LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

ubiquitin protein ligase - putative

Species:

Leishmania infantum

UniProt:

A4ICE3_LEIIN

TriTrypDb:

LINF_360053000

Length:

1067

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.369
CLV_C14_Caspase3-7	327	331	PF00656	0.574
CLV_C14_Caspase3-7	786	790	PF00656	0.492
CLV_C14_Caspase3-7	881	885	PF00656	0.556
CLV_C14_Caspase3-7	942	946	PF00656	0.352
CLV_NRD_NRD_1	1	3	PF00675	0.443
CLV_NRD_NRD_1	106	108	PF00675	0.412
CLV_NRD_NRD_1	219	221	PF00675	0.546
CLV_NRD_NRD_1	408	410	PF00675	0.397
CLV_NRD_NRD_1	609	611	PF00675	0.378
CLV_NRD_NRD_1	89	91	PF00675	0.482
CLV_NRD_NRD_1	904	906	PF00675	0.542
CLV_NRD_NRD_1	93	95	PF00675	0.463
CLV_NRD_NRD_1	965	967	PF00675	0.467
CLV_PCSK_FUR_1	104	108	PF00082	0.415
CLV_PCSK_FUR_1	747	751	PF00082	0.454
CLV_PCSK_FUR_1	963	967	PF00082	0.466
CLV_PCSK_KEX2_1	106	108	PF00082	0.412
CLV_PCSK_KEX2_1	408	410	PF00082	0.397
CLV_PCSK_KEX2_1	609	611	PF00082	0.378
CLV_PCSK_KEX2_1	746	748	PF00082	0.452
CLV_PCSK_KEX2_1	749	751	PF00082	0.459
CLV_PCSK_KEX2_1	89	91	PF00082	0.482
CLV_PCSK_KEX2_1	904	906	PF00082	0.542
CLV_PCSK_KEX2_1	965	967	PF00082	0.467
CLV_PCSK_PC1ET2_1	746	748	PF00082	0.452
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.459
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.443
CLV_PCSK_SKI1_1	1040	1044	PF00082	0.458
CLV_PCSK_SKI1_1	128	132	PF00082	0.379
CLV_PCSK_SKI1_1	214	218	PF00082	0.540
CLV_PCSK_SKI1_1	3	7	PF00082	0.391
CLV_PCSK_SKI1_1	409	413	PF00082	0.411
CLV_PCSK_SKI1_1	451	455	PF00082	0.488
CLV_PCSK_SKI1_1	616	620	PF00082	0.289
CLV_PCSK_SKI1_1	746	750	PF00082	0.458
CLV_PCSK_SKI1_1	8	12	PF00082	0.350
CLV_PCSK_SKI1_1	814	818	PF00082	0.485
CLV_PCSK_SKI1_1	926	930	PF00082	0.433
CLV_PCSK_SKI1_1	95	99	PF00082	0.456
DEG_APCC_DBOX_1	127	135	PF00400	0.375
DEG_APCC_DBOX_1	706	714	PF00400	0.353
DEG_SCF_FBW7_1	931	938	PF00400	0.408
DOC_CKS1_1	291	296	PF01111	0.547
DOC_CKS1_1	637	642	PF01111	0.351
DOC_CKS1_1	771	776	PF01111	0.487
DOC_CYCLIN_RxL_1	41	51	PF00134	0.325
DOC_CYCLIN_RxL_1	610	623	PF00134	0.308
DOC_CYCLIN_RxL_1	706	716	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	999	1005	PF00134	0.454
DOC_MAPK_DCC_7	977	987	PF00069	0.406
DOC_MAPK_gen_1	214	224	PF00069	0.540
DOC_MAPK_gen_1	749	759	PF00069	0.460
DOC_MAPK_gen_1	820	828	PF00069	0.499
DOC_MAPK_gen_1	963	973	PF00069	0.448
DOC_MAPK_MEF2A_6	128	136	PF00069	0.389
DOC_MAPK_MEF2A_6	349	357	PF00069	0.526
DOC_MAPK_MEF2A_6	36	43	PF00069	0.350
DOC_MAPK_MEF2A_6	570	579	PF00069	0.506
DOC_MAPK_MEF2A_6	763	771	PF00069	0.463
DOC_PIKK_1	155	163	PF02985	0.418
DOC_PP1_RVXF_1	108	114	PF00149	0.373
DOC_PP1_RVXF_1	756	763	PF00149	0.459
DOC_PP1_RVXF_1	924	931	PF00149	0.444
DOC_PP2B_LxvP_1	177	180	PF13499	0.453
DOC_PP2B_LxvP_1	288	291	PF13499	0.544
DOC_SPAK_OSR1_1	758	762	PF12202	0.459
DOC_USP7_MATH_1	1015	1019	PF00917	0.475
DOC_USP7_MATH_1	178	182	PF00917	0.457
DOC_USP7_MATH_1	201	205	PF00917	0.512
DOC_USP7_MATH_1	245	249	PF00917	0.552
DOC_USP7_MATH_1	35	39	PF00917	0.359
DOC_USP7_MATH_1	359	363	PF00917	0.529
DOC_USP7_MATH_1	379	383	PF00917	0.523
DOC_USP7_MATH_1	464	468	PF00917	0.418
DOC_USP7_MATH_1	490	494	PF00917	0.411
DOC_USP7_MATH_1	495	499	PF00917	0.484
DOC_USP7_MATH_1	524	528	PF00917	0.497
DOC_USP7_MATH_1	551	555	PF00917	0.506
DOC_USP7_MATH_1	560	564	PF00917	0.526
DOC_USP7_MATH_1	77	81	PF00917	0.485
DOC_USP7_MATH_1	801	805	PF00917	0.488
DOC_USP7_MATH_1	824	828	PF00917	0.500
DOC_USP7_MATH_1	848	852	PF00917	0.494
DOC_USP7_UBL2_3	217	221	PF12436	0.545
DOC_USP7_UBL2_3	312	316	PF12436	0.576
DOC_WW_Pin1_4	1035	1040	PF00397	0.444
DOC_WW_Pin1_4	241	246	PF00397	0.548
DOC_WW_Pin1_4	290	295	PF00397	0.545
DOC_WW_Pin1_4	297	302	PF00397	0.565
DOC_WW_Pin1_4	375	380	PF00397	0.525
DOC_WW_Pin1_4	434	439	PF00397	0.501
DOC_WW_Pin1_4	515	520	PF00397	0.498
DOC_WW_Pin1_4	636	641	PF00397	0.351
DOC_WW_Pin1_4	770	775	PF00397	0.483
DOC_WW_Pin1_4	851	856	PF00397	0.498
DOC_WW_Pin1_4	864	869	PF00397	0.545
DOC_WW_Pin1_4	889	894	PF00397	0.550
DOC_WW_Pin1_4	931	936	PF00397	0.415
LIG_14-3-3_CanoR_1	165	175	PF00244	0.428
LIG_14-3-3_CanoR_1	2	6	PF00244	0.407
LIG_14-3-3_CanoR_1	206	211	PF00244	0.546
LIG_14-3-3_CanoR_1	282	286	PF00244	0.547
LIG_14-3-3_CanoR_1	349	354	PF00244	0.523
LIG_14-3-3_CanoR_1	36	42	PF00244	0.353
LIG_14-3-3_CanoR_1	44	49	PF00244	0.321
LIG_14-3-3_CanoR_1	772	780	PF00244	0.499
LIG_14-3-3_CanoR_1	781	786	PF00244	0.511
LIG_14-3-3_CanoR_1	849	853	PF00244	0.497
LIG_14-3-3_CanoR_1	877	883	PF00244	0.561
LIG_14-3-3_CanoR_1	89	94	PF00244	0.470
LIG_14-3-3_CanoR_1	963	973	PF00244	0.448
LIG_Actin_WH2_2	801	816	PF00022	0.479
LIG_APCC_ABBA_1	455	460	PF00400	0.468
LIG_APCC_ABBA_1	765	770	PF00400	0.465
LIG_BIR_III_2	1044	1048	PF00653	0.462
LIG_BRCT_BRCA1_1	168	172	PF00533	0.427
LIG_BRCT_BRCA1_1	853	857	PF00533	0.507
LIG_EH1_1	36	44	PF00400	0.353
LIG_eIF4E_1	152	158	PF01652	0.428
LIG_FHA_1	350	356	PF00498	0.524
LIG_FHA_1	38	44	PF00498	0.341
LIG_FHA_1	395	401	PF00498	0.387
LIG_FHA_1	452	458	PF00498	0.482
LIG_FHA_1	637	643	PF00498	0.345
LIG_FHA_1	727	733	PF00498	0.427
LIG_FHA_1	829	835	PF00498	0.478
LIG_FHA_1	907	913	PF00498	0.543
LIG_FHA_1	939	945	PF00498	0.359
LIG_FHA_1	989	995	PF00498	0.444
LIG_FHA_2	367	373	PF00498	0.520
LIG_FHA_2	646	652	PF00498	0.354
LIG_FHA_2	797	803	PF00498	0.503
LIG_FHA_2	940	946	PF00498	0.355
LIG_LIR_Gen_1	343	350	PF02991	0.538
LIG_LIR_Gen_1	766	774	PF02991	0.471
LIG_LIR_Gen_1	995	1004	PF02991	0.459
LIG_LIR_Nem_3	169	175	PF02991	0.418
LIG_LIR_Nem_3	343	347	PF02991	0.546
LIG_LIR_Nem_3	580	586	PF02991	0.478
LIG_LIR_Nem_3	766	771	PF02991	0.466
LIG_LIR_Nem_3	984	990	PF02991	0.410
LIG_LIR_Nem_3	995	999	PF02991	0.461
LIG_NRBOX	483	489	PF00104	0.377
LIG_NRBOX	614	620	PF00104	0.291
LIG_PCNA_yPIPBox_3	110	124	PF02747	0.359
LIG_Pex14_2	853	857	PF04695	0.507
LIG_Rb_LxCxE_1	467	480	PF01857	0.386
LIG_SH2_CRK	608	612	PF00017	0.363
LIG_SH2_NCK_1	556	560	PF00017	0.524
LIG_SH2_STAP1	363	367	PF00017	0.514
LIG_SH2_STAP1	402	406	PF00017	0.375
LIG_SH2_STAT3	402	405	PF00017	0.380
LIG_SH2_STAT5	135	138	PF00017	0.425
LIG_SH2_STAT5	556	559	PF00017	0.526
LIG_SH2_STAT5	624	627	PF00017	0.327
LIG_SH3_3	1045	1051	PF00018	0.456
LIG_SH3_3	288	294	PF00018	0.544
LIG_SH3_3	506	512	PF00018	0.510
LIG_SH3_3	513	519	PF00018	0.502
LIG_SH3_3	576	582	PF00018	0.493
LIG_SH3_3	634	640	PF00018	0.338
LIG_SH3_3	758	764	PF00018	0.456
LIG_SH3_3	842	848	PF00018	0.480
LIG_SH3_3	849	855	PF00018	0.499
LIG_SH3_3	862	868	PF00018	0.536
LIG_SH3_3	980	986	PF00018	0.406
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.368
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.334
LIG_SUMO_SIM_par_1	1050	1056	PF11976	0.457
LIG_SUMO_SIM_par_1	21	27	PF11976	0.344
LIG_SUMO_SIM_par_1	396	401	PF11976	0.385
LIG_TRAF2_1	592	595	PF00917	0.345
LIG_TRAF2_1	69	72	PF00917	0.478
LIG_TRAF2_1	873	876	PF00917	0.568
LIG_UBA3_1	193	202	PF00899	0.426
LIG_WRC_WIRS_1	341	346	PF05994	0.548
LIG_WW_3	227	231	PF00397	0.544
MOD_CDK_SPK_2	1035	1040	PF00069	0.444
MOD_CDK_SPK_2	864	869	PF00069	0.545
MOD_CK1_1	1016	1022	PF00069	0.470
MOD_CK1_1	1056	1062	PF00069	0.449
MOD_CK1_1	248	254	PF00069	0.555
MOD_CK1_1	314	320	PF00069	0.574
MOD_CK1_1	343	349	PF00069	0.541
MOD_CK1_1	351	357	PF00069	0.527
MOD_CK1_1	366	372	PF00069	0.518
MOD_CK1_1	375	381	PF00069	0.524
MOD_CK1_1	401	407	PF00069	0.374
MOD_CK1_1	498	504	PF00069	0.522
MOD_CK1_1	554	560	PF00069	0.519
MOD_CK1_1	667	673	PF00069	0.431
MOD_CK1_1	678	684	PF00069	0.461
MOD_CK1_1	783	789	PF00069	0.498
MOD_CK1_1	80	86	PF00069	0.482
MOD_CK1_1	851	857	PF00069	0.502
MOD_CK1_1	938	944	PF00069	0.353
MOD_CK1_1	953	959	PF00069	0.376
MOD_CK1_1	967	973	PF00069	0.439
MOD_CK1_1	976	982	PF00069	0.406
MOD_CK2_1	123	129	PF00069	0.362
MOD_CK2_1	355	361	PF00069	0.531
MOD_CK2_1	645	651	PF00069	0.347
MOD_CK2_1	66	72	PF00069	0.485
MOD_CK2_1	796	802	PF00069	0.504
MOD_CK2_1	876	882	PF00069	0.568
MOD_CK2_1	913	919	PF00069	0.536
MOD_GlcNHglycan	100	103	PF01048	0.461
MOD_GlcNHglycan	1015	1018	PF01048	0.478
MOD_GlcNHglycan	1055	1058	PF01048	0.456
MOD_GlcNHglycan	199	202	PF01048	0.492
MOD_GlcNHglycan	203	206	PF01048	0.525
MOD_GlcNHglycan	233	236	PF01048	0.557
MOD_GlcNHglycan	258	261	PF01048	0.544
MOD_GlcNHglycan	357	360	PF01048	0.531
MOD_GlcNHglycan	363	366	PF01048	0.513
MOD_GlcNHglycan	48	51	PF01048	0.319
MOD_GlcNHglycan	497	500	PF01048	0.506
MOD_GlcNHglycan	526	529	PF01048	0.502
MOD_GlcNHglycan	543	546	PF01048	0.542
MOD_GlcNHglycan	553	556	PF01048	0.515
MOD_GlcNHglycan	557	560	PF01048	0.524
MOD_GlcNHglycan	68	71	PF01048	0.486
MOD_GlcNHglycan	703	706	PF01048	0.385
MOD_GlcNHglycan	84	88	PF01048	0.482
MOD_GlcNHglycan	884	887	PF01048	0.563
MOD_GlcNHglycan	915	918	PF01048	0.533
MOD_GlcNHglycan	922	925	PF01048	0.484
MOD_GlcNHglycan	952	955	PF01048	0.362
MOD_GlcNHglycan	978	981	PF01048	0.399
MOD_GSK3_1	10	17	PF00069	0.333
MOD_GSK3_1	1011	1018	PF00069	0.477
MOD_GSK3_1	1053	1060	PF00069	0.453
MOD_GSK3_1	197	204	PF00069	0.473
MOD_GSK3_1	206	213	PF00069	0.544
MOD_GSK3_1	241	248	PF00069	0.550
MOD_GSK3_1	252	259	PF00069	0.553
MOD_GSK3_1	280	287	PF00069	0.545
MOD_GSK3_1	308	315	PF00069	0.571
MOD_GSK3_1	345	352	PF00069	0.529
MOD_GSK3_1	355	362	PF00069	0.530
MOD_GSK3_1	375	382	PF00069	0.524
MOD_GSK3_1	385	392	PF00069	0.493
MOD_GSK3_1	394	401	PF00069	0.395
MOD_GSK3_1	447	454	PF00069	0.501
MOD_GSK3_1	490	497	PF00069	0.430
MOD_GSK3_1	507	514	PF00069	0.507
MOD_GSK3_1	541	548	PF00069	0.537
MOD_GSK3_1	551	558	PF00069	0.513
MOD_GSK3_1	560	567	PF00069	0.524
MOD_GSK3_1	62	69	PF00069	0.479
MOD_GSK3_1	667	674	PF00069	0.431
MOD_GSK3_1	678	685	PF00069	0.463
MOD_GSK3_1	779	786	PF00069	0.513
MOD_GSK3_1	824	831	PF00069	0.496
MOD_GSK3_1	851	858	PF00069	0.504
MOD_GSK3_1	878	885	PF00069	0.559
MOD_GSK3_1	889	896	PF00069	0.548
MOD_GSK3_1	906	913	PF00069	0.543
MOD_GSK3_1	931	938	PF00069	0.408
MOD_GSK3_1	972	979	PF00069	0.419
MOD_LATS_1	699	705	PF00433	0.403
MOD_N-GLC_1	231	236	PF02516	0.553
MOD_N-GLC_1	331	336	PF02516	0.564
MOD_N-GLC_1	359	364	PF02516	0.528
MOD_N-GLC_1	667	672	PF02516	0.429
MOD_N-GLC_1	678	683	PF02516	0.457
MOD_N-GLC_1	931	936	PF02516	0.415
MOD_NEK2_1	1011	1016	PF00069	0.477
MOD_NEK2_1	14	19	PF00069	0.326
MOD_NEK2_1	216	221	PF00069	0.544
MOD_NEK2_1	252	257	PF00069	0.556
MOD_NEK2_1	281	286	PF00069	0.546
MOD_NEK2_1	342	347	PF00069	0.546
MOD_NEK2_1	353	358	PF00069	0.530
MOD_NEK2_1	393	398	PF00069	0.416
MOD_NEK2_1	407	412	PF00069	0.399
MOD_NEK2_1	477	482	PF00069	0.367
MOD_NEK2_1	64	69	PF00069	0.486
MOD_NEK2_1	671	676	PF00069	0.434
MOD_NEK2_1	693	698	PF00069	0.461
MOD_NEK2_1	717	722	PF00069	0.356
MOD_NEK2_1	780	785	PF00069	0.518
MOD_NEK2_1	859	864	PF00069	0.530
MOD_NEK2_1	950	955	PF00069	0.352
MOD_NEK2_2	389	394	PF00069	0.460
MOD_NEK2_2	472	477	PF00069	0.377
MOD_NEK2_2	848	853	PF00069	0.496
MOD_NEK2_2	855	860	PF00069	0.521
MOD_PIKK_1	113	119	PF00454	0.353
MOD_PIKK_1	243	249	PF00454	0.548
MOD_PIKK_1	275	281	PF00454	0.539
MOD_PIKK_1	300	306	PF00454	0.564
MOD_PIKK_1	401	407	PF00454	0.374
MOD_PIKK_1	477	483	PF00454	0.370
MOD_PIKK_1	507	513	PF00454	0.507
MOD_PIKK_1	51	57	PF00454	0.345
MOD_PIKK_1	560	566	PF00454	0.524
MOD_PIKK_1	693	699	PF00454	0.457
MOD_PIKK_1	859	865	PF00454	0.529
MOD_PIKK_1	871	877	PF00454	0.569
MOD_PIKK_1	894	900	PF00454	0.537
MOD_PK_1	763	769	PF00069	0.458
MOD_PKA_1	89	95	PF00069	0.469
MOD_PKA_1	965	971	PF00069	0.445
MOD_PKA_2	1	7	PF00069	0.407
MOD_PKA_2	281	287	PF00069	0.546
MOD_PKA_2	348	354	PF00069	0.523
MOD_PKA_2	35	41	PF00069	0.359
MOD_PKA_2	407	413	PF00069	0.402
MOD_PKA_2	780	786	PF00069	0.514
MOD_PKA_2	848	854	PF00069	0.494
MOD_PKA_2	876	882	PF00069	0.568
MOD_PKA_2	89	95	PF00069	0.469
MOD_PKA_2	964	970	PF00069	0.451
MOD_PKB_1	963	971	PF00069	0.450
MOD_Plk_1	359	365	PF00069	0.524
MOD_Plk_1	451	457	PF00069	0.486
MOD_Plk_1	573	579	PF00069	0.502
MOD_Plk_1	667	673	PF00069	0.431
MOD_Plk_1	678	684	PF00069	0.461
MOD_Plk_1	801	807	PF00069	0.484
MOD_Plk_2-3	876	882	PF00069	0.568
MOD_Plk_4	1	7	PF00069	0.407
MOD_Plk_4	10	16	PF00069	0.330
MOD_Plk_4	1003	1009	PF00069	0.447
MOD_Plk_4	1057	1063	PF00069	0.452
MOD_Plk_4	130	136	PF00069	0.385
MOD_Plk_4	21	27	PF00069	0.344
MOD_Plk_4	37	43	PF00069	0.343
MOD_Plk_4	394	400	PF00069	0.395
MOD_Plk_4	465	471	PF00069	0.407
MOD_Plk_4	472	478	PF00069	0.379
MOD_Plk_4	671	677	PF00069	0.435
MOD_Plk_4	732	738	PF00069	0.456
MOD_Plk_4	763	769	PF00069	0.458
MOD_Plk_4	801	807	PF00069	0.484
MOD_Plk_4	824	830	PF00069	0.496
MOD_Plk_4	848	854	PF00069	0.494
MOD_Plk_4	939	945	PF00069	0.359
MOD_ProDKin_1	1035	1041	PF00069	0.441
MOD_ProDKin_1	241	247	PF00069	0.550
MOD_ProDKin_1	290	296	PF00069	0.547
MOD_ProDKin_1	297	303	PF00069	0.563
MOD_ProDKin_1	375	381	PF00069	0.524
MOD_ProDKin_1	434	440	PF00069	0.503
MOD_ProDKin_1	515	521	PF00069	0.498
MOD_ProDKin_1	636	642	PF00069	0.346
MOD_ProDKin_1	770	776	PF00069	0.486
MOD_ProDKin_1	851	857	PF00069	0.502
MOD_ProDKin_1	864	870	PF00069	0.546
MOD_ProDKin_1	889	895	PF00069	0.548
MOD_ProDKin_1	931	937	PF00069	0.415
MOD_SUMO_rev_2	204	213	PF00179	0.539
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.546
TRG_ENDOCYTIC_2	608	611	PF00928	0.374
TRG_ER_diArg_1	104	107	PF00400	0.425
TRG_ER_diArg_1	407	409	PF00400	0.399
TRG_ER_diArg_1	608	610	PF00400	0.391
TRG_ER_diArg_1	88	90	PF00400	0.490
TRG_ER_diArg_1	904	906	PF00400	0.542
TRG_ER_diArg_1	963	966	PF00400	0.464
TRG_NES_CRM1_1	279	292	PF08389	0.545
TRG_NES_CRM1_1	812	823	PF08389	0.487
TRG_NLS_MonoExtC_3	216	221	PF00514	0.544
TRG_NLS_MonoExtC_3	745	750	PF00514	0.457
TRG_NLS_MonoExtN_4	214	221	PF00514	0.543
TRG_NLS_MonoExtN_4	746	753	PF00514	0.459
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	958	962	PF00026	0.419