Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICE2_LEIIN

TriTrypDb:

LINF_360082400

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.416
CLV_PCSK_SKI1_1	155	159	PF00082	0.302
CLV_PCSK_SKI1_1	203	207	PF00082	0.281
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DOC_MAPK_gen_1	20	28	PF00069	0.699
DOC_MAPK_gen_1	212	220	PF00069	0.309
DOC_MAPK_MEF2A_6	125	133	PF00069	0.345
DOC_PP1_RVXF_1	201	208	PF00149	0.243
DOC_PP1_RVXF_1	212	218	PF00149	0.266
DOC_PP1_SILK_1	151	156	PF00149	0.334
DOC_USP7_MATH_1	149	153	PF00917	0.436
DOC_WW_Pin1_4	29	34	PF00397	0.513
LIG_14-3-3_CanoR_1	155	164	PF00244	0.264
LIG_14-3-3_CanoR_1	37	41	PF00244	0.473
LIG_EVH1_1	15	19	PF00568	0.469
LIG_FHA_1	145	151	PF00498	0.472
LIG_FHA_1	68	74	PF00498	0.497
LIG_FHA_2	140	146	PF00498	0.426
LIG_FHA_2	156	162	PF00498	0.289
LIG_FHA_2	2	8	PF00498	0.690
LIG_FHA_2	211	217	PF00498	0.293
LIG_IBAR_NPY_1	44	46	PF08397	0.513
LIG_LIR_Gen_1	216	225	PF02991	0.319
LIG_LIR_Nem_3	192	198	PF02991	0.416
LIG_LIR_Nem_3	216	220	PF02991	0.274
LIG_LIR_Nem_3	223	228	PF02991	0.269
LIG_SH2_NCK_1	56	60	PF00017	0.438
LIG_SH2_PTP2	118	121	PF00017	0.293
LIG_SH2_STAT3	46	49	PF00017	0.412
LIG_SH2_STAT5	107	110	PF00017	0.298
LIG_SH2_STAT5	118	121	PF00017	0.269
LIG_SH2_STAT5	143	146	PF00017	0.433
LIG_SH3_3	13	19	PF00018	0.631
LIG_SH3_3	82	88	PF00018	0.568
LIG_TRAF2_1	72	75	PF00917	0.520
MOD_CK1_1	139	145	PF00069	0.462
MOD_CK1_1	32	38	PF00069	0.509
MOD_CK2_1	139	145	PF00069	0.406
MOD_CK2_1	155	161	PF00069	0.220
MOD_CK2_1	54	60	PF00069	0.658
MOD_GlcNHglycan	56	59	PF01048	0.605
MOD_GSK3_1	32	39	PF00069	0.484
MOD_GSK3_1	89	96	PF00069	0.490
MOD_NEK2_1	1	6	PF00069	0.638
MOD_PIKK_1	136	142	PF00454	0.524
MOD_PIKK_1	155	161	PF00454	0.283
MOD_PKA_1	203	209	PF00069	0.281
MOD_PKA_2	36	42	PF00069	0.635
MOD_Plk_4	107	113	PF00069	0.285
MOD_Plk_4	139	145	PF00069	0.419
MOD_Plk_4	149	155	PF00069	0.289
MOD_Plk_4	203	209	PF00069	0.244
MOD_Plk_4	93	99	PF00069	0.471
MOD_ProDKin_1	29	35	PF00069	0.513
MOD_SUMO_rev_2	163	172	PF00179	0.367
MOD_SUMO_rev_2	197	205	PF00179	0.290
TRG_ENDOCYTIC_2	118	121	PF00928	0.274
TRG_ER_diArg_1	212	215	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D9	Leptomonas seymouri	75%	100%
A0A0S4KL40	Bodo saltans	57%	100%
A0A1X0NLP9	Trypanosomatidae	61%	100%
A0A1X0NWX9	Trypanosomatidae	40%	80%
A0A3Q8IJZ1	Leishmania donovani	29%	86%
A0A3Q8ILM8	Leishmania donovani	98%	100%
A0A3R7M5V2	Trypanosoma rangeli	61%	100%
A0A3R7NIU7	Trypanosoma rangeli	27%	91%
A0A3S5ISC8	Trypanosoma rangeli	36%	80%
A4HGI7	Leishmania braziliensis	84%	100%
A4IC69	Leishmania infantum	29%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0A7N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	77%
E9AUD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q051	Leishmania major	90%	100%
V5BB20	Trypanosoma cruzi	38%	80%