Fe2OG dioxygenase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily - putative

Species:

Leishmania infantum

UniProt:

A4ICE7_LEIIN

TriTrypDb:

LINF_360059000

Length:

715

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.452
CLV_C14_Caspase3-7	607	611	PF00656	0.615
CLV_C14_Caspase3-7	71	75	PF00656	0.524
CLV_NRD_NRD_1	10	12	PF00675	0.600
CLV_NRD_NRD_1	198	200	PF00675	0.419
CLV_NRD_NRD_1	30	32	PF00675	0.718
CLV_NRD_NRD_1	478	480	PF00675	0.468
CLV_NRD_NRD_1	526	528	PF00675	0.466
CLV_NRD_NRD_1	708	710	PF00675	0.662
CLV_PCSK_KEX2_1	179	181	PF00082	0.408
CLV_PCSK_KEX2_1	198	200	PF00082	0.280
CLV_PCSK_KEX2_1	30	32	PF00082	0.718
CLV_PCSK_KEX2_1	363	365	PF00082	0.350
CLV_PCSK_KEX2_1	478	480	PF00082	0.468
CLV_PCSK_KEX2_1	526	528	PF00082	0.518
CLV_PCSK_KEX2_1	566	568	PF00082	0.313
CLV_PCSK_KEX2_1	619	621	PF00082	0.644
CLV_PCSK_KEX2_1	708	710	PF00082	0.685
CLV_PCSK_KEX2_1	9	11	PF00082	0.595
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.410
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.350
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.313
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.644
CLV_PCSK_PC1ET2_1	708	710	PF00082	0.685
CLV_PCSK_PC7_1	5	11	PF00082	0.536
CLV_PCSK_SKI1_1	179	183	PF00082	0.485
CLV_PCSK_SKI1_1	490	494	PF00082	0.325
CLV_PCSK_SKI1_1	526	530	PF00082	0.429
DEG_APCC_DBOX_1	478	486	PF00400	0.492
DOC_CDC14_PxL_1	582	590	PF14671	0.556
DOC_CKS1_1	351	356	PF01111	0.442
DOC_CKS1_1	403	408	PF01111	0.314
DOC_CKS1_1	514	519	PF01111	0.402
DOC_CKS1_1	581	586	PF01111	0.441
DOC_MAPK_MEF2A_6	312	320	PF00069	0.445
DOC_MAPK_MEF2A_6	662	669	PF00069	0.461
DOC_MAPK_MEF2A_6	97	106	PF00069	0.326
DOC_PP2B_LxvP_1	575	578	PF13499	0.422
DOC_PP2B_LxvP_1	667	670	PF13499	0.479
DOC_USP7_MATH_1	183	187	PF00917	0.542
DOC_USP7_MATH_1	481	485	PF00917	0.382
DOC_USP7_MATH_1	576	580	PF00917	0.530
DOC_USP7_MATH_1	76	80	PF00917	0.587
DOC_USP7_MATH_2	242	248	PF00917	0.478
DOC_USP7_MATH_2	354	360	PF00917	0.467
DOC_WW_Pin1_4	226	231	PF00397	0.618
DOC_WW_Pin1_4	253	258	PF00397	0.398
DOC_WW_Pin1_4	350	355	PF00397	0.373
DOC_WW_Pin1_4	402	407	PF00397	0.302
DOC_WW_Pin1_4	513	518	PF00397	0.445
DOC_WW_Pin1_4	580	585	PF00397	0.419
DOC_WW_Pin1_4	61	66	PF00397	0.467
DOC_WW_Pin1_4	611	616	PF00397	0.737
LIG_14-3-3_CanoR_1	180	188	PF00244	0.521
LIG_14-3-3_CanoR_1	214	221	PF00244	0.637
LIG_14-3-3_CanoR_1	542	551	PF00244	0.342
LIG_APCC_ABBA_1	424	429	PF00400	0.379
LIG_BRCT_BRCA1_1	246	250	PF00533	0.432
LIG_BRCT_BRCA1_1	578	582	PF00533	0.444
LIG_Clathr_ClatBox_1	315	319	PF01394	0.413
LIG_CtBP_PxDLS_1	230	234	PF00389	0.533
LIG_EH1_1	171	179	PF00400	0.477
LIG_eIF4E_1	188	194	PF01652	0.330
LIG_FHA_1	105	111	PF00498	0.493
LIG_FHA_1	148	154	PF00498	0.371
LIG_FHA_1	159	165	PF00498	0.381
LIG_FHA_1	169	175	PF00498	0.374
LIG_FHA_1	188	194	PF00498	0.238
LIG_FHA_1	323	329	PF00498	0.354
LIG_FHA_1	46	52	PF00498	0.647
LIG_FHA_1	514	520	PF00498	0.493
LIG_FHA_1	545	551	PF00498	0.339
LIG_FHA_1	677	683	PF00498	0.518
LIG_FHA_2	351	357	PF00498	0.392
LIG_FHA_2	363	369	PF00498	0.331
LIG_FHA_2	370	376	PF00498	0.338
LIG_LIR_Apic_2	498	504	PF02991	0.348
LIG_LIR_Gen_1	185	196	PF02991	0.355
LIG_LIR_Gen_1	275	285	PF02991	0.495
LIG_LIR_Gen_1	38	47	PF02991	0.545
LIG_LIR_Nem_3	119	124	PF02991	0.397
LIG_LIR_Nem_3	185	191	PF02991	0.374
LIG_LIR_Nem_3	275	280	PF02991	0.506
LIG_LIR_Nem_3	38	44	PF02991	0.540
LIG_LIR_Nem_3	498	503	PF02991	0.374
LIG_MYND_1	207	211	PF01753	0.460
LIG_PAM2_1	258	270	PF00658	0.448
LIG_PCNA_yPIPBox_3	265	277	PF02747	0.446
LIG_Pex14_2	277	281	PF04695	0.360
LIG_PTB_Apo_2	522	529	PF02174	0.498
LIG_SH2_CRK	400	404	PF00017	0.365
LIG_SH2_CRK	501	505	PF00017	0.462
LIG_SH2_GRB2like	457	460	PF00017	0.599
LIG_SH2_SRC	457	460	PF00017	0.504
LIG_SH2_STAP1	41	45	PF00017	0.543
LIG_SH2_STAP1	645	649	PF00017	0.458
LIG_SH2_STAT3	156	159	PF00017	0.488
LIG_SH2_STAT3	451	454	PF00017	0.472
LIG_SH2_STAT5	188	191	PF00017	0.462
LIG_SH2_STAT5	333	336	PF00017	0.318
LIG_SH2_STAT5	337	340	PF00017	0.316
LIG_SH2_STAT5	433	436	PF00017	0.306
LIG_SH2_STAT5	570	573	PF00017	0.382
LIG_SH3_1	254	260	PF00018	0.414
LIG_SH3_3	254	260	PF00018	0.406
LIG_SH3_3	263	269	PF00018	0.401
LIG_SH3_3	449	455	PF00018	0.406
LIG_SH3_3	483	489	PF00018	0.313
LIG_SH3_3	511	517	PF00018	0.536
LIG_SUMO_SIM_par_1	435	441	PF11976	0.286
LIG_SUMO_SIM_par_1	663	668	PF11976	0.469
LIG_TRAF2_1	340	343	PF00917	0.328
LIG_TRAF2_1	353	356	PF00917	0.442
LIG_TRAF2_1	365	368	PF00917	0.331
LIG_TRAF2_1	649	652	PF00917	0.569
LIG_WRC_WIRS_1	188	193	PF05994	0.347
LIG_WRC_WIRS_1	346	351	PF05994	0.344
LIG_WRC_WIRS_1	447	452	PF05994	0.448
MOD_CDC14_SPxK_1	616	619	PF00782	0.786
MOD_CDK_SPxK_1	613	619	PF00069	0.788
MOD_CDK_SPxxK_3	613	620	PF00069	0.581
MOD_CK1_1	186	192	PF00069	0.393
MOD_CK1_1	212	218	PF00069	0.550
MOD_CK1_1	229	235	PF00069	0.721
MOD_CK1_1	311	317	PF00069	0.601
MOD_CK1_1	32	38	PF00069	0.612
MOD_CK1_1	359	365	PF00069	0.441
MOD_CK1_1	380	386	PF00069	0.325
MOD_CK1_1	441	447	PF00069	0.364
MOD_CK1_1	46	52	PF00069	0.589
MOD_CK1_1	544	550	PF00069	0.342
MOD_CK1_1	602	608	PF00069	0.637
MOD_CK1_1	609	615	PF00069	0.682
MOD_CK1_1	623	629	PF00069	0.596
MOD_CK2_1	336	342	PF00069	0.371
MOD_CK2_1	350	356	PF00069	0.418
MOD_CK2_1	362	368	PF00069	0.342
MOD_CK2_1	369	375	PF00069	0.313
MOD_Cter_Amidation	476	479	PF01082	0.461
MOD_GlcNHglycan	246	249	PF01048	0.459
MOD_GlcNHglycan	308	311	PF01048	0.596
MOD_GlcNHglycan	338	341	PF01048	0.298
MOD_GlcNHglycan	45	48	PF01048	0.675
MOD_GlcNHglycan	495	498	PF01048	0.450
MOD_GlcNHglycan	593	596	PF01048	0.559
MOD_GlcNHglycan	602	605	PF01048	0.633
MOD_GlcNHglycan	610	614	PF01048	0.665
MOD_GlcNHglycan	625	628	PF01048	0.568
MOD_GlcNHglycan	705	708	PF01048	0.622
MOD_GlcNHglycan	88	91	PF01048	0.553
MOD_GSK3_1	154	161	PF00069	0.353
MOD_GSK3_1	168	175	PF00069	0.358
MOD_GSK3_1	179	186	PF00069	0.326
MOD_GSK3_1	32	39	PF00069	0.610
MOD_GSK3_1	369	376	PF00069	0.430
MOD_GSK3_1	405	412	PF00069	0.343
MOD_GSK3_1	438	445	PF00069	0.383
MOD_GSK3_1	533	540	PF00069	0.527
MOD_GSK3_1	576	583	PF00069	0.479
MOD_GSK3_1	591	598	PF00069	0.459
MOD_GSK3_1	602	609	PF00069	0.605
MOD_GSK3_1	66	73	PF00069	0.607
MOD_GSK3_1	670	677	PF00069	0.587
MOD_GSK3_1	708	715	PF00069	0.605
MOD_N-GLC_1	35	40	PF02516	0.702
MOD_N-GLC_1	465	470	PF02516	0.410
MOD_N-GLC_1	67	72	PF02516	0.482
MOD_NEK2_1	172	177	PF00069	0.391
MOD_NEK2_1	306	311	PF00069	0.571
MOD_NEK2_1	373	378	PF00069	0.500
MOD_NEK2_1	442	447	PF00069	0.352
MOD_NEK2_1	60	65	PF00069	0.473
MOD_NEK2_1	686	691	PF00069	0.467
MOD_NEK2_2	446	451	PF00069	0.422
MOD_NEK2_2	465	470	PF00069	0.300
MOD_OFUCOSY	371	377	PF10250	0.438
MOD_PIKK_1	209	215	PF00454	0.567
MOD_PIKK_1	586	592	PF00454	0.437
MOD_PKA_1	179	185	PF00069	0.506
MOD_PKA_1	708	714	PF00069	0.571
MOD_PKA_2	17	23	PF00069	0.728
MOD_PKA_2	179	185	PF00069	0.506
MOD_PKA_2	197	203	PF00069	0.301
MOD_PKA_2	29	35	PF00069	0.654
MOD_PKA_2	541	547	PF00069	0.344
MOD_PKA_2	552	558	PF00069	0.391
MOD_PKA_2	708	714	PF00069	0.571
MOD_PKB_1	284	292	PF00069	0.449
MOD_Plk_1	186	192	PF00069	0.374
MOD_Plk_1	465	471	PF00069	0.411
MOD_Plk_1	621	627	PF00069	0.754
MOD_Plk_4	160	166	PF00069	0.470
MOD_Plk_4	272	278	PF00069	0.392
MOD_Plk_4	311	317	PF00069	0.485
MOD_Plk_4	345	351	PF00069	0.559
MOD_Plk_4	377	383	PF00069	0.341
MOD_Plk_4	435	441	PF00069	0.300
MOD_Plk_4	446	452	PF00069	0.366
MOD_Plk_4	481	487	PF00069	0.374
MOD_Plk_4	678	684	PF00069	0.447
MOD_Plk_4	686	692	PF00069	0.420
MOD_ProDKin_1	226	232	PF00069	0.618
MOD_ProDKin_1	253	259	PF00069	0.401
MOD_ProDKin_1	350	356	PF00069	0.380
MOD_ProDKin_1	402	408	PF00069	0.302
MOD_ProDKin_1	513	519	PF00069	0.446
MOD_ProDKin_1	580	586	PF00069	0.423
MOD_ProDKin_1	61	67	PF00069	0.462
MOD_ProDKin_1	611	617	PF00069	0.733
MOD_SUMO_for_1	649	652	PF00179	0.368
MOD_SUMO_rev_2	355	359	PF00179	0.417
MOD_SUMO_rev_2	49	57	PF00179	0.444
MOD_SUMO_rev_2	659	664	PF00179	0.583
MOD_SUMO_rev_2	688	697	PF00179	0.454
TRG_DiLeu_BaEn_1	488	493	PF01217	0.296
TRG_DiLeu_BaEn_1	660	665	PF01217	0.520
TRG_DiLeu_BaEn_4	342	348	PF01217	0.403
TRG_ENDOCYTIC_2	188	191	PF00928	0.341
TRG_ENDOCYTIC_2	400	403	PF00928	0.349
TRG_ENDOCYTIC_2	41	44	PF00928	0.563
TRG_ENDOCYTIC_2	433	436	PF00928	0.330
TRG_ENDOCYTIC_2	572	575	PF00928	0.388
TRG_ER_diArg_1	197	199	PF00400	0.491
TRG_ER_diArg_1	284	287	PF00400	0.503
TRG_ER_diArg_1	478	480	PF00400	0.468
TRG_ER_diArg_1	526	528	PF00400	0.518
TRG_ER_diArg_1	9	11	PF00400	0.598
TRG_NES_CRM1_1	659	672	PF08389	0.505
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL8	Leptomonas seymouri	65%	100%
A0A0S4JGT6	Bodo saltans	44%	100%
A0A1X0P422	Trypanosomatidae	44%	100%
A0A3S7XBU8	Leishmania donovani	100%	100%
A0A422NC22	Trypanosoma rangeli	48%	100%
A4HQ12	Leishmania braziliensis	79%	100%
D0A8V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0R7	Leishmania major	93%	100%
V5AP55	Trypanosoma cruzi	46%	100%