Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICE4_LEIIN

TriTrypDb:

LINF_360059200

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.634
CLV_NRD_NRD_1	118	120	PF00675	0.557
CLV_NRD_NRD_1	203	205	PF00675	0.413
CLV_NRD_NRD_1	222	224	PF00675	0.501
CLV_NRD_NRD_1	247	249	PF00675	0.735
CLV_NRD_NRD_1	251	253	PF00675	0.727
CLV_NRD_NRD_1	271	273	PF00675	0.591
CLV_NRD_NRD_1	43	45	PF00675	0.578
CLV_PCSK_FUR_1	116	120	PF00082	0.597
CLV_PCSK_KEX2_1	116	118	PF00082	0.596
CLV_PCSK_KEX2_1	203	205	PF00082	0.413
CLV_PCSK_KEX2_1	222	224	PF00082	0.501
CLV_PCSK_KEX2_1	247	249	PF00082	0.701
CLV_PCSK_KEX2_1	251	253	PF00082	0.694
CLV_PCSK_KEX2_1	273	275	PF00082	0.620
CLV_PCSK_KEX2_1	340	342	PF00082	0.563
CLV_PCSK_KEX2_1	43	45	PF00082	0.578
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.536
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.684
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.694
CLV_PCSK_PC7_1	247	253	PF00082	0.718
CLV_PCSK_SKI1_1	104	108	PF00082	0.614
CLV_PCSK_SKI1_1	167	171	PF00082	0.526
CLV_PCSK_SKI1_1	196	200	PF00082	0.525
CLV_PCSK_SKI1_1	247	251	PF00082	0.733
CLV_PCSK_SKI1_1	4	8	PF00082	0.643
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_CYCLIN_RxL_1	18	26	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.529
DOC_MAPK_gen_1	284	294	PF00069	0.621
DOC_PP4_FxxP_1	267	270	PF00568	0.743
DOC_USP7_MATH_1	226	230	PF00917	0.680
DOC_USP7_MATH_1	314	318	PF00917	0.739
DOC_USP7_MATH_1	32	36	PF00917	0.631
DOC_WW_Pin1_4	236	241	PF00397	0.724
DOC_WW_Pin1_4	250	255	PF00397	0.754
DOC_WW_Pin1_4	266	271	PF00397	0.714
DOC_WW_Pin1_4	304	309	PF00397	0.693
DOC_WW_Pin1_4	317	322	PF00397	0.724
LIG_14-3-3_CanoR_1	182	188	PF00244	0.482
LIG_14-3-3_CanoR_1	234	240	PF00244	0.640
LIG_14-3-3_CanoR_1	30	39	PF00244	0.599
LIG_BRCT_BRCA1_1	165	169	PF00533	0.481
LIG_deltaCOP1_diTrp_1	275	283	PF00928	0.642
LIG_FHA_1	145	151	PF00498	0.631
LIG_FHA_2	134	140	PF00498	0.671
LIG_FHA_2	147	153	PF00498	0.679
LIG_FHA_2	168	174	PF00498	0.497
LIG_FHA_2	197	203	PF00498	0.454
LIG_FHA_2	291	297	PF00498	0.536
LIG_FHA_2	68	74	PF00498	0.426
LIG_LIR_Apic_2	282	286	PF02991	0.683
LIG_LIR_Apic_2	83	88	PF02991	0.589
LIG_LIR_Gen_1	137	144	PF02991	0.583
LIG_LIR_Gen_1	70	80	PF02991	0.451
LIG_LIR_Nem_3	137	143	PF02991	0.595
LIG_LIR_Nem_3	166	171	PF02991	0.455
LIG_LIR_Nem_3	176	181	PF02991	0.418
LIG_LIR_Nem_3	335	339	PF02991	0.557
LIG_LIR_Nem_3	70	75	PF02991	0.421
LIG_MAD2	21	29	PF02301	0.553
LIG_MLH1_MIPbox_1	165	169	PF16413	0.481
LIG_NRBOX	299	305	PF00104	0.644
LIG_PCNA_yPIPBox_3	297	309	PF02747	0.652
LIG_Pex14_1	276	280	PF04695	0.682
LIG_PTB_Apo_2	204	211	PF02174	0.420
LIG_PTB_Apo_2	66	73	PF02174	0.437
LIG_PTB_Phospho_1	66	72	PF10480	0.435
LIG_SH2_CRK	178	182	PF00017	0.437
LIG_SH2_CRK	339	343	PF00017	0.697
LIG_SH2_CRK	85	89	PF00017	0.706
LIG_SH2_GRB2like	336	339	PF00017	0.550
LIG_SH2_NCK_1	72	76	PF00017	0.531
LIG_SH2_NCK_1	85	89	PF00017	0.712
LIG_SH2_SRC	255	258	PF00017	0.668
LIG_SH2_STAT3	288	291	PF00017	0.634
LIG_SH2_STAT5	216	219	PF00017	0.456
LIG_SH2_STAT5	46	49	PF00017	0.446
LIG_SH3_3	26	32	PF00018	0.622
LIG_SH3_3	275	281	PF00018	0.608
LIG_TRAF2_1	151	154	PF00917	0.584
LIG_TRAF2_1	293	296	PF00917	0.500
LIG_TYR_ITSM	174	181	PF00017	0.479
LIG_TYR_ITSM	68	75	PF00017	0.532
LIG_WRC_WIRS_1	168	173	PF05994	0.433
MOD_CDC14_SPxK_1	269	272	PF00782	0.648
MOD_CDK_SPK_2	304	309	PF00069	0.693
MOD_CDK_SPxK_1	266	272	PF00069	0.674
MOD_CDK_SPxxK_3	266	273	PF00069	0.672
MOD_CK1_1	130	136	PF00069	0.597
MOD_CK1_1	146	152	PF00069	0.597
MOD_CK1_1	229	235	PF00069	0.762
MOD_CK1_1	317	323	PF00069	0.734
MOD_CK2_1	146	152	PF00069	0.615
MOD_CK2_1	196	202	PF00069	0.447
MOD_CK2_1	250	256	PF00069	0.687
MOD_CK2_1	276	282	PF00069	0.624
MOD_CK2_1	290	296	PF00069	0.420
MOD_CK2_1	67	73	PF00069	0.433
MOD_GlcNHglycan	125	128	PF01048	0.724
MOD_GlcNHglycan	224	227	PF01048	0.560
MOD_GlcNHglycan	229	232	PF01048	0.598
MOD_GlcNHglycan	316	319	PF01048	0.747
MOD_GlcNHglycan	58	61	PF01048	0.519
MOD_GlcNHglycan	77	80	PF01048	0.446
MOD_GlcNHglycan	82	85	PF01048	0.570
MOD_GSK3_1	123	130	PF00069	0.647
MOD_GSK3_1	144	151	PF00069	0.613
MOD_GSK3_1	163	170	PF00069	0.484
MOD_GSK3_1	222	229	PF00069	0.617
MOD_GSK3_1	235	242	PF00069	0.689
MOD_LATS_1	165	171	PF00433	0.460
MOD_N-GLC_1	144	149	PF02516	0.629
MOD_NEK2_1	163	168	PF00069	0.503
MOD_NEK2_1	2	7	PF00069	0.580
MOD_NEK2_1	23	28	PF00069	0.477
MOD_NEK2_1	233	238	PF00069	0.792
MOD_NEK2_1	74	79	PF00069	0.443
MOD_NEK2_2	183	188	PF00069	0.481
MOD_PKA_1	222	228	PF00069	0.678
MOD_PKA_2	222	228	PF00069	0.641
MOD_PKA_2	233	239	PF00069	0.640
MOD_Plk_1	127	133	PF00069	0.699
MOD_Plk_1	173	179	PF00069	0.404
MOD_Plk_2-3	148	154	PF00069	0.673
MOD_Plk_2-3	290	296	PF00069	0.617
MOD_Plk_4	173	179	PF00069	0.422
MOD_Plk_4	196	202	PF00069	0.447
MOD_ProDKin_1	236	242	PF00069	0.725
MOD_ProDKin_1	250	256	PF00069	0.753
MOD_ProDKin_1	266	272	PF00069	0.712
MOD_ProDKin_1	304	310	PF00069	0.696
MOD_ProDKin_1	317	323	PF00069	0.722
MOD_SUMO_rev_2	148	158	PF00179	0.642
TRG_DiLeu_BaEn_4	295	301	PF01217	0.603
TRG_ENDOCYTIC_2	178	181	PF00928	0.409
TRG_ENDOCYTIC_2	339	342	PF00928	0.554
TRG_ENDOCYTIC_2	46	49	PF00928	0.450
TRG_ENDOCYTIC_2	72	75	PF00928	0.414
TRG_ER_diArg_1	116	119	PF00400	0.599
TRG_ER_diArg_1	203	205	PF00400	0.413
TRG_ER_diArg_1	250	252	PF00400	0.727
TRG_ER_diArg_1	271	274	PF00400	0.693
TRG_ER_diArg_1	341	344	PF00400	0.640
TRG_ER_diArg_1	42	44	PF00400	0.566
TRG_NLS_MonoExtC_3	339	344	PF00514	0.581
TRG_PTS1	343	346	PF00515	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P554	Leptomonas seymouri	66%	92%
A0A1X0P394	Trypanosomatidae	39%	87%
A0A3Q8IRL6	Leishmania donovani	100%	100%
A0A3R7NA51	Trypanosoma rangeli	49%	97%
A4HQ14	Leishmania braziliensis	81%	100%
D0A8V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q0R5	Leishmania major	90%	98%
V5BDN3	Trypanosoma cruzi	48%	100%