LeishMANIAdb
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Putative eukaryotic translation initiation factor 3 subunit 8

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative eukaryotic translation initiation factor 3 subunit 8
Gene product:
eukaryotic translation initiation factor 3 subunit 8 - putative
Species:
Leishmania infantum
UniProt:
A4ICD8_LEIIN
TriTrypDb:
LINF_360081900
Length:
731

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 3 subunit 8

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 10
GO:0032991 protein-containing complex 1 10
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICD8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD8

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0003743 translation initiation factor activity 4 10
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0008135 translation factor activity, RNA binding 3 10
GO:0031369 translation initiation factor binding 3 10
GO:0045182 translation regulator activity 1 10
GO:0090079 translation regulator activity, nucleic acid binding 2 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 364 368 PF00656 0.501
CLV_C14_Caspase3-7 9 13 PF00656 0.571
CLV_NRD_NRD_1 208 210 PF00675 0.579
CLV_NRD_NRD_1 229 231 PF00675 0.535
CLV_NRD_NRD_1 232 234 PF00675 0.571
CLV_NRD_NRD_1 330 332 PF00675 0.246
CLV_NRD_NRD_1 351 353 PF00675 0.261
CLV_NRD_NRD_1 598 600 PF00675 0.525
CLV_NRD_NRD_1 642 644 PF00675 0.509
CLV_NRD_NRD_1 93 95 PF00675 0.575
CLV_PCSK_KEX2_1 229 231 PF00082 0.527
CLV_PCSK_KEX2_1 332 334 PF00082 0.245
CLV_PCSK_KEX2_1 351 353 PF00082 0.262
CLV_PCSK_KEX2_1 600 602 PF00082 0.511
CLV_PCSK_KEX2_1 642 644 PF00082 0.509
CLV_PCSK_KEX2_1 83 85 PF00082 0.473
CLV_PCSK_PC1ET2_1 332 334 PF00082 0.262
CLV_PCSK_PC1ET2_1 600 602 PF00082 0.439
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.473
CLV_PCSK_SKI1_1 132 136 PF00082 0.420
CLV_PCSK_SKI1_1 17 21 PF00082 0.741
CLV_PCSK_SKI1_1 233 237 PF00082 0.551
CLV_PCSK_SKI1_1 244 248 PF00082 0.465
CLV_PCSK_SKI1_1 309 313 PF00082 0.301
CLV_PCSK_SKI1_1 485 489 PF00082 0.302
CLV_PCSK_SKI1_1 498 502 PF00082 0.182
CLV_PCSK_SKI1_1 76 80 PF00082 0.488
DEG_Nend_UBRbox_3 1 3 PF02207 0.621
DEG_SPOP_SBC_1 5 9 PF00917 0.705
DOC_CYCLIN_yClb1_LxF_4 126 131 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 501 504 PF00134 0.462
DOC_MAPK_gen_1 132 140 PF00069 0.492
DOC_MAPK_gen_1 209 217 PF00069 0.464
DOC_MAPK_gen_1 229 237 PF00069 0.257
DOC_MAPK_MEF2A_6 338 345 PF00069 0.516
DOC_MAPK_MEF2A_6 381 390 PF00069 0.535
DOC_MAPK_RevD_3 339 352 PF00069 0.545
DOC_PP1_RVXF_1 126 132 PF00149 0.586
DOC_PP1_RVXF_1 307 314 PF00149 0.516
DOC_PP2B_LxvP_1 500 503 PF13499 0.445
DOC_USP7_MATH_1 5 9 PF00917 0.705
DOC_USP7_MATH_1 55 59 PF00917 0.504
DOC_USP7_UBL2_3 146 150 PF12436 0.507
DOC_USP7_UBL2_3 247 251 PF12436 0.475
DOC_USP7_UBL2_3 596 600 PF12436 0.500
DOC_WW_Pin1_4 478 483 PF00397 0.519
DOC_WW_Pin1_4 547 552 PF00397 0.586
LIG_14-3-3_CanoR_1 601 607 PF00244 0.431
LIG_14-3-3_CanoR_1 619 628 PF00244 0.435
LIG_Actin_WH2_2 295 311 PF00022 0.516
LIG_Actin_WH2_2 376 393 PF00022 0.501
LIG_Actin_WH2_2 451 468 PF00022 0.485
LIG_Actin_WH2_2 557 574 PF00022 0.381
LIG_BRCT_BRCA1_1 341 345 PF00533 0.501
LIG_deltaCOP1_diTrp_1 240 248 PF00928 0.467
LIG_deltaCOP1_diTrp_1 73 82 PF00928 0.400
LIG_EH_1 29 33 PF12763 0.662
LIG_eIF4E_1 288 294 PF01652 0.545
LIG_FHA_1 142 148 PF00498 0.522
LIG_FHA_1 289 295 PF00498 0.538
LIG_FHA_1 364 370 PF00498 0.452
LIG_FHA_1 422 428 PF00498 0.471
LIG_FHA_1 548 554 PF00498 0.597
LIG_FHA_1 622 628 PF00498 0.402
LIG_FHA_2 175 181 PF00498 0.504
LIG_FHA_2 211 217 PF00498 0.491
LIG_FHA_2 35 41 PF00498 0.565
LIG_FHA_2 585 591 PF00498 0.521
LIG_GBD_Chelix_1 515 523 PF00786 0.300
LIG_IBAR_NPY_1 532 534 PF08397 0.532
LIG_LIR_Gen_1 178 188 PF02991 0.541
LIG_LIR_Gen_1 297 307 PF02991 0.466
LIG_LIR_Gen_1 374 383 PF02991 0.537
LIG_LIR_Gen_1 587 593 PF02991 0.455
LIG_LIR_Gen_1 620 630 PF02991 0.502
LIG_LIR_Gen_1 662 673 PF02991 0.393
LIG_LIR_Nem_3 130 134 PF02991 0.395
LIG_LIR_Nem_3 178 184 PF02991 0.550
LIG_LIR_Nem_3 297 302 PF02991 0.463
LIG_LIR_Nem_3 304 310 PF02991 0.423
LIG_LIR_Nem_3 342 348 PF02991 0.544
LIG_LIR_Nem_3 374 380 PF02991 0.503
LIG_LIR_Nem_3 494 500 PF02991 0.431
LIG_LIR_Nem_3 587 592 PF02991 0.525
LIG_LIR_Nem_3 662 668 PF02991 0.377
LIG_NRBOX 518 524 PF00104 0.508
LIG_NRP_CendR_1 728 731 PF00754 0.688
LIG_PCNA_PIPBox_1 110 119 PF02747 0.593
LIG_PCNA_PIPBox_1 407 416 PF02747 0.516
LIG_PCNA_yPIPBox_3 407 418 PF02747 0.516
LIG_PCNA_yPIPBox_3 443 454 PF02747 0.516
LIG_PCNA_yPIPBox_3 652 661 PF02747 0.444
LIG_Pex14_1 242 246 PF04695 0.357
LIG_Pex14_1 248 252 PF04695 0.363
LIG_Pex14_2 32 36 PF04695 0.682
LIG_Rb_pABgroove_1 339 347 PF01858 0.545
LIG_REV1ctd_RIR_1 250 259 PF16727 0.525
LIG_SH2_CRK 181 185 PF00017 0.523
LIG_SH2_CRK 360 364 PF00017 0.516
LIG_SH2_CRK 497 501 PF00017 0.480
LIG_SH2_CRK 544 548 PF00017 0.418
LIG_SH2_GRB2like 212 215 PF00017 0.494
LIG_SH2_GRB2like 616 619 PF00017 0.453
LIG_SH2_NCK_1 544 548 PF00017 0.530
LIG_SH2_SRC 406 409 PF00017 0.496
LIG_SH2_STAP1 181 185 PF00017 0.525
LIG_SH2_STAT5 212 215 PF00017 0.451
LIG_SH2_STAT5 288 291 PF00017 0.510
LIG_SH2_STAT5 307 310 PF00017 0.327
LIG_SH2_STAT5 420 423 PF00017 0.510
LIG_SH2_STAT5 542 545 PF00017 0.418
LIG_SH2_STAT5 576 579 PF00017 0.405
LIG_SH2_STAT5 602 605 PF00017 0.455
LIG_SH2_STAT5 616 619 PF00017 0.354
LIG_SH2_STAT5 665 668 PF00017 0.372
LIG_SUMO_SIM_anti_2 136 145 PF11976 0.537
LIG_SUMO_SIM_anti_2 316 322 PF11976 0.516
LIG_SUMO_SIM_anti_2 364 375 PF11976 0.513
LIG_SUMO_SIM_anti_2 608 613 PF11976 0.429
LIG_SUMO_SIM_par_1 136 145 PF11976 0.499
LIG_TRAF2_1 303 306 PF00917 0.545
LIG_TRAF2_1 37 40 PF00917 0.631
LIG_TYR_ITIM 358 363 PF00017 0.516
LIG_TYR_ITIM 566 571 PF00017 0.461
LIG_TYR_ITSM 177 184 PF00017 0.389
LIG_WRC_WIRS_1 310 315 PF05994 0.501
LIG_WRC_WIRS_1 586 591 PF05994 0.504
MOD_CDK_SPxxK_3 478 485 PF00069 0.545
MOD_CK1_1 15 21 PF00069 0.593
MOD_CK1_1 238 244 PF00069 0.459
MOD_CK1_1 362 368 PF00069 0.516
MOD_CK1_1 517 523 PF00069 0.545
MOD_CK1_1 623 629 PF00069 0.479
MOD_CK1_1 650 656 PF00069 0.466
MOD_CK1_1 8 14 PF00069 0.568
MOD_CK2_1 130 136 PF00069 0.479
MOD_CK2_1 174 180 PF00069 0.602
MOD_CK2_1 210 216 PF00069 0.546
MOD_CK2_1 294 300 PF00069 0.516
MOD_CK2_1 34 40 PF00069 0.540
MOD_CK2_1 4 10 PF00069 0.568
MOD_CK2_1 556 562 PF00069 0.559
MOD_CK2_1 591 597 PF00069 0.555
MOD_CK2_1 602 608 PF00069 0.276
MOD_CK2_1 71 77 PF00069 0.427
MOD_CMANNOS 33 36 PF00535 0.685
MOD_GlcNHglycan 186 191 PF01048 0.539
MOD_GlcNHglycan 216 220 PF01048 0.458
MOD_GlcNHglycan 224 227 PF01048 0.466
MOD_GlcNHglycan 396 399 PF01048 0.288
MOD_GlcNHglycan 519 522 PF01048 0.316
MOD_GlcNHglycan 593 596 PF01048 0.438
MOD_GlcNHglycan 655 658 PF01048 0.500
MOD_GSK3_1 284 291 PF00069 0.550
MOD_GSK3_1 359 366 PF00069 0.484
MOD_GSK3_1 372 379 PF00069 0.392
MOD_GSK3_1 390 397 PF00069 0.445
MOD_GSK3_1 4 11 PF00069 0.651
MOD_GSK3_1 426 433 PF00069 0.479
MOD_GSK3_1 543 550 PF00069 0.500
MOD_GSK3_1 584 591 PF00069 0.476
MOD_GSK3_1 617 624 PF00069 0.499
MOD_GSK3_1 647 654 PF00069 0.433
MOD_GSK3_1 681 688 PF00069 0.569
MOD_N-GLC_1 294 299 PF02516 0.316
MOD_N-GLC_1 367 372 PF02516 0.198
MOD_N-GLC_1 617 622 PF02516 0.495
MOD_N-GLC_1 651 656 PF02516 0.461
MOD_N-GLC_1 671 676 PF02516 0.440
MOD_N-GLC_1 71 76 PF02516 0.524
MOD_NEK2_1 215 220 PF00069 0.360
MOD_NEK2_1 359 364 PF00069 0.502
MOD_NEK2_1 396 401 PF00069 0.519
MOD_NEK2_1 4 9 PF00069 0.653
MOD_NEK2_1 421 426 PF00069 0.486
MOD_NEK2_1 464 469 PF00069 0.549
MOD_NEK2_1 614 619 PF00069 0.432
MOD_NEK2_2 602 607 PF00069 0.398
MOD_PIKK_1 301 307 PF00454 0.495
MOD_PKA_1 229 235 PF00069 0.559
MOD_PKA_2 229 235 PF00069 0.531
MOD_PKA_2 390 396 PF00069 0.501
MOD_Plk_1 15 21 PF00069 0.619
MOD_Plk_1 215 221 PF00069 0.432
MOD_Plk_1 266 272 PF00069 0.357
MOD_Plk_1 367 373 PF00069 0.469
MOD_Plk_1 620 626 PF00069 0.487
MOD_Plk_1 650 656 PF00069 0.467
MOD_Plk_1 671 677 PF00069 0.440
MOD_Plk_1 71 77 PF00069 0.520
MOD_Plk_2-3 10 16 PF00069 0.711
MOD_Plk_2-3 130 136 PF00069 0.541
MOD_Plk_4 15 21 PF00069 0.738
MOD_Plk_4 284 290 PF00069 0.557
MOD_Plk_4 367 373 PF00069 0.455
MOD_Plk_4 483 489 PF00069 0.545
MOD_Plk_4 514 520 PF00069 0.455
MOD_Plk_4 623 629 PF00069 0.460
MOD_ProDKin_1 478 484 PF00069 0.519
MOD_ProDKin_1 547 553 PF00069 0.591
MOD_SUMO_for_1 50 53 PF00179 0.604
MOD_SUMO_for_1 526 529 PF00179 0.480
MOD_SUMO_rev_2 124 134 PF00179 0.535
TRG_DiLeu_BaEn_1 136 141 PF01217 0.464
TRG_DiLeu_BaEn_1 496 501 PF01217 0.492
TRG_DiLeu_BaEn_1 608 613 PF01217 0.439
TRG_DiLeu_BaEn_2 87 93 PF01217 0.495
TRG_DiLeu_BaEn_4 142 148 PF01217 0.481
TRG_ENDOCYTIC_2 181 184 PF00928 0.530
TRG_ENDOCYTIC_2 212 215 PF00928 0.475
TRG_ENDOCYTIC_2 307 310 PF00928 0.445
TRG_ENDOCYTIC_2 360 363 PF00928 0.445
TRG_ENDOCYTIC_2 497 500 PF00928 0.445
TRG_ENDOCYTIC_2 544 547 PF00928 0.413
TRG_ENDOCYTIC_2 568 571 PF00928 0.369
TRG_ENDOCYTIC_2 665 668 PF00928 0.378
TRG_ER_diArg_1 228 230 PF00400 0.555
TRG_ER_diArg_1 331 334 PF00400 0.514
TRG_ER_diArg_1 599 602 PF00400 0.501
TRG_ER_diArg_1 641 643 PF00400 0.500
TRG_NLS_Bipartite_1 83 98 PF00514 0.489
TRG_NLS_MonoExtN_4 596 603 PF00514 0.441
TRG_Pf-PMV_PEXEL_1 132 136 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 150 154 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 443 447 PF00026 0.245

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I262 Leptomonas seymouri 76% 99%
A0A1X0NL84 Trypanosomatidae 38% 100%
A0A3Q8IWP7 Leishmania donovani 100% 100%
A0A422NVW4 Trypanosoma rangeli 39% 100%
A4HQM0 Leishmania braziliensis 93% 100%
A7E471 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 22% 84%
E9AUD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q055 Leishmania major 98% 100%
Q54X97 Dictyostelium discoideum 23% 78%
Q6BJF7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 22% 86%
Q6P1V4 Xenopus tropicalis 23% 79%
Q6PFQ2 Danio rerio 22% 79%
V5DDW8 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS