Cytochrome c oxidase subunit I

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit IX - putative

Species:

Leishmania infantum

UniProt:

A4ICE1_LEIIN

TriTrypDb:

LINF_360082300

Length:

124

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), Cytochrome c oxidase subunit I

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4ICE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.623
CLV_PCSK_KEX2_1	10	12	PF00082	0.440
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.478
CLV_PCSK_SKI1_1	3	7	PF00082	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_MAPK_gen_1	10	17	PF00069	0.706
DOC_USP7_MATH_1	16	20	PF00917	0.679
LIG_14-3-3_CanoR_1	3	9	PF00244	0.630
LIG_FHA_1	10	16	PF00498	0.705
LIG_FHA_1	34	40	PF00498	0.593
LIG_LIR_Apic_2	37	43	PF02991	0.608
LIG_LIR_Gen_1	54	65	PF02991	0.342
LIG_LIR_Gen_1	66	75	PF02991	0.490
LIG_LIR_Nem_3	54	60	PF02991	0.354
LIG_LIR_Nem_3	66	72	PF02991	0.485
LIG_Pex14_1	95	99	PF04695	0.408
LIG_SH2_CRK	40	44	PF00017	0.605
LIG_SH3_3	108	114	PF00018	0.455
MOD_CK1_1	9	15	PF00069	0.632
MOD_GlcNHglycan	115	118	PF01048	0.699
MOD_GlcNHglycan	73	78	PF01048	0.693
MOD_GlcNHglycan	80	83	PF01048	0.722
MOD_NEK2_1	6	11	PF00069	0.614
MOD_PIKK_1	86	92	PF00454	0.498
MOD_Plk_1	95	101	PF00069	0.474
MOD_SUMO_rev_2	89	94	PF00179	0.418
TRG_ENDOCYTIC_2	47	50	PF00928	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P812	Leptomonas seymouri	93%	100%
A0A0S4KK00	Bodo saltans	65%	93%
A0A1X0NL41	Trypanosomatidae	80%	100%
A0A3Q8IM95	Leishmania donovani	100%	100%
A0A422NW07	Trypanosoma rangeli	79%	100%
A4HQM3	Leishmania braziliensis	92%	100%
D0A3S7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AUD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q052	Leishmania major	99%	100%