LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICD7_LEIIN
TriTrypDb:
LINF_360081800
Length:
298

Annotations

LeishMANIAdb annotations

Might be part of a yet-unknown kinetoplastid enzyme

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4ICD7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.561
CLV_NRD_NRD_1 267 269 PF00675 0.601
CLV_NRD_NRD_1 67 69 PF00675 0.541
CLV_PCSK_KEX2_1 129 131 PF00082 0.573
CLV_PCSK_KEX2_1 67 69 PF00082 0.542
CLV_PCSK_PC1ET2_1 129 131 PF00082 0.656
CLV_PCSK_SKI1_1 132 136 PF00082 0.556
CLV_PCSK_SKI1_1 187 191 PF00082 0.546
CLV_PCSK_SKI1_1 215 219 PF00082 0.595
CLV_PCSK_SKI1_1 254 258 PF00082 0.548
DEG_Nend_Nbox_1 1 3 PF02207 0.752
DOC_CYCLIN_RxL_1 184 192 PF00134 0.437
DOC_CYCLIN_RxL_1 71 82 PF00134 0.324
DOC_MAPK_gen_1 129 138 PF00069 0.364
DOC_MAPK_MEF2A_6 129 138 PF00069 0.377
DOC_MAPK_MEF2A_6 198 206 PF00069 0.397
DOC_MAPK_NFAT4_5 131 139 PF00069 0.358
DOC_PP1_RVXF_1 99 105 PF00149 0.305
DOC_SPAK_OSR1_1 39 43 PF12202 0.398
DOC_USP7_MATH_1 16 20 PF00917 0.734
DOC_USP7_MATH_1 226 230 PF00917 0.436
DOC_USP7_UBL2_3 84 88 PF12436 0.336
DOC_WW_Pin1_4 79 84 PF00397 0.325
LIG_14-3-3_CanoR_1 131 137 PF00244 0.348
LIG_14-3-3_CanoR_1 39 48 PF00244 0.420
LIG_BRCT_BRCA1_1 229 233 PF00533 0.397
LIG_deltaCOP1_diTrp_1 143 153 PF00928 0.333
LIG_EH1_1 39 47 PF00400 0.359
LIG_eIF4E_1 260 266 PF01652 0.239
LIG_FHA_1 41 47 PF00498 0.359
LIG_FHA_2 123 129 PF00498 0.388
LIG_IRF3_LxIS_1 48 55 PF10401 0.475
LIG_LIR_Gen_1 150 159 PF02991 0.332
LIG_LIR_Gen_1 200 208 PF02991 0.328
LIG_LIR_Gen_1 28 34 PF02991 0.587
LIG_LIR_Nem_3 150 156 PF02991 0.330
LIG_LIR_Nem_3 19 23 PF02991 0.660
LIG_LIR_Nem_3 211 216 PF02991 0.375
LIG_LIR_Nem_3 28 33 PF02991 0.559
LIG_LYPXL_yS_3 213 216 PF13949 0.434
LIG_MYND_1 10 14 PF01753 0.725
LIG_PCNA_PIPBox_1 253 262 PF02747 0.409
LIG_PCNA_yPIPBox_3 250 260 PF02747 0.416
LIG_SH2_CRK 169 173 PF00017 0.304
LIG_SH2_CRK 20 24 PF00017 0.669
LIG_SH2_CRK 261 265 PF00017 0.359
LIG_SH2_CRK 30 34 PF00017 0.559
LIG_SH2_CRK 63 67 PF00017 0.305
LIG_SH2_SRC 20 23 PF00017 0.684
LIG_SH2_STAP1 169 173 PF00017 0.304
LIG_SH2_STAP1 261 265 PF00017 0.302
LIG_SH2_STAP1 30 34 PF00017 0.605
LIG_SH2_STAT5 196 199 PF00017 0.339
LIG_SH2_STAT5 73 76 PF00017 0.315
LIG_SH3_3 20 26 PF00018 0.635
LIG_SH3_3 261 267 PF00018 0.394
LIG_SUMO_SIM_par_1 77 82 PF11976 0.311
LIG_TRAF2_1 125 128 PF00917 0.410
LIG_TYR_ITIM 61 66 PF00017 0.341
LIG_UBA3_1 202 210 PF00899 0.367
LIG_UBA3_1 245 250 PF00899 0.375
MOD_CDK_SPK_2 79 84 PF00069 0.325
MOD_CK1_1 224 230 PF00069 0.427
MOD_CK1_1 4 10 PF00069 0.753
MOD_CK1_1 44 50 PF00069 0.439
MOD_CK2_1 120 126 PF00069 0.379
MOD_CK2_1 278 284 PF00069 0.492
MOD_GlcNHglycan 191 194 PF01048 0.573
MOD_GlcNHglycan 295 298 PF01048 0.773
MOD_GlcNHglycan 3 6 PF01048 0.541
MOD_GlcNHglycan 54 57 PF01048 0.409
MOD_GSK3_1 272 279 PF00069 0.497
MOD_GSK3_1 285 292 PF00069 0.453
MOD_GSK3_1 40 47 PF00069 0.421
MOD_N-GLC_1 179 184 PF02516 0.579
MOD_N-GLC_1 227 232 PF02516 0.643
MOD_N-GLC_2 72 74 PF02516 0.556
MOD_NEK2_1 1 6 PF00069 0.719
MOD_NEK2_1 189 194 PF00069 0.399
MOD_NEK2_1 40 45 PF00069 0.328
MOD_NEK2_1 52 57 PF00069 0.399
MOD_PIKK_1 158 164 PF00454 0.412
MOD_PIKK_1 272 278 PF00454 0.483
MOD_PIKK_1 285 291 PF00454 0.388
MOD_PKA_2 241 247 PF00069 0.393
MOD_PKB_1 130 138 PF00069 0.411
MOD_Plk_1 227 233 PF00069 0.401
MOD_Plk_2-3 120 126 PF00069 0.448
MOD_Plk_4 152 158 PF00069 0.369
MOD_Plk_4 241 247 PF00069 0.353
MOD_Plk_4 41 47 PF00069 0.395
MOD_ProDKin_1 79 85 PF00069 0.334
MOD_SUMO_for_1 10 13 PF00179 0.755
MOD_SUMO_for_1 249 252 PF00179 0.404
MOD_SUMO_rev_2 103 111 PF00179 0.341
MOD_SUMO_rev_2 177 186 PF00179 0.394
MOD_SUMO_rev_2 281 288 PF00179 0.557
MOD_SUMO_rev_2 82 91 PF00179 0.409
TRG_DiLeu_BaEn_2 198 204 PF01217 0.421
TRG_ENDOCYTIC_2 169 172 PF00928 0.304
TRG_ENDOCYTIC_2 20 23 PF00928 0.640
TRG_ENDOCYTIC_2 213 216 PF00928 0.401
TRG_ENDOCYTIC_2 260 263 PF00928 0.336
TRG_ENDOCYTIC_2 30 33 PF00928 0.573
TRG_ENDOCYTIC_2 63 66 PF00928 0.309
TRG_ER_diArg_1 130 132 PF00400 0.408
TRG_ER_diArg_1 37 40 PF00400 0.591
TRG_ER_diArg_1 66 68 PF00400 0.345
TRG_NES_CRM1_1 95 108 PF08389 0.330
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.616

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8V1 Leptomonas seymouri 73% 100%
A0A0S4KJI8 Bodo saltans 36% 100%
A0A1X0NLH2 Trypanosomatidae 54% 100%
A0A3Q8IKF0 Leishmania donovani 99% 100%
A0A422NVW1 Trypanosoma rangeli 55% 100%
A4HQL9 Leishmania braziliensis 82% 100%
D0A3S2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AUD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q056 Leishmania major 93% 100%
V5AXP5 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS