3_1 63 70 PF00069 0.464
MOD_GSK3_1 634 641 PF00069 0.490
MOD_GSK3_1 645 652 PF00069 0.367
MOD_N-GLC_1 502 507 PF02516 0.371
MOD_NEK2_1 136 141 PF00069 0.426
MOD_NEK2_1 21 26 PF00069 0.588
MOD_NEK2_1 412 417 PF00069 0.567
MOD_NEK2_1 453 458 PF00069 0.511
MOD_NEK2_1 545 550 PF00069 0.480
MOD_NEK2_1 598 603 PF00069 0.492
MOD_NEK2_1 638 643 PF00069 0.559
MOD_NEK2_1 675 680 PF00069 0.578
MOD_NEK2_2 502 507 PF00069 0.371
MOD_PIKK_1 208 214 PF00454 0.541
MOD_PIKK_1 262 268 PF00454 0.501
MOD_PIKK_1 545 551 PF00454 0.492
MOD_PKA_2 136 142 PF00069 0.544
MOD_PKA_2 205 211 PF00069 0.445
MOD_PKA_2 21 27 PF00069 0.561
MOD_PKA_2 516 522 PF00069 0.524
MOD_PKA_2 617 623 PF00069 0.440
MOD_PKA_2 632 638 PF00069 0.522
MOD_PKA_2 83 89 PF00069 0.601
MOD_PKA_2 93 99 PF00069 0.640
MOD_Plk_1 426 432 PF00069 0.650
MOD_Plk_1 502 508 PF00069 0.488
MOD_Plk_1 509 515 PF00069 0.499
MOD_Plk_1 675 681 PF00069 0.500
MOD_Plk_2-3 575 581 PF00069 0.545
MOD_Plk_4 24 30 PF00069 0.627
MOD_Plk_4 331 337 PF00069 0.541
MOD_Plk_4 374 380 PF00069 0.634
MOD_Plk_4 42 48 PF00069 0.289
MOD_Plk_4 427 433 PF00069 0.714
MOD_Plk_4 502 508 PF00069 0.427
MOD_Plk_4 516 522 PF00069 0.457
MOD_Plk_4 617 623 PF00069 0.504
MOD_Plk_4 63 69 PF00069 0.477
MOD_Plk_4 675 681 PF00069 0.522
MOD_ProDKin_1 223 229 PF00069 0.576
MOD_ProDKin_1 259 265 PF00069 0.384
MOD_ProDKin_1 404 410 PF00069 0.579
MOD_ProDKin_1 454 460 PF00069 0.685
MOD_ProDKin_1 558 564 PF00069 0.760
MOD_ProDKin_1 88 94 PF00069 0.682
MOD_SUMO_for_1 31 34 PF00179 0.488
MOD_SUMO_rev_2 355 363 PF00179 0.534
TRG_DiLeu_BaEn_1 243 248 PF01217 0.496
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.434
TRG_DiLeu_BaLyEn_6 141 146 PF01217 0.409
TRG_DiLeu_BaLyEn_6 448 453 PF01217 0.589
TRG_ENDOCYTIC_2 479 482 PF00928 0.426
TRG_ENDOCYTIC_2 536 539 PF00928 0.524
TRG_ENDOCYTIC_2 670 673 PF00928 0.623
TRG_ER_diArg_1 420 422 PF00400 0.691
TRG_Pf-PMV_PEXEL_1 134 138 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 420 424 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 451 455 PF00026 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBJ6 Leptomonas seymouri 37% 100%
A0A3Q8INV1 Leishmania donovani 100% 100%
A4HPB2 Leishmania braziliensis 75% 100%
E9AT23 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q1H5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS